Leon van Kempen

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi The tumor microenvironment: a critical determinant of neoplastic evolution
    Leon C L T van Kempen
    University Medical Center Nijmegen, Department of Pathology, Nijmegen, The Netherlands
    Eur J Cell Biol 82:539-48. 2003
  2. ncbi Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma
    Leon C L T van Kempen
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    J Pathol 204:333-9. 2004
  3. ncbi Stromal responses in human primary melanoma of the skin
    Leon C L Van Kempen
    Department of Pathology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Front Biosci 10:2922-31. 2005
  4. ncbi Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma
    Leon C L T van Kempen
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Cancer 122:1019-29. 2008
  5. pmc Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
    Delphine Javelaud
    Institut Curie, University Center, Building 110, Orsay, France
    Mol Cancer 10:2. 2011
  6. pmc Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression
    Ilse Roodink
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Pathol 173:1873-81. 2008

Collaborators

Detail Information

Publications6

  1. ncbi The tumor microenvironment: a critical determinant of neoplastic evolution
    Leon C L T van Kempen
    University Medical Center Nijmegen, Department of Pathology, Nijmegen, The Netherlands
    Eur J Cell Biol 82:539-48. 2003
    ....
  2. ncbi Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma
    Leon C L T van Kempen
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    J Pathol 204:333-9. 2004
    ..These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC...
  3. ncbi Stromal responses in human primary melanoma of the skin
    Leon C L Van Kempen
    Department of Pathology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Front Biosci 10:2922-31. 2005
    ..g., carcinomas. This review discusses potential critical modulators of melanoma growth: turn-over of the most abundant extracellular matrix protein in skin (i.e. type I collagen), the early inflammatory response and angiogenesis...
  4. ncbi Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma
    Leon C L T van Kempen
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Cancer 122:1019-29. 2008
    ....
  5. pmc Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
    Delphine Javelaud
    Institut Curie, University Center, Building 110, Orsay, France
    Mol Cancer 10:2. 2011
    ..TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN protein levels co-exist with active autocrine TGF-β signaling in cancer cells is yet to be understood...
  6. pmc Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression
    Ilse Roodink
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Pathol 173:1873-81. 2008
    ..These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand...