J A Schalken

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Validation of molecular targets in prostate cancer
    Jack A Schalken
    Department of Experimental Urology, Radboud University Nijmegen Medical Center, Geert Grooteplein 30, Nijmegen, The Netherlands
    BJU Int 96:23-9. 2005
  2. ncbi request reprint Molecular aspects of hormone-independent prostate cancer
    Jack A Schalken
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 100:52-5. 2007
  3. doi request reprint Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer
    Maciej Salagierski
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:70-8. 2010
  4. pmc Personalized management in low-risk prostate cancer: the role of biomarkers
    Siebren Dijkstra
    Department of Urology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Prostate Cancer 2012:327104. 2012
  5. pmc Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
    Gisèle H J M Leyten
    Department of Urology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Int J Mol Sci 14:11347-55. 2013
  6. ncbi request reprint Predicting prostate biopsy outcome using a PCA3-based nomogram in a Polish cohort
    Maciej Salagierski
    267 Experimental Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 33:553-7. 2013
  7. pmc A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH
    Nicolas Wicker
    Laboratoire de Bioinformatique et de Génomique lntégratives, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
    BMC Genomics 8:84. 2007
  8. ncbi request reprint Cellular and molecular biology of the prostate: stem cell biology
    Jack A Schalken
    University Medical Center Nijmegen, Nijmegen, Netherlands
    Urology 62:11-20. 2003
  9. ncbi request reprint Molecular and cellular prostate biology: origin of prostate-specific antigen expression and implications for benign prostatic hyperplasia
    J A Schalken
    Department of Urology, University of Nijmegen, The Netherlands
    BJU Int 93:5-9. 2004
  10. ncbi request reprint New targets for therapy in prostate cancer: differential display code 3 (DD3(PCA3)), a highly prostate cancer-specific gene
    Jack A Schalken
    University Medical Center, Nijmegen, Netherlands
    Urology 62:34-43. 2003

Detail Information

Publications79

  1. ncbi request reprint Validation of molecular targets in prostate cancer
    Jack A Schalken
    Department of Experimental Urology, Radboud University Nijmegen Medical Center, Geert Grooteplein 30, Nijmegen, The Netherlands
    BJU Int 96:23-9. 2005
    ..Determining where best to search for a molecular target, and validating whether the target is associated with a sufficiently aggressive malignant process to justify further study is difficult, but the potential benefits are enormous...
  2. ncbi request reprint Molecular aspects of hormone-independent prostate cancer
    Jack A Schalken
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 100:52-5. 2007
  3. doi request reprint Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer
    Maciej Salagierski
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:70-8. 2010
    ..Our aim was to assess the diagnostic performance of a new PCA3 isoform (PCA3-TS4) and to study the interactions between PCA3 and BMCC1 in PrCa...
  4. pmc Personalized management in low-risk prostate cancer: the role of biomarkers
    Siebren Dijkstra
    Department of Urology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Prostate Cancer 2012:327104. 2012
    ..This paper provides an overview of the current available serum-, urine-, and tissue-based biomarkers in PCa and evaluates the clinical usefulness of these biomarkers in the detection and management of low-risk PCa...
  5. pmc Value of PCA3 to Predict Biopsy Outcome and Its Potential Role in Selecting Patients for Multiparametric MRI
    Gisèle H J M Leyten
    Department of Urology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Int J Mol Sci 14:11347-55. 2013
    ..Thus, PCA3 could be used to select patients that require MRI. However, in patients with a negative PCA3 and high clinical suspicion of PCa, a multiparametric MRI should also be done...
  6. ncbi request reprint Predicting prostate biopsy outcome using a PCA3-based nomogram in a Polish cohort
    Maciej Salagierski
    267 Experimental Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 33:553-7. 2013
    ..Aim: To determine whether the PCA3 score can be used relative to PCa clinical variables to predict biopsy outcome...
  7. pmc A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH
    Nicolas Wicker
    Laboratoire de Bioinformatique et de Génomique lntégratives, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
    BMC Genomics 8:84. 2007
    ..The correlation as well as the discriminative power of these platforms has never been compared statistically on a significant set of human patient samples...
  8. ncbi request reprint Cellular and molecular biology of the prostate: stem cell biology
    Jack A Schalken
    University Medical Center Nijmegen, Nijmegen, Netherlands
    Urology 62:11-20. 2003
    ....
  9. ncbi request reprint Molecular and cellular prostate biology: origin of prostate-specific antigen expression and implications for benign prostatic hyperplasia
    J A Schalken
    Department of Urology, University of Nijmegen, The Netherlands
    BJU Int 93:5-9. 2004
  10. ncbi request reprint New targets for therapy in prostate cancer: differential display code 3 (DD3(PCA3)), a highly prostate cancer-specific gene
    Jack A Schalken
    University Medical Center, Nijmegen, Netherlands
    Urology 62:34-43. 2003
    ..Although further studies are needed, gene therapies based on identification to delineate the range of transcription factors that interact with the DD3(PCA3) promoter represent a promising area for preclinical investigation...
  11. ncbi request reprint Differential expression of ferritin heavy chain in a rat transitional cell carcinoma progression model
    J A Vet
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Biochim Biophys Acta 1360:39-44. 1997
    ..The exact clinical relevance for the differential expression of ferritin H in human bladder cancer remains to be determined...
  12. ncbi request reprint A rabbit model to tissue engineer the bladder
    J E Nuininga
    Department of Urology, Pediatric Urology Center, University Medical Center, Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biomaterials 25:1657-61. 2004
    ..In this model, besides tissue regeneration, also some of the clinical problems are seen such as encrustation of foreign body material in the bladder. These aspects are subject for further pre-clinical studies in this animal model...
  13. ncbi request reprint The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Prostate 67:1432-8. 2007
    ..To determine the value of loss of expression of E-cadherin and cadherin associated molecules as prognostic markers for prostate cancer patients in a long-term follow-up study...
  14. ncbi request reprint Differential expression of vimentin in rat prostatic tumors
    M J Bussemakers
    Department of Urology, Urological Research Laboratory, University of Nijmegen, The Netherlands
    Biochem Biophys Res Commun 182:1254-9. 1992
    ..Nucleotide sequence analysis and computer-assisted database comparison revealed that pBUS51 was highly homologous to vimentin and therefore likely the rat homolog of this protein...
  15. ncbi request reprint Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis
    M J Bussemakers
    Department of Urology, Radboud University Hospital, Nijmegen, The Netherlands
    Cancer Res 51:606-11. 1991
    ..The overexpression of high mobility group protein I(Y) correlates rather with metastatic ability than with growth rate; hence it may serve as a valuable marker to identify progressionally advanced prostate cancer cells...
  16. ncbi request reprint Conventional bladder wash cytology performed by four experts versus quantitative image analysis
    H G van der Poel
    Department of Urology, University Hospital, Nijmegen, The Netherlands
    Mod Pathol 10:976-82. 1997
    ..Image analysis was superior to cytologic analysis for the prediction of tumor recurrence after normal findings at cystoscopic examination...
  17. ncbi request reprint Differential expression of keratins in the basal and luminal compartments of rat prostatic epithelium during degeneration and regeneration
    A P Verhagen
    Department of Urology, University of Nijmegen, The Netherlands
    Prostate 13:25-38. 1988
    ..These findings support the idea of a relationship between basal and luminal cells as being members of the same lineage of differentiation...
  18. ncbi request reprint Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomas
    J B de Kok
    Department of Clinical Chemistry, University Hospital Nijmegen, Nijmegen, The Netherlands
    Int J Cancer 87:217-20. 2000
    ..We conclude that standardized real-time measurement of hTERT expression can be used for early tumor detection and may be used for determination of prognosis in urothelial cell carcinomas of the bladder...
  19. ncbi request reprint Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer
    R Umbas
    Department of Urology Urological Research Laboratories, University Hospital, Nijmegen, The Netherlands
    Cancer Res 52:5104-9. 1992
    ..Taken together, these findings suggest that further exploration of E-cadherin as a candidate invasion suppressor molecule in human prostate cancer is warranted...
  20. ncbi request reprint Intravesical gemcitabine: a phase 1 and pharmacokinetic study
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 45:182-6. 2004
    ..We investigated the use of three dose levels of gemcitabine when given intravesically in humans for safety and pharmacokinetic research...
  21. ncbi request reprint Diagnostic efficacy of the ImmunoCyt test to detect superficial bladder cancer recurrence
    J L Vriesema
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Urology 58:367-71. 2001
    ..The validity of ImmunoCyt was insufficient to justify the omission of cystoscopy in patients in follow-up for superficial UCC...
  22. ncbi request reprint Identification and partial characterization of two steroid 5 alpha-reductase isozymes in the canine prostate
    P N Span
    Department of Medicine, University Hospital St Radboud, Nijmegen, The Netherlands
    Prostate 34:222-30. 1998
    ..However, no information is available on the existence or characteristics of canine 5 alpha-reductase isozymes...
  23. pmc p53 mutations have no additional prognostic value over stage in bladder cancer
    J A Vet
    Department of Urology, University Hospital, Nijmegen, The Netherlands
    Br J Cancer 70:496-500. 1994
    ..Nevertheless, these results imply that p53 is involved in the clinical behaviour of bladder cancer; its role in the progression of superficial cancer to invasive disease merits further attention...
  24. ncbi request reprint Isolation and characterization of the promoter of the human prostate cancer-specific DD3 gene
    G W Verhaegh
    Urology Research Laboratory, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 275:37496-503. 2000
    ..We show that the high mobility group I(Y) protein binds to one of the DNase-I-protected areas and recruits another, yet unidentified, protein to the DD3 promoter in LNCaP cells...
  25. ncbi request reprint Urinary NMP22 and karyometry in the diagnosis and follow-up of patients with superficial bladder cancer
    J A Witjes
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Eur Urol 33:387-91. 1998
    ..To study the value of two outpatient urine tests with regard to the diagnosis and recurrence of bladder tumors...
  26. ncbi request reprint Analysis of expression of chorionic gonadotrophin transcripts in prostate cancer by quantitative Taqman and a modified molecular beacon RT-PCR
    P N Span
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Endocrinol 172:489-95. 2002
    ..In contrast, hCG beta 3, 5 and 8 transcripts were found in normal tissue and did not differ in prostate cancer, arguing against a specific role of these transcripts in the development of prostate cancer...
  27. ncbi request reprint Expression of basal cell keratins in human prostate cancer metastases and cell lines
    G J van Leenders
    Department of Pathology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Pathol 195:563-70. 2001
    ..Accumulation of intermediate cells in regressed and hormone-escaped prostate cancer indicates that for their survival, these cells are androgen-independent...
  28. ncbi request reprint Superficial and metachronous invasive bladder carcinomas are clonally related
    J L Vriesema
    Department of Urology, University Medical Centre Nijmegen, The Netherlands
    Int J Cancer 93:699-702. 2001
    ..All tumors arose from the same progenitor cell. These results support the concept of a clonal origin of superficial and metachronous invasive bladder UCCs...
  29. ncbi request reprint The Bard BTA test: its mode of action, sensitivity and specificity, compared to cytology of voided urine, in the diagnosis of superficial bladder cancer
    D H Schamhart
    Department of Urology, University of Amsterdam, Nijmegen, The Netherlands
    Eur Urol 34:99-106. 1998
    ..In this study, the mode of action, sensitivity and specificity of the Bard(R) BTA test, detecting a tumor-associated release of a basement membrane complex, was addressed and compared with voided urine cytology (VUC)...
  30. ncbi request reprint DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer
    Daphne Hessels
    Department of Experimental Urology, Nijmegen Center for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:8-15; discussion 15-6. 2003
    ..DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed...
  31. ncbi request reprint Innovations in serum and urine markers in prostate cancer current European research in the P-Mark project
    M P M Q van Gils
    Department of Urology, Erasmus MC, CA Rotterdam, The Netherlands
    Eur Urol 48:1031-41. 2005
    ..In addition, novel markers will be identified in the same biorepositories by different mass spectrometry techniques...
  32. ncbi request reprint Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin
    K Tomita
    Urology Research Laboratory, University Hospital Nijmegen, Nijmegen, 6500 HB, The Netherlands
    Biochem Biophys Res Commun 267:870-4. 2000
    ..This resulted not only in the correct assembly of E-cadherin/alpha-catenin complexes at the cell membrane but also in localization of ALCAM to cell-cell contacts, indicating that indeed alpha-catenin affects ALCAM localization...
  33. doi request reprint Measuring therapeutic efficacy in the changing paradigm of castrate-resistant prostate cancer
    P F Mulders
    Department of Urology, Radboud University Nijmegen Medical Center, Postbus, Nijmegen, The Netherlands
    Prostate Cancer Prostatic Dis 12:241-6. 2009
    ....
  34. ncbi request reprint Partial sequencing and tissue distribution of the canine isoforms of steroid 5alpha-reductase type I and type II
    P N Span
    Department of Chemical Endocrinology, University Medical Center Sint Radboud, Nijmegen, The Netherlands
    Prostate 44:233-9. 2000
    ..The dog is regarded to be a valid model to test the effects of 5alpha-reductase inhibitors on prostatic growth. However, limited information is available on the characteristics or even existence of 5alpha-reductase isozymes in this species...
  35. ncbi request reprint Decreased expression of alpha-catenin is associated with poor prognosis of patients with localized renal cell carcinoma
    T Shimazui
    Urological Research Laboratory, University Hospital, Nijmegen, The Netherlands
    Int J Cancer 74:523-8. 1997
    ....
  36. ncbi request reprint Detailed analysis of histopathological parameters in radical prostatectomy specimens and PCA3 urine test results
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 68:1215-22. 2008
    ..PCA3 has proven to be of value in the diagnosis of PCa. However, so far few attempts have been made to investigate the prognostic value of PCA3. Our objective was to further investigate the prognostic value of PCA3...
  37. doi request reprint Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues
    Paul N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 102:177-82. 2008
    ....
  38. ncbi request reprint Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma
    Boukje A C van Dijk
    Department of Epidemiology, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Cancer Causes Control 19:125-34. 2008
    ..We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC)...
  39. ncbi request reprint CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomas
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Cancer 116:282-4. 2005
    ..Our results suggest, in contrast to those of Guo et al. (Nat Med 2004;10:374-81), that the oncogene CDC91L1 is not overexpressed at the mRNA level in urothelial cell carcinomas and cannot be used to predict the course of the disease...
  40. doi request reprint Predictive value of PCA3 in urinary sediments in determining clinico-pathological characteristics of prostate cancer
    Daphne Hessels
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:10-6. 2010
    ..In this study, PCA3 was correlated with clinical stage, biopsy Gleason score (GS), radical prostatectomy GS, tumor volume, and pathological stage to assess its potential as predictor of PCa aggressiveness...
  41. ncbi request reprint Applicability of biomarkers in the early diagnosis of prostate cancer
    Daphne Hessels
    Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Expert Rev Mol Diagn 4:513-26. 2004
    ..This could subsequently lead to a reduction of the number of unnecessary biopsies...
  42. ncbi request reprint Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
    Karin Grabmaier
    Laboratory for Experimental Urology, 190 RT NCMLS, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Oncogene 23:5624-31. 2004
    ..In conclusion, HIF-1alpha and Sp1, in combination with CBP/p300, are crucial elements for G250MN expression in ccRCC, and CAIXG250 can be regarded as a unique HIF-1alpha target gene in ccRCC...
  43. ncbi request reprint Site-specific familial aggregation of prostate cancer
    Bas A J Verhage
    Center for Prevention and Health Services Research PZO, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Cancer 109:611-7. 2004
    ..5; 95% CI = 1.7-3.6). Cancers at other sites did not coaggregate with PC. Our data suggest that familial PC, at least in this Western European population, is site-specific, not part of an inherited cancer syndrome...
  44. ncbi request reprint Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence
    I J Schultz
    Department of Clinical Chemistry 564, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Anticancer Res 23:3327-31. 2003
    ..Expression of the inhibitor of apoptosis protein survivin is up-regulated in many tumors of epithelial origin and frequently shows a relationship with disease prognosis...
  45. doi request reprint An in vitro model for preclinical testing of endocrine therapy combinations for prostate cancer
    Minja J Pfeiffer
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:1524-32. 2010
    ..Our objective was to generate a novel cell line model representing the endocrine treatment naive prostate cancer for testing treatments that target the androgen receptor (AR) and androgen metabolism...
  46. doi request reprint Preliminary evaluation of the effect of dutasteride on PCA3 in post-DRE urine sediments: a randomized, open-label, parallel-group pilot study
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 69:1624-34. 2009
    ..This was the first study to investigate the effect of dutasteride on the new PCa marker PCA3, longitudinally and in a dose dependent manner...
  47. pmc Intermediate cells in human prostate epithelium are enriched in proliferative inflammatory atrophy
    Geert J L H van Leenders
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Am J Pathol 162:1529-37. 2003
    ..The finding of a large number of highly proliferating intermediate cells in PIA provides further support that these cells may serve as preferred target cells in prostate carcinogenesis...
  48. ncbi request reprint The time-resolved fluorescence-based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Cancer Res 13:939-43. 2007
    ..In a previous single institution study, the PCA3 urine test clearly proved to be of diagnostic value. Therefore, the diagnostic performance of the PCA3 urine test was validated in a multicenter study...
  49. pmc Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study
    Kjeld P van Houwelingen
    Department of Urology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Cancer 5:57. 2005
    ..We studied the VHL mutation status in a large population-based case group...
  50. ncbi request reprint Branching activity in the human prostate: a closer look at the structure of small glandular buds
    Y Xue
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Eur Urol 39:222-31. 2001
    ..Our object was to demonstrate, on the basis of immunophenotype, loci that harbor the potential for branching activity within the adult human prostate...
  51. ncbi request reprint Increased expression of retroviral sequences in progressionally advanced rat prostatic tumors
    M J Bussemakers
    Department of Urology Urological Research Laboratory, University of Nijmegen, The Netherlands
    Biochem Biophys Res Commun 182:318-24. 1992
    ..The importance of overexpression of retroviral sequences in advanced prostatic cancer remains unclear...
  52. ncbi request reprint Prognostic value of p53 for high risk superficial bladder cancer with long-term followup
    P M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 177:80-3. 2007
    ..We determined the value of p53 mutation, as demonstrated by mutation analysis, in a clinically selected group of high risk patients with superficial bladder cancer...
  53. ncbi request reprint Treatment options in hormone resistant prostate cancer
    P H M de Mulder
    Department of Medical Oncology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Ann Oncol 13:95-102. 2002
  54. ncbi request reprint Cadherin-11 is expressed in detrusor smooth muscle cells and myofibroblasts of normal human bladder
    Kamiel A J Kuijpers
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 52:1213-21. 2007
    ..We therefore hypothesised that the physical adhesion between detrusor smooth muscle cells and myofibroblasts is mediated by cadherin-11. The aim of this study was to test this hypothesis...
  55. ncbi request reprint Molecular PCA3 diagnostics on prostatic fluid
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 67:881-7. 2007
    ..In this study, we evaluated the PCA3 test on prostatic fluid and compared this with the PCA3 test on urine in a clinical research setting...
  56. doi request reprint The use of PCA3 in the diagnosis of prostate cancer
    Daphne Hessels
    NovioGendix, Nijmegen, The Netherlands
    Nat Rev Urol 6:255-61. 2009
    ..This Review describes the translation of the molecular marker PCA3 from the research laboratory to clinical practice...
  57. ncbi request reprint Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer
    Daphne Hessels
    Experimental Urology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Cancer Res 13:5103-8. 2007
    ..We studied the diagnostic usefulness of TMPRSS2-ERG fusion transcripts as well as the combination of prostate cancer antigen 3 (PCA3) RNA and TMPRSS2-ERG fusion transcripts in urinary sediments after digital rectal examination (DRE)...
  58. ncbi request reprint Epithelial cell differentiation in the human prostate epithelium: implications for the pathogenesis and therapy of prostate cancer
    Geert J L H van Leenders
    Department of Pathology, University Medical Center St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Crit Rev Oncol Hematol 46:S3-10. 2003
    ..Targeting intermediate cells by inhibition of their peptide growth factor receptors, therefore, offers novel treatment modalities for prostate cancer...
  59. ncbi request reprint Pharmacokinetics of intravesical gemcitabine: a preclinical study in pigs
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:615-9. 2003
    ..It has been shown to be effective and well tolerated when given systemically. We investigated the use of this agent administered intravesically in pigs for histological studies of the bladder and pharmacokinetic research...
  60. ncbi request reprint Rabbit urethra replacement with a defined biomatrix or small intestinal submucosa
    J E Nuininga
    Pediatric Urology Center, Department of Urology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:266-71. 2003
    ..The evaluation of collagen-based biomatrix (SIS COOK((R))) in comparison to a biochemically reconstructed biomatrix for replacement of the urethra in a rabbit model as a preclinical model...
  61. ncbi request reprint Allelic imbalance in hereditary and sporadic prostate cancer
    Bas A J Verhage
    Department of Urology, University Medical Center Nijmegen, The Netherlands
    Prostate 54:50-7. 2003
    ....
  62. doi request reprint Stem cell characteristics in prostate cancer cell lines
    Minja J Pfeiffer
    Department of Urology, Radboud University Nijmegen Medical Centre, NL 6500HB Nijmegen, The Netherlands
    Eur Urol 57:246-54. 2010
    ..Recent studies indicate the presence of a small, stem-like cell population in several human cancers that is crucial for the tumour (re)population...
  63. ncbi request reprint The predictive value of p53, p27(kip1), and alpha-catenin for progression in superficial bladder carcinoma
    Barthold Ph Schrier
    Department of Urology, Radboud University Nijmegen, Medical Centre, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 50:76-82. 2006
    ..The aim of the study was to confirm the predictive value of cell cycle regulatory proteins, p53 and p27(kip1), and the cell adhesion complex protein alpha-catenin, for progression in patients with superficial bladder carcinoma...
  64. ncbi request reprint Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer
    Paula M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 52:464-8. 2007
    ..We aimed to study the association between presence of (high-risk) HPV DNA, p53 status, and clinical outcome in bladder cancer patients. This study must be seen as a preliminary study to investigate this potentially important problem...
  65. ncbi request reprint Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Lambertus A Kiemeney
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Cancer 42:3219-27. 2006
    ..We studied the association between both polymorphisms and the risk of bladder cancer...
  66. ncbi request reprint Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: an in vitro study
    Antoine G van der Heijden
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Urol 173:1375-80. 2005
    ..However, the working mechanism of this combination therapy is not fully understood. In the current in vitro study we investigated the differences in cytotoxicity of 4 chemotherapeutic agents at 37C or 43C...
  67. ncbi request reprint Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: results from the Netherlands Cohort Study
    Leo J Schouten
    Department of Epidemiology, NUTRIM, Maastricht University, The Netherlands
    J Hypertens 23:1997-2004. 2005
    ..Hypertension and/or antihypertensive medication are reported to be risk factors of renal cell carcinoma (RCC). We investigated whether these risk factors are associated with von Hippel-Lindau gene (VHL) mutations in RCC...
  68. ncbi request reprint Role of complex cadherins in cell-cell adhesion evaluated by spheroid formation in renal cell carcinoma cell lines
    Toru Shimazui
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Oncol Rep 11:357-60. 2004
    ..In conclusion, E-cadherin and cadherin-6 are shown to act in cell-cell adhesion whereas N-cadherin might play a somewhat different role from cell-cell adhesion in RCC cell lines...
  69. ncbi request reprint Molecular markers for prostate cancer
    Mark A Reynolds
    Gen Probe Incorporated, 10210 Genetic Center Drive, San Diego, CA 92121, USA
    Cancer Lett 249:5-13. 2007
    ..The goal of current research is to apply genomic assays to noninvasive specimens such as blood and urine. Progress in this area is the subject of this review...
  70. ncbi request reprint Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer
    Bas A J Verhage
    Department of Urology 252 EPIB, University Medical Centre Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Int J Cancer 100:683-5. 2002
    ..6, 95% CI 2.0-6.4) compared to C-only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1-6.8 and OR = 1.7, 95% CI 0.4-6.6, respectively) compared to CC genotypes...
  71. ncbi request reprint DD3(PCA3), a very sensitive and specific marker to detect prostate tumors
    Jacques B de Kok
    Department of Clinical Chemistry, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    Cancer Res 62:2695-8. 2002
    ..Consequently, DD3 measurements may be used for clinical application in prostate needle biopsies or bodily fluids such as blood, ejaculate, urine, or prostate massage fluid...
  72. ncbi request reprint The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy
    Keishi Kashibuchi
    Department of Urology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Urol 14:789-94. 2007
    ..To determine the value of the loss of expression of E-cadherin and cadherin associated molecules as useful markers for both prognosis and chemosensitivity in bladder cancer patients who have undergone radical cystectomy...
  73. ncbi request reprint hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis
    Ira Kogan
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Cancer Res 66:3531-40. 2006
    ....
  74. ncbi request reprint Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers
    Vinata B Lokeshwar
    Department of Urology, University of Miami, Miami, Florida 33101, USA
    Urology 66:35-63. 2005
    ..Therefore, use of bladder tumor markers in the management of patients with bladder cancer will require the willingness of both urologists and clinicians to accept them...
  75. ncbi request reprint Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers
    Tomonori Habuchi
    Department of Urology, Kyoto University, Kyoto, Japan
    Urology 66:64-74. 2005
    ....
  76. ncbi request reprint The prognostic value of E-cadherin, alpha-, beta-, and gamma-catenin in urothelial cancer of the upper urinary tract
    Keishi Kashibuchi
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    Eur Urol 49:839-45; discussion 845. 2006
    ..To determine the value of loss of the expression of E-cadherin and cadherin-associated molecules as useful markers for both prognosis and bladder recurrence in patients with upper urinary tract cancer...
  77. ncbi request reprint Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia
    Chaidir A Mochtar
    Department of Urology G4 105 1, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    BJU Int 97:852-5. 2006
    ..There was a small effect on perceived quality of life but this was not reflected in other variables that measured the treatment response more directly...
  78. ncbi request reprint Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system
    Evert Van Garderen
    Department of Pathology, Utrecht University, Utrecht, The Netherlands
    Mol Cell Endocrinol 197:153-65. 2002
    ..Consistent with the findings on the canine GHR, different GHR transcripts in human mammary cancer cells and prostate cancer cells were detected encoding the full-length plasma membrane GHR and putative GHBPs...
  79. ncbi request reprint Engineered FGF-2 expression induces glandular epithelial hyperplasia in the murine prostatic dorsal lobe
    Naoko Konno-Takahashi
    Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Urol 46:126-32. 2004
    ..This supports the paracrine/autocrine growth of prostatic epithelial/stromal cells in the pathogenesis of BPH and invasive prostate cancer...