A F H Stalenhoef

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study
    Elke Arts
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 14:R116. 2012
  2. pmc Cardiac complication after experimental human malaria infection: a case report
    An Emmie Nieman
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Malar J 8:277. 2009
  3. pmc Analysis of queries sent to PubMed at the point of care: observation of search behaviour in a medical teaching hospital
    Arjen Hoogendam
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Med Inform Decis Mak 8:42. 2008
  4. ncbi request reprint Blurred vision
    A F H Stalenhoef
    Department of General Internal Medicine and Vascular Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 65:461-2. 2007
  5. ncbi request reprint [Secondary prevention of recurrent stroke by lowering cholesterol levels and blood pressure]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde en Vasculaire Geneeskunde, 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:2127-30. 2006
  6. ncbi request reprint [Statins available from chemist shops will not positively affect health]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Interne Geneeskunde, Huispost 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 151:1405. 2007
  7. ncbi request reprint [No reason to start treatment with statins in patients with moderate to severe heart failure]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde en Vasculaire Geneeskunde, kamer 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 152:486-8. 2008
  8. doi request reprint Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL
    Anton F H Stalenhoef
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Lipidol 19:355-61. 2008
  9. doi request reprint The benefit of statins in non-cardiac vascular surgery patients
    Anton F H Stalenhoef
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Vasc Surg 49:260-5. 2009
  10. doi request reprint Efficacy and safety of dalcetrapib in type 2 diabetes mellitus and/or metabolic syndrome patients, at high cardiovascular disease risk
    A F H Stalenhoef
    Department of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes Obes Metab 14:30-9. 2012

Detail Information

Publications100

  1. pmc High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study
    Elke Arts
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 14:R116. 2012
    ..In this study, we investigated whether HDL2-chol and HDL3-chol concentrations differ between RA patients and healthy controls, and whether these levels are related to the level of RA disease activity...
  2. pmc Cardiac complication after experimental human malaria infection: a case report
    An Emmie Nieman
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Malar J 8:277. 2009
    ..Apart from acute coronary syndrome, myocarditis can be considered as a final diagnosis, but the true nature and patho-physiological explanation of the event remain unclear...
  3. pmc Analysis of queries sent to PubMed at the point of care: observation of search behaviour in a medical teaching hospital
    Arjen Hoogendam
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Med Inform Decis Mak 8:42. 2008
    ..The objectives of our study were to identify queries that are likely to retrieve relevant articles by relating PubMed search techniques and tools to the number of articles retrieved and the selection of articles for further reading...
  4. ncbi request reprint Blurred vision
    A F H Stalenhoef
    Department of General Internal Medicine and Vascular Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 65:461-2. 2007
  5. ncbi request reprint [Secondary prevention of recurrent stroke by lowering cholesterol levels and blood pressure]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde en Vasculaire Geneeskunde, 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:2127-30. 2006
    ..However, high-dose statin therapy should be given only after careful selection of the stroke patient at very high risk because of its high cost, adverse effects and a possible increase in haemorrhagic stroke...
  6. ncbi request reprint [Statins available from chemist shops will not positively affect health]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Interne Geneeskunde, Huispost 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 151:1405. 2007
    ..The use of statins as compensation for an unhealthy lifestyle is not desirable and there is a danger that patients with high vascular risk would receive treatment without being adequately supervised...
  7. ncbi request reprint [No reason to start treatment with statins in patients with moderate to severe heart failure]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde en Vasculaire Geneeskunde, kamer 463, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 152:486-8. 2008
    ..There were no signs of any pleiotropic effects of statins in patients with heart failure. There seems to be no indication to start treatment with statins in patients with moderate to severe heart failure...
  8. doi request reprint Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL
    Anton F H Stalenhoef
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Lipidol 19:355-61. 2008
    ..Hypertriglyceridemia is characterized by the presence of cholesterol-rich remnant-like lipoproteins and small dense LDL particles, both of which are believed to contribute to cardiovascular disease risk...
  9. doi request reprint The benefit of statins in non-cardiac vascular surgery patients
    Anton F H Stalenhoef
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Vasc Surg 49:260-5. 2009
    ..Prospective randomized trials to answer these questions cannot be performed anymore, however, because all vascular patients should receive statin treatment as secondary prevention of cardiovascular disease...
  10. doi request reprint Efficacy and safety of dalcetrapib in type 2 diabetes mellitus and/or metabolic syndrome patients, at high cardiovascular disease risk
    A F H Stalenhoef
    Department of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes Obes Metab 14:30-9. 2012
    ..The aim of this analysis was to investigate the lipid modifying efficacy and safety of dalcetrapib in patients with T2DM and/or metabolic syndrome...
  11. ncbi request reprint Effect of rosuvastatin on insulin sensitivity in patients with familial combined hyperlipidaemia
    E ter Avest
    Department of Medicine, Radboud University Nijmegen, Medical Centre, The Netherlands
    Eur J Clin Invest 35:558-64. 2005
    ..This study was designed to evaluate the effect of rosuvastatin on serum lipids and insulin sensitivity in nondiabetic subjects with familial combined hyperlipidaemia (FCH), a population characterized by decreased insulin sensitivity...
  12. doi request reprint Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients
    C Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 68:868-72. 2009
    ..The aim of this study was to investigate the effects of tumour necrosis factor (TNF) inhibition on the antioxidative capacity of HDL in RA...
  13. ncbi request reprint Atorvastatin and simvastatin in patients on hemodialysis: effects on lipoproteins, C-reactive protein and in vivo oxidized LDL
    Judith M van den Akker
    Department of Internal Medicine, Rijnstate Hospital of Arnhem, Arnhem, The Netherlands
    J Nephrol 16:238-44. 2003
    ..Moreover, statins may exhibit additional inhibitory effects on the atherogenesis, such as a modulation of the immune system as triggered by oxidatively modified LDL and a reduction of the inflammatory marker C-reactive protein (CRP)...
  14. ncbi request reprint The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia
    G M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, Nijmegen, The Netherlands
    Int J Obes (Lond) 30:892-8. 2006
    ..Leptin exerts its effect through the leptin receptor (LEPR). The aim of this study is to determine whether the Gln223Arg polymorphism in the LEPR gene contributes to FCH and its associated phenotypes...
  15. ncbi request reprint Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study
    Mario J Veerkamp
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Circulation 109:2980-5. 2004
    ..This result emphasizes the need for reevaluation of the diagnostic criteria for FCH...
  16. doi request reprint Impact of waist circumference versus adiponectin level on subclinical atherosclerosis: a cross-sectional analysis in a sample from the general population
    S Holewijn
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Intern Med 267:588-98. 2010
    ....
  17. ncbi request reprint Non-invasive measurements of atherosclerosis (NIMA): current evidence and future perspectives
    S Holewijn
    Department of General Internal Medicine, Division of Vascular Meicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 68:388-99. 2010
    ..Future prospective studies should focus on repeated measures of NIMA to reveal the main determinants of the different NIMA and evaluate the predictive value of baseline versus repeated measurements...
  18. doi request reprint Apolipoprotein B, non-HDL cholesterol and LDL cholesterol for identifying individuals at increased cardiovascular risk
    S Holewijn
    Division of Vascular Medicine, Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Intern Med 268:567-77. 2010
    ....
  19. ncbi request reprint Effects of rosuvastatin on endothelial function in patients with familial combined hyperlipidaemia (FCH)
    Ewoud ter Avest
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Med Res Opin 21:1469-76. 2005
    ....
  20. ncbi request reprint Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS)
    E M G Jacobs
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 65:425-33. 2007
    ..Family screening has been suggested as a sophisticated model for the early detection of HFE-related hereditary haemochromatosis (HH). However, until now, controlled studies on the morbidity and mortality in families with HH are lacking...
  21. ncbi request reprint Proportion of oxidized LDL relative to plasma apolipoprotein B does not change during statin therapy in patients with heterozygous familial hypercholesterolemia
    L J H van Tits
    Radboud University Nijmegen Medical Centre, Department of General Internal Medicine 564, Geert Grooteplein Zuid 8, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Atherosclerosis 185:307-12. 2006
    ..The effect of cholesterol-lowering therapy on plasma level of oxidized LDL is not clear...
  22. ncbi request reprint Non-transferrin-bound iron is associated with plasma level of soluble intercellular adhesion molecule-1 but not with in vivo low-density lipoprotein oxidation
    L J H van Tits
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 194:272-8. 2007
    ..Excess body iron is associated with increased cardiovascular disease risk, possibly via non-transferrin-bound iron (NTBI)-mediated enhancement of inflammation and oxidation of low-density lipoprotein (LDL)...
  23. ncbi request reprint Cholesterol in end-stage renal disease: the good, the bad or the ugly?
    S H A Diepeveen
    Department of Internal Medicine, Isala Clinics, Zwolle, The Netherlands
    Neth J Med 66:53-61. 2008
    ..Treatment with the antioxidant vitamin E has not equivocally been shown to be beneficial in this population. This review tries to put data from literature on dyslipidaemia and oxidative stress in ESRD in perspective...
  24. ncbi request reprint Anti-inflammatory effects of troglitazone in nondiabetic obese subjects independent of changes in insulin sensitivity
    L J H van Tits
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Neth J Med 63:250-5. 2005
    ..We investigated whether, in the absence of changes in glucose, thiazolidinediones (TZDs) have anti-inflammatory effects and whether improvement of insulin sensitivity correlates with suppression of inflammatory markers...
  25. ncbi request reprint Role of insulin resistance in familial combined hyperlipidemia
    M J Veerkamp
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1026-31. 2005
    ..Therefore, we explored the role of insulin resistance in FCH lipid phenotype expression...
  26. doi request reprint Brachial artery diameter is related to cardiovascular risk factors and intima-media thickness
    S Holewijn
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Clin Invest 39:554-60. 2009
    ..We determined the relation of FMD, BAD and NMD with known CV risk factors and intima-media thickness (IMT), a well-established surrogate marker of atherosclerosis, in a community-based population, the Nijmegen Biomedical Study (NBS)...
  27. ncbi request reprint Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: results of a 5-year follow-up study
    Mario J Veerkamp
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arterioscler Thromb Vasc Biol 22:274-82. 2002
    ..We demonstrate that apoB and small dense LDL are attractive new candidates for defining FCH. Further studies are indicated to evaluate the role of apoB and small dense LDL as diagnostic criteria for FCH...
  28. ncbi request reprint A genome-wide linkage scan for homocysteine levels suggests three regions of interest
    S H H M Vermeulen
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    J Thromb Haemost 4:1303-7. 2006
    ..Extensive candidate gene studies have identified several genetic variants, including the MTHFR 677C>T, that influence tHcy levels, but so far only part of the genetic variation in tHcy can be explained...
  29. ncbi request reprint Endothelial function in familial combined hyperlipidaemia
    E ter Avest
    Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Clin Invest 37:381-9. 2007
    ....
  30. ncbi request reprint Haplotype analyses of the APOA5 gene in patients with familial combined hyperlipidemia
    Gerly M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochim Biophys Acta 1772:81-8. 2007
    ..Furthermore, the effects of variants in the APOA5 gene on carotid intima-media thickness (IMT) and cardiovascular disease (CVD) were examined...
  31. ncbi request reprint [Hereditary haemochromatosis: novel genes, novel diseases and hepcidin]
    J P H Bergmans
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HS Nijmegen
    Ned Tijdschr Geneeskd 151:1121-7. 2007
    ....
  32. ncbi request reprint The Asp299Gly Toll-like receptor 4 polymorphism in advanced aortic atherosclerosis
    M J Hommels
    Department of Internal Medicine, Cardiovascular Research Institute Maastricht CARIM and Maastricht University Hospital, Maastricht, The Netherlands
    Neth J Med 65:203-7. 2007
    ..To explore a potential atheroprotective effect, we studied the association between the Asp299Gly polymorphism and atherosclerosis in hypertensive patients undergoing angiography for suspected renovascular disease...
  33. pmc Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis
    C Popa
    Rheumatology Department, UMC St Radboud, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:303-5. 2005
    ....
  34. ncbi request reprint Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial
    S H A Diepeveen
    Department of Internal Medicine, Isala Clinics, Location Weezenlanden, Zwolle, The Netherlands
    J Intern Med 257:438-45. 2005
    ..The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients...
  35. ncbi request reprint Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
  36. doi request reprint Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2
    L J H van Tits
    Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 214:345-9. 2011
    ..Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  37. doi request reprint Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case-control study
    E F H van Bommel
    Department of Internal Medicine, Albert Schweitzer Hospital, P O Box 444, 3300 AK, Dordrecht, The Netherlands
    Rheumatol Int 31:201-8. 2011
    ..81; P = 0.007). Data suggest a differing innate immune response to OxLDL in patients with chronic periaortitis compared to controls. Whether this response is causally related to chronic periaortitis development remains to be clarified...
  38. ncbi request reprint [Diagnosis of 5 patients with possible primary hemochromatosis]
    E M G Jacobs
    Afd Algemene Inwendige Geneeskunde, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 147:666-70. 2003
    ..In case of doubt as to the diagnosis, histological examination of the liver with a qualitative or quantitative iron determination is the golden standard...
  39. ncbi request reprint The case for case reports in the Netherlands Journal of Medicine
    J P H Drenth
    Department of Gastroenterology, Radbound University Nijmengen Medical Center, The Netherlands
    Neth J Med 64:262-4. 2006
  40. ncbi request reprint Oxidative stress in patients with end-stage renal disease prior to the start of renal replacement therapy
    Sabine H A Diepeveen
    Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Nephron Clin Pract 98:c3-7. 2004
    ..The present study compares three different methods: plasma lipid peroxides, the newly developed measurement of circulating oxidized LDL (Ox-LDL) particles and the frequently used copper-induced LDL oxidation lag time...
  41. ncbi request reprint Diagnostic criteria in relation to the pathogenesis of familial combined hyperlipidemia
    Jacqueline de Graaf
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Semin Vasc Med 4:229-40. 2004
    ..A disturbed adipose tissue metabolism that results in an increased plasma free fatty acid pool may be the culprit in the pathogenesis of FCH...
  42. pmc Metabolic pathogenesis of familial combined hyperlipidaemia with emphasis on insulin resistance, adipose tissue metabolism and free fatty acids
    Jacqueline de Graaf
    Department of Medicine, Division of General Internal Medicine 541, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J R Soc Med 95:46-53. 2002
  43. ncbi request reprint Variation in non-invasive measurements of vascular function in healthy volunteers during daytime
    Ewoud ter Avest
    Department of Medicine, Division of General Internal Medicine, University Medical Center, Nijmegen, The Netherlands
    Clin Sci (Lond) 108:425-31. 2005
    ....
  44. doi request reprint Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis
    Calin Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 36:724-30. 2009
    ..We investigated the effects of longterm therapeutic tumor necrosis factor (TNF) blockade on adipocytokine concentrations in patients with RA...
  45. ncbi request reprint Effects of atorvastatin and simvastatin on low-density lipoprotein subfraction profile, low-density lipoprotein oxidizability, and antibodies to oxidized low-density lipoprotein in relation to carotid intima media thickness in familial hypercholesterolemi
    Lambertus J H van Tits
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Investig Med 52:177-84. 2004
    ..Little is known about the effects of statins on the quality of circulating low-density lipoprotein (LDL) in relation to atherosclerosis progression...
  46. ncbi request reprint High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia
    Jacqueline de Graaf
    Department of Medicine, Division of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 92:1269-75. 2007
    ..In other populations, high remnant-like particles cholesterol (RLP-C) levels are an independent risk factor for CVD...
  47. ncbi request reprint Pulse wave velocity in familial combined hyperlipidemia
    Ewoud ter Avest
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Hypertens 20:263-9. 2007
    ....
  48. ncbi request reprint Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release
    Mihai G Netea
    Department of Medicine, University Medical Center Nijmegen, The Netherlands
    J Immunol 173:1477-82. 2004
    ..Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4...
  49. pmc Evaluation of PubMed filters used for evidence-based searching: validation using relative recall
    Arjen Hoogendam
    Internal Medicine, Department of General Internal Medicine and Department of Medical Informatics, Radboud University Nijmegen Medical Centre, P O Box 9101, Nijmegen, The Netherlands
    J Med Libr Assoc 97:186-93. 2009
    ..The research sought to determine the value of PubMed filters and combinations of filters in literature selected for systematic reviews on therapy-related clinical questions...
  50. pmc Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 60:517-24. 2011
    ..In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance...
  51. pmc Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1503-7. 2007
    ..In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients...
  52. ncbi request reprint The effect of the initiation of renal replacement therapy on lipid profile and oxidative stress during the first 6 months of treatment
    Sabine H A Diepeveen
    Department of Internal Medicine, Isala Clinics, Location Weezenlanden, Zwolle, The Netherlands
    Clin Chim Acta 361:112-8. 2005
    ..In the present study we investigated the effects of the initiation of both hemo- and peritoneal dialysis therapy on lipoproteins and parameters of LDL oxidation...
  53. ncbi request reprint Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile
    Gerly M van der Vleuten
    Department of Medicine and Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Lipid Res 46:2398-404. 2005
    ..This finding implies a role of adipose tissue metabolism in the pathophysiology of FCH...
  54. doi request reprint Adiponectin multimer distribution in patients with familial combined hyperlipidemia
    Tim B Koenen
    Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochem Biophys Res Commun 376:164-8. 2008
    ..2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution...
  55. ncbi request reprint Neutrophil superoxide-anion generating capacity in chronic smoking: effect of long-term alpha-tocopherol therapy
    Lambertus J H van Tits
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen
    J Biosci 28:23-7. 2003
    ....
  56. ncbi request reprint What is the role of non-invasive measurements of atherosclerosis in individual cardiovascular risk prediction?
    Ewoud ter Avest
    Division of General Internal Medicine, Department of Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Sci (Lond) 112:507-16. 2007
    ....
  57. ncbi request reprint JTT-705: is there still future for a CETP inhibitor after torcetrapib?
    Alexander J M Rennings
    Radboud University Nijmegen Medical Centre, Department of Internal Medicine, 460, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Opin Investig Drugs 17:1589-97. 2008
    ..However, negative Phase III studies on clinical end points with the CETP inhibitor torcetrapib challenge the future perspectives of other CETP inhibitors such as JTT-705...
  58. pmc Answers to questions posed during daily patient care are more likely to be answered by UpToDate than PubMed
    Arjen Hoogendam
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Med Internet Res 10:e29. 2008
    ..UpToDate and PubMed are popular sources for medical information. Data regarding the efficiency of PubMed and UpToDate in daily medical care are lacking...
  59. doi request reprint The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis
    Suzanne Holewijn
    Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Endocrinol Metab 94:2893-9. 2009
    ..Furthermore, we determined the impact of three different definitions of the MetS...
  60. doi request reprint Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study
    Esther M G Jacobs
    Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Hepatol 50:174-83. 2009
    ..Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH...
  61. ncbi request reprint Thioredoxin interacting protein in Dutch families with familial combined hyperlipidemia
    Gerly M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Med Genet A 130:73-5. 2004
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html...
  62. ncbi request reprint A comparative study with rosuvastatin in subjects with metabolic syndrome: results of the COMETS study
    Anton F H Stalenhoef
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Heart J 26:2664-72. 2005
    ..The efficacy and safety of rosuvastatin, atorvastatin, and placebo were compared in patients with the metabolic syndrome...
  63. doi request reprint Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients
    Tim B Koenen
    Departments of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 94:4453-7. 2009
    ..Whether such TZD-dependent morphological changes occur in adipose tissue of insulin-resistant patients is unclear...
  64. ncbi request reprint Remnant particles are the major determinant of an increased intima media thickness in patients with familial combined hyperlipidemia (FCH)
    Ewoud ter Avest
    Department of Medicine, 463 Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Atherosclerosis 191:220-6. 2007
    ....
  65. ncbi request reprint Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosis
    Lambertus J H van Tits
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochem Biophys Res Commun 345:371-6. 2006
    ..Mean lag-phase of in vitro LDL oxidation was also not significantly different between both study groups. Conclusion: these findings do not support the hypothesis that NTBI promotes oxidative modification of plasma LDL...
  66. ncbi request reprint Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia
    Ewoud ter Avest
    Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Sci (Lond) 112:131-9. 2007
    ..However, aging-related post-maturation increases in adipose tissue mass also appear to contribute to an aggravation and/or modulation of this genetically determined apoB overproduction...
  67. ncbi request reprint Elevated leptin levels in subjects with familial combined hyperlipidemia are associated with the increased risk for CVD
    Gerly M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 183:355-60. 2005
    ..These increased leptin levels are associated with an increased risk for CVD both in FCH patients and non-FCH subjects, independent of BMI, insulin resistance and gender...
  68. ncbi request reprint Plasma homocysteine in subjects with familial combined hyperlipidemia
    M J Veerkamp
    Department of Medicine, Division of General Internal Medicine, 541, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Atherosclerosis 166:111-7. 2003
    ..No associations were observed between plasma homocysteine concentration and plasma lipid and lipoprotein levels, including small dense low density lipoprotein, nor between homocysteine concentration and insulin resistance...
  69. ncbi request reprint The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia
    Gerly M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Lipid Res 48:193-200. 2007
    ..In conclusion, the previously identified risk haplotype of USF1 showed a suggestive association with FCH and contributed to the related lipid traits in our Dutch FCH families...
  70. ncbi request reprint Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia
    M G Netea
    University Medical Center, St Radboud, Nijmegen, The Netherlands
    Eur J Clin Invest 34:94-9. 2004
    ..We have investigated whether the presence of the Asp299Gly polymorphism in patients with familial hypercholesterolaemia (FH) has a similar protective effect, and whether it influences the effects of HMG-CoA reductase treatment...
  71. ncbi request reprint [Cardiovascular prevention in the over-80 age group is beneficial]
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Inwendige Geneeskunde, Huispost 463, Posts 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 152:26. 2008
    ..Therefore, old age is no reason in itself to withhold cardiovascular preventive treatment...
  72. ncbi request reprint Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome
    Anna Simon
    Department of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Clin Pharmacol Ther 75:476-83. 2004
    ..These data offer preliminary evidence for the hypothesis that simvastatin may improve inflammatory attacks in the hyper-IgD syndrome. This highlights the anti-inflammatory properties of HMG-CoA reductase inhibition...
  73. ncbi request reprint [Broader indication for treatment with statins; the 'heart protection study']
    A F H Stalenhoef
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:1921-3. 2002
    ..Lifestyle and/or age are not exclusion criteria for treatment with statins. The expiration of patents of some statins and modifications to the reimbursement system in 2003 could lead to cost reductions...
  74. ncbi request reprint The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Lipid Res 48:751-62. 2007
    ..Current investigations assessing the impact of anti-TNF agents on intermediary metabolism suggest that TNF-alpha blockade may improve insulin resistance and lipid profiles in patients with chronic inflammatory diseases...
  75. ncbi request reprint Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands Biochemistry, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Lipid Res 43:1065-71. 2002
    ..This may represent an important pathogenetic mechanism in atherogenesis induced by hyperlipoproteinemia...
  76. doi request reprint Effects of ubiquinone (coenzyme Q10) on myopathy in statin users
    Carel F Schaars
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Lipidol 19:553-7. 2008
    ..The aim of the present article is to review published data on the association between coenzyme Q10 and statin-associated myopathy...
  77. pmc Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection
    Mihai G Netea
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e4237. 2009
    ..Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines...
  78. ncbi request reprint Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis
    Alieke G Vonk
    Division of General Internal Medicine, Department of Medicine, University Medical Center, Nijmegen, The Netherlands
    Med Mycol 42:341-8. 2004
    ..This study suggests that lipoproteins play a significant role in host defense against candidiasis...
  79. pmc TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 104:16645-50. 2007
    ....
  80. ncbi request reprint Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels
    Jacqueline de Graaf
    Department of General Internal Medicine, University Medical Centre Nijmegen, The Netherlands
    Br J Nutr 88:479-88. 2002
    ..8 g/d) is effective in lowering blood total and LDL-cholesterol levels in subjects with mild hypercholesterolaemia and thus may be helpful in reducing the risk of CHD in these individuals...
  81. ncbi request reprint Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia
    Femke de Beer
    Department of General Internal Medicine, Leiden University Medical Center, Gaubius Laboratory, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:294-9. 2002
    ..In addition, in female apoE2 homozygotes, the expression increases with age; this increase is most likely due to the loss of estrogen production...
  82. ncbi request reprint The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 10:451-5. 2003
    ..We studied the long-term effects of statins on femoral IMT and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study...
  83. ncbi request reprint Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 105:2159-65. 2002
    ..This study describes the first results using this CETP inhibitor in humans...
  84. ncbi request reprint Paraoxonase (PON1) is associated with familial combined hyperlipidemia
    Thomas M van Himbergen
    Department of Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, The Netherlands
    Atherosclerosis 199:87-94. 2008
    ..0 (95% CI, 1.3-19.1, P=0.02)). In conclusion, in this population of subjects from well-defined families with FCH, PON1 is biochemically and genetically associated with FCH...
  85. ncbi request reprint Anti-TNF therapy and plasma HDL cholesterol concentration
    Calin Popa
    Atherosclerosis 182:375; author reply 377. 2005
  86. ncbi request reprint Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia
    Mieke D Trip
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Cardiol 91:604-6. 2003
  87. ncbi request reprint Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Cardiol 95:264-6. 2005
    ....
  88. ncbi request reprint Can we exclude the TXNIP gene as a candidate gene for familial combined hyperlipidemia?
    Gerly M van der Vleuten
    Am J Med Genet A 140:1010-2. 2006
  89. ncbi request reprint Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy
    Anne G Semb
    Cardiologic Department, Aker Hospital, Oslo, Norway
    J Am Coll Cardiol 41:275-9. 2003
    ..In the present study, we investigated the effects of statins on serum levels of soluble CD40 ligand (sCD40L) in patients with familial hypercholesterolemia (FH)...
  90. ncbi request reprint Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, P O Box 22 700, 1105 AZ, Amsterdam, The Netherlands
    Atherosclerosis 165:361-6. 2002
    ..High sensitivity C-reactive protein (hs-CRP) has emerged as the best studied and most promising marker of inflammation in atherosclerotic vascular disease...
  91. doi request reprint Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women
    Thomas M van Himbergen
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Atherosclerosis 199:408-14. 2008
    ..3-69.5, P < 0.0001, multivariate model). In conclusion, this study shows that in middle-aged women paraoxonase activity was associated with an increased risk for AMI and that the risk was modified by the effects of smoking...
  92. ncbi request reprint The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Risk 10:121-8. 2003
    ..This review discusses the diagnosis and management of the metabolic syndrome and examines the potential of future treatment options...
  93. ncbi request reprint The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 173:261-7. 2004
    ..The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enhanced risk for atherosclerosis...
  94. doi request reprint Simvastatin with or without ezetimibe in familial hypercholesterolemia
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 358:1431-43. 2008
    ..Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on the progression of atherosclerosis remains unknown...
  95. ncbi request reprint Management of mixed hyperlipidaemia
    Anton F H Stalenhoef
    Eur Heart J 26:856-7. 2005
  96. ncbi request reprint Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia
    Thomas M van Himbergen
    Research Laboratory of the Department of Clinical Chemistry, UMC Utrecht, Utrecht, The Netherlands T M van
    Biochem Biophys Res Commun 333:787-93. 2005
    ..22, P = 0.03), independent of baseline linoleic acid levels. These findings support an anti-oxidative role for PON1 in patients with FH, and thus may give insight into the functioning of PON1 in vivo...
  97. ncbi request reprint Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  98. ncbi request reprint A review of CETP and its relation to atherosclerosis
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Lipid Res 45:1967-74. 2004
    ..This review discusses the potential of CETP inhibitors to protect against atherosclerosis in the context of the current knowledge of CETP function in both rodents and humans...
  99. ncbi request reprint Diagnosing familial hypercholesterolaemia: the relevance of genetic testing
    Emily S van Aalst-Cohen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 27:2240-6. 2006
    ..We therefore set out to determine in these patients whether patients with a DNA diagnosis would differ significantly from those diagnosed clinically...
  100. ncbi request reprint Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia
    Thomas M van Himbergen
    Research Laboratory, Department of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Lipid Res 46:445-51. 2005
    ..001; paraoxonase activity: r = 0.23, P = 0.01; diazoxonase activity: r = 0.29, P < 0.001; arylesterase activity: r = 0.19, P = 0.03). Our observations support the hypothesis that both PON1 levels and activity preserve HDL-C in plasma...