M G Netea

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi request reprint Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Microbiol 10:2058-66. 2008
  2. ncbi request reprint Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence
    M G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Clin Microbiol Infect 12:404-9. 2006
  3. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
  4. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
  5. pmc Inflammasome-independent modulation of cytokine response by autophagy in human cells
    Tania O Crişan
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e18666. 2011
  6. pmc Genetic susceptibility to Candida infections
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Nijmegen, The Netherlands
    EMBO Mol Med 5:805-13. 2013
  7. pmc STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e29248. 2011
  8. pmc Role of Dectin-2 for host defense against systemic infection with Candida glabrata
    Daniela C Ifrim
    Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
    Infect Immun 82:1064-73. 2014
  9. pmc Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans
    Sanne P Smeekens
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    Nat Commun 4:1342. 2013
  10. pmc Toward identification of the genetic risk profile for cryptococcal disease in HIV-infected patients
    Mihai G Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    MBio 4:e00798-13. 2013

Detail Information

Publications171 found, 100 shown here

  1. doi request reprint Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Microbiol 10:2058-66. 2008
    ..Conclusively, dectin-1 synergizes with both TLR2 and TLR4 pathways for the production of TNF-alpha in human primary PBMCs and in monocyte-derived macrophages...
  2. ncbi request reprint Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence
    M G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Clin Microbiol Infect 12:404-9. 2006
    ..Thus, signals mediated by recognition receptors are not only beneficial to the host, but in certain situations can be used by pathogenic fungi to escape immune recognition and promote infection...
  3. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
    ..We concluded that recognition of C. albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. albicans cell wall...
  4. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
    ..These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans...
  5. pmc Inflammasome-independent modulation of cytokine response by autophagy in human cells
    Tania O Crişan
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e18666. 2011
    ..In conclusion, autophagy modulates the secretion of proinflammatory cytokines in human cells through an inflammasome-independent pathway, and this is a novel mechanism that may be targeted in inflammatory diseases...
  6. pmc Genetic susceptibility to Candida infections
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Nijmegen, The Netherlands
    EMBO Mol Med 5:805-13. 2013
    ..This review is part of the review series on host-pathogen interactions. See more reviews from this series...
  7. pmc STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e29248. 2011
    ..The challenge for the future is to translate this knowledge into novel strategies for the treatment of this severe immunodeficiency...
  8. pmc Role of Dectin-2 for host defense against systemic infection with Candida glabrata
    Daniela C Ifrim
    Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
    Infect Immun 82:1064-73. 2014
    ..glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen. ..
  9. pmc Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans
    Sanne P Smeekens
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    Nat Commun 4:1342. 2013
    ..These findings indicate that the type I interferon pathway is a main signature of Candida-induced inflammation and has a crucial role in anti-Candida host defence in humans...
  10. pmc Toward identification of the genetic risk profile for cryptococcal disease in HIV-infected patients
    Mihai G Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    MBio 4:e00798-13. 2013
    ....
  11. doi request reprint Training innate immunity: the changing concept of immunological memory in innate host defence
    Mihai G Netea
    Department of Medicine and, Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Clin Invest 43:881-4. 2013
    ..This concept represents a paradigm change in immunity, and its putative role in resistance to reinfection may represent the next step in the design of future vaccines. ..
  12. pmc Role of the Candida albicans MNN1 gene family in cell wall structure and virulence
    Steven Bates
    College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, UK
    BMC Res Notes 6:294. 2013
    ..Here we report the first analysis of the MNN1 gene family, which contains six members predicted to act as α-1,3 mannosyltransferases in the terminal stages of glycosylation...
  13. doi request reprint TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors
    Rob J W Arts
    Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    J Leukoc Biol 93:209-15. 2013
    ..Moreover, TREM-1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM-1 influences TLR and NLR pathways are still largely elusive...
  14. doi request reprint Primary immunodeficiencies of pattern recognition receptors
    M G Netea
    Department of Medicine and Nijmegen, Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Intern Med 272:517-27. 2012
    ..Their discovery has led to important insights into the pathophysiology of infections, and may offer potential novel therapeutic targets for immunotherapy...
  15. pmc Interplay between Candida albicans and the mammalian innate host defense
    Shih Chin Cheng
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Infect Immun 80:1304-13. 2012
    ..albicans, ranging from how the host recognizes, responds, and clears C. albicans infection to how C. albicans evades, dampens, and escapes from host innate immunity...
  16. pmc Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Str, 12462 Athens, Greece
    Crit Care 15:R27. 2011
    ..Down-regulation of ex-vivo cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase-1 activation and conversion of pro-interleukin-1β into interleukin-1β (IL-1β)...
  17. pmc Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630]
    Cornelia W Hoedemaekers
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 9:R790-7. 2005
    ....
  18. pmc Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
    Oliver Kumpf
    Department of Anesthesiology, Intensive Care Medicine and Pain Management, HANSE Klinikum Stralsund, Grosse Parower Strasse 47 53, Stralsund 18435, Germany
    Crit Care 14:R103. 2010
    ....
  19. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
    ..The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection...
  20. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  21. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  22. ncbi request reprint Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  23. pmc From the Th1/Th2 paradigm towards a Toll-like receptor/T-helper bias
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Antimicrob Agents Chemother 49:3991-6. 2005
  24. ncbi request reprint Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release
    Mihai G Netea
    Department of Medicine, University Medical Center Nijmegen, The Netherlands
    J Immunol 173:1477-82. 2004
    ..Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4...
  25. ncbi request reprint NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 34:2052-9. 2004
    ..In conclusion, defective NOD2 function results in a pro-inflammatory cytokine bias after stimulation of mononuclear cells with TLR2 stimuli, and this could contribute to the overwhelming inflammation seen in Crohn's disease...
  26. ncbi request reprint NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype
    M G Netea
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 63:305-8. 2005
    ..e. a gain of function. In previous papers we proposed the former, since we could show decreased cytokine production with a net proinflammatory status after exposure to muramyl dipeptide (MDP)...
  27. ncbi request reprint Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release
    Mihai G Netea
    Department of Medicine, Radboud University Medical Center Nijmegen, The Netherlands
    J Immunol 174:6518-23. 2005
    ..Thus, interaction between NOD2 and specific TLR pathways may represent an important modulatory mechanism of innate immune responses...
  28. ncbi request reprint Toll-like receptors as an escape mechanism from the host defense
    Mihai G Netea
    Department of Medicine, University Medical Center, St Radboud, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Trends Microbiol 12:484-8. 2004
    ..Thus, TLR signals are not only beneficial to the host, but in certain situations the activation of particular TLR responses by microorganisms might serve as an escape mechanism from the host defense...
  29. ncbi request reprint Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors
    Mihai G Netea
    Division of Infectious Diseases, B168 University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Leukoc Biol 80:1454-61. 2006
    ..This latter finding supports the concept that TREM-1 provides optimal amplification of cytokine-induced inflammation during the initiation of host defense...
  30. ncbi request reprint Recognition of fungal pathogens by toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Curr Pharm Des 12:4195-201. 2006
    ..These recent developments provide crucial information for understanding the mechanisms of fungal recognition by cells of the immune system, and provide hope for designing new therapeutical approaches to fungal infections...
  31. ncbi request reprint Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Immunol 39:1914-22. 2009
    ..In conclusion, we have dissected the molecular mechanisms responsible for IL-1beta production by M. tuberculosis, and that may contribute to a deeper knowledge of the mechanisms of cell activation by M. tuberculosis...
  32. doi request reprint Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 48:897-903. 2010
    ..This suggests a heavier reliance of in vivo antifungal host defense on lectin receptors than on TLRs, a notion compatible with the clinical picture in individuals deficient in MyD88/TLRs or dectin-1/CARD9...
  33. pmc IL-1beta processing in host defense: beyond the inflammasomes
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen Center for Infections, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    PLoS Pathog 6:e1000661. 2010
    ..In conclusion, IL-1beta/IL-18 processing during infection is a complex process in which the inflammasomes are only one of several activation mechanisms...
  34. ncbi request reprint Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen University, The Netherlands
    J Leukoc Biol 75:749-55. 2004
    ..Finally, the crucial role of TLRs for the host defense against infections has been strengthened recently by the description of patients partially defective in the TLR-activation pathways...
  35. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  36. ncbi request reprint Innate immune mechanisms for recognition and uptake of Candida species
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Trends Immunol 31:346-53. 2010
    ..In addition, the consequence of genetic defects in dectin-1 and dectin-1-mediated signalling and the role of Th17-dependent mechanisms for the mucosal antifungal defence are discussed...
  37. ncbi request reprint Chronic yersiniosis due to defects in the TLR5 and NOD2 recognition pathways
    M G Netea
    Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Neth J Med 68:310-5. 2010
    ..In conclusion, we describe a patient in whom specific defects in the TLR5 and NOD2 recognition pathways led to chronic yersiniosis...
  38. ncbi request reprint Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    FEMS Immunol Med Microbiol 52:118-23. 2008
    ..In conclusion, TLR6 is involved in the recognition of C. albicans and modulates the Th1/Th2 cytokine balance, but this results in a mild phenotype with a normal susceptibility of TLR6-/- mice to Candida infection...
  39. ncbi request reprint An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
    ..In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens...
  40. ncbi request reprint Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?
    Mihai G Netea
    Department of Medicine 541, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Immunol 24:254-8. 2003
  41. doi request reprint Trained immunity: a memory for innate host defense
    Mihai G Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cell Host Microbe 9:355-61. 2011
    ..Understanding trained immunity will revolutionize our view of host defense and immunological memory, and could lead to defining a new class of vaccines and immunotherapies...
  42. ncbi request reprint Recognition of fungal pathogens by Toll-like receptors
    M G Netea
    Department of Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein 8, P O Box 9101, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 23:672-6. 2004
    ..These new data have substantially increased our knowledge of the recognition of fungal pathogens, and the study of TLRs remains one of the most active areas of research in the field of fungal infections...
  43. ncbi request reprint Defects of pattern recognition: primary immunodeficiencies of the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Opin Pharmacol 11:412-22. 2011
    ..Their discovery leads to crucial insight in the pathophysiology of infections, and offer therapeutic targets for future immunotherapy...
  44. ncbi request reprint Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways
    M G Netea
    Division of General Internal Medicine, Department of Medicine, Nijmegen University Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 31:2529-38. 2001
    ..In conclusion, TNF and LT play a central role in the lethality due to E. coli LPS, whereas the lethal effects of S. typhimurium LPS are mediated through mechanisms also involving other cytokines such as IFN-gamma, IL-1 and IL-18...
  45. ncbi request reprint Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Eur J Immunol 30:3057-60. 2000
    ....
  46. ncbi request reprint Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 172:3712-8. 2004
    ..In conclusion, C. albicans induces immunosuppression through TLR2-derived signals that mediate increased IL-10 production and survival of Treg cells. This represents a novel mechanism in the pathogenesis of fungal infections...
  47. ncbi request reprint Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2
    Gerben Ferwerda
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 82:1011-8. 2007
    ..paratuberculosis. These results demonstrate that TLR2, TLR4, and NOD2 are involved in the recognition of M. paratuberculosis by the innate immune system...
  48. ncbi request reprint The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Biol Chem 280:35859-67. 2005
    ..Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease...
  49. ncbi request reprint Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
  50. ncbi request reprint The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Infect Dis 185:1483-9. 2002
    ..In conclusion, TLR4-defective C3H/HeJ mice are more susceptible to C. albicans infection, and this is associated with impaired chemokine expression and neutrophil recruitment...
  51. ncbi request reprint An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
    ..The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent...
  52. ncbi request reprint Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
    M G Netea
    Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 164:2644-9. 2000
    ..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved...
  53. doi request reprint Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients
    C Popa
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 68:868-72. 2009
    ..The aim of this study was to investigate the effects of tumour necrosis factor (TNF) inhibition on the antioxidative capacity of HDL in RA...
  54. ncbi request reprint Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response
    T Sprong
    Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Leukoc Biol 70:283-8. 2001
    ..The principal conclusion is that non-LPS parts of N. meningitidis may play a role in the pathogenesis of meningococcal sepsis by inducing substantial TNF-alpha, IL-1beta, and IFN-gamma production...
  55. pmc IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
    Mihai G Netea
    Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:16309-14. 2005
    ..The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression of IL-32 in colon mucosa suggest a role of IL-32 in the pathogenesis of Crohn's disease...
  56. pmc Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens
    R J Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:5025-30. 2001
    ..In contrast to its role in the interactions between staphylococci and host cells, IL-18 does not appear to play a major role in superantigen-induced IFN-gamma...
  57. doi request reprint Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus
    G R C Zilverschoon
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Obes (Lond) 32:1407-14. 2008
    ..Paradoxically, concentrations of circulating IL-18 in obese subjects and in patients with type 2 diabetes are increased. The objective of this study is to provide an explanation for this paradox...
  58. doi request reprint Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion
    A W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Scand J Rheumatol 38:282-90. 2009
    ..The aim of our study was to determine whether Toll-like receptor (TLR)-mediated stimulation of monocytes and dendritic cells (DCs) contributes to the higher levels of CCL18 in SSc...
  59. ncbi request reprint Recombinant murine granulocyte colony-stimulating factor protects against acute disseminated Candida albicans infection in nonneutropenic mice
    B J Kullberg
    Department of Medicine, Catholic University Nijmegen and University Hospital, The Netherlands
    J Infect Dis 177:175-81. 1998
    ..These results indicate that rG-CSF enhances host resistance to disseminated candidiasis in nonneutropenic mice through activation of granulocytes and their recruitment to the site of infection...
  60. pmc Role of interleukin-18 in host defense against disseminated Candida albicans infection
    Rogier J L Stuyt
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Infect Immun 70:3284-6. 2002
    ..There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma...
  61. pmc Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency
    F L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 159:57-64. 2010
    ..These data demonstrate that defective IL-17 production in response to specific pathogens can differ between patients with HIES and that the extent of the defective Th17 response determines their clinical phenotype...
  62. ncbi request reprint Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    J Immunol 163:1498-505. 1999
    ..albicans...
  63. doi request reprint Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process
    E J Giamarellos-Bourboulis
    Department of Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 68:273-8. 2009
    ..In the present study we have investigated whether production of proinflammatory cytokines by crystals was exacerbated during costimulation with Toll-like receptor (TLR) ligands...
  64. pmc Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Infect Immun 65:2663-7. 1997
    ..This latter phenomenon was probably due to increased binding of yeast cells to macrophages of LDLR-/- mice. These data suggest that hyperlipoproteinemia is deleterious in systemic candidiasis...
  65. ncbi request reprint CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1455-63. 2002
    ..In conclusion, absence of CD40/CD40L interactions results in increased susceptibility to disseminated infection with C. albicans through decreased NO-dependent killing of Candida by macrophages...
  66. ncbi request reprint Cytokine production of stimulated whole blood cultures in rheumatoid arthritis patients receiving short-term infliximab therapy
    Calin Popa
    Department of Internal Medicine, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cytokine 30:72-7. 2005
    ....
  67. ncbi request reprint Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Microbes Infect 6:985-9. 2004
    ..albicans hyphae. Effective handling of large numbers of C. albicans is the prime task of the innate immune system consisting of large numbers of neutrophils and monocytes...
  68. ncbi request reprint Delayed clearance of intraabdominal abscesses caused by Candida albicans in tumor necrosis factor-alpha- and lymphotoxin-alpha-deficient mice
    Alieke G Vonk
    Nijmegen University Center for Infectious Diseases and Department of Medicine, Nijmegen, The Netherlands
    J Infect Dis 186:1815-22. 2002
    ..In conclusion, TNF and LT are critical to the stimulation of effector cells that leads to elimination of Candida from abscesses...
  69. ncbi request reprint The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
    ..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
  70. ncbi request reprint Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 38:184-91. 2008
    ..This demonstrates that both caspase-1-dependent and -independent mechanisms are involved in the synergy between NOD2 and TLR...
  71. ncbi request reprint Candida-specific interferon-gamma deficiency and toll-like receptor polymorphisms in patients with chronic mucocutaneous candidiasis
    C A A van der Graaf
    Department of Internal Medicine 541, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 61:365-9. 2003
    ..These data support the hypothesis that deficient IFNgamma production is involved in the pathogenesis of CMC, whereas a role for genetic polymorphisms of Toll-like receptor 2 and 4 is not obvious in these patients...
  72. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  73. ncbi request reprint Salmonella septicemia in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: association with decreased interferon-gamma production and Toll-like receptor 4 expression
    Mihai G Netea
    University Medical Center St Radboud, and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Arthritis Rheum 48:1853-7. 2003
    ..The aim of this study was to identify the mechanisms involved in the increased susceptibility of anti-TNF-treated patients to intracellular microorganisms...
  74. doi request reprint Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2
    L J H van Tits
    Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 214:345-9. 2011
    ..Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  75. pmc Toll-like receptor 2 controls expansion and function of regulatory T cells
    Roger P M Sutmuller
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:485-94. 2006
    ..albicans outgrowth. This demonstrates that in vivo TLR2 also controls the function of Tregs and establishes a direct link between TLRs and the control of immune responses through Tregs...
  76. ncbi request reprint Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction
    Mihai G Netea
    Department of Medicine 541, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands
    J Infect Dis 188:320-6. 2003
    ..Therefore, phenotypic switching during germination may be an important escape mechanism of A. fumigatus that results in counteracting the host defense...
  77. ncbi request reprint Host defence against disseminated Candida albicans infection and implications for antifungal immunotherapy
    Alieke G Vonk
    Radboud University Nijmegen Medical Center, Department of Medicine 463, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Opin Biol Ther 6:891-903. 2006
    ..Here, the authors review the chronological events in the pathogenesis of disseminated candidiasis that aid in predicting the impact of existing immunotherapy and the development of future immunomodulating strategies...
  78. ncbi request reprint Circulating galectin-3 in infections and non-infectious inflammatory diseases
    J ten Oever
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:1605-10. 2013
    ..Although galectin-3 does not discriminate between bacterial and Candida sepsis, the sequential use of CRP and galectin-3 in distinguishing infectious diseases from non-infectious inflammation may be superior to CRP alone...
  79. pmc Modulation of muramyl dipeptide stimulation of cytokine production by blood components
    J H M van der Meer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80602, USA
    Clin Exp Immunol 156:428-33. 2009
    ..The inhibition of MDP stimulation was dependent upon cellular components, with erythrocyte-derived haemoglobin and neutrophils collaborating in the inhibition of MDP effects in whole blood...
  80. ncbi request reprint Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells
    M G Netea
    Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 30:541-9. 2000
    ..In conclusion, acellular components of C. pneumoniae are a potent stimulus for cytokine production, and this mechanism may have an important role in the inflammatory aspects of atherogenesis...
  81. ncbi request reprint Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia
    M G Netea
    University Medical Center, St Radboud, Nijmegen, The Netherlands
    Eur J Clin Invest 34:94-9. 2004
    ..We have investigated whether the presence of the Asp299Gly polymorphism in patients with familial hypercholesterolaemia (FH) has a similar protective effect, and whether it influences the effects of HMG-CoA reductase treatment...
  82. ncbi request reprint Severely impaired IL-12/IL-18/IFNgamma axis in patients with hyper IgE syndrome
    M G Netea
    Radboud University Medical Centre and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Eur J Clin Invest 35:718-21. 2005
    ..The aim of this study was to investigate whether activation of the interleukin-12/interleukin-18/interferon-gamma axis, known to be crucial for the activation of cellular immune responses, is impaired in patients with HIES...
  83. ncbi request reprint The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  84. doi request reprint Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:1087-96. 2009
    ..The aim of the present study was to investigate the pathways of IL-1beta production induced by Candida albicans in human monocytes...
  85. ncbi request reprint Influence of endogenous pro-inflammatory cytokines on neutrophil-mediated damage of Candida albicans pseudohyphae, quantified in a modified tetrazolium dye assay
    Alieke G Vonk
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Med Mycol 43:551-7. 2005
    ....
  86. pmc Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans
    Chantal A A Van der Graaf
    Department of Medicine, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Vaccine Immunol 13:423-5. 2006
    ..Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans...
  87. ncbi request reprint Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands
    J Leukoc Biol 79:860-6. 2006
    ..These data indicate that the NOD2fs mutation results in a loss-of-function phenotype in human myeloid DC and imply decreased immune regulation by IL-10 as a possible mechanism for this mutation in CD...
  88. pmc Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, 6500 HB Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 107:3030-3. 2010
    ..The absence of ROS in CGD monocytes may explain the presence of an inflammatory phenotype characterized by granulomas and inflammatory bowel disease occurring in CGD patients...
  89. ncbi request reprint Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:3409-17. 2003
    ..In conclusion, the anticandidal effects of endogenous IL-18 are mediated late during the infection by assuring a proper IFN-gamma response and promoting the infiltration of the site of infection by monocytes...
  90. ncbi request reprint Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis
    Alieke G Vonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 193:1419-26. 2006
    ..It is, however, unknown whether they provide protection through similar mechanisms. We investigated the effect of endogenous IL-1 alpha and IL-1 beta on disseminated C. albicans infection...
  91. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
  92. doi request reprint The macrophage mannose receptor induces IL-17 in response to Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Host Microbe 5:329-40. 2009
    ..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...
  93. ncbi request reprint Plasmodium falciparum infection causes proinflammatory priming of human TLR responses
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Immunol 179:162-71. 2007
    ..Taken together, P.f. primes human TLR responses toward a more proinflammatory cytokine profile both in vitro and in vivo, a characteristic exceptional among microorganisms...
  94. ncbi request reprint Autophagy is redundant for the host defense against systemic Candida albicans infections
    S P Smeekens
    Department of Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 33:711-22. 2014
    ..Based on these complementary in vitro and in vivo studies, it can be concluded that autophagy is redundant for the host response against systemic infections with C. albicans. ..
  95. doi request reprint Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression
    H J Jansen
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity, 6525 GA, Nijmegen, The Netherlands
    Endocrinology 153:5866-74. 2012
    ..Autophagy may function to dampen inflammatory gene expression and thereby limit excessive inflammation in adipose tissue during obesity...
  96. pmc Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis
    C Popa
    Rheumatology Department, UMC St Radboud, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:303-5. 2005
    ....
  97. ncbi request reprint Hypoglycaemia downregulates endotoxin-induced production of tumour necrosis factor-alpha, but does not affect IL-1beta, IL-6, or IL-10
    B E de Galan
    Department of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cytokine 22:71-6. 2003
    ..We conclude that hypoglycaemia specifically downregulates TNFalpha production capacity. Diabetic patients already have a suppressed TNFalpha production capacity at non-hypoglycaemic levels...
  98. ncbi request reprint Reduced adrenal response and increased mortality after systemic Klebsiella pneumoniae infection in interleukin-6-deficient mice
    F H van Enckevort
    Department of Endocrinology 531, Nijmegen University Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 12:581-6. 2001
    ..Furthermore, the reduced adrenal response may be an explanation for the strong inflammatory response with higher TNF-alpha plasma levels in IL-6-/- mice...
  99. ncbi request reprint Increased voluntary exercise in mice deficient for tumour necrosis factor-alpha and lymphotoxin-alpha
    M G Netea
    Department of Medicine, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Eur J Clin Invest 37:737-41. 2007
    ..We hypothesized that proinflammatory cytokines, in particular tumour necrosis factor-alpha (TNFalpha) and lymphotoxin-alpha (LT) transmit signals leading to fatigue...
  100. pmc Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e7818. 2009
    ..714T>G (p.Y238X) polymorphism is associated with lower disease susceptibility or severity in IBD and to investigate the level of dectin-1 expression in inflamed and non-inflamed colon tissue of IBD patients...
  101. ncbi request reprint TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 184:1280-91. 2010
    ....