- Manders P, Tjan Heijnen V, Span P, Grebenchtchikov N, Foekens J, Beex L, et al. Predictive impact of urokinase-type plasminogen activator: plasminogen activator inhibitor type-1 complex on the efficacy of adjuvant systemic therapy in primary breast cancer. Cancer Res. 2004;64:659-64 pubmed..The results of this study imply that the expression of uPA:PAI-1 complex independently predicts the efficacy of adjuvant chemotherapy in patients with primary breast cancer. ..
- Manders P, Tjan Heijnen V, Span P, Grebenchtchikov N, Geurts Moespot A, van Tienoven D, et al. The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer. Thromb Haemost. 2004;91:514-21 pubmed..Further studies are warranted to explain this underlying resistance to endocrine therapy when uPA:PAI-I levels are high. ..