Frank L van de Veerdonk

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi request reprint Deficient Candida-specific T-helper 17 response during sepsis
    Frank L van de Veerdonk
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 206:1798-802. 2012
  2. doi request reprint IL-18 serum concentration is markedly elevated in acute EBV infection and can serve as a marker for disease severity
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    J Infect Dis 206:197-201. 2012
  3. pmc IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
    Frank L van de Veerdonk
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:3001-5. 2012
  4. doi request reprint Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    FEMS Microbiol Rev 34:1063-75. 2010
  5. doi request reprint Inflammasome activation and IL-1β and IL-18 processing during infection
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Trends Immunol 32:110-6. 2011
  6. ncbi request reprint Patient with fever and diarrhea
    Frank Leo van de Veerdonk
    Department of Internal Medicine, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Clin Infect Dis 42:994-5, 1051-2. 2006
  7. pmc Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency
    F L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 159:57-64. 2010
  8. doi request reprint Legionella pneumophila DNA in serum samples during Legionnaires' disease in relation to C-reactive protein levels
    F L van de Veerdonk
    Department of Internal Medicine, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:371-6. 2009
  9. ncbi request reprint Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
  10. ncbi request reprint Redundant role of TLR9 for anti-Candida host defense
    Frank Leo van de Veerdonk
    Immunobiology 213:613-20. 2008

Collaborators

Detail Information

Publications53

  1. doi request reprint Deficient Candida-specific T-helper 17 response during sepsis
    Frank L van de Veerdonk
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 206:1798-802. 2012
    ....
  2. doi request reprint IL-18 serum concentration is markedly elevated in acute EBV infection and can serve as a marker for disease severity
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    J Infect Dis 206:197-201. 2012
    ..Therefore, IL-18 and ferritin may represent infection markers for viral infections such as EBV, similar to CRP for bacterial infections...
  3. pmc IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
    Frank L van de Veerdonk
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:3001-5. 2012
    ..These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra, and that IL-38 and IL-36Ra have similar biological effects on immune cells by engaging the IL-36 receptor...
  4. doi request reprint Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    FEMS Microbiol Rev 34:1063-75. 2010
    ..This review presents an overview of novel strategies in the prevention and treatment of Candida infections, with a special focus on adjuvant immunotherapy...
  5. doi request reprint Inflammasome activation and IL-1β and IL-18 processing during infection
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Trends Immunol 32:110-6. 2011
    ..We highlight alternative mechanisms for processing IL-1β and IL-18 during infection, which involve extracellular cleavage of the inactive cytokines by neutrophil-derived serine proteases or proteases released from cytotoxic T cells...
  6. ncbi request reprint Patient with fever and diarrhea
    Frank Leo van de Veerdonk
    Department of Internal Medicine, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Clin Infect Dis 42:994-5, 1051-2. 2006
  7. pmc Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency
    F L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 159:57-64. 2010
    ..These data demonstrate that defective IL-17 production in response to specific pathogens can differ between patients with HIES and that the extent of the defective Th17 response determines their clinical phenotype...
  8. doi request reprint Legionella pneumophila DNA in serum samples during Legionnaires' disease in relation to C-reactive protein levels
    F L van de Veerdonk
    Department of Internal Medicine, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:371-6. 2009
    ..L. pneumophila DNA in serum on the day of admission correlates with high CRP levels, but not with the severity of the disease...
  9. ncbi request reprint Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  10. ncbi request reprint Redundant role of TLR9 for anti-Candida host defense
    Frank Leo van de Veerdonk
    Immunobiology 213:613-20. 2008
    ..albicans. However, the cytokine defect in TLR9-/- mice is compensated by alternative pathways, and the TLR9-dependent pathway seems to be redundant in the disseminated candidiasis model in mice...
  11. pmc Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Str, 12462 Athens, Greece
    Crit Care 15:R27. 2011
    ..Down-regulation of ex-vivo cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase-1 activation and conversion of pro-interleukin-1β into interleukin-1β (IL-1β)...
  12. doi request reprint Neutrophil-mediated inhibition of proinflammatory cytokine responses
    Mark S Gresnigt
    Department of Medicine, Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud, The Netherlands
    J Immunol 189:4806-15. 2012
    ..This observation suggest that PMNs might play a important regulatory role in the host defense against C. albicans and can be important for understanding the regulation of inflammation in general...
  13. pmc Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)
    Kathrin Buffen
    Department of Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Biol Chem 288:8658-66. 2013
    ..Our results thus demonstrate the induction of autophagy, which, in turn, modulates cytokine production by B. burgdorferi for the first time...
  14. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010
    ..In fact, it is the excessive consumption of food or alcohol that elicits the inflammation of the acute gout attack. The aim of this study was to identify the precise mechanism that initiates flares of gouty arthritis...
  15. doi request reprint Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3
    Mark S Gresnigt
    Department of Medicine, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands
    J Immunol 190:5629-39. 2013
    ....
  16. pmc Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, 6500 HB Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 107:3030-3. 2010
    ..The absence of ROS in CGD monocytes may explain the presence of an inflammatory phenotype characterized by granulomas and inflammatory bowel disease occurring in CGD patients...
  17. ncbi request reprint Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    Theo S Plantinga
    Department of Medicine, Radboud University, Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Gut 60:1229-35. 2011
    ..Here, the effect of ATG16L1 genetic variation on cytokine responses has been assessed in humans...
  18. ncbi request reprint Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Immunol 39:1914-22. 2009
    ..In conclusion, we have dissected the molecular mechanisms responsible for IL-1beta production by M. tuberculosis, and that may contribute to a deeper knowledge of the mechanisms of cell activation by M. tuberculosis...
  19. doi request reprint The classical CD14⁺⁺ CD16⁻ monocytes, but not the patrolling CD14⁺ CD16⁺ monocytes, promote Th17 responses to Candida albicans
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:2915-24. 2011
    ..In conclusion, both monocyte subsets have potent innate antifungal properties, but only CD14(++) CD16(-) monocytes are capable of inducing a potent Th17 response to C. albicans, an important component of antifungal host defense...
  20. doi request reprint Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:1087-96. 2009
    ..The aim of the present study was to investigate the pathways of IL-1beta production induced by Candida albicans in human monocytes...
  21. doi request reprint The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses
    Mark S Gresnigt
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Eur J Immunol 43:416-26. 2013
    ..These data describe that IL-36-dependent signals are a novel cytokine pathway that regulates Th responses induced by A. fumigatus, and demonstrate a role for TLR4 and dectin-1 in the induction of IL-36γ...
  22. pmc STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e29248. 2011
    ..The challenge for the future is to translate this knowledge into novel strategies for the treatment of this severe immunodeficiency...
  23. pmc Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism
    Marije Oosting
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:172-81. 2011
    ..As IL-17 has been implicated in the pathogenesis of chronic Lyme disease, these data suggest that caspase-1 targeting may represent a new immunomodulatory strategy for the treatment of complications of late stage Lyme disease...
  24. doi request reprint Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 34:407-11. 2010
    ..These data demonstrate that IL-17 does not have a major contribution to the inflammatory pathology leading to organ failure in fungal sepsis and support the concept that the IL-17 pathway is protective in antifungal host defense...
  25. pmc Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease
    Marije Oosting
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    Infect Immun 79:4681-7. 2011
    ..burgdorferi-induced IL-17 production in vitro and that an IL-23R gene SNP leads to impaired IL-17 production. However, the IL-23R gene polymorphism is not crucial for the pathogenesis of chronic Lyme...
  26. doi request reprint The anti-CD20 antibody rituximab reduces the Th17 cell response
    Frank L van de Veerdonk
    Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Arthritis Rheum 63:1507-16. 2011
    ..The present study was undertaken to investigate the mechanism of action of rituximab in RA...
  27. doi request reprint The macrophage mannose receptor induces IL-17 in response to Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Host Microbe 5:329-40. 2009
    ..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...
  28. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
    ..These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans...
  29. pmc Cytokine production assays reveal discriminatory immune defects in adults with recurrent infections and noninfectious inflammation
    Jaap Ten Oever
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Vaccine Immunol 21:1061-9. 2014
    ....
  30. ncbi request reprint Th17 responses and host defense against microorganisms: an overview
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    BMB Rep 42:776-87. 2009
    ..It has become evident that the type of microorganisms and the setting in which they trigger the Th17 response determines the outcome of the delicate balance that exists between Th17 induced protection and immunopathogenesis...
  31. doi request reprint Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Interferon Cytokine Res 32:159-68. 2012
    ..In addition, cells from CGD patients did not display a defective L-tryptophan metabolism...
  32. pmc Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis
    Renoud J Marijnissen
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e38889. 2012
    ..We investigated whether exposure to a minute amount of C. albicans in the arthritic joint altered the local cytokine environment, leading to enhanced Th17 expansion and resulting in a more destructive arthritis...
  33. doi request reprint The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    Int Immunol 22:889-95. 2010
    ..albicans and that PGE2 is induced by the fungal components mannan and β-glucan that are recognized by the MR and the dectin-1/TLR2 pathway, respectively...
  34. pmc Genetic susceptibility to Candida infections
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Nijmegen, The Netherlands
    EMBO Mol Med 5:805-13. 2013
    ..This review is part of the review series on host-pathogen interactions. See more reviews from this series...
  35. ncbi request reprint Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    APMIS 118:1000-7. 2010
    ..In conclusion, IL-1RI-mediated signals are crucial in mediating mortality occurring as a result of lethal endotoxaemia. Investigation of IL-1-mediated pathways in IL-1 knock-out mice is complicated by a distorted homeostasis of IL-1Rs...
  36. pmc Inflammasome is a central player in the induction of obesity and insulin resistance
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity, 6525 GA Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:15324-9. 2011
    ..These findings reveal a critical function of the inflammasome in obesity and insulin resistance, and suggest inhibition of the inflammasome as a potential therapeutic strategy...
  37. doi request reprint Severe Candida spp. infections: new insights into natural immunity
    Jos W M Van der Meer
    Department Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Antimicrob Agents 36:S58-62. 2010
    ..These studies also provide insights into how acquired risk factors for fungal infection operate, and may lead to new approaches for immunotherapy...
  38. ncbi request reprint The role of NLRs and TLRs in the activation of the inflammasome
    Mihai G Netea
    Radboud University Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation and Immunity N4i, Department of Medicine, Geert Grooteplein 8, 6525 GA Nijmegen, Netherlands
    Expert Opin Biol Ther 8:1867-72. 2008
    ..Caspase-1 forms a protein platform called the inflammasome, together with proteins of the nucleotide-binding oligomerization domain-like receptor (NLR) family...
  39. pmc Inflammasome-independent modulation of cytokine response by autophagy in human cells
    Tania O Crişan
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e18666. 2011
    ..In conclusion, autophagy modulates the secretion of proinflammatory cytokines in human cells through an inflammasome-independent pathway, and this is a novel mechanism that may be targeted in inflammatory diseases...
  40. doi request reprint The effects of in vivo B-cell depleting therapy on ex-vivo cytokine production
    Sanne P Smeekens
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Transpl Immunol 28:183-8. 2013
    ..A single dose of rituximab treatment added to standard immunosuppressive therapy in renal transplant patients did not influence the production of IL-17 or other monocyte- or T-cell derived cytokines after ex-vivo stimulation...
  41. doi request reprint Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections
    Jaap Ten Oever
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect 65:490-5. 2012
    ....
  42. ncbi request reprint Defects of pattern recognition: primary immunodeficiencies of the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Opin Pharmacol 11:412-22. 2011
    ..Their discovery leads to crucial insight in the pathophysiology of infections, and offer therapeutic targets for future immunotherapy...
  43. pmc Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Innate Immun 6:253-62. 2014
    ..However, it is unknown whether the genetic defects in these patients also affect the skin and mucosal microbiome, which in turn may influence host defense mechanisms...
  44. pmc A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist
    Mark S Gresnigt
    Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    PLoS Pathog 10:e1003936. 2014
    ..However, the observation that GAG can also protect mice from allergy and colitis makes GAG or a derivative structure of GAG a potential treatment compound for IL-1 driven inflammatory diseases. ..
  45. doi request reprint STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 365:54-61. 2011
    ..Patients with recessive CMC and autoimmunity have mutations in the autoimmune regulator AIRE. The cause of autosomal dominant CMC is unknown...
  46. ncbi request reprint Pathogenesis of invasive candidiasis
    Frank L van de Veerdonk
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Opin Crit Care 16:453-9. 2010
    ..In the present review, we describe the host defense mechanisms against Candida that are responsible for counteracting mucosal invasion, and eliminating the pathogen once invasion has taken place...
  47. pmc Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
    Corine E Delsing
    Department of Internal Medicine, Division of Experimental Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    BMC Infect Dis 14:166. 2014
    ....
  48. doi request reprint Pattern recognition receptors and their role in invasive aspergillosis
    Mark S Gresnigt
    Department of Medicine, Radboud University, Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Ann N Y Acad Sci 1273:60-7. 2012
    ..This knowledge may pave the way for novel diagnostic and immunomodulatory treatment strategies that are needed to overcome the high mortality associated with invasive A. fumigatus infection in immunocompromised patients...
  49. ncbi request reprint Host-microbe interactions: innate pattern recognition of fungal pathogens
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Opin Microbiol 11:305-12. 2008
    ..This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen...
  50. doi request reprint Biology of IL-36 cytokines and their role in disease
    Mark S Gresnigt
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Nijmegen Institute for Infection, Inflammation, and Immunity N4i, The Netherlands
    Semin Immunol 25:458-65. 2013
    ..In this review the discovery and biological function of the cytokines IL-36α, IL-36β, IL-36γ and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases. ..