T J M Ruers

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators
    Renate R J de Groot-Besseling
    Department of Pathology, University Medical Centre Nijmegen, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Cancer 6:149. 2006
  2. ncbi request reprint Radiofrequency for the treatment of liver tumours
    T J M Ruers
    Department of Surgery, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Dig Surg 22:245-53. 2005
  3. ncbi request reprint Comparison between local ablative therapy and chemotherapy for non-resectable colorectal liver metastases: a prospective study
    Theo J M Ruers
    Department of Surgery, Division of Surgical Oncology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Ann Surg Oncol 14:1161-9. 2007
  4. ncbi request reprint Detection of disseminated tumour cells in blood and bone marrow samples of patients undergoing hepatic resection for metastasis of colorectal cancer
    F A Vlems
    Department of Surgery, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Surg 90:989-95. 2003
  5. ncbi request reprint Comparison of multiphase CT, FDG-PET and intra-operative ultrasound in patients with colorectal liver metastases selected for surgery
    B Wiering
    Department of Surgical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Surg Oncol 14:818-26. 2007
  6. ncbi request reprint Efficacy of fluorine-18-deoxyglucose positron emission tomography in detecting tumor recurrence after local ablative therapy for liver metastases: a prospective study
    B S Langenhoff
    Department of Surgery, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Oncol 20:4453-8. 2002
  7. doi request reprint Resection of liver metastases in patients with breast cancer: survival and prognostic factors
    G A M van Walsum
    Department of Surgery, TweeSteden Hospital, Tilburg, The Netherlands
    Eur J Surg Oncol 38:910-7. 2012
  8. ncbi request reprint The role of FDG-PET in the selection of patients with colorectal liver metastases
    B Wiering
    Department of Surgical Oncology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, HB, Nijmegen, The Netherlands
    Ann Surg Oncol 14:771-9. 2007
  9. doi request reprint Efficacy of follow-up after surgical treatment of colorectal liver metastases
    B S Langenhoff
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Surg Oncol 35:180-6. 2009
  10. ncbi request reprint Relevance of disseminated tumour cells in blood and bone marrow of patients with solid epithelial tumours in perspective
    F A Vlems
    Department of Surgery, University Medical Centre Nijmegen, 6500 HB, Nijmegen, The Netherlands
    Eur J Surg Oncol 29:289-302. 2003

Collaborators

Detail Information

Publications49

  1. pmc Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators
    Renate R J de Groot-Besseling
    Department of Pathology, University Medical Centre Nijmegen, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Cancer 6:149. 2006
    ....
  2. ncbi request reprint Radiofrequency for the treatment of liver tumours
    T J M Ruers
    Department of Surgery, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Dig Surg 22:245-53. 2005
    ..Within the multimodality treatment of neuroendocrine metastases, RFA may deserve a place for either intention to cure (rare) or debulking with the aim of reduction of symptoms or prolongation of life...
  3. ncbi request reprint Comparison between local ablative therapy and chemotherapy for non-resectable colorectal liver metastases: a prospective study
    Theo J M Ruers
    Department of Surgery, Division of Surgical Oncology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Ann Surg Oncol 14:1161-9. 2007
    ..Evidence on the efficacy over systemic chemotherapy is, however, extremely weak. In this prospective study we aim to assess the additional benefits of local tumour ablation...
  4. ncbi request reprint Detection of disseminated tumour cells in blood and bone marrow samples of patients undergoing hepatic resection for metastasis of colorectal cancer
    F A Vlems
    Department of Surgery, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Surg 90:989-95. 2003
    ..The aim of this study was to evaluate whether the presence of disseminated tumour cells in blood and bone marrow could predict extrahepatic tumour recurrence...
  5. ncbi request reprint Comparison of multiphase CT, FDG-PET and intra-operative ultrasound in patients with colorectal liver metastases selected for surgery
    B Wiering
    Department of Surgical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Surg Oncol 14:818-26. 2007
    ..Here, we evaluate the predictive value of CT and FDG-PET of the liver and extrahepatic findings compared to findings during laparotomy and 6 months follow-up...
  6. ncbi request reprint Efficacy of fluorine-18-deoxyglucose positron emission tomography in detecting tumor recurrence after local ablative therapy for liver metastases: a prospective study
    B S Langenhoff
    Department of Surgery, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Oncol 20:4453-8. 2002
    ....
  7. doi request reprint Resection of liver metastases in patients with breast cancer: survival and prognostic factors
    G A M van Walsum
    Department of Surgery, TweeSteden Hospital, Tilburg, The Netherlands
    Eur J Surg Oncol 38:910-7. 2012
    ..The aim of this observational study was to evaluate the effectiveness and safety of resection of liver metastases from breast cancer and to identify prognostic factors for overall survival...
  8. ncbi request reprint The role of FDG-PET in the selection of patients with colorectal liver metastases
    B Wiering
    Department of Surgical Oncology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, HB, Nijmegen, The Netherlands
    Ann Surg Oncol 14:771-9. 2007
    ..The aim of the present study was to evaluate whether an additional fluorine-18-deoxyglucose positron emission tomography (FDG-PET) improves patient selection and therefore adds value to select patients for curative liver resection...
  9. doi request reprint Efficacy of follow-up after surgical treatment of colorectal liver metastases
    B S Langenhoff
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Surg Oncol 35:180-6. 2009
    ..This study assesses the efficacy of intensive follow-up after resection of CLM...
  10. ncbi request reprint Relevance of disseminated tumour cells in blood and bone marrow of patients with solid epithelial tumours in perspective
    F A Vlems
    Department of Surgery, University Medical Centre Nijmegen, 6500 HB, Nijmegen, The Netherlands
    Eur J Surg Oncol 29:289-302. 2003
    ....
  11. ncbi request reprint Investigations for a multi-marker RT-PCR to improve sensitivity of disseminated tumor cell detection
    F A Vlems
    Departments of Surgery, Pathology, University Medical Center, Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 23:179-86. 2003
    ....
  12. ncbi request reprint Prudent application of radiofrequency ablation in resectable colorectal liver metastasis
    A J A Bremers
    Department of Surgery, Division of Abdominal Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Surg Oncol 33:752-6. 2007
    ..Lesion based recurrence is probably more appropriate to predict results of RFA in surgically resectable H-CRC and figures may be good enough to consider RFA an alternative treatment in high risk patients...
  13. ncbi request reprint Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma
    K Havenga
    Department of Surgery, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Surg Oncol 29:662-4. 2003
    ..We report the value of sentinel lymph node (SLN) biopsy and fluorodeoxyglucose-positron emission tomography (FDG-PET) in relation to SLN biopsy in staging primary cutaneous melanoma...
  14. ncbi request reprint FDG-PET for prediction of survival of patients with metastatic colorectal carcinoma
    L F De Geus-Oei
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Oncol 17:1650-5. 2006
    ..The current study focuses on the prognostic value of pretreatment metabolic activity in metastases as measured with [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET), as an indicator of survival in colorectal cancer...
  15. doi request reprint Long-term global quality of life in patients treated for colorectal liver metastases
    B Wiering
    Department of Surgery, Division of Surgical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Surg 98:565-71; discussion 571-2. 2011
    ..This study investigated the impact of surgical and systemic treatment on HRQoL in patients undergoing hepatic resection for colorectal metastases...
  16. ncbi request reprint Quality of life after surgical treatment of colorectal liver metastases
    B S Langenhoff
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Surg 93:1007-14. 2006
    ..The aim of this prospective study was to evaluate the impact of surgery on health-related quality of life (HRQoL) of patients with colorectal liver metastases...
  17. ncbi request reprint Cryosurgery of tumor tissue causes endotoxin tolerance through an inflammatory response
    J J A Joosten
    Department of Surgery, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 23:427-32. 2003
    ..In this study enhancement of this inflammatory response and its possible additive antitumor effect is evaluated in a mouse tumor model...
  18. doi request reprint New targeted probes for radioimaging of angiogenesis
    T H Stollman
    Department of Surgery, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Methods 48:188-92. 2009
    ..Here the preclinical and clinical studies with these new tracers to image angiogenesis in tumors are reviewed...
  19. ncbi request reprint Computer-based decision making in medicine: A model for surgery of colorectal liver metastases
    B S Langenhoff
    Department of Surgery, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Surg Oncol 33:S111-7. 2007
    ..In this study conjoint analysis is used to develop a decision model to help clinicians selecting patients eligible for surgery of liver metastases...
  20. doi request reprint Management of patients with asymptomatic colorectal cancer and synchronous irresectable metastases
    M G W Scheer
    Department of Surgery, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ann Oncol 19:1829-35. 2008
    ..Resection of the primary tumor followed by chemotherapy when possible versus systemic chemotherapy followed by resection of the primary tumor when necessary are compared in this systematic review...
  21. ncbi request reprint Hepatic veno-occlusive disease after neoadjuvant treatment of colorectal liver metastases with oxaliplatin: a lesson of the month
    A P Schouten van der Velden
    Department of Surgery, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Surg Oncol 34:353-5. 2008
    ..Histopathological examination revealed hepatic veno-occlusive disease, which is an infrequent reported side effect of oxaliplatin...
  22. doi request reprint Optical sensing for tumor detection in the liver
    D J Evers
    Department of Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Eur J Surg Oncol 39:68-75. 2013
    ..We investigated whether DRS could discriminate metastatic tumor tissue from normal liver tissue and thus if this technique would have potential for further implementation into surgical instruments or radiological intervention tools...
  23. ncbi request reprint Value of positron emission tomography with [F-18]fluorodeoxyglucose in patients with colorectal liver metastases: a prospective study
    T J M Ruers
    Departments of Surgery, Nuclear Medicine, and Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Oncol 20:388-95. 2002
    ..To assess prospectively the value of fluor-18-deoxyglucose (FDG) positron emission tomography (PET), in addition to conventional diagnostic methods (CDM), as a staging modality in candidates for resection of colorectal liver metastases...
  24. pmc Limitations of cytokeratin 20 RT-PCR to detect disseminated tumour cells in blood and bone marrow of patients with colorectal cancer: expression in controls and downregulation in tumour tissue
    F A Vlems
    Department of Surgery, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pathol 55:156-63. 2002
    ..The results of this study have been considered in relation to the controversial results in the literature to elucidate the usefulness of cytokeratin 20 (CK20) RT-PCR to detect disseminated tumour cells further...
  25. doi request reprint Treatment dilemmas in patients with synchronous colorectal liver metastases
    T J M Ruers
    Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Recent Results Cancer Res 196:37-49. 2012
    ..In the present article retrospective studies are analyzed in order to define the best possible treatment strategy for patients with synchronous colorectal liver metastases...
  26. pmc Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity
    M H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    Br J Cancer 95:896-905. 2006
    ..Therefore, in situ tumour destruction in combination with immune modulation creates a unique, 'in situ DC-vaccine' that is readily applicable in the clinic without prior knowledge of tumour antigens...
  27. ncbi request reprint Mitotic activity index in interval breast cancers
    R P R Groenendijk
    Department of Surgery, IJsselland Hospital, P O Box 690, Prins Constantijnweg 2, 2906 ZC Capelle a d IJssel, The Netherlands
    Eur J Surg Oncol 29:29-31. 2003
    ..The MAI is lower in screen detected tumours, correlating with less aggressive biological behaviour in this group. In this study the MAI is compared between screen detected, interval and symptomatic breast cancers...
  28. ncbi request reprint A cardiogastric fistula after gastric tube interposition. A case report and review of literature
    A P Schouten van der Velden
    Department of Surgery, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Surg Oncol 95:79-82. 2007
    ..A patient is presented with massive hematemesis caused by a fistula between the left cardiac atrium and a gastric tube interposition, which was constructed after esophagectomy for esophageal cancer 3 years earlier...
  29. ncbi request reprint Outgrowth of human liver metastases after resection of the primary colorectal tumor: a shift in the balance between apoptosis and proliferation
    Charlotte F J M Peeters
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    Int J Cancer 119:1249-53. 2006
    ..Our data show that in human cancer patients, a primary tumor may inhibit the growth of its liver metastases...
  30. ncbi request reprint Difference between free circulating plasma and serum DNA in patients with colorectal liver metastases
    Myriam A M A Thijssen
    Department of Clinical Chemistry, University Medical Centre Nijmegen, The Netherlands
    Anticancer Res 22:421-5. 2002
    ..However, it is unclear whether DNA from plasma or from serum better reflects the clinical status...
  31. ncbi request reprint Evaluation of image registration in PET/CT of the liver and recommendations for optimized imaging
    Wouter V Vogel
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Nucl Med 48:910-9. 2007
    ..The impact of these issues was evaluated for both hybrid PET/CT and software fusion, focused on imaging of the liver...
  32. ncbi request reprint Role of FDG-PET in the diagnosis and treatment of colorectal liver metastases
    Bastiaan Wiering
    University Medical Center Nijmegen, Department of Nuclear Medicine, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Rev Anticancer Ther 4:607-13. 2004
    ..FDG-PET and computerized tomography are complimentary techniques in staging and restaging patients with advanced colorectal cancer. The combination of these two modalities significantly impacts upon patient management...
  33. ncbi request reprint Anti-tumor activity of a combination of plasminogen activator and captopril in a human melanoma xenograft model
    Renate R J de Groot-Besseling
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Int J Cancer 112:329-34. 2004
    ..Administration of tPA alone had only a marginal effect on tumor growth. Captopril alone reduced tumor growth by about 60%, whereas treatment with both captopril and tPA resulted in 83% inhibition of tumor growth...
  34. doi request reprint Increased metabolic activity of indolent liver metastases after resection of a primary colorectal tumor
    Marian G W Scheer
    Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Nucl Med 49:887-91. 2008
    ....
  35. ncbi request reprint Vascular density in colorectal liver metastases increases after removal of the primary tumor in human cancer patients
    Charlotte F J M Peeters
    Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Cancer 112:554-9. 2004
    ..Resection of the primary tumor results in an increased vascularization of metastatic lesions...
  36. ncbi request reprint Responsiveness of the generic EQ-5D summary measure compared to the disease-specific EORTC QLQ C-30
    Paul F M Krabbe
    Department of Medical Technology Assessment, University Medical Centre, Nijmegen, Nijmegen, The Netherlands
    Qual Life Res 13:1247-53. 2004
    ....
  37. ncbi request reprint The impact of fluor-18-deoxyglucose-positron emission tomography in the management of colorectal liver metastases
    Bastiaan Wiering
    Department of Surgery, Radboud University Medical Center Nijmegen, The Netherlands
    Cancer 104:2658-70. 2005
    ..FDG-PET can be considered a useful tool in preoperative staging and produced superior results compared with conventional diagnostic modalities, especially for excluding or detecting extrahepatic disease...
  38. ncbi request reprint Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer
    Hanneke W M van Laarhoven
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 64:473-82. 2006
    ....
  39. pmc Colorectal cancer: the role of PET/CT in recurrence
    Wouter V Vogel
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Imaging 5:S143-9. 2005
    ..When available, PET/CT currently appears the diagnostic tool of choice. In the near future, combined PET/MRI may further enhance the diagnostic algorithm...
  40. ncbi request reprint Progressive loss of endothelial P-selectin expression with increasing malignancy in colorectal cancer
    Charlotte F J M Peeters
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    Lab Invest 85:248-56. 2005
    ..We suggest that downregulation of endothelial P-selectin expression is a mechanism by which CRC lesions evade inflammatory regression and, thereby, progress to a more advanced stage of malignancy...
  41. pmc FDG-PET in colorectal cancer
    Lioe Fee de Geus-Oei
    Department of Nuclear Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Imaging 6:S71-81. 2006
    ..This review aims to outline the current and future role of FDG-PET in the field of colorectal cancer...
  42. doi request reprint Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody
    Thamar H Stollman
    Department of Surgery, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Int J Cancer 122:2310-4. 2008
    ..VEGF-A-expressing tumors could be clearly visualized on planar scintigraphic images from 24-hr post injection onwards. In conclusion, VEGF-A expression in tumors can be visualized specifically with radiolabeled anti-VEGF-A-mAb...
  43. pmc Most patients with colorectal tumors at young age do not visit a cancer genetics clinic
    Lucia I H Overbeek
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
    Dis Colon Rectum 51:1249-54. 2008
    ..This study examined the referral process for genetic counseling at a cancer genetics clinic in patients with colorectal cancer and to search for determinants of variation in this referral process...
  44. ncbi request reprint In situ tumor ablation creates an antigen source for the generation of antitumor immunity
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Res 64:4024-9. 2004
    ..These results illustrate that in situ tumor destruction can provide a useful antigen source for the induction of antitumor immunity, provided that additional immunostimulatory signals are coadministered...
  45. ncbi request reprint Quantification of human DNA in feces as a diagnostic test for the presence of colorectal cancer
    Corne H W Klaassen
    Department of Pathology, Canisius Wilhelmina Hospital, NL 6532 SZ Nijmegen, The Netherlands
    Clin Chem 49:1185-7. 2003
  46. ncbi request reprint Dendritic cells: tools and targets for antitumor vaccination
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Expert Rev Vaccines 4:699-710. 2005
    ....
  47. ncbi request reprint Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer
    Michel F P van der Jagt
    Department of Surgery, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Lett 237:289-97. 2006
    ..In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P=0.017) association with overall survival...
  48. ncbi request reprint Critical analysis of the treatment of non-palpable breast cancer: toward a less invasive future?
    Richard P R Groenendijk
    Department of Surgery, IJssellandHospital, P O Box 690, 2900 AR, Capelle aan den IJssel, The Netherlands
    World J Surg 26:285-9. 2002
    ..Inpatients with small breast cancer tumors future developments in treatment must be aimed at the use of less invasive techniques, reducing morbidity while maintaining high levels of disease-free survival...
  49. ncbi request reprint Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Res 66:7285-92. 2006
    ..Therefore, in situ tumor destruction in combination with CpG-oligodeoxynucleotide administration creates a unique "in situ DC vaccine" that is readily applicable in the clinic...