Frans G M Russel

Summary

Affiliation: Radboud University
Country: The Netherlands

Publications

  1. ncbi Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
    Frans G M Russel
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    Trends Pharmacol Sci 29:200-7. 2008
  2. ncbi Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats
    Julliette E M van Eerd
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:528-33. 2006
  3. ncbi Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    Remon A M H van Aubel
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 288:F327-33. 2005
  4. ncbi Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Nutr 103:1836-43. 2010
  5. ncbi Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Pflugers Arch 454:321-34. 2007
  6. ncbi Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Eur J Pharmacol 584:390-7. 2008
  7. ncbi Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    Pascal H E Smeets
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Am Soc Nephrol 15:2828-35. 2004
  8. ncbi Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 37:417-23, e1. 2009
  9. ncbi Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 318:1194-202. 2006
  10. ncbi Reducing renal uptake of radiolabeled peptides using albumin fragments
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 49:1506-11. 2008

Collaborators

Detail Information

Publications64

  1. ncbi Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
    Frans G M Russel
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    Trends Pharmacol Sci 29:200-7. 2008
    ..This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes...
  2. ncbi Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats
    Julliette E M van Eerd
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:528-33. 2006
    ..In the present study, we analyzed the effects of several plasma expanders on the renal uptake of 111In-octreotide in rats and mice...
  3. ncbi Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    Remon A M H van Aubel
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 288:F327-33. 2005
    ..We propose MRP4 as a candidate transporter for urinary urate excretion and suggest that MRP4 may also mediate hepatic export of urate into the circulation, because of its basolateral expression in the liver...
  4. ncbi Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Nutr 103:1836-43. 2010
    ..9-fold higher than from the 'mixed diet' (16 %). This extrinsic labelling technique can measure precisely the vitamin A equivalency of beta-carotene in oil capsules, but it does not represent the effect of different dietary matrices...
  5. ncbi Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Pflugers Arch 454:321-34. 2007
    ..Our data indicate that NO, produced locally by renal iNOS, regulates the expression of ABC transporters in vivo. Furthermore, we showed, for the first time, expression and subcellular localization of Abcb11/Bsep in rat kidney...
  6. ncbi Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Eur J Pharmacol 584:390-7. 2008
    ..001). These findings indicate that NO, produced by iNOS, is responsible for a down-regulation of the influx carriers, Oct1 and Oct2...
  7. ncbi Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    Pascal H E Smeets
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Am Soc Nephrol 15:2828-35. 2004
    ..MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion...
  8. ncbi Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 37:417-23, e1. 2009
    ..To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury...
  9. ncbi Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 318:1194-202. 2006
    ..Up-regulation of MRP2 in the kidney may be interpreted as part of a protective mechanism...
  10. ncbi Reducing renal uptake of radiolabeled peptides using albumin fragments
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 49:1506-11. 2008
    ....
  11. ncbi Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Pharmacol Exp Ther 315:912-20. 2005
    ..Thus, short-term exposure to ET-1 or gentamicin resulted in long-term protection against a second insult...
  12. ncbi Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules
    Femke M van de Water
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Drug Metab Dispos 34:1393-7. 2006
    ..v. injection, where it selectively suppresses gene function in the proximal tubules. Therefore, i.v. administered siRNA provides a novel experimental and potential therapeutic tool for gene silencing in the kidney...
  13. ncbi The role of ATP binding cassette transporters in tissue defense and organ regeneration
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 328:3-9. 2009
    ..This review focuses on the role of ABC transporters in tissue defense and regeneration, with specific attention to P-gp and BCRP in organ regeneration and repair...
  14. ncbi Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4)
    Azza A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pharmacol 74:964-71. 2008
    ..A homology model of MRP4 showed that Arg375 and Arg998 face right into the central aqueous pore of MRP4. We conclude that positively charged amino acids in transmembrane helices 6 and 12 contribute to the MRP4 substrate-binding pocket...
  15. ncbi Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Mol Pharm 9:1351-60. 2012
    ....
  16. ncbi Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels
    Richard Engbersen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharmacol 681:75-9. 2012
    ..We conclude that sulfonylurea drugs exert differential effects on vascular smooth muscle K(ATP) channels. Our results suggest that glibenclamide and glimepiride will interact with these channels at therapeutic concentrations...
  17. ncbi Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism
    Richard Engbersen
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Br J Pharmacol 145:1069-75. 2005
    ..We conclude that micromolar concentrations of glibenclamide interfere with mitochondrial bioenergetics and, therefore, should be used with care for inhibition of epithelial K(ATP) channels...
  18. ncbi Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Medical Centre, Radboud University, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomed Biotechnol 2010:525180. 2010
    ..These findings indicate that at least two pathways regulate P-gp expression in the kidney during endotoxemia...
  19. ncbi Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations
    Henricus A M Mutsaers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e18438. 2011
    ..Moreover, calculated Ki values are below the maximal plasma concentrations of the tested toxins. In conclusion, this study shows that several uremic toxins inhibit active transport by MRP4 and BCRP at clinically relevant concentrations...
  20. ncbi Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Biochem Pharmacol 84:366-73. 2012
    ..They, however, might interact with the substrates during rearrangement of helixes for substrate translocation, funneling the substrates to the exit site in the outward-facing conformation...
  21. ncbi Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
    Reginald A Kavishe
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Malar J 8:205. 2009
    ..In order to understand the molecular mechanisms underlying drug resistance, characterization of these transporters is essential. The aim of this study was to characterize and localize putative ABC transporters...
  22. ncbi Short-term beneficial effects of methylene blue on kidney damage in septic shock patients
    Suzanne Heemskerk
    Radboud University, Nijmegen Medical Centre, Department of Pharmacology and Toxicology, Nijmegen Center for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 34:350-4. 2008
    ..In this study we investigated the short-term effect of methylene blue (MB), an inhibitor of the NO pathway, on kidney damage and function in septic shock patients...
  23. ncbi Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 287:F33-8. 2004
    ..Together, these data indicate that ET regulation of Mrp2 involves activation of guanylyl cyclase and generation of cGMP. Signaling by cGMP follows NO release and precedes PKC activation...
  24. ncbi Mechanisms of renal anionic drug transport
    Azza A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharmacol 585:245-55. 2008
    ....
  25. ncbi Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology (149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 1:853-62. 2006
    ....
  26. ncbi Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children
    Reginald A Kavishe
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 81:363-5. 2009
    ..0% against 10.3% mild malaria, P = 0.004). We concluded that GSTP1 and possibly GSTM1 may protect against severe falciparum malaria in children...
  27. ncbi Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines
    Femke M van de Water
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Pharm Sci 30:36-44. 2007
    ..Mrp dependent transport was most likely mediated by Mrp4. In future, these cell lines may be used as in vitro models to study drug transport...
  28. ncbi Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport
    Azza A K El Sheikh
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Department of Pharmacology and Toxicology 149, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 320:229-35. 2007
    ..Our data suggest that the inhibition by NSAIDs of renal MTX efflux via MRP2 and MRP4 is a potential new site and mechanism contributing to the overall interaction between these drugs...
  29. ncbi Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin
    Femke M van de Water
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Res 54:429-35. 2006
    ..These rat intestinal and renal cell lines appear to be suitable for further characterisation of ET-1 function and its role in pathophysiological processes in epithelial cells...
  30. ncbi Iron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Nephrol Dial Transplant 20:2646-53. 2005
    ..CONCLUSIONS: Addition of an iron chelator to the preservation solution UW did not improve kidney function after both CS and CP. Iron chelation is not able to prevent cold-induced damage in the isolated perfused rat kidney...
  31. ncbi Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury
    Suzanne Heemskerk
    Department of Intensive Care Medicine and the Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Rev Nephrol 5:629-40. 2009
    ..In this Review, the selective inhibition of iNOS as a potential novel treatment for sepsis-induced AKI is discussed...
  32. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides
    Aloys L A Sesink
    Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pharmacol 67:1999-2006. 2005
    ..In conclusion, Bcrp1 limits net intestinal absorption of quercetin by pumping quercetin glucuronides back into the lumen...
  33. ncbi The ABCs of multidrug resistance in malaria
    Jan B Koenderink
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Parasitol 26:440-6. 2010
    ..Here, we give an overview of the Plasmodium ABC family members with reference to their possible role in multidrug resistance...
  34. ncbi Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule
    Sylvie A Terlouw
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 301:578-85. 2002
    ..Together, these findings indicate that exposure of renal proximal tubules to heavy metals initially leads to reduced Mrp2 function but is followed by an induction in Mrp2-mediated transport after long-term exposure...
  35. ncbi The heme-heme oxygenase system in wound healing; implications for scar formation
    Frank A D T G Wagener
    Department of Orthodontics and Oral Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Drug Targets 11:1571-85. 2010
    ..A better understanding of the heme-heme oxygenase system as target during wound healing may result in novel strategies to reduce scar formation...
  36. ncbi Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Toxicol Sci 129:225-33. 2012
    ..Eventually, this leads to hepatic iron loading associated with APAP cytotoxicity...
  37. ncbi Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones
    Anita C A Dankers
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cell Tissue Res 349:551-63. 2012
    ..In conclusion, localization of Bcrp in endocrine organs together with the efficient allosteric inhibition of the efflux pump by steroid hormones are suggestive for a role for BCRP in steroid hormone regulation...
  38. ncbi Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Drug Metab Dispos 40:1076-9. 2012
    ..These results are in line with the pharmacokinetic profile of coumarin and suggest that MRP3 and MRP4 are the main transporters involved in the excretion of the coumarin metabolite 7-HC-G from liver and kidney...
  39. ncbi Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP)
    Rick Greupink
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharm Sci 44:487-96. 2011
    ..However, under normal conditions, NTCP-mediated uptake of this drug seems not to be a significant hepatocellular uptake pathway...
  40. ncbi Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Transplant 19:1195-208. 2010
    ..Furthermore, we demonstrate that transporter-deficient bone marrow contained significantly more monocytes, granulocytes, and early outgrowth endothelial progenitor cells...
  41. ncbi Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule
    Brigitte Prevoo
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 338:362-71. 2011
    ..This up-regulation may be nephroprotective, enhancing efflux of metabolic wastes and toxicants during cell and tissue stress...
  42. ncbi Therapeutic implications of renal anionic drug transporters
    Rosalinde Masereeuw
    Dept of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Ther 126:200-16. 2010
    ..This review highlights recent knowledge of the renal organic anion system with special reference to the therapeutic implications associated with variations in transporter activity and drug interactions...
  43. ncbi Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions
    Femke M van de Water
    Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Drug Metab Rev 37:443-71. 2005
    ..This review discusses current knowledge on the renal characteristics of MRP1-9, with specific focus on their regulation...
  44. ncbi Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats
    Rosalinde Masereeuw
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    J Am Soc Nephrol 14:2741-9. 2003
    ..We conclude that the renal clearance of the Mrp2 substrates calcein and fluo-3 is significantly reduced in TR(-) rat; for LY, the absence of the transporter may be compensated for by (an)other organic anion transporter(s)...
  45. ncbi Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport
    Sylvie A Terlouw
    Department of Pharmacology and Toxicology 233, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochem Pharmacol 65:1393-405. 2003
    ..This commentary discusses the current knowledge of endogenous and exogenous influences on renal anionic xenobiotic excretion...
  46. ncbi Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e49524. 2012
    ..In conclusion, using this urinary proteomics approach we demonstrate CA3, SOD1 and, most importantly, CaM as potential human biomarkers for APAP-induced liver injury...
  47. ncbi In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity
    Rick Greupink
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Toxicol Sci 129:35-48. 2012
    ..In conclusion, pharmacophore modeling was successfully used to identify compounds that inhibit NTCP. Our approach represents an important first step toward the in silico flagging of potential cholestasis-inducing molecules...
  48. ncbi HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis
    Frank A D T G Wagener
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3388-93. 2008
    ..The aim of this study was to determine whether the (GT)n-repeat length within the HMOX1 promoter region is associated with RA disease severity and radiographic joint damage...
  49. ncbi Mass spectrometry analysis of hepcidin peptides in experimental mouse models
    Harold Tjalsma
    Laboratory of Genetic, Endocrine and Metabolic Diseases, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e16762. 2011
    ....
  50. ncbi Preserved vascular reactivity of rat renal arteries after cold storage
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cryobiology 48:95-8. 2004
    ..Since 24h of cold storage considerable damages renal tubular cells both in vitro and after kidney transplantation, these results suggest that renal arteries are less sensitive to cold-induced damage than tubular cells...
  51. ncbi Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Drug Metab Dispos 39:1294-302. 2011
    ....
  52. ncbi Insights into the role of bone marrow-derived stem cells in renal repair
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Kidney Blood Press Res 31:104-10. 2008
    ..In this review the advantages and shortcomings of our procedure are critically discussed and compared with other methods described...
  53. ncbi Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis
    Alwin Scharstuhl
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS ONE 4:e6688. 2009
    ..We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated the underlying mechanism of this process...
  54. ncbi Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:432-6. 2006
    ..The infusion of GELO did not cause any side effects. CONCLUSION: GELO effectively reduces the renal uptake of 111In-OCT. In contrast to currently used mixtures of amino acids, GELO does not cause any side effects...
  55. ncbi Effect of drugs on renal development
    Michiel F Schreuder
    Department of Pediatric Nephrology, 804, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 6:212-7. 2011
    ..Because the effects of many widely used drugs have not been unraveled thus far, more research is needed to study the effect on renal development and long-term renal sequelae after drug treatment during nephrogenesis...
  56. ncbi The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP
    Remon A M H van Aubel
    Department of Pharmacology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    J Am Soc Nephrol 13:595-603. 2002
    ..It is concluded that MRP4 is a novel apical organic anion transporter and the putative efflux pump for cAMP and cGMP in human kidney proximal tubules...
  57. ncbi Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Nutr 101:1837-45. 2009
    ..In conclusion, this extrinsic labelling technique cannot measure effects of mixed vegetables and fruits matrices, but can measure precisely the vitamin A equivalency of the beta-carotene in oil capsules...
  58. ncbi The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats
    Esther W H Bodde
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:780-91. 2008
    ..Low amounts of sustained released rhBMP-2 were sufficient to bridge critically sized defects. A substantial amount of rhBMP-2 was retained in the implants because of the slow release rate and the limited degradation...
  59. ncbi Modeling mitochondrial dysfunctions in the brain: from mice to men
    Megan E Breuer
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Inherit Metab Dis 35:193-210. 2012
    ....
  60. ncbi Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules
    Rosalinde Masereeuw
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, HB, Nijmegen, The Netherlands
    AAPS J 14:883-94. 2012
    ..Insight in these processes is of importance because variations in transporter activity due to certain (disease) conditions could lead to significant changes in drug efficacy or toxicity...
  61. ncbi Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio
    Karl M Weigand
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochim Biophys Acta 1818:1269-73. 2012
    ....
  62. ncbi Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus
    Tanya M Bisseling
    Department of Pharmacology-Toxicology, University Medical Center, Nijmegen, The Netherlands
    Am J Obstet Gynecol 192:973-9. 2005
    ..CONCLUSION: In the fetoplacental circulation, KATP channels and KV channels significantly contribute to baseline vascular tone. In diabetes, vascular KATP channel function is impaired...
  63. ncbi Hypothermia causes a marked injury to rat proximal tubular cells that is aggravated by all currently used preservation solutions
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cryobiology 47:82-91. 2003
    ..Iron-dependent MPT is suggested to play a role in this damage. Strategies to prevent cold-induced injury should aim at reducing the availability of "free" iron...
  64. ncbi Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype
    Reginald A Kavishe
    Department of Pharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 75:827-9. 2006
    ..We conclude that the GSTM1-null genotype is associated with malaria with complications...