Leon van Kempen
Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands
- The tumor microenvironment: a critical determinant of neoplastic evolutionLeon C L T van Kempen
University Medical Center Nijmegen, Department of Pathology, Nijmegen, The Netherlands
Eur J Cell Biol 82:539-48. 2003....
- Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinomaLeon C L T van Kempen
Department of Pathology, University Medical Centre Nijmegen, The Netherlands
J Pathol 204:333-9. 2004..These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC...
- Stromal responses in human primary melanoma of the skinLeon C L Van Kempen
Department of Pathology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Front Biosci 10:2922-31. 2005..g., carcinomas. This review discusses potential critical modulators of melanoma growth: turn-over of the most abundant extracellular matrix protein in skin (i.e. type I collagen), the early inflammatory response and angiogenesis...
- Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanomaLeon C L T van Kempen
Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Cancer 122:1019-29. 2008....
- Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expressionDelphine Javelaud
Institut Curie, University Center, Building 110, Orsay, France
Mol Cancer 10:2. 2011..TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN protein levels co-exist with active autocrine TGF-β signaling in cancer cells is yet to be understood...
- Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progressionIlse Roodink
Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Am J Pathol 173:1873-81. 2008..These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand...