R J E Laheij

..From the successes as well as the problems we experienced the quality of future pragmatic trials may benefit...

..Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach have been identified as species from the oral cavity...

..Our data suggest that the ethanol concentrations of the consumed beverages, and not interindividual variations in the activities of first-pass alcohol-metabolizing enzymes, are associated with gastrointestinal symptoms in alcoholics...

..Grouping of patients based on a predominant dyspeptic symptom is frequently employed in management strategies for dyspepsia. Such subdivision, however, suggests that dyspeptic symptom patterns are constant over time...

..No consensus has yet been reached concerning diagnostic and medical strategies. We conducted a randomized trial to assess the effectiveness of three management strategies for patients with uninvestigated persistent dyspeptic symptoms...

..Bacteria and viruses have been detected in the stomach of patients during acid-suppressive therapy...

..The aim of this study was to assess whether gastric acid suppression improves upper gastrointestinal symptoms in patients using low-dose aspirin for cardiovascular disease...

..Drugs for the management of cardiovascular disease may provoke gastrointestinal discomfort and complications...

..However, several meta-analyses investigating the association between Helicobacter pylori infection and nonulcer dyspepsia reported contradictory results...

..Therefore, the aim of this study was to investigate the prevalence of primary clarithromycin and/or metronidazole resistant H. pylori strains over a six-year period (1997-2002) in a regional hospital...

..Serotonin is associated with symptoms of the irritable bowel syndrome, its action is terminated by the serotonin transporter protein...

..We studied the performance of an iFOBT (OC-Sensor) in colorectal cancer (CRC) screening at different cutoffs...

..However, the high eradication rates make it difficult to study factors associated with therapy failure in small populations. In order to overcome this problem we performed a meta-analysis...

..Limited information is available about anxiety, depression and psychotropic medication use in patients referred for gastrointestinal endoscopy...

..Usually alarming symptoms are used for this matter, but their diagnostic value is by no means clear...

..We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic colorectal cancer patients...

..The aim of this study was to assess the association between BMI and gastrointestinal disorders in patients referred for endoscopy...

..05). In conclusion, the GI symptom questionnaire is understandable and has good reproducibility for measuring the presence of GI symptoms, although symptom severity is consistently rated higher when reported by interview...

..The aim of this study was to assess the association between general practitioners' referral indications and endoscopic findings...

..Individual biological characteristics, such as condition of gastric mucosa, might contribute to selection of the most appropriate acid suppression treatment strategy...

..Recently, the Dutch National Health Council recommended to introduce nationwide colorectal cancer screening, using an immunochemical faecal occult blood test...

..Upper gastrointestinal discomfort decreases the already impaired health status of patients with cardiovascular disease...

..There is conflicting evidence whether pretreatment influences the efficacy of H. pylori eradication. The aim of this study was to investigate the influence of pretreatment on cure rates of H. pylori eradication...

..Meanwhile, lifestyle habits have changed and important treatment options have been introduced. This might have influenced symptom prevalence...

..A high level of gastric acid secretion is considered to be a risk factor for reflux oesophagitis or Barrett's oesophagus. Corpus gastritis may have a protective effect on the oesophagus, because of decreased gastric acid output...

..05). CONCLUSIONS: Severity of gastrointestinal symptoms is the most important factor in affecting health status, followed by the numbers and type of gastrointestinal symptoms...

..2, 95% CI 1.1-4.4). CONCLUSION: One biopsy from the antrum or corpus seems to be inadequate to diagnose the presence of H. pylori on the mucosa. Patients with an infection exclusively in the corpus more often had worse mucosa pathology...

..However, if one completes SMT the data suggest a greater chance of staying clean in the long term than those completing RD-GA...

..Of the remaining patients, five (2%) had ACG. Deficiency of vitamin B12 is common among subjects with coronary heart disease. Up to 20% of these deficiencies are related to ACG...

..02). Fifty-one percent of the patients were infected with H. pylori, and fewer infected patients were vitamin B(12) deficient...

..To determine from the EUROSTAR registry the incidence of stent-graft kink, predictive factors for kinking, and the consequences of this complication on graft patency and aneurysm exclusion...

..This study was performed to evaluate the long-term data of patients treated with the first generation of commercially available stent grafts...

..This study aims to compare the current prevalence of upper gastrointestinal endoscopic findings to the prevalence 15 years ago...

..CONCLUSION: Delayed deaths are a considerable proportion of procedure-related deaths after EVAR within the revised time frame...

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..The aim of the study was to investigate the incidence of peptic ulcers in a population-based cohort using bioequivalent low-dose acetylsalicylic acid (80 mg) or effervescent calcium carbasalate (100 mg)...

..This study aimed to assess the effectiveness of the serotonin and norepinephrine reuptake inhibitor venlafaxine in patients with functional dyspepsia...

..11 micromol/L are a significant and independent risk factor for recurrent cardiovascular events in patients hospitalized for ACS, although total plasma homocysteine levels have no predictive value...

..48, 95% CI: 0.26-0.89). The frequency of the GSTM1 null genotype is significantly lower in alcoholic CP patients, especially young female. This suggests that GSTM1 null alcohol users, particularly young female, are less susceptible to CP...

..To avoid the limitations of this study, the results of randomized clinical trials must determine if EVAR offers a safe and durable alternative to open AAA repair...

..The aim of this study was to assess the influence of the use of endograft extensions during the primary EVAR procedure on the short- and long-term outcome...

..75 (range, 0.19-3.01) compared with wild type. The COX-1 A-842G/C50T SNP does not influence the risk for developing peptic ulcer bleeding...

..Alcoholics above age 43 had more difficulty describing feelings (odds ratio=4.1, confidence interval=1.5-11.4). Almost all measured gastrointestinal symptoms in alcoholics were associated with scores on an alexithymia questionnaire...

..This study is conducted to determine whether rapid detoxification under general anaesthesia results in higher levels of opioid abstinence than rapid detoxification without anaesthesia...

..48; 95% CI [0.05-4.32]). In conclusion, Helicobacter pylori infection is not a risk factor for low vitamin B12 levels in alcohol dependent patients...

..CONCLUSIONS: Treat and test management for patients with dyspeptic symptoms is safe and does not lead to additional diagnostic testing or use of medication when compared to prompt endoscopy...

..Recently, a genetic polymorphism in UGT1A7 was possibly associated with an increased risk for CP. We investigated whether polymorphisms in the genes for UGT1A1, UGT1A6 and UGT1A8 modified the risk for CP...

..To compare differences in the applicability and incidence of postoperative adverse events among stent-grafts used for repair of infrarenal aortic aneurysms...

..Further assessment is indicated to evaluate the effectiveness of different frequencies of surveillance visits...

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..After 3 months, there were no longer differences between groups. CONCLUSIONS: Short-term health-related quality of life benefits were found after endovascular repair compared with standard open surgery...

..Assessing alexithymia in patients with gastrointestinal (GI) symptoms before endoscopy might therefore be useful in selecting patients who are more prone to functional GI disorders...

..An elevated plasma homocysteine level is an established risk factor for cardiovascular disease. Vitamin B12 plays a key role in homocysteine metabolism and could be the main factor in causing cardiovascular disease as well...

..To investigate the influence of diabetes mellitus on outcome after endovascular abdominal aortic aneurysm (AAA) repair...

..To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection...

..Therefore we determined whether polymorphisms in the genes for alcohol dehydrogenase 3 (ADH3) or cytochrome p450 2E1 (CYP2E1) predispose to the development of CP...

..The life expectancy of patients at high risk who are considered for EAR should be longer than 1 year before any realistic gain in life span can be anticipated...

..However, when adjusted for age and medical risk factors, the use of statin in patients who underwent EVAR was still independently associated with reduced overall mortality...