P Pickkers

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection
    Koen S Simons
    Department of Intensive Care Medicine 632, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Intensive Care Med 36:504-11. 2010
  2. pmc Systemic inflammation decreases pain threshold in humans in vivo
    Moniek de Goeij
    Department of Anesthesiology, Pain and Palliative Medicine RUNMC, Nijmegen, The Netherlands
    PLoS ONE 8:e84159. 2013
  3. doi request reprint The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial
    Lucas T van Eijk
    Haematologica 99:579-87. 2014
  4. doi request reprint Body mass index is associated with hospital mortality in critically ill patients: an observational cohort study
    Peter Pickkers
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 41:1878-83. 2013
  5. pmc Tubular reabsorption and local production of urine hepcidin-25
    Hilde P E Peters
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Nephrol 14:70. 2013
  6. pmc The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study
    Frank Mp van Haren
    Intensive Care Department, The Canberra Hospital, Canberra, Australia
    Ann Intensive Care 1:44. 2011
  7. ncbi request reprint Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury
    Harmke D Kiers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nephrol Dial Transplant 28:345-51. 2013
  8. doi request reprint Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury
    Esther Peters
    Department of Intensive Care Medicine, Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 344:2-7. 2013
  9. doi request reprint Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study
    Jenneke Leentjens
    Radboud University Nijmegen Medical Centre, Department of Intensive Care Medicine, Geert Grooteplein zuid 10, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 186:838-45. 2012
  10. pmc Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500HB, The Netherlands
    Crit Care 15:R297. 2011

Detail Information

Publications96

  1. pmc F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection
    Koen S Simons
    Department of Intensive Care Medicine 632, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Intensive Care Med 36:504-11. 2010
    ..To assess the value of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) combined with CT in critically ill patients suspected of having an infection...
  2. pmc Systemic inflammation decreases pain threshold in humans in vivo
    Moniek de Goeij
    Department of Anesthesiology, Pain and Palliative Medicine RUNMC, Nijmegen, The Netherlands
    PLoS ONE 8:e84159. 2013
    ..Changes in pain threshold during systemic inflammation evoked by human endotoxemia, were evaluated with three quantitative sensory testing methods...
  3. doi request reprint The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial
    Lucas T van Eijk
    Haematologica 99:579-87. 2014
    ..Clinicaltrials.gov identifier:01349699). ..
  4. doi request reprint Body mass index is associated with hospital mortality in critically ill patients: an observational cohort study
    Peter Pickkers
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 41:1878-83. 2013
    ..Conflicting results for critically ill patients are reported. Therefore, we wished to investigate the association of body mass index and hospital mortality in critically ill patients...
  5. pmc Tubular reabsorption and local production of urine hepcidin-25
    Hilde P E Peters
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Nephrol 14:70. 2013
    ..It has been suggested that urine hepcidin may protect by attenuating heme-mediated injury, but processes involved in urine hepcidin excretion are unknown...
  6. pmc The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study
    Frank Mp van Haren
    Intensive Care Department, The Canberra Hospital, Canberra, Australia
    Ann Intensive Care 1:44. 2011
    ..abstract:..
  7. ncbi request reprint Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury
    Harmke D Kiers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nephrol Dial Transplant 28:345-51. 2013
    ..While models that predict dialysis and CS-AKI defined by the RIFLE criteria are available, their predictive power and clinical applicability have not been compared head to head...
  8. doi request reprint Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury
    Esther Peters
    Department of Intensive Care Medicine, Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 344:2-7. 2013
    ..In this Perspectives article, we discuss the clinical activity of AP and its putative molecular modes of action, and we speculate on its use to treat and possibly prevent sepsis-associated AKI...
  9. doi request reprint Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study
    Jenneke Leentjens
    Radboud University Nijmegen Medical Centre, Department of Intensive Care Medicine, Geert Grooteplein zuid 10, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 186:838-45. 2012
    ..Although IFN-γ and granulocyte-macrophage colony-stimulating factor (GM-CSF) restore immune competence of ex vivo stimulated leukocytes of patients with sepsis, effects on immunoparalysis in vivo are not known...
  10. pmc Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500HB, The Netherlands
    Crit Care 15:R297. 2011
    ..We examined plasma biomarkers in delirious and nondelirious patients and the role of these biomarkers on long-term cognitive function...
  11. pmc Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial
    Peter Pickkers
    Department of Intensive Care, Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Center, Geert Grooteplein zuid 10, Nijmegen, 6525 GA, The Netherlands
    Crit Care 16:R14. 2012
    ....
  12. pmc Dipyridamole augments the antiinflammatory response during human endotoxemia
    Bart P Ramakers
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands
    Crit Care 15:R289. 2011
    ..We studied the effects of oral dipyridamole treatment on innate immunity and organ injury during human experimental endotoxemia...
  13. pmc Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, Nijmegen, 6500HB, The Netherlands
    Proteome Sci 9:13. 2011
    ..abstract:..
  14. pmc Does subarachnoid haemorrhage affect the innate immune response?
    Matthijs Kox
    Intensive Care Med 33:1303; author reply 1304. 2007
  15. pmc Short-term beneficial effects of methylene blue on kidney damage in septic shock patients
    Suzanne Heemskerk
    Radboud University, Nijmegen Medical Centre, Department of Pharmacology and Toxicology, Nijmegen Center for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 34:350-4. 2008
    ..In this study we investigated the short-term effect of methylene blue (MB), an inhibitor of the NO pathway, on kidney damage and function in septic shock patients...
  16. pmc Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Geert Grooteplein zuid 10, PO Box 9201, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R9. 2011
    ..However, the association between inflammation, hepcidin release and anemia has not been demonstrated in this group of patients. Therefore, we explored the association between hepcidin and sepsis-associated anemia...
  17. pmc The nature of unmeasured anions in critically ill patients
    Miriam A M Moviat
    Crit Care 12:416. 2008
  18. pmc Implementation of a delirium assessment tool in the ICU can influence haloperidol use
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre P, O, Box 9101, Internal post 685, Nijmegen, 6500HB, The Netherlands
    Crit Care 13:R131. 2009
    ..The purpose of this study was to evaluate the implementation of the confusion assessment method-ICU (CAM-ICU) and the effect of its use on frequency and duration of haloperidol use...
  19. pmc Endotoxemia-induced inflammation and the effect on the human brain
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500HB, The Netherlands
    Crit Care 14:R81. 2010
    ..Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described...
  20. pmc Microvascular permeability during experimental human endotoxemia: an open intervention study
    Lucas T G J van Eijk
    Department of Intensive Care Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care 9:R157-64. 2005
    ..The present study was undertaken to determine whether endotoxin administration to human volunteers can be used as a model to study the sepsis-associated increase in microvascular permeability...
  21. pmc Physicians' and nurses' opinions on selective decontamination of the digestive tract and selective oropharyngeal decontamination: a survey
    Irene P Jongerden
    Department of Intensive Care Medicine, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Crit Care 14:R132. 2010
    ..Through regular questionnaires we determined expectations concerning SDD (effectiveness) and experience with SDD and SOD (workload and patient friendliness), as perceived by nurses and physicians...
  22. pmc Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630]
    Cornelia W Hoedemaekers
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 9:R790-7. 2005
    ....
  23. pmc The impact of delirium on the prediction of in-hospital mortality in intensive care patients
    Mark van den Boogaard
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, Nijmegen 6500HB, The Netherlands
    Crit Care 14:R146. 2010
    ..The aim of the current study was to evaluate whether delirium, present within 24 hours after ICU admission, improves the predictive value of the APACHE-II score...
  24. pmc Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients
    Miriam Moviat
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care 10:R14. 2006
    ..Using the Stewart approach, we studied the mechanism of action of acetazolamide in critically ill patients with a metabolic alkalosis...
  25. ncbi request reprint Hypothesis: Normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill
    P Pickkers
    Department of Intensive Care Medicine 519, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Neth J Med 62:143-50. 2004
    ..To support our hypothesis, effects of glucose and insulin on cytokine release and effects of glucose, insulin, and cytokines on host defence, cardiac function and coagulation will be reviewed...
  26. ncbi request reprint Vascular endothelial growth factor is increased during the first 48 hours of human septic shock and correlates with vascular permeability
    Peter Pickkers
    Department of Intensive Care Medicine, University Medical Centre, St Radboud, 6500 HB Nijmegen, The Netherlands
    Shock 24:508-12. 2005
    ..The role of VEGF in sepsis-associated increased microvascular permeability needs further exploration and may represent a new therapeutic target...
  27. pmc Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury
    Bart P Ramakers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R3. 2011
    ..In addition, we studied whether subjects with the common 34C > T nonsense variant (rs17602729) of adenosine monophosphate deaminase (AMPD1), which predicts increased adenosine formation, have less inflammation-induced injury...
  28. ncbi request reprint In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia
    Peter Pickkers
    Department of Intensive Care Medicine 551, Radboud University Nijmegen Medical Centre, GeertGrooteplein 10, PO Box 9101, 6500HB, Nijmegen, Netherlands
    Circulation 114:414-21. 2006
    ..In the present study, we examined whether K-channel blockers and/or nitric oxide (NO) synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia...
  29. doi request reprint Clinical pharmacology of exogenously administered alkaline phosphatase
    P Pickkers
    Department of Intensive Care Medicine 551, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Clin Pharmacol 65:393-402. 2009
    ..To evaluate the clinical pharmacology of exogenous alkaline phosphatase (AP)...
  30. ncbi request reprint Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm
    Peter Pickkers
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Shock 22:320-5. 2004
    ..The possible role of potassium channel blockers during sepsis-induced potassium channel activation and vasodilation in humans needs further elucidation...
  31. ncbi request reprint Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients
    E J Abbink
    Division of General Internal Medicine, Department of Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Diabet Med 19:136-43. 2002
    ..Based on these data, we hypothesized that, in contrast to glibenclamide, chronic treatment of Type 2 diabetic patients with glimepiride or metformin will not impair the vasodilator function of K(ATP) opening in vivo...
  32. ncbi request reprint Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 35:1464-9. 2007
    ..To determine gender differences in the innate immune response and vascular reactivity during human endotoxemia...
  33. pmc Non-adherence to antimicrobial treatment guidelines results in more broad-spectrum but not more appropriate therapy
    L B J van der Velden
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:1561-8. 2012
    ..This did not result in a higher rate of susceptibility of the isolated pathogens to the prescribed empirical therapy...
  34. doi request reprint C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Crit Care Med 38:2139-45. 2010
    ..We examined the immunomodulating properties of C1-esterase inhibitor during human experimental endotoxemia, in which the innate immune system is activated in the absence of activation of the classic complement pathway...
  35. ncbi request reprint The role of cytokines and inducible nitric oxide synthase in endotoxemia-induced endothelial dysfunction
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Cardiovasc Pharmacol 55:595-600. 2010
    ....
  36. ncbi request reprint Pulmonary infection, and not systemic inflammation, accounts for increased concentrations of exhaled nitric oxide in patients with septic shock
    J ten Oever
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Breath Res 7:036003. 2013
    ..04). Exhaled NO did not correlate with markers of disease severity, systemic inflammation and haemodynamic instability. These data indicate that the infected lungs are the source of exhaled NO. ..
  37. pmc Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
    M van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, Netherlands
    BMJ 344:e420. 2012
    ..To develop and validate a delirium prediction model for adult intensive care patients and determine its additional value compared with prediction by caregivers...
  38. pmc Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia
    M Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 171:231-6. 2013
    ..In conclusion, plasma levels of vitamin D are not correlated with the LPS-induced TNF, IL-6 and IL-10 cytokine response in humans in vivo. These findings question the direct role of vitamin D in modulation of the innate immune response...
  39. ncbi request reprint Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes
    E J Abbink
    Division of General Internal Medicine, Department of Medicine, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Sci (Lond) 102:307-14. 2002
    ..This implies that glibenclamide may affect defensive mechanisms under conditions of K(ATP) channel activation...
  40. ncbi request reprint Internal medicine residents' knowledge about sepsis: effects of a teaching intervention
    M Tromp
    Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 67:312-5. 2009
    ..0001 compared with test 1), resulting in a mean score of 7.6 +/- 1.1. Our single teaching intervention resulted in improved and sustained knowledge on the assessment of symptoms, diagnosis and treatment of sepsis...
  41. doi request reprint Serial and panel analyses of biomarkers do not improve the prediction of bacteremia compared to one procalcitonin measurement
    M Tromp
    Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect 65:292-301. 2012
    ..We evaluated the value of a single biomarker, biomarker panels, biomarkers combined with clinical signs of sepsis, and serial determinations of biomarkers in the prediction of bacteremia in patients with sepsis...
  42. doi request reprint α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury
    M Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Br J Anaesth 107:559-66. 2011
    ....
  43. ncbi request reprint Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig
    Peter Pickkers
    Department of Intensive Care Medicine 519, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Pharmacol 466:281-7. 2003
    ..At high concentrations (10(-4)-10(-3) mol l(-1)) loop diuretics exert only weak direct relaxant effects on isolated human subcutaneous resistance arteries compared to the vasorelaxant effects in rat and guinea pig mesenteric vessels...
  44. doi request reprint Lipopolysaccharide-stimulated whole blood cytokine production does not predict the inflammatory response in human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Innate Immun 16:248-53. 2010
    ..1), respectively. Comparison between in vitro and in vivo stimulation with LPS shows no correlation between the amount of cytokines produced. In vitro cytokine production, therefore, does not predict the in vivo inflammatory response...
  45. ncbi request reprint No elevation of glutathione S-transferase-a1-1 by amiodarone loading in intensive care unit patients with atrial fibrillation
    M Hilkens
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anaesth Intensive Care 37:281-5. 2009
    ..Amiodarone does not cause elevation of GSTA1-1 as a marker of subclinical liver injury in haemodynamically stable intensive care unit patients with atrial fibrillation...
  46. ncbi request reprint Nitric oxide does not contribute to inflammation-induced hypoferremia in humans
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Haematol 118:149-52. 2007
  47. doi request reprint Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury
    Suzanne Heemskerk
    Department of Intensive Care Medicine and the Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Rev Nephrol 5:629-40. 2009
    ..In this Review, the selective inhibition of iNOS as a potential novel treatment for sepsis-induced AKI is discussed...
  48. doi request reprint Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals
    Jan T Groothuis
    Department of Physiology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hypertension 55:636-43. 2010
    ....
  49. ncbi request reprint Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Endotoxin Res 11:287-93. 2005
    ..This effect is associated with a reduction in symptoms, whereas the changes in hemodynamic parameters are not influenced by prehydration...
  50. doi request reprint The complement system is activated in a biphasic pattern after coronary artery bypass grafting
    Cornelia Hoedemaekers
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Thorac Surg 89:710-6. 2010
    ..The routes of complement activation and deactivation after cardiac surgery are not clear. The aim of this study was to analyze routes of complement activation after uncomplicated CABG...
  51. doi request reprint The role of nurses in the recognition and treatment of patients with sepsis in the emergency department: a prospective before-and-after intervention study
    Mirjam Tromp
    Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Radboud University Nijmegen Medical Centre, The Netherlands
    Int J Nurs Stud 47:1464-73. 2010
    ..Although the SSC supplies tools to measure and improve the quality of care for patients with sepsis, effective implementation remains troublesome and no recommendations concerning the role of nurses are given...
  52. ncbi request reprint Guideline implementation results in a decrease of pressure ulcer incidence in critically ill patients
    Erik H De Laat
    Centre for Quality of Care Research, Nursing Science Section, Radboud University Nijmegen Medical Centre, The Netherlands
    Crit Care Med 35:815-20. 2007
    ..To describe the short-term and long-term effects of a hospital-wide pressure ulcer prevention and treatment guideline on both the incidence and the time to the onset of pressure ulcers in critically ill patients...
  53. ncbi request reprint Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1864-6. 2005
    ..These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system...
  54. doi request reprint Inflammation-induced hepatotoxicity in humans
    Bart P Ramakers
    Departments of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 31:151-6. 2009
    ..In septic shock patients, GSTA1-1 may represent a useful marker for early liver injury...
  55. ncbi request reprint Regulation of hepcidin: insights from biochemical analyses on human serum samples
    Erwin H J M Kemna
    Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood Cells Mol Dis 40:339-46. 2008
    ..Future studies are needed to validate the combined utility of this predictive algorithm together with actual measured hepcidin levels in clinical diagnosis...
  56. doi request reprint Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Shock 31:581-5. 2009
    ..01), but not when tolerance was present on day 5 (P = 0.61). Human endotoxemia results in endothelial dysfunction that can be adequately detected with different methods and was restored with development of LPS tolerance...
  57. ncbi request reprint Early postoperative 30 degrees lateral positioning after coronary artery surgery: influence on cardiac output
    Erik de Laat
    Division of Nursing Science, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Nurs 16:654-61. 2007
    ..We investigated whether: (i) Early postoperative lateral position after coronary artery bypass surgery may have a negative influence on the cardiac output and (ii) Whether turning procedures cause practical problems...
  58. ncbi request reprint Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia
    Wim van der Meer
    Department of Clinical Chemistry, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Endotoxin Res 13:94-100. 2007
    ..058, P = 0.54), suggesting that neutrophil CD64 expression might be a quantitative marker for innate immunity that could easily be used in the clinical setting...
  59. ncbi request reprint Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study
    Bernard G Fikkers
    Department of Intensive Care, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Chest 125:1805-14. 2004
    ..Part 2: To analyze the potential mechanisms for the development of emphysema and pneumothorax in human cadaver models...
  60. ncbi request reprint Macrophage migration inhibitory factor (MIF) in meningococcal septic shock and experimental human endotoxemia
    Tom Sprong
    Department of General Internal Medicine, The Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Shock 27:482-7. 2007
    ..Macrophage migration inhibitory factor cannot be detected in a human endotoxemia model and is not produced by whole blood cells incubated with LPS or meningococci...
  61. ncbi request reprint TNFalpha and IL-1beta exert no direct vasoactivity in human isolated resistance arteries
    Peter Pickkers
    Division of General Internal Medicine, Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cytokine 20:244-6. 2002
    ..We conclude that, in contrast with some animal experiments, these cytokines exert no direct vasoactivity in human resistance arteries...
  62. ncbi request reprint Implementation of a new policy results in a decrease of pressure ulcer frequency
    Erik H De Laat
    Nursing Science Section, Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Qual Health Care 18:107-12. 2006
    ..To determine the effects of a new policy on the efficiency of pressure ulcer care...
  63. ncbi request reprint Causes of death in intensive care patients with a low APACHE II score
    A van Berkel
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 70:455-9. 2012
    ..The aim of this study was to evaluate the demographics, course of disease, and causes of death in this specific group of ICU patients...
  64. doi request reprint Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury
    M Kox
    Department of Intensive Care Medicine, Radboud University, Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Neurology 70:480-5. 2008
    ..Since the cholinergic anti-inflammatory pathway can be pharmacologically modulated in humans, it could represent a novel approach to prevent infections in patients with TBI...
  65. ncbi request reprint Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations
    B P Ramakers
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands
    Curr Drug Metab 9:679-85. 2008
    ....
  66. ncbi request reprint The effect of systemic iNOS inhibition during human endotoxemia on the development of tolerance to different TLR-stimuli
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Innate Immun 14:153-9. 2008
    ..The role of NO in the development of tolerance is different for the various TLRs stimulated and pro- and anti-inflammatory cytokines measured...
  67. ncbi request reprint The effects of implementation of the Surviving Sepsis Campaign in the Netherlands
    M Tromp
    Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 69:292-8. 2011
    ..In the Netherlands, the resuscitation bundle compliance improved significantly from 7% at baseline to 27% after two years (p=0.002). Internationally, the resuscitation bundle compliance increased significantly from 11 to 31% (p...
  68. ncbi request reprint Plasma obtained during human endotoxemia increases endothelial albumin permeability in vitro
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 25:358-62. 2006
    ..Thus, cultured human endothelial monolayers provide a model to study sepsis-associated vascular changes...
  69. doi request reprint Development of endotoxin tolerance in humans in vivo
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Crit Care Med 37:1261-7. 2009
    ..It is unclear if this mechanism accounts for the development of LPS tolerance in humans in vivo...
  70. doi request reprint Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders
    Joyce J C Kroot
    Laboratory of Genetic, Endocrine and Metabolic Diseases, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 56:1570-9. 2010
    ..Hepcidin is instrumental in the diagnosis and monitoring of iron metabolism disorders, but reliable methods for its quantification in serum are sparse, as is knowledge of their relative analytical strengths and clinical utility...
  71. doi request reprint Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 37:417-23, e1. 2009
    ..To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury...
  72. doi request reprint GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochem Pharmacol 78:863-72. 2009
    ..GTS-21 may be promising from a therapeutic perspective because of its suitability for human use...
  73. doi request reprint Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Innate Immun 15:360-7. 2009
    ..0 and 0.6, respectively). Also, no significant changes in annexin A5 targeting were found in the control group. So, in this model, LPS-tolerance does not protect against ischemia-reperfusion injury in humans in vivo...
  74. ncbi request reprint Complicating infectious foci in patients with Staphylococcus aureus or Streptococcus species bacteraemia
    M L H Cuijpers
    Department of Internal Medicine, 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 26:105-13. 2007
    ....
  75. ncbi request reprint Trends in the outcomes of Dutch haematological patients receiving intensive care support
    M van Vliet
    Department of Haematology, Radboud University Medical Center, Nijmegen, The Netherlands
    Neth J Med 72:107-12. 2014
    ..This study was conducted to determine trends in outcome of allogeneic haematopoietic stem cell transplant (HSCT) recipients transferred to the intensive care unit in a Dutch tertiary care hospital...
  76. ncbi request reprint Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study
    M van den Boogaard
    Department of Intensive Care Medicine, Radboud University Medical Center, P O 6101 Internal Post 710, 6500 HB, Nijmegen, The Netherlands
    Intensive Care Med 40:361-9. 2014
    ..Recalibration and determining discriminative power, internationally, of the existing delirium prediction model (PRE-DELIRIC) for intensive care patients...
  77. ncbi request reprint Epidemiology, risk and prevention of pressure ulcers in critically ill patients: a literature review
    E H E W de Laat
    Pressure Ulcer Care, Radboud University Nijmegen Medical Centre, The Netherlands
    J Wound Care 15:269-75. 2006
    ..New nursing interventions and pressure-redistributing devices in intensive care units, and specific risk factors affecting critically ill patients, mean that different factors must be taken into consideration in preventing pressure ulcers...
  78. ncbi request reprint IFN-gamma is not induced through increased plasma concentrations of interleukin-12/interleukin-18 during human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine 519, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 16:191-3. 2005
    ..In contrast, IFN-gamma showed an increase from 106.6 +/- 57.1 to 152.7 +/- 57.8 (p < 0.005). These results indicate that pathways other than the IL-12/IL-18 axis may induce IFN-gamma production in human endotoxemia...
  79. ncbi request reprint A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury
    Dick H J Thijssen
    Department of Physiology, Institute of Fundamental and Clinical Movement Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein Noord 21, 6525 EZ, Nijmegen, The Netherlands
    Arterioscler Thromb Vasc Biol 27:325-31. 2007
    ..In this study, we assess the contribution of ET-1 to the increased vascular tone in the extremely deconditioned legs of spinal cord-injured (SCI) individuals before and after exercise training...
  80. pmc Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
    Bart Ferwerda
    Department of Internal Medicine and Nijmegen Institute for Infectious Inflammation and Immunity, Radboud University Nijmegen Medical Center, HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 106:10272-7. 2009
    ..This combination of functional and genetic data provides unique insights to our understanding of the pathogenesis of sepsis...
  81. ncbi request reprint Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury
    Suzanne Heemskerk
    Department of Pharmacology and Toxicology 149, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 1:853-62. 2006
    ....
  82. doi request reprint Risk factors for the deterioration of oxygenation ratio in ventilated intensive care unit patients: a retrospective cohort study
    Ilma W F Fick
    Radboud University Nijmegen Medical Center, PO Box 9101, 6500HB Nijmegen, The Netherlands
    J Crit Care 25:3-9. 2010
    ....
  83. ncbi request reprint Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury
    Jos J A Eijkenboom
    Department of Intensive Care Medicine 519, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 31:664-7. 2005
    ..We determined the extent and site of tubular injury and examined if GST excretion may predict a clinically relevant change in renal function...
  84. ncbi request reprint Severe vagal response after endotoxin administration in humans
    Lucas T G J van Eijk
    Department of Intensive Care Medicine 519, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 30:2279-81. 2004
    ..Worldwide, thousands of volunteers have received endotoxin, and adverse events are rarely reported. The aim of this report was to increase awareness of specific risks of the intravenous administration of endotoxin to human volunteers...
  85. ncbi request reprint The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation
    Bart P Ramakers
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands
    Cytokine 35:95-9. 2006
    ..These findings suggest that well-known anti-inflammatory effects of adenosine agonists on LPS-induced inflammation cannot be extrapolated to situations in which stimulation of other TLR subtypes is involved...
  86. ncbi request reprint Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries
    Matthijs Kox
    Clinical Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, QEQM Wing, St Mary s Hospital, South Wharf Road, London W2 1NY, UK
    Vascul Pharmacol 46:195-200. 2007
    ..LPS-induced hyporeactivity in vitro is mediated by activation of SFK. Selective inhibitors of SFK may have therapeutic potential in the management of septic shock...
  87. ncbi request reprint Protective effects of adenosine A2A agonist during hemorrhagic shock: a simple intervention may result in a complex response
    Bart P Ramakers
    Crit Care Med 34:3059; author reply 3059-60. 2006
  88. ncbi request reprint Role of potassium channel blockade in the treatment of sepsis-induced vascular hyporeactivity
    Mirrin Dorresteijn
    Crit Care Med 34:2867-8; author reply 2868-9. 2006
  89. ncbi request reprint Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans
    Jan N de Hoon
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastrict University, The Netherlands
    Clin Pharmacol Ther 73:312-21. 2003
    ....
  90. ncbi request reprint Renal effects of nitric oxide during sepsis: another two-edged sword?
    Suzanne Heemskerk
    Am J Respir Crit Care Med 176:419-20; author reply 420. 2007
  91. ncbi request reprint Cardiac surgery for infective endocarditis, complicated by septic cardioembolic stroke
    Jeroen Schouten
    Stroke 38:e31. 2007
  92. ncbi request reprint A possible role for the cholinergic anti-inflammatory pathway in increased mortality observed in critically ill patients receiving nicotine replacement therapy
    Matthijs Kox
    Crit Care Med 35:2468-9; author reply 2469. 2007
  93. doi request reprint Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice
    Feico J J Halbertsma
    Maxima Medical Centre, Veldhoven, The Netherlands
    Crit Care Med 36:2403-6. 2008
    ....
  94. doi request reprint Volume therapy and innate immune response during systemic inflammation or sepsis
    Mirrin J Dorresteijn
    Crit Care Med 36:1028; author reply 1028-9. 2008
  95. doi request reprint Contribution of various metabolites to the "unmeasured" anions in critically ill patients with metabolic acidosis
    Miriam Moviat
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Crit Care Med 36:752-8. 2008
    ..The chemical nature of these anions is for the most part unknown. We hypothesized that amino acids, uric acid, and organic acids could contribute to the SIG...