Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands
Manders P, Tjan Heijnen V, Span P, Grebenchtchikov N, Foekens J, Beex L, et al. Predictive impact of urokinase-type plasminogen activator: plasminogen activator inhibitor type-1 complex on the efficacy of adjuvant systemic therapy in primary breast cancer. Cancer Res. 2004;64:659-64 pubmed
..The results of this study imply that the expression of uPA:PAI-1 complex independently predicts the efficacy of adjuvant chemotherapy in patients with primary breast cancer. ..
Manders P, Tjan Heijnen V, Span P, Grebenchtchikov N, Geurts Moespot A, van Tienoven D, et al. The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer. Thromb Haemost. 2004;91:514-21 pubmed
..Further studies are warranted to explain this underlying resistance to endocrine therapy when uPA:PAI-I levels are high. ..