P N Span

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 118:1241-7. 2006
  2. pmc Carbonic anhydrase IX expression is more predictive than prognostic in breast cancer
    P N Span
    Br J Cancer 96:1309; author reply 1310. 2007
  3. pmc Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients
    Marie Christine W Gast
    Department of Pharmacy and Pharmacology, Netherlands Cancer Institute Slotervaart Hospital, Amsterdam, The Netherlands
    BMC Cancer 8:389. 2008
  4. ncbi Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Oncogene 22:4898-904. 2003
  5. ncbi E1AF expression levels are not associated with prognosis in human breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Breast Cancer Res Treat 79:129-31. 2003
  6. ncbi Matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs: a prognostic marker for good clinical outcome in human breast carcinoma
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, The Netherlands
    Cancer 97:2710-5. 2003
  7. ncbi Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer?
    Paul N Span
    Department of Chemical Endocrinology, RAdboud University of Nimegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 52:1693-700. 2006
  8. ncbi Survivin is an independent prognostic marker for risk stratification of breast cancer patients
    Paul N Span
    Departments of Chemical Endocrinology, Clinical Chemistry, Medical Oncology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1986-93. 2004
  9. pmc Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
    P N Span
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Cancer 89:271-6. 2003
  10. ncbi High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer
    Paul N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Breast Cancer Res Treat 98:223-30. 2006

Detail Information

Publications73

  1. ncbi ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 118:1241-7. 2006
    ..In summary, ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma...
  2. pmc Carbonic anhydrase IX expression is more predictive than prognostic in breast cancer
    P N Span
    Br J Cancer 96:1309; author reply 1310. 2007
  3. pmc Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients
    Marie Christine W Gast
    Department of Pharmacy and Pharmacology, Netherlands Cancer Institute Slotervaart Hospital, Amsterdam, The Netherlands
    BMC Cancer 8:389. 2008
    ..We conducted a retrospective follow-up study in which we investigated sera of high-risk primary breast cancer patients, to search for proteins predictive of recurrence free survival...
  4. ncbi Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Oncogene 22:4898-904. 2003
    ..Differences in literature on the presumed prognostic value of cyclin-E may be due to differences in treatment. Assessment of cyclin-E levels can aid in improving adjuvant treatment selection...
  5. ncbi E1AF expression levels are not associated with prognosis in human breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Breast Cancer Res Treat 79:129-31. 2003
    ..Furthermore, no association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, or lymph node involvement was found...
  6. ncbi Matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs: a prognostic marker for good clinical outcome in human breast carcinoma
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, The Netherlands
    Cancer 97:2710-5. 2003
    ..Its expression is essential for normal vasculogenesis. Down-regulation of RECK has been implicated in tumor angiogenesis and progression...
  7. ncbi Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer?
    Paul N Span
    Department of Chemical Endocrinology, RAdboud University of Nimegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 52:1693-700. 2006
    ..In this study, we assessed whether the survivin splice variants modulate or add to the prognostic value of total survivin in breast cancer...
  8. ncbi Survivin is an independent prognostic marker for risk stratification of breast cancer patients
    Paul N Span
    Departments of Chemical Endocrinology, Clinical Chemistry, Medical Oncology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1986-93. 2004
    ..Results in previous qualitative studies of the association of the apoptosis inhibitor survivin with prognosis of breast cancer patients have been contradictory...
  9. pmc Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
    P N Span
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Cancer 89:271-6. 2003
    ..Thus, the determination of CA9 levels could aid in the selection of patients who will not benefit from adjuvant therapy, and whose prognosis will more likely improve with other treatment modalities...
  10. ncbi High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer
    Paul N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Breast Cancer Res Treat 98:223-30. 2006
    ..024, log-rank). Thus, high levels of survivin are mainly related with a poor response to endocrine therapy, but a good response to chemotherapy. This phenomenon might be related to the different functions of survivin...
  11. doi Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues
    Paul N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 102:177-82. 2008
    ....
  12. doi Harmonisation of multi-centre real-time reverse-transcribed PCR results of a candidate prognostic marker in breast cancer: an EU-FP6 supported study of members of the EORTC - PathoBiology Group
    P N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Cancer 45:74-81. 2009
    ..Assessment of intra- and inter-laboratory variation in multi-centre real-time reverse-transcribed PCR (qRT-PCR)-based mRNA quantification of a prognostic marker in breast cancer using external quality assurance (EQA)...
  13. ncbi Mammaglobin is associated with low-grade, steroid receptor-positive breast tumors from postmenopausal patients, and has independent prognostic value for relapse-free survival time
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Oncol 22:691-8. 2004
    ..The tumor mRNA expression levels of mammaglobin, a novel breast-specific and breast cancer-associated marker, were correlated with disease outcome in 280 patients with primary breast cancer...
  14. ncbi Complex of urokinase-type plasminogen activator with its type 1 inhibitor predicts poor outcome in 576 patients with lymph node-negative breast carcinoma
    Peggy Manders
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Cancer 101:486-94. 2004
    ..Both uPA and PAI-1 are established prognostic factors for patients with breast carcinoma. In the current study, the authors investigated whether the complex of uPA with PAI-1 is also associated with the natural course of this malignancy...
  15. doi DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Natl Cancer Inst 102:54-68. 2010
    ..We investigated the role of dendritic cell-specific transcript (DC-SCRIPT) as coregulator of these nuclear receptors and as a prognostic factor in breast cancer...
  16. ncbi Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma
    Peggy Manders
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cancer 98:2125-32. 2003
    ..In the current study, the authors investigated whether there was an association between VEGF levels in tumor tissues and response rates to first-line, systemic therapy in patients with advanced breast carcinoma...
  17. ncbi Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model
    L Heijmen
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Contrast Media Mol Imaging 9:237-45. 2014
    ..The increase in hypoxia, however, could not be demonstrated by pimonidazole/FMISO, possibly because distribution of these tracers is hampered by bevacizumab-induced effects on vascular permeability and perfusion...
  18. ncbi Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pathol 202:395-402. 2004
    ..0003). Thus, high tumour levels of the matrix metalloproteinases inhibitor and pro-apoptotic factor TIMP-3 are associated with successful tamoxifen treatment of patients with breast cancer...
  19. pmc Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes
    Remko R Bosch
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Biochem J 384:349-55. 2004
    ..Combined with the present findings, these results suggest that the liberation of PKClambda from PKCbeta(II) is an important factor in the regulation of GLUT1 distribution in 3T3-L1 adipocytes...
  20. ncbi Reduced adrenal response to bacterial lipopolysaccharide in interleukin-6-deficient mice
    F H van Enckevort
    Department of Endocrinology, University Medical Centre Nijmegen, The Netherlands
    J Endocrinol Invest 24:786-95. 2001
    ..The reduced adrenal response after LPS administration found in IL-6 -/- mice indicates a distinct role for IL-6 in the activation of the HPA axis by LPS...
  21. ncbi Vascular endothelial growth factor levels do not predict efficacy of systemic adjuvant treatment as assessed in 1127 breast cancer patients
    P Manders
    Department of Chemical Endocrinology 530, University Medical Centre Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Int J Oncol 25:511-7. 2004
    ..We conclude that tumor levels of VEGF do not predict the efficacy of adjuvant endocrine therapy or chemotherapy in patients with primary breast cancer...
  22. ncbi EORTC Receptor and Biomarker Study Group Report: a sandwich enzyme-linked immunosorbent assay for vascular endothelial growth factor in blood and tumor tissue extracts
    P N Span
    Department of Chemical Endocrinology, University Medical Centre, Nijmegen, The Netherlands
    Int J Biol Markers 15:184-91. 2000
    ..In conclusion, a sensitive, robust and specific VEGF ELISA has been developed. Research into the prognostic value of VEGF employing this assay is currently underway...
  23. ncbi Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Oncogene 21:8506-9. 2002
    ..This seems - at least in part - to be attributable to its role in transcriptional regulation of factors involved in angiogenesis (VEGF), and extracellular matrix remodeling (PAI-1)...
  24. ncbi Identification and partial characterization of two steroid 5 alpha-reductase isozymes in the canine prostate
    P N Span
    Department of Medicine, University Hospital St Radboud, Nijmegen, The Netherlands
    Prostate 34:222-30. 1998
    ..However, no information is available on the existence or characteristics of canine 5 alpha-reductase isozymes...
  25. ncbi Analysis of expression of chorionic gonadotrophin transcripts in prostate cancer by quantitative Taqman and a modified molecular beacon RT-PCR
    P N Span
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Endocrinol 172:489-95. 2002
    ..In contrast, hCG beta 3, 5 and 8 transcripts were found in normal tissue and did not differ in prostate cancer, arguing against a specific role of these transcripts in the development of prostate cancer...
  26. ncbi Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 diabetes
    Marie Jose J Pouwels
    Division of General Internal Medicine, Department of Medicine, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 87:5179-84. 2002
    ..These results do not support the hypothesis that accumulation of products of the hexosamine pathway plays a major role in hyperglycemia-induced insulin resistance...
  27. doi Serum vascular endothelial growth factor: a prognostic factor in cervical cancer
    Petra L M Zusterzeel
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Cancer Res Clin Oncol 135:283-90. 2009
    ..To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator...
  28. ncbi Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model
    E M Hendriksen
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Microvasc Res 77:96-103. 2009
    ....
  29. doi Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochim Biophys Acta 1806:193-9. 2010
    ..In this review, we will focus on novel insights in balancing NR activity via NR crosstalk and DC-SCRIPT/ZNF366, a bi-functional NR coregulator. The impact on breast cancer development and prognosis will be discussed...
  30. pmc Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis
    P L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:368-74. 2005
    ..To assess the expression and localisation of the new metalloproteinase inhibitor RECK, an inhibitor of matrix metalloproteinase-14 (MMP-14) secretion and activity, in the synovial membrane of patients with rheumatoid arthritis (RA)...
  31. ncbi Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue
    Marie Jose J Pouwels
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, The Netherlands
    J Clin Endocrinol Metab 89:5132-7. 2004
    ....
  32. ncbi Identifying estrogen receptor target genes
    Willem Jan Welboren
    Department of Molecular Biology, NCMLS Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Oncol 1:138-43. 2007
    ..Chromatin immunoprecipitation (ChIP) can yield all ER genomic target sites. Coupling of ChIP with genome-wide tiling arrays allows for the genome-wide unbiased identification of direct ER target sequences...
  33. doi EGFR-inhibition enhances apoptosis in irradiated human head and neck xenograft tumors independent of effects on DNA repair
    H Stegeman
    a Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Radiat Res 180:414-21. 2013
    ..This lack of correlation may be related to differential effects of cetuximab and radiotherapy on ERK1/2 signaling and a decreased induction of apoptosis by cetuximab and radiotherapy in the resistant model. ..
  34. doi Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant pheochromocytoma/paraganglioma
    P N Span
    Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The
    Endocr Relat Cancer 18:323-31. 2011
    ..Moreover, overexpression of aHIF and VEGF marks a higher metastatic potential in PGL...
  35. ncbi Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients
    Peggy Manders
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Clin Cancer Res 9:6363-70. 2003
    ..We investigated the association between VEGF levels in tumor tissue and the effect of radiotherapy for relapse-free survival (RFS) and overall survival (OS) in node-negative breast cancer...
  36. ncbi Predictive impact of urokinase-type plasminogen activator: plasminogen activator inhibitor type-1 complex on the efficacy of adjuvant systemic therapy in primary breast cancer
    Peggy Manders
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Cancer Res 64:659-64. 2004
    ..The results of this study imply that the expression of uPA:PAI-1 complex independently predicts the efficacy of adjuvant chemotherapy in patients with primary breast cancer...
  37. ncbi Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer
    Eva Kolwijck
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Oncol Rep 23:579-84. 2010
    ....
  38. ncbi The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer
    Peggy Manders
    Department of Chemical Endocrinology, 530, University Medical Centre Nijmegen, P O Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Thromb Haemost 91:514-21. 2004
    ..Further studies are warranted to explain this underlying resistance to endocrine therapy when uPA:PAI-I levels are high...
  39. ncbi Hexosamines are unlikely to function as a nutrient-sensor in 3T3-L1 adipocytes: a comparison of UDP-hexosamine levels after increased glucose flux and glucosamine treatment
    Remko R Bosch
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, The Netherlands
    Endocrine 23:17-24. 2004
    ....
  40. ncbi Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane
    Remko R Bosch
    Department of Chemical Endocrinology, University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Mol Endocrinol 17:1230-9. 2003
    ..The observation that PKCbetaII influences the rate of glucose uptake through manipulation of GLUT-1 expression levels at the plasma membrane might reveal a yet unidentified regulatory mechanism involved in glucose homeostasis...
  41. doi The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer
    Eva Kolwijck
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Clin Invest 40:591-9. 2010
    ..We investigated whether cathepsins in ovarian cyst fluid (oCF) were associated with disease outcome in patients with epithelial ovarian cancer (EOC)...
  42. ncbi Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats
    Remko R Bosch
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Endocrine 20:247-52. 2003
    ....
  43. ncbi Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes
    Jacques B de Kok
    Department of Clinical Chemistry, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Lab Invest 85:154-9. 2005
    ..We recommend this gene for future studies to standardize gene expression measurements in cancer research and tumor diagnostics until a definite gold standard has been determined...
  44. ncbi Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue
    Hedi L Claahsen-van der Grinten
    Radboud University Nijmegen Medical Centre, Department of Paediatric Endocrinology 833, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 92:3674-80. 2007
    ..In male patients with congenital adrenal hyperplasia (CAH), testicular adrenal rest tumors are frequently found that may interfere with gonadal function...
  45. doi Breast cancer size estimation with MRI in BRCA mutation carriers and other high risk patients
    R M Mann
    Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen, The Netherlands
    Eur J Radiol 82:1416-22. 2013
    ..Guidelines recommend invariably breast MRI screening for these patients and therapy is thus based on these findings. However, the accuracy of breast MRI for staging purposes is only tested in sporadic cancers...
  46. ncbi Quantitative detection of peripheral thyroglobulin mRNA has limited clinical value in the follow-up of thyroid cancer patients
    P N Span
    Department of Chemical Endocrinology, Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Clin Biochem 40:94-9. 2003
    ..Several earlier reports suggest that measuring Tg mRNA by reverse-transcriptase polymerase chain reaction (RT-PCR) could be of value, especially in patients with Tg autoantibodies...
  47. ncbi Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue
    Nicolai Grebenchtchikov
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1356-63. 2004
    ..The aim of the present study was to develop an ELISA to measure BCAR1 quantitatively in extracts of human breast cancer tissue...
  48. doi Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach
    L Heijmen
    Department of Medical Oncology 452, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Invest New Drugs 31:881-90. 2013
    ..Bevacizumab after progression resulted in significant changes in the tumor proliferation and microenvironment compared to discontinuation of bevacizumab. FDG-PET may be sensitive to BBP-induced effects...
  49. ncbi Short-term glucosamine infusion does not affect insulin sensitivity in humans
    M J Pouwels
    Divisions of General Internal Medicine, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 86:2099-103. 2001
    ..These results do not support involvement of the hexosamine pathway in the regulation of insulin sensitivity in humans, at least not in the short-term setting...
  50. ncbi Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats
    S W J Janssen
    Department of Animal Physiology, Faculty of Science, University of Nijmegen, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Endocrinol Invest 26:508-15. 2003
    ..Therefore, it is highly unlikely that these changes are caused by chronic hyperglycemia...
  51. ncbi Molecular beacon reverse transcription-PCR of human chorionic gonadotropin-beta-3, -5, and -8 mRNAs has prognostic value in breast cancer
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Chem 49:1074-80. 2003
    ..The beta-subunit of human chorionic gonadotropin (hCG) is encoded by four genes, of which expression of the hCGbeta-3, -5, and -8 genes could have prognostic value in breast cancer...
  52. ncbi Partial sequencing and tissue distribution of the canine isoforms of steroid 5alpha-reductase type I and type II
    P N Span
    Department of Chemical Endocrinology, University Medical Center Sint Radboud, Nijmegen, The Netherlands
    Prostate 44:233-9. 2000
    ..The dog is regarded to be a valid model to test the effects of 5alpha-reductase inhibitors on prostatic growth. However, limited information is available on the characteristics or even existence of 5alpha-reductase isozymes in this species...
  53. ncbi Reduced adrenal response and increased mortality after systemic Klebsiella pneumoniae infection in interleukin-6-deficient mice
    F H van Enckevort
    Department of Endocrinology 531, Nijmegen University Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 12:581-6. 2001
    ..Furthermore, the reduced adrenal response may be an explanation for the strong inflammatory response with higher TNF-alpha plasma levels in IL-6-/- mice...
  54. doi Metalloproteinases and their regulators in colorectal cancer
    Michel F P van der Jagt
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Surg Oncol 101:259-69. 2010
    ..In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC...
  55. ncbi Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer
    Michel F P van der Jagt
    Department of Surgery, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Lett 237:289-97. 2006
    ..In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P=0.017) association with overall survival...
  56. pmc ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
    Willem Jan Welboren
    Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    EMBO J 28:1418-28. 2009
    ..Furthermore, our data identify genes preferentially regulated by tamoxifen but not by E2 or fulvestrant. Thus (partial) antagonist loaded ERalpha acts mechanistically different on E2-activated and E2-repressed genes...
  57. pmc Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors
    Eva Kolwijck
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, The Netherlands
    J Cancer Res Clin Oncol 136:771-8. 2010
    ..In cancer, an extracellular and membrane bound localization of cathepsins contribute to the invasion of tumor cells at the basement membrane...
  58. ncbi Occurrence of postmenopausal-like acidic follicle-stimulating hormone (FSH) isoforms precedes the rise of FSH before menopause
    Chris M G Thomas
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fertil Steril 92:613-9. 2009
    ..To assess the glycoform distribution patterns of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the menstrual cycle at different ages and FSH levels, after menopause, and with premature ovarian failure (POF)...
  59. ncbi Application of a newly developed ELISA for BCAR1 protein for prediction of clinical benefit of tamoxifen therapy in patients with advanced breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Clin Chem 50:1445-7. 2004
  60. ncbi Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer
    Matthias Kotzsch
    Institute of Pathology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Eur J Cancer 41:2760-8. 2005
    ..Therefore, considering the prognostic impact of two proteolytic factors stemming from complementary protease systems may improve the prediction of disease recurrence in breast cancer...
  61. ncbi Concerns about mammaglobin assays
    Paul N Span
    Clin Chem 51:474-5. 2005
  62. ncbi The prognostic value of BCAR1 in patients with primary breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam
    Clin Cancer Res 10:6194-202. 2004
    ..Here, we study the prognostic value of quantitative BCAR1 levels in a large series of breast cancer specimens...
  63. ncbi Molecular profiling of platinum resistant ovarian cancer
    Jozien Helleman
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands
    Int J Cancer 118:1963-71. 2006
    ..A larger independent multicentre study should further confirm whether this 9-gene set can identify the patients who will not respond to platinum-based chemotherapy and could benefit from other therapies...
  64. ncbi Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer
    John A Foekens
    Department of Medical Oncology, Erasmus Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 24:1665-71. 2006
    ..The aim of this study was to validate this gene signature in an independent more diverse population of LNN patients from multiple institutions...
  65. ncbi Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells
    Angela Dittmer
    Klinik fur Gynakologie, Universitat Halle, Ernst Grube Strasse 40, 06120 Halle, Germany
    J Biol Chem 281:14563-72. 2006
    ..Our data suggest that PTHrP has a profound effect on gene expression in breast cancer cells and, as a consequence, contributes to the regulation of important cellular activities, such as migration and proliferation...
  66. ncbi Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer
    Leon Holzscheiter
    Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Clin Chem 52:1070-9. 2006
    ..The human tissue kallikrein gene family (KLK1 to KLK15) encodes a group of 15 serine proteases (hK1 to hK15), several of which have been implicated in cancer-related processes...
  67. ncbi Is survivin expression nevertheless related to disease outcome in breast cancer?
    Paul N Span
    Breast Cancer Res Treat 103:109. 2007
  68. ncbi Mammaglobin as molecular marker of breast cancer (micro)metastases
    Paul N Span
    Clin Cancer Res 11:7043; author reply 7044. 2005
  69. doi Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma
    Julia L Zhong
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom
    Mol Cancer Res 6:383-94. 2008
    ..These data indicate that selective expression of ADAM-15 variants in breast cancers could play an important role in determining tumor aggressiveness by interplay with intracellular signaling pathways...
  70. ncbi Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA
    Julia C Biermann
    Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, D 81675 Munich, Germany
    Int J Mol Med 21:251-9. 2008
    ..In conclusion, the implementation of mRNA quantification of uPA and PAI-1 in breast tumors is unable to serve as a one-to-one substitution for antigen determination by ELISA...
  71. ncbi Re: p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy
    Paul N Span
    J Natl Cancer Inst 99:738. 2007
  72. doi Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion
    Ana Gutierrez-Fernandez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain
    Cancer Res 68:2755-63. 2008
    ..On this basis, we propose that MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human...