Ronald P Van Rij
Affiliation: Radboud University
Country: The Netherlands
Schuster S, Zirkel F, Kurth A, van Cleef K, Drosten C, Van Rij R, et al
. A unique nodavirus with novel features: mosinovirus expresses two subgenomic RNAs, a capsid gene of unknown origin, and a suppressor of the antiviral RNA interference pathway. J Virol. 2014;88:13447-59 pubmed publisher
..Our results show that complete genome segments can be exchanged beyond the species level and suggest that insects harbor a large repertoire of exceptional viruses. ..
Van Rij R, Berezikov E. Small RNAs and the control of transposons and viruses in Drosophila. Trends Microbiol. 2009;17:163-71 pubmed publisher
..Furthermore, the detection of viral siRNAs of both (+) and (-) polarity implicates double-stranded RNA replication intermediates as the Dicer substrates that mediate antiviral defense. ..
van Cleef K, van Mierlo J, Miesen P, Overheul G, Fros J, Schuster S, et al
. Mosquito and Drosophila entomobirnaviruses suppress dsRNA- and siRNA-induced RNAi. Nucleic Acids Res. 2014;42:8732-44 pubmed publisher
..Together, our data indicate that mosquito-specific viruses may encode RNAi antagonists to suppress antiviral RNAi. ..
Bronkhorst A, Van Rij R. The long and short of antiviral defense: small RNA-based immunity in insects. Curr Opin Virol. 2014;7:19-28 pubmed publisher
..Here, we review recent insights into the mechanism of antiviral RNAi, viral small RNA profiles, and viral counter-defense mechanisms in insects. ..