Rinke Stienstra

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
  2. pmc The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen 6525 GA, The Netherlands
    Cell Metab 12:593-605. 2010
  3. pmc Inflammasome is a central player in the induction of obesity and insulin resistance
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity, 6525 GA Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:15324-9. 2011
  4. doi request reprint The inflammasome puts obesity in the danger zone
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    Cell Metab 15:10-8. 2012
  5. pmc MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice
    Dov B Ballak
    Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e89615. 2014
  6. doi request reprint Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients
    Tim B Koenen
    Departments of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 94:4453-7. 2009
  7. doi request reprint The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation
    Edwin J P van Asseldonk
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Obesity (Silver Spring) 18:2234-6. 2010
  8. pmc Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 60:517-24. 2011
  9. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010

Detail Information

Publications9

  1. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  2. pmc The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen 6525 GA, The Netherlands
    Cell Metab 12:593-605. 2010
    ....
  3. pmc Inflammasome is a central player in the induction of obesity and insulin resistance
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity, 6525 GA Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:15324-9. 2011
    ..These findings reveal a critical function of the inflammasome in obesity and insulin resistance, and suggest inhibition of the inflammasome as a potential therapeutic strategy...
  4. doi request reprint The inflammasome puts obesity in the danger zone
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    Cell Metab 15:10-8. 2012
    ..These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes...
  5. pmc MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice
    Dov B Ballak
    Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e89615. 2014
    ....
  6. doi request reprint Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients
    Tim B Koenen
    Departments of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 94:4453-7. 2009
    ..Whether such TZD-dependent morphological changes occur in adipose tissue of insulin-resistant patients is unclear...
  7. doi request reprint The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation
    Edwin J P van Asseldonk
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Obesity (Silver Spring) 18:2234-6. 2010
    ..Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine...
  8. pmc Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 60:517-24. 2011
    ..In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance...
  9. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010
    ..In fact, it is the excessive consumption of food or alcohol that elicits the inflammation of the acute gout attack. The aim of this study was to identify the precise mechanism that initiates flares of gouty arthritis...