T R D J Radstake

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase
    Arjen B Blom
    University Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 48:1002-14. 2003
  2. ncbi Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 66:1334-8. 2007
  3. ncbi Genetics of systemic sclerosis: an update
    Jasper C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Rheumatol Rep 14:11-21. 2012
  4. ncbi Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    BMC Immunol 7:23. 2006
  5. ncbi Experimental stress in inflammatory rheumatic diseases: a review of psychophysiological stress responses
    Sabine J M de Brouwer
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R89. 2010
  6. ncbi Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
  7. ncbi The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study
    Laurent Jacq
    GenHotel EA3886, Evry Paris VII Universities, 91057 Evry Genopole Cedex, France
    Arthritis Res Ther 9:R63. 2007
  8. ncbi Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
  9. ncbi Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e5981. 2009
  10. ncbi Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences
    T R D J Radstake
    Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:1737-43. 2005

Detail Information

Publications63

  1. ncbi Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase
    Arjen B Blom
    University Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 48:1002-14. 2003
    ..These data suggest that disturbed expression of FcgammaR on mature synovial macrophages is involved in the pathology of RA...
  2. ncbi Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 66:1334-8. 2007
    ..CCL18 and CXCL16 are two chemokines that facilitate T cell attraction by APC, of which a role in the pathogenesis of RA has been suggested...
  3. ncbi Genetics of systemic sclerosis: an update
    Jasper C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Rheumatol Rep 14:11-21. 2012
    ..This year has been of particular interest due to the publication of a large genome-wide association study, further investigations into gene-gene interactions, and the tendency to validate genetic results in functional models...
  4. ncbi Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    BMC Immunol 7:23. 2006
    ..In this study we provide new insights in the regulation of CCL18 secretion by monocytes and dendritic cells...
  5. ncbi Experimental stress in inflammatory rheumatic diseases: a review of psychophysiological stress responses
    Sabine J M de Brouwer
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R89. 2010
    ....
  6. ncbi Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
    ..This study demonstrates that IL-13 overexpression during ICA diminished both chondrocyte death and MMP-mediated VDIPEN expression, even though joint inflammation was enhanced...
  7. ncbi The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study
    Laurent Jacq
    GenHotel EA3886, Evry Paris VII Universities, 91057 Evry Genopole Cedex, France
    Arthritis Res Ther 9:R63. 2007
    ..002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene...
  8. ncbi Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
    ..To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA)...
  9. ncbi Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e5981. 2009
    ..Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc)...
  10. ncbi Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences
    T R D J Radstake
    Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:1737-43. 2005
    ..Dendritic cell (DC) function is largely tailored by Fc gamma receptors (Fc gamma R) and is critical for every immune response...
  11. ncbi Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis
    T R D J Radstake
    Department of Rheumatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:1532-8. 2005
    ..Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA...
  12. ncbi Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis
    T R D J Radstake
    Department of Rheumatology, University Medical Centre Nijmegen, Geertgroote plein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 63:1556-63. 2004
    ..To investigate potential differences in phenotype and behaviour of immature (iDC) and mature dendritic cells (mDC) from patients with RA and healthy subjects...
  13. ncbi The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 54:3828-37. 2006
    ..The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function...
  14. ncbi The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Hum Immunol 70:130-3. 2009
    ..Our results demonstrate that the functional variant -2518A>G of CCL2 is not implicated in the susceptibility or phenotype of SSc...
  15. ncbi Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1525-30. 2007
    ..Therefore, the question of whether two functional variants in MIF are associated with the response to tumour necrosis factor (TNF)alpha-neutralising and GC treatments in RA was investigated...
  16. ncbi Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors
    T R D J Radstake
    Department of Rheumatology, University Medical Centre Nijmegen, The Netherlands
    Ann Rheum Dis 64:359-67. 2005
    ..Dendritic cells (DC) have a role in the regulation of immunity and tolerance, attracting inflammatory cells by the production of various chemokines (CK). Fc gamma receptors (Fc gamma R) may be involved in regulation of the DC function...
  17. ncbi Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
    T R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 68:1739-45. 2009
    ..Tumour necrosis factor alpha (TNFalpha) neutralising antibody constructs are increasingly being used to treat rheumatoid arthritis (RA)...
  18. ncbi High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering
    T R D J Radstake
    Department of Experimental Rheumatology, University Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 63:696-702. 2004
    ..To assess whether DC from RA produce altered cytokine levels and whether this is regulated by triggering of Fc gamma receptors (FcgammaR)...
  19. ncbi Regulation of CXCL16 expression and secretion by myeloid cells is not altered in rheumatoid arthritis
    A W T van Lieshout
    Departments of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 68:1036-43. 2009
    ..To date, little is known about the regulation of CXCL16 on monocytes/macrophages and DCs. The aim of this study was to elucidate how CXCL16 expression is regulated in healthy donors and patients with RA...
  20. ncbi Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)
    M F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands
    Ann Rheum Dis 68:1486-93. 2009
    ..Toll-like receptors (TLR) probably play a role in synovial inflammation and may also contribute to the understanding of the role of infections in RA...
  21. ncbi Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion
    A W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Scand J Rheumatol 38:282-90. 2009
    ..The aim of our study was to determine whether Toll-like receptor (TLR)-mediated stimulation of monocytes and dendritic cells (DCs) contributes to the higher levels of CCL18 in SSc...
  22. ncbi Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis
    L van Bon
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1539-47. 2010
    ..Systemic sclerosis (SSc) is an autoimmune disease and accumulating evidence suggests a role for Toll-like receptor (TLR)-mediated activation of dendritic cells (DCs)...
  23. ncbi The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis
    E J M Toonen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 67:1174-7. 2008
    ....
  24. ncbi Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation
    M H Wenink
    Department of Rheumatology, Nijmegen Center of Infection, Inflammation and Immunity and Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 71:80-3. 2012
    ..We investigated whether Abatacept might reduce proinflammatory cytokine production by macrophages upon contact with cytokine activated T cells and/or stimulation with TLR ligands...
  25. ncbi Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis
    A W T van Lieshout
    Department of Rhumatology, University Medical Centre Nijmegen, Geert Grooteplein 8, 6500 HB Nijmegen, Netherlands
    Ann Rheum Dis 64:408-14. 2005
    ..These data suggest a novel pathway by which the neutralisation of TNF alpha might exert its therapeutic effects...
  26. ncbi Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients
    C Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 68:868-72. 2009
    ..The aim of this study was to investigate the effects of tumour necrosis factor (TNF) inhibition on the antioxidative capacity of HDL in RA...
  27. ncbi The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    M F Roelofs
    Radboud University Nijmegen Medical Centre, The Netherlands
    Arthritis Rheum 52:2313-22. 2005
    ..CONCLUSION: TLRs are involved in the regulation of DC activation and cytokine production. We hypothesize that various TLR ligands in the joint trigger multiple TLRs simultaneously, favoring the breakthrough of tolerance in RA...
  28. ncbi Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis
    P L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:368-74. 2005
    ..To assess the expression and localisation of the new metalloproteinase inhibitor RECK, an inhibitor of matrix metalloproteinase-14 (MMP-14) secretion and activity, in the synovial membrane of patients with rheumatoid arthritis (RA)...
  29. ncbi A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators
    J C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 64:264-71. 2012
    ..To investigate whether polymorphisms in Toll-like receptor (TLR) genes, previously reported to be associated with immune-mediated diseases, are involved in systemic sclerosis (SSc)...
  30. ncbi Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:3856-65. 2004
    ..The synergistic effect of IL-12 and IL-18 on T cell IFNgamma production seems to regulate expression of TLR-2 and TLR-4 in the synovial tissue of RA patients...
  31. ncbi Fc gamma receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis
    M H Wenink
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 64:103-8. 2006
    ..When DC are envisaged as useful targets in the light of DC immunotherapy in RA, detailed knowledge on the regulatory pathways of Fc gammaR in RA is of paramount importance...
  32. ncbi Gene expression profiling in rheumatoid arthritis: current concepts and future directions
    E J M Toonen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 67:1663-9. 2008
    ..We suggest that both sets of genes include interesting candidate genes for further study in RA...
  33. ncbi The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  34. ncbi The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 35:558-61. 2008
    ..To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA)...
  35. ncbi The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e5903. 2009
    ..Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc...
  36. ncbi Role of Fcgamma receptors IIA, IIIA, and IIIB in susceptibility to rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Rheumatol 30:926-33. 2003
    ....
  37. ncbi Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions
    Robbert van der Voort
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Scences, University Medical Center St Radboud, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    J Leukoc Biol 77:739-47. 2005
    ..CCL18/DC-CK1 may therefore function as an agonist (for naive T and B cells) and as an antagonist for CCR3-expressing leukocytes such as eosinophils...
  38. ncbi The FAS -670A>G polymorphism influences susceptibility to systemic sclerosis phenotypes
    J Broen
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 60:3815-20. 2009
    ..To investigate the possible role of the FAS -670A>G functional polymorphism in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype...
  39. ncbi Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis
    Calin Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 36:724-30. 2009
    ..We investigated the effects of longterm therapeutic tumor necrosis factor (TNF) blockade on adipocytokine concentrations in patients with RA...
  40. ncbi Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology Research and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, The Netherlands
    J Immunol 176:7021-7. 2006
    ..These findings suggest a role for HSPB8 during the inflammatory process in autoimmune diseases such as RA...
  41. ncbi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..We confirmed two known loci and identified four novel ones for shared CD-RA genetic risk. Most of the shared loci further emphasize a role for adaptive and innate immunity in these diseases...
  42. ncbi The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease
    Mark H Wenink
    Department of Rheumatology, Nijmegen Centre of Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, The Netherlands
    J Immunol 183:4509-20. 2009
    ..This TLR4-FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway...
  43. ncbi TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop
    Mark H Wenink
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Immunol 183:6960-70. 2009
    ..This shift in T cell responses was inherent to the inability of TLR2-stimulated DCs to produce IL-12p70 and was dependent on the production of IL-1 and IL-6...
  44. ncbi Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Genet 42:426-9. 2010
    ..39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors...
  45. ncbi Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1503-7. 2007
    ..In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients...
  46. ncbi Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis
    Marieke J H Coenen
    Radboud University, Nijmegen Medical Centre, Department of Human Genetics, Internal Mail 855, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pharmacogenomics 8:761-73. 2007
    ..Nevertheless, replication and large prospective studies will be needed to demonstrate the validity of the identified genetic markers before implementation into daily clinical practice...
  47. ncbi Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 56:2957-67. 2007
    ..The objective of this study was to investigate the involvement of TLR-4 activation in the development and progression of autoimmune destructive arthritis...
  48. ncbi Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 118:205-16. 2008
    ....
  49. ncbi Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?
    K C M Santegoets
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    FEBS Lett 585:3660-6. 2011
    ..In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings...
  50. ncbi MIF production by dendritic cells is differentially regulated by Toll-like receptors and increased during rheumatoid arthritis
    Calin Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cytokine 36:51-6. 2006
    ..The secretion of MIF by dendritic cells is differentially regulated by TLRs. In addition, TNF-alpha, RANKL, and CD40L augment MIF production by DCs and thus play a potential role in the amplification of the inflammatory loop in RA...
  51. ncbi An update on an immune system that goes awry in systemic sclerosis
    L van Bon
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Rheumatol 23:505-10. 2011
    ..This review aims to provide an overview of the recent data that emerged, further substantiating the critical role of innate immunity in systemic sclerosis (SSc)...
  52. ncbi HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis
    Frank A D T G Wagener
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3388-93. 2008
    ..The aim of this study was to determine whether the (GT)n-repeat length within the HMOX1 promoter region is associated with RA disease severity and radiographic joint damage...
  53. ncbi Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints
    Robbert van der Voort
    Nijmegen Center for Molecular Life Sciences, University Medical Center St. Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:1381-91. 2005
    ..CONCLUSION: These data provide evidence that enhanced production of CXCL16 in RA synovia leads to recruitment of CXCR6+ memory T cells, thereby contributing to the inflammatory cascade associated with RA pathology...
  54. ncbi CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement
    Linda M P le Blanc
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurosci Lett 397:145-8. 2006
    ..CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system...
  55. ncbi A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis
    T W van Hal
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Int J Rheumatol 2011:824972. 2011
    ..By providing an overview of the mechanisms at play and the possible therapeutic avenues that have emerged, we hope to stimulate researchers to provide novel clues into the conundrum in SSc patients...
  56. ncbi Circulating CXCL16 is not related to circulating oxLDL in patients with rheumatoid arthritis
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre and Nijmegen Centre of Molecular Life Sciences, The Netherlands
    Biochem Biophys Res Commun 355:392-7. 2007
    ..These data suggest that binding of oxLDL by soluble CXCL16 does not play a role in atherosclerosis and, although confirmation in larger studies is needed, that circulating CXCL16 is not related to the presence of CVD in patients with RA...
  57. ncbi The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions
    Mieke F Roelofs
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:338-48. 2008
  58. ncbi Macrophage migration inhibitory factor and its genetic association with arthritis: a work in progress
    Timothy R D J Radstake
    Department of Medicine and Pathology, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven, CT 06520-8031, USA
    Curr Rheumatol Rep 9:343-4. 2007
  59. ncbi Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis
    Behrooz Z Alizadeh
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 16:2552-9. 2007
    ..If replicated, our findings would suggest FcgRIIa*519G as a common risk factor for auto-immune diseases. This may have clinical implications with regard to efficacy or safety of antibody-based immuno-modulator therapies...
  60. ncbi Graves' disease in a patient with rheumatoid arthritis during treatment with anti-tumor necrosis factor-alpha
    Antoine W T van Lieshout
    J Rheumatol 35:938-9. 2008
  61. ncbi Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases
    Alexandra Zhernakova
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 81:1284-8. 2007
    ..72 [95% CI 0.61-0.86]). Our results replicate and extend the association found in the KIAA1109/Tenr/IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases...
  62. ncbi Association of STAT4 with rheumatoid arthritis: a replication study in three European populations
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    ....
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