Martin Oti

Summary

Affiliation: Radboud University Nijmegen
Country: The Netherlands

Publications

  1. pmc Conserved co-expression for candidate disease gene prioritization
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA, Nijmegen, The Netherlands
    BMC Bioinformatics 9:208. 2008
  2. doi request reprint Web tools for the prioritization of candidate disease genes
    Martin Oti
    Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, 2010, Darlinghurst, NSW, Australia
    Methods Mol Biol 760:189-206. 2011
  3. pmc The biological coherence of human phenome databases
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Am J Hum Genet 85:801-8. 2009
  4. pmc Analysis of genome-wide association study data using the protein knowledge base
    Sara Ballouz
    Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
    BMC Genet 12:98. 2011
  5. doi request reprint Phenome connections
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Trends Genet 24:103-6. 2008
  6. pmc Prediction of human disease genes by human-mouse conserved coexpression analysis
    Ugo Ala
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    PLoS Comput Biol 4:e1000043. 2008
  7. pmc Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes
    Nicki Tiffin
    South African National Bioinformatics Institute, University of the Western Cape, Bellville, 7535, South Africa
    Nucleic Acids Res 34:3067-81. 2006
  8. doi request reprint Conservation of divergent transcription in fungi
    Philip R Kensche
    Center for Molecular and Biomolecular Informatics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands
    Trends Genet 24:207-11. 2008

Collaborators

Detail Information

Publications8

  1. pmc Conserved co-expression for candidate disease gene prioritization
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA, Nijmegen, The Netherlands
    BMC Bioinformatics 9:208. 2008
    ..Here we examine whether co-expression across multiple species is also a better prioritizer of disease genes than is co-expression between human genes alone...
  2. doi request reprint Web tools for the prioritization of candidate disease genes
    Martin Oti
    Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, 2010, Darlinghurst, NSW, Australia
    Methods Mol Biol 760:189-206. 2011
    ..In this chapter, we give an overview of computational tools that can be used for this purpose, all of which are freely available over the web...
  3. pmc The biological coherence of human phenome databases
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Am J Hum Genet 85:801-8. 2009
    ..More generally, we propose that curation and more systematic annotation of human phenome databases can greatly improve the power of the phenotype for genetic disease analysis...
  4. pmc Analysis of genome-wide association study data using the protein knowledge base
    Sara Ballouz
    Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
    BMC Genet 12:98. 2011
    ..A major benefit of multi-locus comparison is that it compensates for some shortcomings of current statistical analyses that test the frequency of each SNP in isolation for the phenotype population versus control...
  5. doi request reprint Phenome connections
    Martin Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Trends Genet 24:103-6. 2008
    ..Their results imply that the human phenome can be viewed as a landscape of interrelated diseases, reflecting overlapping molecular causation...
  6. pmc Prediction of human disease genes by human-mouse conserved coexpression analysis
    Ugo Ala
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    PLoS Comput Biol 4:e1000043. 2008
    ..However, so far, gene coexpression has not been used very successfully to prioritize positional candidates...
  7. pmc Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes
    Nicki Tiffin
    South African National Bioinformatics Institute, University of the Western Cape, Bellville, 7535, South Africa
    Nucleic Acids Res 34:3067-81. 2006
    ..Two genes, LPL and BCKDHA, are common to these two sets. We also present a set of secondary candidates for T2D (94 genes) and for obesity (116 genes) with 58 genes in common to both diseases...
  8. doi request reprint Conservation of divergent transcription in fungi
    Philip R Kensche
    Center for Molecular and Biomolecular Informatics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands
    Trends Genet 24:207-11. 2008
    ..The functional interactions of the proteins encoded by the conserved divergent gene pairs indicate a potential for protein function prediction in eukaryotes...