Peter M van der Kraan

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi request reprint Stem cell therapy in osteoarthritis: a step too far?
    Peter M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    BioDrugs 27:175-80. 2013
  2. doi request reprint Understanding developmental mechanisms in the context of osteoarthritis
    Peter M van der Kraan
    Department of Rheumatology, Radboud University Medical Centre, Geert Grooteplein 26 28, 6525 GA, Nijmegen, The Netherlands
    Curr Rheumatol Rep 15:333. 2013
  3. doi request reprint Osteoarthritis year 2012 in review: biology
    P M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 20:1447-50. 2012
  4. doi request reprint Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
    P M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, 6525 Nijmegen, The Netherlands
    Osteoarthritis Cartilage 20:223-32. 2012
  5. doi request reprint TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 17:1539-45. 2009
  6. doi request reprint Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 18:735-41. 2010
  7. ncbi request reprint Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Centre, Geert Grooteplein 28, Nijmegen, The Netherlands
    Ageing Res Rev 7:106-13. 2008
  8. ncbi request reprint Osteophytes: relevance and biology
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 15:237-44. 2007
  9. pmc Age-dependent alteration of TGF-β signalling in osteoarthritis
    Peter M van der Kraan
    Department of Rheumatology, Radboud University Nijmegen Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Cell Tissue Res 347:257-65. 2012
  10. pmc Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 7:R1338-47. 2005

Collaborators

Detail Information

Publications31

  1. doi request reprint Stem cell therapy in osteoarthritis: a step too far?
    Peter M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    BioDrugs 27:175-80. 2013
    ..Stem cell therapy is a remedy with the potential for a great future; however, this outlook could be jeopardized if this treatment is introduced too early into clinical practice...
  2. doi request reprint Understanding developmental mechanisms in the context of osteoarthritis
    Peter M van der Kraan
    Department of Rheumatology, Radboud University Medical Centre, Geert Grooteplein 26 28, 6525 GA, Nijmegen, The Netherlands
    Curr Rheumatol Rep 15:333. 2013
    ....
  3. doi request reprint Osteoarthritis year 2012 in review: biology
    P M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 20:1447-50. 2012
    ....
  4. doi request reprint Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
    P M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, 6525 Nijmegen, The Netherlands
    Osteoarthritis Cartilage 20:223-32. 2012
    ..To review the literature on the role and regulation of chondrocyte terminal differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a conceptual model of primary OA development...
  5. doi request reprint TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 17:1539-45. 2009
    ..This review is focused on the modulation of receptor-Smad signaling and how this modulation can affect chondrocyte differentiation and potentially osteoarthritis development...
  6. doi request reprint Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 18:735-41. 2010
    ..This review is focused on these opposed roles of BMPs in OA development and progression...
  7. ncbi request reprint Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Centre, Geert Grooteplein 28, Nijmegen, The Netherlands
    Ageing Res Rev 7:106-13. 2008
    ..The loss of this differentiation block, maybe as a result of changes in chondrocyte TGF beta signalling, results in combination with normal joint loading in cartilage degeneration and OA...
  8. ncbi request reprint Osteophytes: relevance and biology
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 15:237-44. 2007
    ..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
  9. pmc Age-dependent alteration of TGF-β signalling in osteoarthritis
    Peter M van der Kraan
    Department of Rheumatology, Radboud University Nijmegen Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Cell Tissue Res 347:257-65. 2012
    ..The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype...
  10. pmc Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 7:R1338-47. 2005
    ..In conclusion, TGF-beta appears to play an important role in repair of cartilage and a lack of TGF-beta responsiveness in old mice might be at the root of OA development...
  11. pmc A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 12:201. 2010
    ..In this paper we summarize concepts in OA, its link with ageing and disturbed growth factor responses, and a potential role of TGFbeta signaling in OA development...
  12. doi request reprint Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
    ..Our data suggest that dominant ALK1 signaling results in deviant chondrocyte behavior, thereby contributing to age-related cartilage destruction and OA...
  13. doi request reprint Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1
    Arjen B Blom
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 60:501-12. 2009
    ..The present study was undertaken to characterize the expression pattern of Wnt and Fz genes during experimental OA and to determine the function of selected genes in experimental and human OA...
  14. doi request reprint Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells
    Genoveva T H Heldens
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Tissue Eng Part A 18:45-54. 2012
    ....
  15. ncbi request reprint STRO-1 selected rat dental pulp stem cells transfected with adenoviral-mediated human bone morphogenetic protein 2 gene show enhanced odontogenic differentiation
    Xuechao Yang
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Tissue Eng 13:2803-12. 2007
    ..After BMP2 gene transfection, these cells had the ability to differentiate into odontoblast phenotype, even without the addition of odontogenic supplements to the medium...
  16. ncbi request reprint Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system
    Alwin Scharstuhl
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center Nijmegen, Geert Grooteplein Zuid 26 28, 6525 GA, Nijmegen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 786:271-7. 2003
    ..In conclusion, our large-scale protein expression procedure results in high quantities of purified solRII, which is a powerful tool to study the natural role of TGF-beta...
  17. pmc TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St, Radboud University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 8:R65. 2006
    ..TGFbeta-induced synovial fibrosis was blocked by locally inhibiting TGFbeta signaling in the synovial lining by simultaneously transfecting it with an adenovirus overexpressing Smad7...
  18. pmc Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
    ..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix...
  19. ncbi request reprint Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
    Alwin Scharstuhl
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:3442-51. 2003
    ..The aim of this study was to elucidate the role of endogenous TGFbeta and BMP during papain-induced OA-like changes in mice...
  20. ncbi request reprint Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3
    Arjen B Blom
    Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 56:147-57. 2007
    ..To explore the involvement of synovial macrophages in early cartilage damage in osteoarthritis (OA), and to identify the role of matrix metalloproteinase 3 (MMP-3) in the pathology of early and late OA...
  21. ncbi request reprint To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy
    Arjen B Blom
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre Nijmegen, The Netherlands
    Curr Drug Targets 11:620-9. 2010
    ....
  22. doi request reprint Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function
    Fons A J van de Loo
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:3313-23. 2012
    ..To determine the expression of suppressor of cytokine signaling 3 (SOCS-3) in human articular chondrocytes and its functional consequences...
  23. ncbi request reprint Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair
    Alwin Scharstuhl
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 169:507-14. 2002
    ..In conclusion, we show for the first time that endogenous TGF-beta is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss...
  24. ncbi request reprint Cytokine targeting in osteoarthritis
    Arjen B Blom
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Drug Targets 8:283-92. 2007
    ..g. with or without marked synovial activation, treatment may be focused mainly on suppression of catabolism or stimulation of anabolism, but combination therapy seems most warranted...
  25. doi request reprint TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling
    Dennis F G Remst
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26 28, 6525 GA, Nijmegen, The Netherlands
    Cell Tissue Res 355:163-71. 2014
    ..We showed, in osteoarthritic hSF, that TGF-ß induced PLOD2/LH2 via ALK5 Smad2/3P. This elevation of LH2b in osteoarthritic hSF makes LH2b an interesting target to interfere with osteoarthritis-related persistent fibrosis. ..
  26. pmc Elevated levels of numerous cytokines in drainage fluid after primary total hip arthroplasty
    Huub J L van der Heide
    Department of Orthopaedic Surgery, Radboud University Nijmegen Medical Centre, The Netherlands
    Int Orthop 34:1099-102. 2010
    ..We found a strong correlation between the different pro-inflammatory cytokines. The IL-6 to IL-10 ratio were also raised, showing a pro-inflammatory predominance. Levels were much higher than those previously shown in serum...
  27. ncbi request reprint Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Geert Grooteplein 26 28, GA 6525, Nijmegen, The Netherlands
    Biomaterials 25:1497-504. 2004
    ..Development of animal models that can be used for tissue engineering experiments and mimic end stage arthritic diseases is needed...
  28. doi request reprint A theranostic agent to enhance osteogenic and magnetic resonance imaging properties of calcium phosphate cements
    Manuela Ventura
    Department of Biomaterials, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 35:2227-33. 2014
    ..Moreover, the TA was released during CPC degradation and was not incorporated into the newly formed bone. In conclusion, the described TA was shown to be suitable for longitudinal material degradation and bone healing studies. ..
  29. pmc Biological effects of rinsing morsellised bone grafts before and after impaction
    Gerjon Hannink
    Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int Orthop 33:861-6. 2009
    ..Osteogenic differentiation of hMSCs was inhibited by the fluid. Results from our study leave us only able to speculate whether rinsing grafts again after impaction has a beneficial effect on the incorporation process or not...
  30. doi request reprint Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice
    Monique C M Balemans
    Department of Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Dev Biol 386:395-407. 2014
    ..The increased expression of bone developmental genes in the Ehmt1(+/-) mice likely contributes to their cranial dysmorphisms and might be explained by diminished Ehmt1-induced H3K9 dimethylation. ..
  31. doi request reprint Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Toxicol Sci 129:225-33. 2012
    ..Eventually, this leads to hepatic iron loading associated with APAP cytotoxicity...