Peter LEM van Lent

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation
    Wouter Hofkens
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e54016. 2013
  2. doi request reprint Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
    Peter L E M van Lent
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1466-76. 2012
  3. pmc Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
  4. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
  5. doi request reprint S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis
    Peter L van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3353-64. 2010
  6. doi request reprint Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy
    Peter L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Biol 85:860-71. 2009
  7. doi request reprint Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis
    P L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3776-87. 2008
  8. ncbi request reprint Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis
    P L E M van Lent
    Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Building 850, Geert Grooteplein 26 28, Nijmegen, The Netherlands
    Ann Rheum Dis 67:1750-8. 2008
  9. doi request reprint Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis
    P L E M van Lent
    Department of Rhumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 60:2954-65. 2009
  10. ncbi request reprint Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation
    Peter L van Lent
    Rheumatology Department, Radboud University Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 54:3868-77. 2006

Collaborators

Detail Information

Publications19

  1. pmc Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation
    Wouter Hofkens
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e54016. 2013
    ..To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis...
  2. doi request reprint Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
    Peter L E M van Lent
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1466-76. 2012
    ..To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)...
  3. pmc Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
    ..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix...
  4. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
    ..This study demonstrates that IL-13 overexpression during ICA diminished both chondrocyte death and MMP-mediated VDIPEN expression, even though joint inflammation was enhanced...
  5. doi request reprint S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis
    Peter L van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3353-64. 2010
    ..This study was undertaken to study the active involvement of S100A8, S100A9, and S100A8/S100A9 in FcγR regulation in murine macrophages and synovium during AIA...
  6. doi request reprint Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy
    Peter L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Biol 85:860-71. 2009
    ....
  7. doi request reprint Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis
    P L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3776-87. 2008
    ..To investigate whether S100A8 is actively involved in matrix metalloproteinase (MMP)-mediated chondrocyte activation...
  8. ncbi request reprint Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis
    P L E M van Lent
    Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Building 850, Geert Grooteplein 26 28, Nijmegen, The Netherlands
    Ann Rheum Dis 67:1750-8. 2008
    ..To study the active involvement of Myeloid-related proteins S100A8 and S100A9 in joint inflammation and cartilage destruction during antigen-induced arthritis (AIA)...
  9. doi request reprint Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis
    P L E M van Lent
    Department of Rhumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 60:2954-65. 2009
    ..This study was undertaken to investigate the role of SR-AI/II in mediating severe cartilage destruction in antigen-induced arthritis (AIA)...
  10. ncbi request reprint Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation
    Peter L van Lent
    Rheumatology Department, Radboud University Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 54:3868-77. 2006
    ..To determine the relationship between synovial inflammation and the concomitant occurrence of cartilage and bone erosion during conditions of variable inflammation using various Fcgamma receptor knockout (FcgammaR(-/-)) mice...
  11. pmc Toll-like receptor 4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcgammaR expression by interleukin 10
    P L E M van Lent
    Department of Rheumatology and Advanced Therapeutics, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 66:334-40. 2007
    ..To study the role of Toll-like receptor (TLR)2 and 4 in the onset of joint inflammation and cartilage destruction during immune complex-mediated arthritis (ICA), and its relationship with FcgammaR expression...
  12. pmc NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R885-95. 2005
    ..Upregulation of FcgammaRI by oxygen radicals may contribute to cartilage destruction...
  13. pmc Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis
    P L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:368-74. 2005
    ..To assess the expression and localisation of the new metalloproteinase inhibitor RECK, an inhibitor of matrix metalloproteinase-14 (MMP-14) secretion and activity, in the synovial membrane of patients with rheumatoid arthritis (RA)...
  14. ncbi request reprint Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation
    P L E M van Lent
    University Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 50:103-11. 2004
    ..To investigate in vivo and in vitro whether macrophages have an intermediate role in transforming growth factor beta (TGFbeta)-induced osteophyte formation...
  15. pmc The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes
    Peter van Lent
    Department of Rheumatology, University Medical Centre St Radboud, UMC Nijmegen Building 850, Geert Grooteplein 26 28, Nijmegen, The Netherlands
    Am J Pathol 163:1839-48. 2003
    ..Infiltrating cells, which fail to express activating FcgammaR although they still become stimulated are no longer capable of inducing severe cartilage destruction...
  16. ncbi request reprint Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression
    N Takahashi
    Department of Rheumatology Research and Advanced Therapeutics, UMC Nijmegen NCMLS, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 13:426-38. 2005
    ....
  17. ncbi request reprint Phenotypic differences in murine chondrocyte cell lines derived from mature articular cartilage
    H M van Beuningen
    Laboratory of Experimental Rheumatology, University Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 10:977-86. 2002
    ..To obtain well characterized immortalized murine chondrocyte cell lines. The cell lines were obtained from mature articular chondrocytes, instead of embryonal cells which are used in most other studies...
  18. ncbi request reprint Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist
    R L Smeets
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 52:2202-11. 2005
    ..To discern the mode of interleukin-1 (IL-1) inhibition of soluble IL-1 receptor accessory protein (sIL-1RAcP) by comparison with IL-1 receptor antagonist (IL-1Ra) in arthritis...