Frans G M Russel

Summary

Affiliation: Radboud University
Country: The Netherlands

Publications

  1. doi request reprint Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
    Frans G M Russel
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    Trends Pharmacol Sci 29:200-7. 2008
  2. ncbi request reprint Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats
    Julliette E M van Eerd
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:528-33. 2006
  3. ncbi request reprint Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    Remon A M H van Aubel
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 288:F327-33. 2005
  4. pmc Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Pflugers Arch 454:321-34. 2007
  5. ncbi request reprint Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Nutr 103:1836-43. 2010
  6. doi request reprint Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Eur J Pharmacol 584:390-7. 2008
  7. ncbi request reprint Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    Pascal H E Smeets
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Am Soc Nephrol 15:2828-35. 2004
  8. doi request reprint Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)
    Anita C A Dankers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochim Biophys Acta 1832:1715-22. 2013
  9. ncbi request reprint Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity
    Frank A D T G Wagener
    Department of Orthodontics and Craniofacial Biology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Pharm Des 19:2698-707. 2013
  10. ncbi request reprint Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 318:1194-202. 2006

Collaborators

Detail Information

Publications72

  1. doi request reprint Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
    Frans G M Russel
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    Trends Pharmacol Sci 29:200-7. 2008
    ..This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes...
  2. ncbi request reprint Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats
    Julliette E M van Eerd
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:528-33. 2006
    ..In the present study, we analyzed the effects of several plasma expanders on the renal uptake of 111In-octreotide in rats and mice...
  3. ncbi request reprint Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    Remon A M H van Aubel
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 288:F327-33. 2005
    ..We propose MRP4 as a candidate transporter for urinary urate excretion and suggest that MRP4 may also mediate hepatic export of urate into the circulation, because of its basolateral expression in the liver...
  4. pmc Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Pflugers Arch 454:321-34. 2007
    ..Our data indicate that NO, produced locally by renal iNOS, regulates the expression of ABC transporters in vivo. Furthermore, we showed, for the first time, expression and subcellular localization of Abcb11/Bsep in rat kidney...
  5. ncbi request reprint Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Nutr 103:1836-43. 2010
    ..9-fold higher than from the 'mixed diet' (16 %). This extrinsic labelling technique can measure precisely the vitamin A equivalency of beta-carotene in oil capsules, but it does not represent the effect of different dietary matrices...
  6. doi request reprint Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Eur J Pharmacol 584:390-7. 2008
    ..001). These findings indicate that NO, produced by iNOS, is responsible for a down-regulation of the influx carriers, Oct1 and Oct2...
  7. ncbi request reprint Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    Pascal H E Smeets
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Am Soc Nephrol 15:2828-35. 2004
    ..MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion...
  8. doi request reprint Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)
    Anita C A Dankers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochim Biophys Acta 1832:1715-22. 2013
    ....
  9. ncbi request reprint Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity
    Frank A D T G Wagener
    Department of Orthodontics and Craniofacial Biology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Pharm Des 19:2698-707. 2013
    ..In conclusion, both HO-1 and BCRP protect against heme-induced toxicity and may thus form novel therapeutic targets for heme-mediated pathologies...
  10. ncbi request reprint Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 318:1194-202. 2006
    ..Up-regulation of MRP2 in the kidney may be interpreted as part of a protective mechanism...
  11. doi request reprint Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 37:417-23, e1. 2009
    ..To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury...
  12. ncbi request reprint Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Pharmacol Exp Ther 315:912-20. 2005
    ..Thus, short-term exposure to ET-1 or gentamicin resulted in long-term protection against a second insult...
  13. doi request reprint Reducing renal uptake of radiolabeled peptides using albumin fragments
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 49:1506-11. 2008
    ....
  14. doi request reprint Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4)
    Azza A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pharmacol 74:964-71. 2008
    ..A homology model of MRP4 showed that Arg375 and Arg998 face right into the central aqueous pore of MRP4. We conclude that positively charged amino acids in transmembrane helices 6 and 12 contribute to the MRP4 substrate-binding pocket...
  15. doi request reprint The role of ATP binding cassette transporters in tissue defense and organ regeneration
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 328:3-9. 2009
    ..This review focuses on the role of ABC transporters in tissue defense and regeneration, with specific attention to P-gp and BCRP in organ regeneration and repair...
  16. ncbi request reprint Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules
    Femke M van de Water
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Drug Metab Dispos 34:1393-7. 2006
    ..v. injection, where it selectively suppresses gene function in the proximal tubules. Therefore, i.v. administered siRNA provides a novel experimental and potential therapeutic tool for gene silencing in the kidney...
  17. doi request reprint Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions
    Rick Greupink
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Pharm Sci 49:819-28. 2013
    ..In addition, our data underline the relevance of modeling transporters on a full mechanistic level to further improve pharmacokinetic and DDI predictions of this sulfonylurea-derivative...
  18. doi request reprint Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Mol Pharm 9:1351-60. 2012
    ....
  19. doi request reprint Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels
    Richard Engbersen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharmacol 681:75-9. 2012
    ..We conclude that sulfonylurea drugs exert differential effects on vascular smooth muscle K(ATP) channels. Our results suggest that glibenclamide and glimepiride will interact with these channels at therapeutic concentrations...
  20. pmc Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations
    Henricus A M Mutsaers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e18438. 2011
    ..Moreover, calculated Ki values are below the maximal plasma concentrations of the tested toxins. In conclusion, this study shows that several uremic toxins inhibit active transport by MRP4 and BCRP at clinically relevant concentrations...
  21. pmc Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism
    Richard Engbersen
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Br J Pharmacol 145:1069-75. 2005
    ..We conclude that micromolar concentrations of glibenclamide interfere with mitochondrial bioenergetics and, therefore, should be used with care for inhibition of epithelial K(ATP) channels...
  22. pmc Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Medical Centre, Radboud University, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomed Biotechnol 2010:525180. 2010
    ..These findings indicate that at least two pathways regulate P-gp expression in the kidney during endotoxemia...
  23. ncbi request reprint Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Toxicol Sci 129:225-33. 2012
    ..Eventually, this leads to hepatic iron loading associated with APAP cytotoxicity...
  24. doi request reprint Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Biochem Pharmacol 84:366-73. 2012
    ..They, however, might interact with the substrates during rearrangement of helixes for substrate translocation, funneling the substrates to the exit site in the outward-facing conformation...
  25. pmc Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
    Reginald A Kavishe
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Malar J 8:205. 2009
    ..In order to understand the molecular mechanisms underlying drug resistance, characterization of these transporters is essential. The aim of this study was to characterize and localize putative ABC transporters...
  26. ncbi request reprint Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 287:F33-8. 2004
    ..Together, these data indicate that ET regulation of Mrp2 involves activation of guanylyl cyclase and generation of cGMP. Signaling by cGMP follows NO release and precedes PKC activation...
  27. pmc Short-term beneficial effects of methylene blue on kidney damage in septic shock patients
    Suzanne Heemskerk
    Radboud University, Nijmegen Medical Centre, Department of Pharmacology and Toxicology, Nijmegen Center for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 34:350-4. 2008
    ..In this study we investigated the short-term effect of methylene blue (MB), an inhibitor of the NO pathway, on kidney damage and function in septic shock patients...
  28. ncbi request reprint In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity
    Rick Greupink
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Toxicol Sci 129:35-48. 2012
    ..In conclusion, pharmacophore modeling was successfully used to identify compounds that inhibit NTCP. Our approach represents an important first step toward the in silico flagging of potential cholestasis-inducing molecules...
  29. doi request reprint Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Toxicol Appl Pharmacol 269:141-9. 2013
    ..Within 24h, however, the liver was able to recover by activating tissue regeneration processes. Hence, the proteins found in urine of DF-treated mice represent kidney damage rather than hepatic injury...
  30. ncbi request reprint Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin
    Femke M van de Water
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Res 54:429-35. 2006
    ..These rat intestinal and renal cell lines appear to be suitable for further characterisation of ET-1 function and its role in pathophysiological processes in epithelial cells...
  31. ncbi request reprint Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport
    Azza A K El-Sheikh
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Department of Pharmacology and Toxicology 149, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 320:229-35. 2007
    ..Our data suggest that the inhibition by NSAIDs of renal MTX efflux via MRP2 and MRP4 is a potential new site and mechanism contributing to the overall interaction between these drugs...
  32. ncbi request reprint Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines
    Femke M van de Water
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Pharm Sci 30:36-44. 2007
    ..Mrp dependent transport was most likely mediated by Mrp4. In future, these cell lines may be used as in vitro models to study drug transport...
  33. doi request reprint Mechanisms of renal anionic drug transport
    Azza A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharmacol 585:245-55. 2008
    ....
  34. ncbi request reprint Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 1:853-62. 2006
    ....
  35. ncbi request reprint Iron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nephrol Dial Transplant 20:2646-53. 2005
    ..We hypothesized that in the CP model iron-dependent cold-induced injury is more pronounced, since oxygen is constantly provided...
  36. ncbi request reprint Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children
    Reginald A Kavishe
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 81:363-5. 2009
    ..0% against 10.3% mild malaria, P = 0.004). We concluded that GSTP1 and possibly GSTM1 may protect against severe falciparum malaria in children...
  37. doi request reprint Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Toxicol Lett 221:219-24. 2013
    ..In conclusion, urinary proteome analysis identified a profile of potentially predictive biomarkers for MTX-induced hepatic fibrosis in psoriasis patients with high cumulative dose of MTX...
  38. ncbi request reprint Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides
    Aloys L A Sesink
    Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pharmacol 67:1999-2006. 2005
    ..In conclusion, Bcrp1 limits net intestinal absorption of quercetin by pumping quercetin glucuronides back into the lumen...
  39. doi request reprint Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury
    Suzanne Heemskerk
    Department of Intensive Care Medicine and the Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Rev Nephrol 5:629-40. 2009
    ..In this Review, the selective inhibition of iNOS as a potential novel treatment for sepsis-induced AKI is discussed...
  40. doi request reprint Interaction of digitalis-like compounds with p-glycoprotein
    Elnaz Gozalpour
    Department of Pharmacology and Toxicology, 149, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Toxicol Sci 131:502-11. 2013
    ..The understanding of the P-gp-DLC interaction improves our insight into DLCs toxicity and might enhance the replacement of digoxin with other DLCs that have less adverse drug effects...
  41. pmc Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice
    Rachel P L van Swelm
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e49524. 2012
    ..In conclusion, using this urinary proteomics approach we demonstrate CA3, SOD1 and, most importantly, CaM as potential human biomarkers for APAP-induced liver injury...
  42. ncbi request reprint Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule
    Sylvie A Terlouw
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 301:578-85. 2002
    ..Together, these findings indicate that exposure of renal proximal tubules to heavy metals initially leads to reduced Mrp2 function but is followed by an induction in Mrp2-mediated transport after long-term exposure...
  43. ncbi request reprint The heme-heme oxygenase system in wound healing; implications for scar formation
    Frank A D T G Wagener
    Department of Orthodontics and Oral Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Drug Targets 11:1571-85. 2010
    ..A better understanding of the heme-heme oxygenase system as target during wound healing may result in novel strategies to reduce scar formation...
  44. doi request reprint The ABCs of multidrug resistance in malaria
    Jan B Koenderink
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Parasitol 26:440-6. 2010
    ..Here, we give an overview of the Plasmodium ABC family members with reference to their possible role in multidrug resistance...
  45. ncbi request reprint Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3
    Elnaz Gozalpour
    Department of Pharmacology and Toxicology, Radboud University Medical Centre, Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
    Mol Pharm 11:1844-55. 2014
    ..Ultimately, this can be of use in the development of DLCs that are less prone to transporter-mediated drug-drug interactions...
  46. doi request reprint Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio
    Karl M Weigand
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochim Biophys Acta 1818:1269-73. 2012
    ....
  47. pmc Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones
    Anita C A Dankers
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cell Tissue Res 349:551-63. 2012
    ..In conclusion, localization of Bcrp in endocrine organs together with the efficient allosteric inhibition of the efflux pump by steroid hormones are suggestive for a role for BCRP in steroid hormone regulation...
  48. doi request reprint Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Drug Metab Dispos 40:1076-9. 2012
    ..These results are in line with the pharmacokinetic profile of coumarin and suggest that MRP3 and MRP4 are the main transporters involved in the excretion of the coumarin metabolite 7-HC-G from liver and kidney...
  49. doi request reprint Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP)
    Rick Greupink
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Eur J Pharm Sci 44:487-96. 2011
    ..However, under normal conditions, NTCP-mediated uptake of this drug seems not to be a significant hepatocellular uptake pathway...
  50. doi request reprint Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Transplant 19:1195-208. 2010
    ..Furthermore, we demonstrate that transporter-deficient bone marrow contained significantly more monocytes, granulocytes, and early outgrowth endothelial progenitor cells...
  51. ncbi request reprint Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions
    Femke M van de Water
    Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Drug Metab Rev 37:443-71. 2005
    ..This review discusses current knowledge on the renal characteristics of MRP1-9, with specific focus on their regulation...
  52. pmc Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule
    Brigitte Prevoo
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 338:362-71. 2011
    ..This up-regulation may be nephroprotective, enhancing efflux of metabolic wastes and toxicants during cell and tissue stress...
  53. ncbi request reprint Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport
    Sylvie A Terlouw
    Department of Pharmacology and Toxicology 233, University Medical Center Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochem Pharmacol 65:1393-405. 2003
    ..This commentary discusses the current knowledge of endogenous and exogenous influences on renal anionic xenobiotic excretion...
  54. ncbi request reprint Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats
    Rosalinde Masereeuw
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    J Am Soc Nephrol 14:2741-9. 2003
    ..We conclude that the renal clearance of the Mrp2 substrates calcein and fluo-3 is significantly reduced in TR(-) rat; for LY, the absence of the transporter may be compensated for by (an)other organic anion transporter(s)...
  55. doi request reprint Therapeutic implications of renal anionic drug transporters
    Rosalinde Masereeuw
    Dept of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Ther 126:200-16. 2010
    ..This review highlights recent knowledge of the renal organic anion system with special reference to the therapeutic implications associated with variations in transporter activity and drug interactions...
  56. doi request reprint Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro
    Anita C A Dankers
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Toxicol Sci 136:382-91. 2013
    ..Our data show the toxicological and clinical relevance of ABC transporters in EDC risk assessment related to testicular toxicity...
  57. ncbi request reprint Preserved vascular reactivity of rat renal arteries after cold storage
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cryobiology 48:95-8. 2004
    ..Since 24h of cold storage considerable damages renal tubular cells both in vitro and after kidney transplantation, these results suggest that renal arteries are less sensitive to cold-induced damage than tubular cells...
  58. pmc Mass spectrometry analysis of hepcidin peptides in experimental mouse models
    Harold Tjalsma
    Laboratory of Genetic, Endocrine and Metabolic Diseases, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e16762. 2011
    ....
  59. doi request reprint Insights into the role of bone marrow-derived stem cells in renal repair
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Kidney Blood Press Res 31:104-10. 2008
    ..In this review the advantages and shortcomings of our procedure are critically discussed and compared with other methods described...
  60. doi request reprint HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis
    Frank A D T G Wagener
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3388-93. 2008
    ..The aim of this study was to determine whether the (GT)n-repeat length within the HMOX1 promoter region is associated with RA disease severity and radiographic joint damage...
  61. pmc Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis
    Alwin Scharstuhl
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS ONE 4:e6688. 2009
    ..We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated the underlying mechanism of this process...
  62. doi request reprint Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4
    Hanneke G M Wittgen
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Drug Metab Dispos 39:1294-302. 2011
    ....
  63. ncbi request reprint Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 47:432-6. 2006
    ..Here, we studied the effects of infusion of low doses of the plasma expander succinylated gelatin (GELO) on the renal uptake of 111In-labeled octreotide (111In-OCT)...
  64. pmc Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules
    Rosalinde Masereeuw
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, HB, Nijmegen, The Netherlands
    AAPS J 14:883-94. 2012
    ..Insight in these processes is of importance because variations in transporter activity due to certain (disease) conditions could lead to significant changes in drug efficacy or toxicity...
  65. ncbi request reprint The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP
    Remon A M H van Aubel
    Department of Pharmacology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    J Am Soc Nephrol 13:595-603. 2002
    ..It is concluded that MRP4 is a novel apical organic anion transporter and the putative efflux pump for cAMP and cGMP in human kidney proximal tubules...
  66. ncbi request reprint Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect
    Carolien A Van Loo-Bouwman
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Nutr 101:1837-45. 2009
    ..In conclusion, this extrinsic labelling technique cannot measure effects of mixed vegetables and fruits matrices, but can measure precisely the vitamin A equivalency of the beta-carotene in oil capsules...
  67. doi request reprint Effect of drugs on renal development
    Michiel F Schreuder
    Department of Pediatric Nephrology, 804, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 6:212-7. 2011
    ..Because the effects of many widely used drugs have not been unraveled thus far, more research is needed to study the effect on renal development and long-term renal sequelae after drug treatment during nephrogenesis...
  68. doi request reprint The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats
    Esther W H Bodde
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:780-91. 2008
    ..Low amounts of sustained released rhBMP-2 were sufficient to bridge critically sized defects. A substantial amount of rhBMP-2 was retained in the implants because of the slow release rate and the limited degradation...
  69. pmc Modeling mitochondrial dysfunctions in the brain: from mice to men
    Megan E Breuer
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Inherit Metab Dis 35:193-210. 2012
    ....
  70. ncbi request reprint Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus
    Tanya M Bisseling
    Department of Pharmacology Toxicology, University Medical Center, Nijmegen, The Netherlands
    Am J Obstet Gynecol 192:973-9. 2005
    ..Because potassium channels play an important role in the regulation of vascular tone, this study explores the impact of diabetes on potassium channel function in the fetoplacental vascular bed...
  71. ncbi request reprint Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype
    Reginald A Kavishe
    Department of Pharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 75:827-9. 2006
    ..We conclude that the GSTM1-null genotype is associated with malaria with complications...
  72. ncbi request reprint Hypothermia causes a marked injury to rat proximal tubular cells that is aggravated by all currently used preservation solutions
    Miranda Bartels-Stringer
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cryobiology 47:82-91. 2003
    ..Iron-dependent MPT is suggested to play a role in this damage. Strategies to prevent cold-induced injury should aim at reducing the availability of "free" iron...