P C M van de Kerkhof

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint The topical treatment of psoriasis
    P C M van de Kerkhof
    Clin Exp Dermatol 30:205-8. 2005
  2. ncbi request reprint Alefacept in the treatment of psoriasis in patients for whom conventional therapies are inadequate
    P Van De Kerkhof
    Department of Dermatology, UMC St Radboud, Nijmegen, The Netherlands
    Dermatology 211:256-63. 2005
  3. doi request reprint Once weekly administration of etanercept 50 mg is efficacious and well tolerated in patients with moderate-to-severe plaque psoriasis: a randomized controlled trial with open-label extension
    P C M van de Kerkhof
    Department of Dermatology, UMC St Radboud, PO Box 9101, 65 HB Nijmegen, The Netherlands
    Br J Dermatol 159:1177-85. 2008
  4. ncbi request reprint Established treatments of psoriasis
    Peter C M van de Kerkhof
    Department of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Curr Drug Targets Inflamm Allergy 3:145-56. 2004
  5. ncbi request reprint Psoriasis of the face and flexures
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dermatolog Treat 18:351-60. 2007
  6. ncbi request reprint The evolution of the psoriatic lesion
    P C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 157:4-15. 2007
  7. ncbi request reprint Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen, Medical Center, Nijmegen, The Netherlands
    Dermatol Ther 19:252-63. 2006
  8. ncbi request reprint The impact of a two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/ Dovobet) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trial
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 151:663-8. 2004
  9. ncbi request reprint Current and future treatment options for acne
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherland
    J Dermatolog Treat 17:198-204. 2006
  10. ncbi request reprint A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting
    P C M van de Kerkhof
    Department of Dermatology, Academisch Medisch Centrum, Meibergdreef 9, 1105 AC Amsterdam, The Netherlands
    Br J Dermatol 155:800-7. 2006

Detail Information

Publications156 found, 100 shown here

  1. ncbi request reprint The topical treatment of psoriasis
    P C M van de Kerkhof
    Clin Exp Dermatol 30:205-8. 2005
  2. ncbi request reprint Alefacept in the treatment of psoriasis in patients for whom conventional therapies are inadequate
    P Van De Kerkhof
    Department of Dermatology, UMC St Radboud, Nijmegen, The Netherlands
    Dermatology 211:256-63. 2005
    ..Many patients with moderate to severe chronic plaque psoriasis fail to respond to or are not appropriate candidates for conventional systemic therapies and/or phototherapy...
  3. doi request reprint Once weekly administration of etanercept 50 mg is efficacious and well tolerated in patients with moderate-to-severe plaque psoriasis: a randomized controlled trial with open-label extension
    P C M van de Kerkhof
    Department of Dermatology, UMC St Radboud, PO Box 9101, 65 HB Nijmegen, The Netherlands
    Br J Dermatol 159:1177-85. 2008
    ..In previous studies, etanercept 25 mg twice weekly (BIW) or 50 mg BIW significantly reduced disease severity in patients with plaque psoriasis and demonstrated a favourable safety profile...
  4. ncbi request reprint Established treatments of psoriasis
    Peter C M van de Kerkhof
    Department of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Curr Drug Targets Inflamm Allergy 3:145-56. 2004
    ..In this article the opportunities and limitations of the available treatments are presented...
  5. ncbi request reprint Psoriasis of the face and flexures
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dermatolog Treat 18:351-60. 2007
    ..4) In case topical therapies are not effective, phototherapy and systemic treatments are indicated. (5) For future drug development the combination of vitamin D3 analogues with low strength corticosteroids is recommended...
  6. ncbi request reprint The evolution of the psoriatic lesion
    P C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 157:4-15. 2007
    ..In this review observations on the evolution from the symptomless skin to lesional skin in patients with psoriasis will be integrated with observations in various animal models of psoriasis...
  7. ncbi request reprint Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen, Medical Center, Nijmegen, The Netherlands
    Dermatol Ther 19:252-63. 2006
    ..Finally, retinoid X receptor ligands and retinoic acid metabolism blocking agents will be introduced as potential future retinoid mimetics in psoriasis...
  8. ncbi request reprint The impact of a two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/ Dovobet) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trial
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 151:663-8. 2004
    ..Psoriasis is a common disease and may have a significant impact on patients' quality of life (QoL)...
  9. ncbi request reprint Current and future treatment options for acne
    Peter C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherland
    J Dermatolog Treat 17:198-204. 2006
    ..Challenging new options comprise blue light, photodynamic therapy, retinoic acid metabolism blocking agents and inhibitors of Th-1 cytokines...
  10. ncbi request reprint A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting
    P C M van de Kerkhof
    Department of Dermatology, Academisch Medisch Centrum, Meibergdreef 9, 1105 AC Amsterdam, The Netherlands
    Br J Dermatol 155:800-7. 2006
    ..In a comparative study in patients visiting the outpatient department once every 14 days, it was shown that calcipotriol was more effective and better tolerated compared with dithranol...
  11. ncbi request reprint Consistent control of psoriasis by continuous long-term therapy: the promise of biological treatments
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 20:639-50. 2006
    ....
  12. ncbi request reprint Recommendations for the topical treatment of psoriasis
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 19:495-9. 2005
    ..Finally, we provide recommendations for the treatment of particular localizations: the scalp and psoriasis at sensitive sites...
  13. ncbi request reprint Psoriasis: severity assessment in clinical practice. Conclusions from workshop discussions and a prospective multicentre survey of psoriasis severity
    Peter C M van de Kerkhof
    Department of Dermatology, Rikshospitalet, Oslo, Norway, and Service de Dermatologie, Universite de Liege, Belgium
    Eur J Dermatol 16:167-71. 2006
    ..In clinical practice, a host of factors must be evaluated alongside possible metric measures. This requires experience and the specialized medical education of those involved in the treatment of patients with psoriasis...
  14. doi request reprint Options for the treatment of psoriasis: a multifactorial approach
    Peter C M van de Kerkhof
    Department of Dermatology, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Dermatol 26:419-23. 2008
    ..In this article, we will provide a patient-based approach on the management of psoriasis, which reconciles the heterogeneity of psoriasis in individual patients...
  15. ncbi request reprint A two-compound product containing calcipotriol and betamethasone dipropionate provides rapid, effective treatment of psoriasis vulgaris regardless of baseline disease severity
    P C M van de Kerkhof
    University Hospital Nijmegen, Nijmegen, The Netherlands
    Dermatology 210:294-9. 2005
    ..A two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/Dovobet) has been evaluated in a large clinical trial programme, providing a wealth of data on the treatment of psoriasis vulgaris...
  16. doi request reprint Improving clinical trial design in psoriasis: Perspectives from the global dermatology community
    Peter van de Kerkhof
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dermatolog Treat 22:187-93. 2011
    ..The majority of studies do not address the important need for long-term treatment...
  17. doi request reprint Novel biologic therapies in development targeting IL-12/IL-23
    P C M van de Kerkhof
    Department of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 24:5-9. 2010
    ..Phase 2 data indicate that ABT-874 is also efficacious in the treatment of moderate-to-severe plaque psoriasis across a range of dosing strategies...
  18. doi request reprint Factors impacting the combination of topical corticosteroid therapies for psoriasis: perspectives from the International Psoriasis Council
    P C M van de Kerkhof
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 25:1130-9. 2011
    ..This review covers features of topical corticosteroid formulations that affect bioavailability, efficacy and safety when used as monotherapy and in combination with other agents for the treatment of mild to moderate psoriasis...
  19. ncbi request reprint Explorative immunohistochemical study to evaluate the addition of a topical corticosteroid in the early phase of alefacept treatment for psoriasis
    H J Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, P O Box 9101, Nijmegen, 6500 HB, The Netherlands
    Arch Dermatol Res 298:457-63. 2007
    ..Once daily treatment with betamethasone dipropionate cream during the first 4 weeks of an intramuscular alefacept course did not provide substantial additional clinical and immunohistochemical improvement...
  20. ncbi request reprint Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study
    M M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Center, Rene Descartesdreef 1, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 155:539-45. 2006
    ..Variations in fluorescence might explain the variable and the mostly partial clinical response of psoriasis seen after photodynamic therapy (PDT)...
  21. doi request reprint Relevance of compartmentalization of T-cell subsets for clinical improvement in psoriasis: effect of immune-targeted antipsoriatic therapies
    R G van Lingen
    Department of Dermatology, Radboud University, Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 159:91-6. 2008
    ..No analyses of T-cell counts in both compartments have been conducted in order to confirm or refute the hypothesized shifts between them...
  22. ncbi request reprint The effects of topical corticosteroids and a coal tar preparation on dithranol-induced irritation in patients with psoriasis
    O Q J Swinkels
    Department of Dermatology University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 16:12-7. 2003
    ....
  23. doi request reprint Distribution of dipeptidyl-peptidase IV on keratinocytes in the margin zone of a psoriatic lesion: a comparison with hyperproliferation and aberrant differentiation markers
    R G van Lingen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arch Dermatol Res 300:561-7. 2008
    ..The abnormal DPPIV distribution in psoriatic skin does not coincide with known markers of aberrant growth and differentiation of keratinocytes, which makes DPPIV (expression and enzyme activity) a marker standing on its own...
  24. ncbi request reprint The Impact of Chronic Skin Disease on Daily Life (ISDL): a generic and dermatology-specific health instrument
    A W M Evers
    Departments of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 158:101-8. 2008
    ....
  25. ncbi request reprint Pulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: effects on T-cell infiltration, epidermal proliferation and keratinization
    H Jorn Bovenschen
    Radboud University Nijmegen Medical Centre, Rene Descartesdreef 1, 6525 GL, Nijmeger, The Netherlands
    J Dermatolog Treat 18:32-9. 2007
    ..Selective photothermolysis of diseased capillaries by pulsed dye laser (PDL) treatment has been described as a mechanism for long-lasting clearance of psoriatic plaques...
  26. ncbi request reprint A double-blind, randomized quantitative comparison of calcitriol ointment and calcipotriol ointment on epidermal cell populations, proliferation and differentiation
    J E M Körver
    Department of Dermatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 156:130-7. 2007
    ..However, studies comparing both treatment modalities are scarce. Especially, there are almost no studies comparing the effects on epidermal cell populations in a quantitative manner...
  27. ncbi request reprint Prevalence of physical symptoms of itch, pain and fatigue in patients with skin diseases in general practice
    E W M Verhoeven
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 156:1346-9. 2007
    ..Although insight into physical symptoms accompanying skin diseases is relevant for the management and treatment of skin diseases, the prevalence of physical symptoms among patients with skin diseases is a rather unexplored territory...
  28. ncbi request reprint Effectiveness and side effects of UVB-phototherapy, dithranol inpatient therapy and a care instruction programme of short contact dithranol in moderate to severe psoriasis
    O Q J Sminkels
    Department of Dermatology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, Netherlands
    Eur J Dermatol 14:159-65. 2004
    ..Comparison between different antipsoriatic treatments should, besides clearing capacity, reconcile duration of remission, safety, patient acceptability and costs...
  29. ncbi request reprint A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: quality-of-life outcomes of a randomized controlled trial of supervised treatment of psoriasis in a day-care setting
    J de Korte
    Department of Dermatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Dermatol 158:375-81. 2008
    ..Quality of life, i.e. the physical, psychological, and social functioning and well-being of the patient, has become an essential outcome measure in chronic skin disease...
  30. ncbi request reprint The effect of the combination of calcipotriol and betamethasone dipropionate versus both monotherapies on epidermal proliferation, keratinization and T-cell subsets in chronic plaque psoriasis
    W H P M Vissers
    Department of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Exp Dermatol 13:106-12. 2004
    ..It is concluded that the action spectra of calcipotriol and betamethasone on the psoriatic plaque are different and that the combination has effects on T-cell subsets, beyond the addition of the effects of monotherapies...
  31. ncbi request reprint An immunohistochemical assessment of the response of the psoriatic lesion to single and repeated applications of high-dose dithranol cream
    O Q J Swinkels
    Department of Dermatology, University Medical Centre Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 15:393-400. 2002
    ..As dithranol does not reduce the number of T lymphocytes, it is attractive to speculate that the combination of dithranol with immunosuppressive treatments might be a very effective combination...
  32. ncbi request reprint Effect of calcipotriol on epidermal cell populations in alefacept-treated psoriatic lesions
    M W F M van Duijnhoven
    Department of Dermatology, UMC St Radboud, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 20:27-33. 2006
    ..Epidermal cell populations were measured quantitatively with this sensitive method...
  33. ncbi request reprint Combining lesional short-contact dithranol therapy of psoriasis with a potent topical corticosteroid
    O Q J Swinkels
    Department of Dermatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 146:621-6. 2002
    ..Out-patient short-contact dithranol treatment is effective with regard to clinical response rate and relapse rate after 1 year. A drawback, however, is the relatively long treatment duration...
  34. ncbi request reprint Assessment of epidermal subpopulations and proliferation in healthy skin, symptomless and lesional skin of spreading psoriasis
    J E M Körver
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 155:688-94. 2006
    ..However, the dynamics of the changes in the epidermal subpopulations-basal cells, transit amplifying cells and differentiated cells-have not been studied in the transition between symptomless and lesional skin...
  35. doi request reprint Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06
    J G M Bergboer
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 167:922-5. 2012
    ..Recent genome-wide association studies have identified several genetic risk factors for psoriasis, but data on their association with age at onset are lacking...
  36. doi request reprint The effect of alefacept on T-cell subsets and cells expressing NK receptors in lesional psoriatic skin: the effects of monotherapy and combination treatment with calcipotriol
    W H P M Vissers
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dermatolog Treat 19:344-50. 2008
    ..Furthermore, the addition of calcipotriol cream to alefacept treatment was studied and compared with alefacept monotherapy...
  37. doi request reprint Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells
    T Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 160:849-57. 2009
    ..Preferential PpIX accumulation has been reported in terminally differentiated cell cultures but ex vivo data are lacking...
  38. ncbi request reprint A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis
    T Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Rene Descartesdreef 1, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 155:429-36. 2006
    ..In these studies different treatment parameters were used, there was a variable clinical response, and a nonhomogeneous fluorescence was seen after irradiation with Wood's light...
  39. doi request reprint No evidence found that childhood onset of psoriasis influences disease severity, future body mass index or type of treatments used
    M E A de Jager
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 24:1333-9. 2010
    ..In more than one-third of the psoriatic population, the first manifestations occur in childhood. Whether the age of onset of psoriasis influences the march of psoriasis is not known...
  40. doi request reprint Three-year registry data on biological treatment for psoriasis: the influence of patient characteristics on treatment outcome
    R J B Driessen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 160:670-5. 2009
    ..Treatment modifications and patient characteristics may influence treatment safety and efficacy. So far, long-term results from the use of biological treatment in clinical practice are lacking...
  41. doi request reprint Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression
    W H P M Vissers
    Department of Dermatology, Radboud University Medical Centre Nijmegen, René Descartes dreef 1, Nijmegen, The Netherlands
    Br J Dermatol 158:705-12. 2008
    ..g. the transcription of proinflammatory cytokines, keratinocyte hyperproliferation and the expression of HLA-DR in lesional psoriatic skin...
  42. doi request reprint Etanercept combined with methotrexate for high-need psoriasis
    R J B Driessen
    Department of Dermatology, Radboud University Medical Centre, PO Box 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 159:460-3. 2008
    ..In these cases it might be indicated to combine etanercept with other conventional treatments. Objectives To provide daily practice safety and efficacy data for etanercept and methotrexate combination therapy...
  43. ncbi request reprint Oral retinoic acid metabolism blocking agent Rambazole for plaque psoriasis: an immunohistochemical study
    H J Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Center, NL 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 156:263-70. 2007
    ..Well-known effects of RA are normalization of aberrant epithelial growth and differentiation. Hence, rambazole might be beneficial in the treatment of plaque psoriasis...
  44. doi request reprint Role of induced negative and positive emotions in sensitivity to itch and pain in women
    A I M van Laarhoven
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 167:262-9. 2012
    ..It has been suggested that negative emotions may play a role in itch and pain. To date, however, the role of emotions has only been studied for pain in experimental studies, not yet for itch...
  45. ncbi request reprint Efficacy of the pulsed dye laser in the treatment of localized recalcitrant plaque psoriasis: a comparative study
    A Erceg
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Rene Descartesdreef 1, PO Box 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 155:110-4. 2006
    ..The treatment of these lesions with a pulsed dye laser (PDL) has been described before, but a comparative study between the PDL and a potent topical treatment has never been performed...
  46. ncbi request reprint The response of uninvolved skin of patients with psoriasis to single and repeated applications of dithranol cream: an immunohistochemical assessment
    O Q J Swinkels
    Department of Dermatology, University Medical Centre Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 15:385-92. 2002
    ....
  47. ncbi request reprint The topical treatment of psoriasis
    P C M van de Kerkhof
    Department of Dermatology, University of Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 16:69-83. 2003
    ....
  48. ncbi request reprint Dermatologists' adherence to the guideline of the Dutch Society of Dermatology and Venereology with respect to the treatment with methotrexate for severe chronic plaque psoriasis: results from a Dutch survey
    M A M Berends
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dermatology 215:45-52. 2007
    ..In 2003, the Dutch guideline 'Photo(chemo) therapy and systemic therapy for severe chronic plaque psoriasis' was established...
  49. doi request reprint Treatment of scalp psoriasis with clobetasol-17 propionate 0.05% shampoo: a study on daily clinical practice
    H J Bovenschen
    Department of Dermatology, Rene Descartesdreef 1, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 24:439-44. 2010
    ..Safety and clinical effectiveness of clobetasol-17 propionate 0.05% shampoo have been shown in patients with scalp psoriasis...
  50. doi request reprint Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion
    M E A de Jager
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dermatology 220:329-32. 2010
    ..In childhood psoriasis, physicians aim for an effective and safe treatment such as with dithranol. This study presents the largest study of dithranol-treated patients described in the literature...
  51. doi request reprint Itch and scratching as predictors of time to clearance of psoriasis with narrow-band ultraviolet B therapy
    A W M Evers
    Department of Medical Psychology 840, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Br J Dermatol 161:542-6. 2009
    ..While several clinical and treatment-related factors predict time to clearance, the effect of itching and scratching on the number of irradiation sessions is insufficiently understood...
  52. ncbi request reprint The effect of the PDE-4 inhibitor (cipamfylline) in two human models of irritant contact dermatitis
    M Kucharekova
    Department of Dermatology, University Medical Centre St Radboud, P O Box 9101, Nijmegen, The Netherlands
    Arch Dermatol Res 295:29-32. 2003
    ..We compared the effect of cipamfylline ointment with a strong corticosteroid (betamethasone-17-valerate) and with a placebo ointment...
  53. doi request reprint Narrowband ultraviolet B therapy in psoriasis: randomized double-blind comparison of high-dose and low-dose irradiation regimens
    M M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 161:1351-6. 2009
    ..Within-subject comparisons do not take into account the systemic effects of UVB phototherapy. The area of the body treated with low-dose UVB may benefit from the systemic effects of the site treated with a higher UVB dose...
  54. ncbi request reprint A multiparameter flow cytometric analysis of the effect of bexarotene on the epidermis of the psoriatic lesion
    M E J Franssen
    Department of Dermatology, University Medical Centre St Radboud Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 149:506-12. 2003
    ..A new retinoid, bexarotene (Targretin), was recently investigated in a large multicentre trial for its efficacy and safety in psoriasis. Bexarotene is a novel retinoid X receptor (RXR)-selective ligand...
  55. doi request reprint The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry
    A M Oostveen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 167:145-9. 2012
    ..Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study...
  56. doi request reprint Safety of treatment with biologics for psoriasis in daily practice: 5-year data
    P P M Van Lümig
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 26:283-91. 2012
    ..The cumulative exposition to biologics is increasing with prolonged treatment with a certain biologic or consecutive biological treatment. However, long-term safety data are limited available...
  57. ncbi request reprint A randomized comparison of an emollient containing skin-related lipids with a petrolatum-based emollient as adjunct in the treatment of chronic hand dermatitis
    M Kucharekova
    Department of Dermatology, University Medical Centre Nijmegen, The Netherlands
    Contact Dermatitis 48:293-9. 2003
    ..However, we could not demonstrate the superiority of this particular emollient containing skin-related lipids in patients with chronic hand dermatitis...
  58. doi request reprint Individual differences in the effect of daily stressors on psoriasis: a prospective study
    E W M Verhoeven
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 161:295-9. 2009
    ....
  59. doi request reprint Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy
    M J P Gerritsen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dermatology 218:193-202. 2009
    ..In conclusion, simple pretreatments or additions to the regular practice of PDT, aimed to optimize intralesional PpIX content, improve the clinical outcome...
  60. ncbi request reprint Psoriasis: consensus on topical therapies
    P C M van de Kerkhof
    Department of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 22:859-70. 2008
    ..Active participants of the group wrote assigned sections of this consensus document with a majority of participants agreed on the conclusions...
  61. ncbi request reprint Identification of lesional CD4+ CD25+ Foxp3+ regulatory T cells in Psoriasis
    H J Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Center, The Netherlands
    Dermatology 213:111-7. 2006
    ..Depletion of CD4+ CD25+ Foxp3+ naturally occurring regulatory T cells (T(reg)) induces autoimmune phenomena. These cells have not yet been fully characterized in the skin of psoriatic patients...
  62. doi request reprint How stress gets under the skin: cortisol and stress reactivity in psoriasis
    A W M Evers
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 163:986-91. 2010
    ..Psychological stressors might contribute to the severity of chronic inflammatory diseases such as psoriasis by dysregulating hypothalamic-pituitary-adrenal (HPA) axis activity...
  63. ncbi request reprint Psychosocial well-being of patients with skin diseases in general practice
    E W M Verhoeven
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 21:662-8. 2007
    ..Although the psychosocial consequences of skin diseases in secondary care has been extensively studied, little is known about the psychosocial well-being of patients with skin diseases in primary care...
  64. ncbi request reprint Monitoring hyperproliferative disorders in human skin: flow cytometry of changing cytokeratin expression
    M E J Franssen
    Department of Dermatology, University Medical Center Nijmegen, The Netherlands
    Cytometry B Clin Cytom 57:32-9. 2004
    ....
  65. doi request reprint CD26/dipeptidyl-peptidase IV in psoriatic skin: upregulation and topographical changes
    R G van Lingen
    Department of Dermatology, Radboud University Medical Centre Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 158:1264-72. 2008
    ..In theory, the expression of CD26/DPP-IV has common grounds with three principal key players of the psoriatic pathogenesis: keratinocytes, T cells and cytokines...
  66. pmc Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis
    A M G Langewouters
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arch Dermatol Res 300:107-13. 2008
    ..The under-representation of CD8+CD45RO+ cells is compatible with the dynamics of acquired immunity, which requires a time log after the relapse of the lesions to differentiate from CD45RA+ naive cells...
  67. ncbi request reprint The differential effect of broad band vs narrow band UVB with respect to photodamage and cutaneous inflammation
    M Tjioe
    Department of Dermatology, University Medical Centre Nijmegen, The Netherlands
    Exp Dermatol 12:729-33. 2003
    ..As narrow band UVB is more effective than broad band UVB, the present study suggests superiority of narrow band UVB as a treatment with a better benefit risk ration...
  68. ncbi request reprint Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction
    M Kucharekova
    Department of Dermatology, University Hospital Nijmegen, The Netherlands
    Contact Dermatitis 46:331-8. 2002
    ..Different models and clinical trials are needed to establish the usefulness in specific conditions of emollients containing skin-related lipids...
  69. ncbi request reprint Flow cytometric assessment of clearance and relapse characteristics in psoriasis vulgaris after treatment with weekly clobetasol lotion under hydrocolloid occlusion versus twice-daily clobetasol ointment
    C P Glade
    Department of Dermatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 15:92-9. 2002
    ....
  70. ncbi request reprint Treatment policy for psoriasis and eczema: a survey among dermatologists in the Netherlands and Belgian Flanders
    Judith H J Roelofzen
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Dermatol 17:416-21. 2007
    ..Despite the carcinogenicity of PUVA, this photochemotherapy is frequently prescribed by dermatologists, mainly in Flanders...
  71. ncbi request reprint Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects
    Jurgen V Smit
    Departments of Dermatology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 50:189-96. 2004
    ..However, no histologic and immunohistochemical studies have been performed to further substantiate these observations...
  72. ncbi request reprint Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late
    W H P M Vissers
    Department of Dermatology, University Medical Centre St Radboud, PO Box 9101, René Descartes dreef 1, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 150:852-9. 2004
    ..T-lymphocyte subsets in particular activated effector memory T cells and natural killer (NK) T cells have been suggested to play an important role in the pathogenesis of psoriasis...
  73. ncbi request reprint The combination of calcipotriol and methotrexate compared with methotrexate and vehicle in psoriasis: results of a multicentre placebo-controlled randomized trial
    E M G J de Jong
    Department of Dermatology, University Hospital Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 148:318-25. 2003
    ..A multicentre, randomized, double-blind, vehicle-controlled, parallel-group study was carried out to study the effect of the addition of calcipotriol ointment to methotrexate (MTX) therapy in patients with psoriasis vulgaris...
  74. ncbi request reprint Immunofluorescent surface labelling, flow sorting and culturing of putative epidermal stem cells derived from small skin punch biopsies
    M M van Rossum
    Department of Dermatology, University Medical Centre, St Radboud, P O Box 9101, NL 6500 HB Nijmegen, The Netherlands
    J Immunol Methods 267:109-17. 2002
    ..In cell suspensions obtained with thermolysin, only sparse colonies were formed. We conclude that our methodology permits the use of small human tissue samples for cell labelling and sorting, while preserving the clonogenic potential...
  75. ncbi request reprint Cost-effectiveness analysis of a psoriasis care instruction programme with dithranol compared with UVB phototherapy and inpatient dithranol treatment
    M Hartman
    Department of Medical Technology Assessment 253 MTA, University Medical Centre St Radbound, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 147:538-44. 2002
    ..This study was part of a large national cost-effectiveness analysis, and was funded by the National Fund for Investigational Medicine of the Health Care Insurance Board...
  76. doi request reprint A new scalp formulation of calcipotriol plus betamethasone dipropionate compared with each of its active ingredients in the same vehicle for the treatment of scalp psoriasis: a randomized, double-blind, controlled trial
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, Centrum St Radboud, Postbus 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 160:170-6. 2009
    ..There is a need for new treatments for scalp psoriasis, as many topical treatments are cosmetically unacceptable and difficult to apply, resulting in poor compliance...
  77. ncbi request reprint Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin
    R G L de Sevaux
    Department of Nephrology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 49:407-12. 2003
    ..No optimal long-term dosing advice is available...
  78. ncbi request reprint The response of normal human skin to single and repeated applications of dithranol cream: an immunohistochemical assessment
    O Q J Swinkels
    Department of Dermatology, University Medical Centre Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 15:262-9. 2002
    ..Our results indicate that an optimal timing for biopsies in future dithranol irritation studies lies between 4 and 8 days after the first dithranol challenge...
  79. ncbi request reprint Long-term efficacy and safety of tacalcitol ointment in patients with chronic plaque psoriasis
    P C M van de Kerkhof
    Department of Dermatology, University Hospital Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 146:414-22. 2002
    ..As psoriasis patients often require continuous treatment optimal therapy has to provide efficacy and a good safety profile over the long term...
  80. ncbi request reprint Effects of oral bexarotene (targretin) on the minimal erythema dose for broadspectrum UVB light
    J V Smit
    Department of Dermatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Skin Pharmacol Appl Skin Physiol 16:237-41. 2003
    ..Further study of bexarotene photo(chemo)therapy in cutaneous T-cell lymphoma and psoriasis is warranted...
  81. ncbi request reprint Generalized and symptom-specific sensitization of chronic itch and pain
    A I M van Laarhoven
    Department of Medical Psychology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 21:1187-92. 2007
    ..g. pain in chronic pain patients (symptom-specific sensitization)...
  82. ncbi request reprint Coal tar in dermatology
    Judith H J Roelofzen
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dermatolog Treat 18:329-34. 2007
    ..New, well-designed, epidemiological studies are necessary to assess the risk of skin tumors and other malignancies after dermatological use of coal tar...
  83. ncbi request reprint Novel quantitative immunofluorescent technique reveals improvements in epidermal cell populations after mild treatment of psoriasis
    Mirella W F M van Duijnhoven
    Department of Dermatology, UMC St Radboud, Nijmegen, The Netherlands
    Acta Derm Venereol 85:311-7. 2005
    ..Although treatment with an emollient showed hardly any clinical response, changes towards a more normal phenotype could already be detected in several epidermal markers using this method...
  84. ncbi request reprint The combination of the Zenon labeling technique and microscopic image analysis to study cell populations in normal and psoriatic epidermis
    Mirella W F M van Duijnhoven
    Department of Dermatology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Cutan Pathol 32:212-9. 2005
    ..Co-expression of different proteins was demonstrated...
  85. ncbi request reprint Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation, and improves differentiation in lesional skin
    Jurgen V Smit
    Department of Dermatology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 51:257-64. 2004
    ..In benign, hyperproliferative, and retinoid sensitive disorders, such as psoriasis, bexarotene has not been evaluated so far and no information on these parameters is available...
  86. ncbi request reprint Immunohistochemical differentiation between inflammatory linear verrucous epidermal nevus (ILVEN) and psoriasis
    W H P M Vissers
    Department of Dermatology, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Dermatol 14:216-20. 2004
    ..T-cell subsets in ILVEN cum psoriasis had an intermediary position...
  87. ncbi request reprint Induction of eruptive benign melanocytic naevi by immune suppressive agents, including biologicals
    H J Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, and Department of Gastroenterology, Gelderse Vallei Hospital, Ede, The Netherlands
    Br J Dermatol 154:880-4. 2006
    ..Eruptive naevi have been described to potentially arise in immune compromised patients...
  88. ncbi request reprint Therapeutic effects of a 12-week course of alefacept on nail psoriasis
    J E M Körver
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 20:1252-5. 2006
    ..Biologicals such as alefacept are the most recent treatment modalities for psoriasis. In the present study we evaluated changes in nail pathology in patients with plaque psoriasis and nail involvement during treatment with alefacept...
  89. doi request reprint Period of remission after treatment with UVA-1 in sclerodermic skin diseases
    E B M Kroft
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 22:839-44. 2008
    ....
  90. ncbi request reprint The role of lesional T cells in recalcitrant psoriasis during infliximab therapy
    H J Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Dermatol 15:454-8. 2005
    ..Further studies are needed to clarify the ambiguous role of conventional pathogenic T cells in plaque psoriasis...
  91. ncbi request reprint Plaque psoriasis vs. atopic dermatitis and lichen planus: a comparison for lesional T-cell subsets, epidermal proliferation and differentiation
    H J Bovenschen
    Department of Dermatology, University Medical Center St Radboud, Nijmegen, René Descartes dreef 1, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Br J Dermatol 153:72-8. 2005
    ..Interestingly, comparative analyses of the disease-specific composition of the lesional T-cell infiltrate in plaque psoriasis and other inflammatory dermatoses have only sparsely been performed...
  92. ncbi request reprint Tacrolimus ointment for the treatment of severe facial plaque psoriasis
    E B M Kroft
    Department of Dermatology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Eur Acad Dermatol Venereol 19:249-51. 2005
    ..Based on the available literature and illustrated by the present case we may conclude that tacrolimus ointment 0.1% can be recommended as a first-line treatment for facial psoriasis...
  93. doi request reprint A cross-sectional study using the Children's Dermatology Life Quality Index (CDLQI) in childhood psoriasis: negative effect on quality of life and moderate correlation of CDLQI with severity scores
    M E A de Jager
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 163:1099-101. 2010
    ..Juvenile psoriasis is a chronic and incurable skin disease that affects approximately 0·7% of children...
  94. ncbi request reprint Flexural versus plaque lesions in psoriasis: an immunohistochemical differentiation
    W H P M Vissers
    Department of Dermatology, University Medical Centre St Radboud, Rene Descartesdreef 1, 6500 HB Nijmegen, The Netherlands
    Eur J Dermatol 15:13-7. 2005
    ..We propose the decreased quantity of lesional CD161+ cells in the dermis of flexural psoriatic lesions may result from chronic microbial challenge in flexural psoriasis...
  95. doi request reprint Switching from etanercept to adalimumab is effective and safe: results in 30 patients with psoriasis with primary failure, secondary failure or intolerance to etanercept
    P P M Van Lümig
    Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 163:838-46. 2010
    ..This also applies to the efficacy and safety of adalimumab in patients previously treated with etanercept. The relationship between the reasons for discontinuation of etanercept and the response to adalimumab is not clear in psoriasis...
  96. doi request reprint Quality of life and sexual health in patients with genital psoriasis
    K A P Meeuwis
    Departments of Dermatology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Br J Dermatol 164:1247-55. 2011
    ..Knowledge about quality of life and sexual health in patients with genital psoriasis is limited...
  97. doi request reprint Psoriasis treatment with etanercept and efalizumab: clinical strategies influencing treatment outcome
    R J B Driessen
    Department of Dermatology, Radboud University Medical Centre, PO Box 9101, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 158:1098-106. 2008
    ..However, the treatment course in clinical practice is different from the setting in which trials are conducted...
  98. doi request reprint Clinical and histological effects of blue light on normal skin
    Marloes M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Photodermatol Photoimmunol Photomed 26:16-21. 2010
    ..Phototherapy with visible light is gaining interest in dermatological practice. Theoretically, blue light could induce biological effects comparable to ultraviolet A (UVA) radiation...
  99. doi request reprint Dimethylfumarate for psoriasis: Pronounced effects on lesional T-cell subsets, epidermal proliferation and differentiation, but not on natural killer T cells in immunohistochemical study
    H Jorn Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Clin Dermatol 11:343-50. 2010
    ..Oral fumaric acid esters are an effective therapy for psoriasis and are believed to exert their effects mainly through their anti-inflammatory properties...
  100. doi request reprint Effectiveness of a multidisciplinary itch-coping training programme in adults with atopic dermatitis
    Andrea W M Evers
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Derm Venereol 89:57-63. 2009
    ..The brief multidisciplinary itch-coping programme in adults with atopic dermatitis considerably reduced itch-scratching patterns, improved their skin status and reduced the use of dermatological care, both in the short and longer term...
  101. ncbi request reprint Functional characterization of beta1-integrin-positive epidermal cell populations
    Michelle M van Rossum
    Departwent of Dermatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Acta Derm Venereol 84:265-70. 2004
    ..Combining flow cytometric sorting, cell culture and image analysis provides powerful means for phenotypical and functional characterization of epidermal subpopulations...