R J E Laheij

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-study
    Gerdine A J Fransen
    Research Institute Caphri, Department of General Practice, Maastricht University, MD Maastricht, The Netherlands
    BMC Med Res Methodol 7:16. 2007
  2. ncbi request reprint Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    JAMA 292:1955-60. 2004
  3. ncbi request reprint Gastrointestinal symptoms and ethanol metabolism in alcoholics
    R J E Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Dig Dis Sci 49:1007-11. 2004
  4. ncbi request reprint Predominant symptom behavior in patients with persistent dyspepsia during treatment
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Clin Gastroenterol 38:490-5. 2004
  5. ncbi request reprint Empirical treatment followed by a test-and-treat strategy is more cost-effective in comparison with prompt endoscopy or radiography in patients with dyspeptic symptoms: a randomized trial in a primary care setting
    R J F Laheij
    Department of Gastroenterology, UMC St Radboud, Medical Diagnostic Centre, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Fam Pract 21:238-43. 2004
  6. ncbi request reprint Assessment of a new rapid urease test (GUT test) to diagnose Helicobacter pylori infection
    R J F Laheij
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 64:317-8. 2006
  7. ncbi request reprint Gastric acid-suppressive therapy and community-acquired respiratory infections
    R J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 18:847-51. 2003
  8. ncbi request reprint Proton-pump inhibitor therapy for acetylsalicylic acid associated upper gastrointestinal symptoms: a randomized placebo-controlled trial
    R J F Laheij
    Department of Gastroenterology, Heart Center, University Medical Center Nijmegen, The Netherlands
    Aliment Pharmacol Ther 18:109-15. 2003
  9. ncbi request reprint The impact of gastrointestinal symptoms on health status in patients with cardiovascular disease
    R J F Laheij
    Department of Gastroenterology, University Medical Center Nijmegen, The Netherlands
    Aliment Pharmacol Ther 17:881-5. 2003
  10. ncbi request reprint Helicobacter pylori infection treatment of nonulcer dyspepsia: an analysis of meta-analyses
    R J F Laheij
    Department of Gastroenterology, UMC St Radboud, Nijmegen, The Netherlands
    J Clin Gastroenterol 36:315-20. 2003

Collaborators

Detail Information

Publications60

  1. pmc Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-study
    Gerdine A J Fransen
    Research Institute Caphri, Department of General Practice, Maastricht University, MD Maastricht, The Netherlands
    BMC Med Res Methodol 7:16. 2007
    ..From the successes as well as the problems we experienced the quality of future pragmatic trials may benefit...
  2. ncbi request reprint Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    JAMA 292:1955-60. 2004
    ..Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach have been identified as species from the oral cavity...
  3. ncbi request reprint Gastrointestinal symptoms and ethanol metabolism in alcoholics
    R J E Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Dig Dis Sci 49:1007-11. 2004
    ..Our data suggest that the ethanol concentrations of the consumed beverages, and not interindividual variations in the activities of first-pass alcohol-metabolizing enzymes, are associated with gastrointestinal symptoms in alcoholics...
  4. ncbi request reprint Predominant symptom behavior in patients with persistent dyspepsia during treatment
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Clin Gastroenterol 38:490-5. 2004
    ..Grouping of patients based on a predominant dyspeptic symptom is frequently employed in management strategies for dyspepsia. Such subdivision, however, suggests that dyspeptic symptom patterns are constant over time...
  5. ncbi request reprint Empirical treatment followed by a test-and-treat strategy is more cost-effective in comparison with prompt endoscopy or radiography in patients with dyspeptic symptoms: a randomized trial in a primary care setting
    R J F Laheij
    Department of Gastroenterology, UMC St Radboud, Medical Diagnostic Centre, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Fam Pract 21:238-43. 2004
    ..No consensus has yet been reached concerning diagnostic and medical strategies. We conducted a randomized trial to assess the effectiveness of three management strategies for patients with uninvestigated persistent dyspeptic symptoms...
  6. ncbi request reprint Assessment of a new rapid urease test (GUT test) to diagnose Helicobacter pylori infection
    R J F Laheij
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 64:317-8. 2006
  7. ncbi request reprint Gastric acid-suppressive therapy and community-acquired respiratory infections
    R J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 18:847-51. 2003
    ..Bacteria and viruses have been detected in the stomach of patients during acid-suppressive therapy...
  8. ncbi request reprint Proton-pump inhibitor therapy for acetylsalicylic acid associated upper gastrointestinal symptoms: a randomized placebo-controlled trial
    R J F Laheij
    Department of Gastroenterology, Heart Center, University Medical Center Nijmegen, The Netherlands
    Aliment Pharmacol Ther 18:109-15. 2003
    ..The aim of this study was to assess whether gastric acid suppression improves upper gastrointestinal symptoms in patients using low-dose aspirin for cardiovascular disease...
  9. ncbi request reprint The impact of gastrointestinal symptoms on health status in patients with cardiovascular disease
    R J F Laheij
    Department of Gastroenterology, University Medical Center Nijmegen, The Netherlands
    Aliment Pharmacol Ther 17:881-5. 2003
    ..Drugs for the management of cardiovascular disease may provoke gastrointestinal discomfort and complications...
  10. ncbi request reprint Helicobacter pylori infection treatment of nonulcer dyspepsia: an analysis of meta-analyses
    R J F Laheij
    Department of Gastroenterology, UMC St Radboud, Nijmegen, The Netherlands
    J Clin Gastroenterol 36:315-20. 2003
    ..However, several meta-analyses investigating the association between Helicobacter pylori infection and nonulcer dyspepsia reported contradictory results...
  11. ncbi request reprint Helicobacter pylori antibiotic resistance in a Dutch region: trends over time
    M J R Janssen
    Department of Gastroenterology and Hepatology 455, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 64:191-5. 2006
    ..Therefore, the aim of this study was to investigate the prevalence of primary clarithromycin and/or metronidazole resistant H. pylori strains over a six-year period (1997-2002) in a regional hospital...
  12. ncbi request reprint Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome
    L A S van Kerkhoven
    Department of Gastroenterology and Hepatology, Radboud University, Nijmegen Medical Center, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 26:979-86. 2007
    ..Serotonin is associated with symptoms of the irritable bowel syndrome, its action is terminated by the serotonin transporter protein...
  13. pmc Cutoff value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme
    L G M van Rossum
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Br J Cancer 101:1274-81. 2009
    ..We studied the performance of an iFOBT (OC-Sensor) in colorectal cancer (CRC) screening at different cutoffs...
  14. ncbi request reprint Meta-analysis: the influence of pre-treatment with a proton pump inhibitor on Helicobacter pylori eradication
    M J R Janssen
    Department of Gastroenterology and Hepatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 21:341-5. 2005
    ..However, the high eradication rates make it difficult to study factors associated with therapy failure in small populations. In order to overcome this problem we performed a meta-analysis...
  15. ncbi request reprint Anxiety, depression and psychotropic medication use in patients with persistent upper and lower gastrointestinal symptoms
    L A S van Kerkhoven
    Department of Gastroenterology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Aliment Pharmacol Ther 21:1001-6. 2005
    ..Limited information is available about anxiety, depression and psychotropic medication use in patients referred for gastrointestinal endoscopy...
  16. ncbi request reprint Meta-analysis: the diagnostic value of alarm symptoms for upper gastrointestinal malignancy
    G A J Fransen
    Department of General Practice, Maastricht University, Maastricht, The Netherlands
    Aliment Pharmacol Ther 20:1045-52. 2004
    ..Usually alarming symptoms are used for this matter, but their diagnostic value is by no means clear...
  17. ncbi request reprint Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests
    L G M van Rossum
    Departments of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 67:182-6. 2009
    ..We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with symptomatic colorectal cancer patients...
  18. ncbi request reprint Gastrointestinal disorders and symptoms: does body mass index matter?
    M G H van Oijen
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 64:45-9. 2006
    ..The aim of this study was to assess the association between BMI and gastrointestinal disorders in patients referred for endoscopy...
  19. ncbi request reprint Evaluation of a gastrointestinal symptoms questionnaire
    H J Bovenschen
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, P O Box 9101, NL 6500 HB, Nijmegen, The Netherlands
    Dig Dis Sci 51:1509-15. 2006
    ..05). In conclusion, the GI symptom questionnaire is understandable and has good reproducibility for measuring the presence of GI symptoms, although symptom severity is consistently rated higher when reported by interview...
  20. ncbi request reprint Is there any association between referral indications for open-access upper gastrointestinal endoscopy and endoscopic findings?
    L A S van Kerkhoven
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Endoscopy 39:502-6. 2007
    ..The aim of this study was to assess the association between general practitioners' referral indications and endoscopic findings...
  21. doi request reprint Influence of gastric mucosal status on success of stepwise acid suppressive therapy for dyspepsia
    C J Van Marrewijk
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 30:82-9. 2009
    ..Individual biological characteristics, such as condition of gastric mucosa, might contribute to selection of the most appropriate acid suppression treatment strategy...
  22. ncbi request reprint [Nationwide colorectal cancer screening]
    L G M van Rossum
    Afdeling Epidemiologie, Biostatistiek en Health Technology Assessment van het Universitair Medisch Centrum St Radboud
    Ned Tijdschr Tandheelkd 117:263-7. 2010
    ..Recently, the Dutch National Health Council recommended to introduce nationwide colorectal cancer screening, using an immunochemical faecal occult blood test...
  23. ncbi request reprint Health-related quality of life in patients with cardiovascular disease--the effect of upper gastrointestinal symptom treatment
    L G M van Rossum
    Department of Gastroenterology, Heart Center, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Aliment Pharmacol Ther 19:1099-104. 2004
    ..Upper gastrointestinal discomfort decreases the already impaired health status of patients with cardiovascular disease...
  24. ncbi request reprint The influence of pretreatment on cure rates of Helicobacter pylori eradication
    M J R Janssen
    Department of Gastroenterology and Hepatology 547, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 62:192-6. 2004
    ..There is conflicting evidence whether pretreatment influences the efficacy of H. pylori eradication. The aim of this study was to investigate the influence of pretreatment on cure rates of H. pylori eradication...
  25. ncbi request reprint Gastrointestinal symptoms are still common in a general Western population
    L A S van Kerkhoven
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 66:18-22. 2008
    ..Meanwhile, lifestyle habits have changed and important treatment options have been introduced. This might have influenced symptom prevalence...
  26. ncbi request reprint Corpus gastritis in patients with endoscopic diagnosis of reflux oesophagitis and Barrett's oesophagus
    R J F Laheij
    Department of Gastroenterology, University Hospital, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 16:887-91. 2002
    ..A high level of gastric acid secretion is considered to be a risk factor for reflux oesophagitis or Barrett's oesophagus. Corpus gastritis may have a protective effect on the oesophagus, because of decreased gastric acid output...
  27. ncbi request reprint Health-related quality of life of patients with gastrointestinal symptoms
    H J Bovenschen
    Department of Gastroenterology and Hepatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 20:311-9. 2004
    ..Little is known about the variation in health-related quality of life among patients with different presentations of gastrointestinal symptoms...
  28. ncbi request reprint The importance of corpus biopsies for the determination of Helicobacter pylori infection
    M C van IJzendoorn
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 63:141-5. 2005
    ..Furthermore, we explored the conditions associated with the presence of H. pylori in the corpus...
  29. ncbi request reprint Rapid detoxification from opioid dependence under general anaesthesia versus standard methadone tapering: abstinence rates and withdrawal distress experiences
    Paul F M Krabbe
    Department of Medical Technology Assessment, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Addict Biol 8:351-8. 2003
    ..However, if one completes SMT the data suggest a greater chance of staying clean in the long term than those completing RD-GA...
  30. ncbi request reprint Gastric status and vitamin B12 levels in cardiovascular patients
    Martijn G H van Oijen
    Department of Medicine, Division of Gastroenterology, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Dig Dis Sci 52:2186-9. 2007
    ..Of the remaining patients, five (2%) had ACG. Deficiency of vitamin B12 is common among subjects with coronary heart disease. Up to 20% of these deficiencies are related to ACG...
  31. ncbi request reprint Association of aspirin use with vitamin B12 deficiency (results of the BACH study)
    Martijn G H van Oijen
    Department of Gastroenterology, Heartcenter, University Medical Center, Nijmegen, The Netherlands
    Am J Cardiol 94:975-7. 2004
    ..02). Fifty-one percent of the patients were infected with H. pylori, and fewer infected patients were vitamin B(12) deficient...
  32. ncbi request reprint Frequency, predictive factors, and consequences of stent-graft kink following endovascular AAA repair
    Gerdine A J Fransen
    Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Endovasc Ther 10:913-8. 2003
    ..To determine from the EUROSTAR registry the incidence of stent-graft kink, predictive factors for kinking, and the consequences of this complication on graft patency and aneurysm exclusion...
  33. ncbi request reprint Long-term results of endovascular abdominal aortic aneurysm treatment with the first generation of commercially available stent grafts
    Lina J Leurs
    EUROSTAR Data Registry Centre, Department of Vascular Surgery, Catharina Hospital, Michelangelolaan 2, 5602 ZA Eindhoven, The Netherlands
    Arch Surg 142:33-41; discussion 42. 2007
    ..This study was performed to evaluate the long-term data of patients treated with the first generation of commercially available stent grafts...
  34. ncbi request reprint Open-access upper gastrointestinal endoscopy a decade after the introduction of proton pump inhibitors and helicobacter pylori eradication: a shift in endoscopic findings
    Lieke A S van Kerkhoven
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Digestion 75:227-31. 2007
    ..This study aims to compare the current prevalence of upper gastrointestinal endoscopic findings to the prevalence 15 years ago...
  35. ncbi request reprint Procedure-related mortality of endovascular abdominal aortic aneurysm repair using revised reporting standards
    Gosen Gabriel Koning
    Rev Bras Cir Cardiovasc 22:7-13; discussion 13-4. 2007
    ..The aim of this study was to evaluate the definition of Procedure-related mortality after endovascular aneurysm repair (EVAR) as defined by the Committee for Standardized Reporting Practices in Vascular Surgery...
  36. ncbi request reprint Impact of CYP2C9 genotype on pharmacokinetics: are all NSAIDs the same?
    Martijn G H van Oijen
    Gastroenterology 133:2073-4; author reply 2074-5. 2007
  37. ncbi request reprint Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging
    Marc R Engelbrecht
    Department of Radiology, University Medical Center Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Radiology 229:248-54. 2003
    ....
  38. doi request reprint Peptic ulcerations are related to systemic rather than local effects of low-dose aspirin
    Martijn G H van Oijen
    Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:309-13. 2008
    ..The aim of the study was to investigate the incidence of peptic ulcers in a population-based cohort using bioequivalent low-dose acetylsalicylic acid (80 mg) or effervescent calcium carbasalate (100 mg)...
  39. doi request reprint Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial
    Lieke A S van Kerkhoven
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:746-52; quiz 718. 2008
    ..This study aimed to assess the effectiveness of the serotonin and norepinephrine reuptake inhibitor venlafaxine in patients with functional dyspepsia...
  40. doi request reprint Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome
    Martijn G H van Oijen
    Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Am J Cardiol 102:135-9. 2008
    ..11 micromol/L are a significant and independent risk factor for recurrent cardiovascular events in patients hospitalized for ACS, although total plasma homocysteine levels have no predictive value...
  41. ncbi request reprint Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis
    Mariette Verlaan
    Department of Medicine, Division of Gastroenterology and Hepatology, University Medical Centre, St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Med Genet A 120:34-9. 2003
    ..48, 95% CI: 0.26-0.89). The frequency of the GSTM1 null genotype is significantly lower in alcoholic CP patients, especially young female. This suggests that GSTM1 null alcohol users, particularly young female, are less susceptible to CP...
  42. ncbi request reprint Outcome after endovascular abdominal aortic aneurysm repair: a meta-analysis
    Luc H B Walschot
    Department of Epidemiology, UMC St Radboud, Nijmegen, The Netherlands
    J Endovasc Ther 9:82-9. 2002
    ..To determine the frequencies of complications and risk factors for complications following endovascular abdominal aortic aneurysm (AAA) repair (EVAR)...
  43. ncbi request reprint The influence of aortic cuffs and iliac limb extensions on the outcome of endovascular abdominal aortic aneurysm repair
    Roel Hobo
    EUROSTAR Data Registry Center, Catharina Hospital, Eindhoven, The Netherlands
    J Vasc Surg 45:79-85. 2007
    ..The aim of this study was to assess the influence of the use of endograft extensions during the primary EVAR procedure on the short- and long-term outcome...
  44. ncbi request reprint Effect of a specific cyclooxygenase-gene polymorphism (A-842G/C50T) on the occurrence of peptic ulcer hemorrhage
    Martijn G H van Oijen
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Dig Dis Sci 51:2348-52. 2006
    ..75 (range, 0.19-3.01) compared with wild type. The COX-1 A-842G/C50T SNP does not influence the risk for developing peptic ulcer bleeding...
  45. ncbi request reprint Prevalence of gastrointestinal symptoms in alcoholics and the relationship with alexithymia
    Leo G M van Rossum
    Department of Gastroenterology and Hepatology MDL 547, University Medical Centre Nijmegen, P O Box 9100, 6500 HB Nijmegen, The Netherlands
    Psychiatry Res 129:107-12. 2004
    ..Alcoholics above age 43 had more difficulty describing feelings (odds ratio=4.1, confidence interval=1.5-11.4). Almost all measured gastrointestinal symptoms in alcoholics were associated with scores on an alexithymia questionnaire...
  46. ncbi request reprint General anaesthesia does not improve outcome in opioid antagonist detoxification treatment: a randomized controlled trial
    Cor A J De Jong
    Novadic Kentron Network for Addiction Treatment Services, Nijmegen Institute for Scientist Practitioners in Addiction, Radboud University Nijmegen, Nijmegen, Netherlands
    Addiction 100:206-15. 2005
    ..This study is conducted to determine whether rapid detoxification under general anaesthesia results in higher levels of opioid abstinence than rapid detoxification without anaesthesia...
  47. ncbi request reprint Vitamin B12 status and its association with Helicobacter pylori infection in alcohol dependent patients
    Martijn G H van Oijen
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Nutr Sci Vitaminol (Tokyo) 50:305-8. 2004
    ..48; 95% CI [0.05-4.32]). In conclusion, Helicobacter pylori infection is not a risk factor for low vitamin B12 levels in alcohol dependent patients...
  48. ncbi request reprint Long-term follow-up of empirical treatment or prompt endoscopy for patients with persistent dyspeptic symptoms?
    Robert J F Laheij
    Department of Gastroenterology, University Hospital Nijmegen, The Netherlands
    Eur J Gastroenterol Hepatol 16:785-9. 2004
    ..There are concerns about the safety and possible high costs of ongoing proton pump inhibitor therapy of empirical management strategies for patients with persistent dyspeptic symptoms...
  49. ncbi request reprint Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis
    Mariette Verlaan
    Department of Medicine, Division of Gastroenterology and Hepatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Pharmacogenetics 14:351-7. 2004
    ..Recently, a genetic polymorphism in UGT1A7 was possibly associated with an increased risk for CP. We investigated whether polymorphisms in the genes for UGT1A1, UGT1A6 and UGT1A8 modified the risk for CP...
  50. ncbi request reprint Risk-adjusted outcome analysis of endovascular abdominal aortic aneurysm repair in a large population: how do stent-grafts compare?
    Corine J Van Marrewijk
    Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Endovasc Ther 12:417-29. 2005
    ..To compare differences in the applicability and incidence of postoperative adverse events among stent-grafts used for repair of infrarenal aortic aneurysms...
  51. ncbi request reprint What determines and are the consequences of surveillance intensity after endovascular abdominal aortic aneurysm repair?
    Lina J Leurs
    EUROSTAR Data Registry Centre, Department of Vascular Surgery, Catharina Hospital, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Ann Vasc Surg 19:868-75. 2005
    ..Further assessment is indicated to evaluate the effectiveness of different frequencies of surveillance visits...
  52. pmc Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid
    Martijn G H van Oijen
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Clin Pharmacol 60:623-8. 2005
    ....
  53. ncbi request reprint Health-related quality of life outcomes following elective open or endovascular AAA repair: a randomized controlled trial
    Patricia E M Lottman
    Department of Medical Technology Assessment, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Endovasc Ther 11:323-9. 2004
    ..To assess health-related quality of life outcomes after endovascular versus open abdominal aortic aneurysm repair...
  54. ncbi request reprint Alexithymia is associated with gastrointestinal symptoms, but does not predict endoscopy outcome in patients with gastrointestinal symptoms
    Lieke A S van Kerkhoven
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Clin Gastroenterol 40:195-9. 2006
    ..Assessing alexithymia in patients with gastrointestinal (GI) symptoms before endoscopy might therefore be useful in selecting patients who are more prone to functional GI disorders...
  55. ncbi request reprint Hyperhomocysteinaemia and vitamin B12 deficiency: the long-term effects in cardiovascular disease
    Martijn G H van Oijen
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cardiology 107:57-62. 2007
    ..An elevated plasma homocysteine level is an established risk factor for cardiovascular disease. Vitamin B12 plays a key role in homocysteine metabolism and could be the main factor in causing cardiovascular disease as well...
  56. ncbi request reprint Influence of diabetes mellitus on the endovascular treatment of abdominal aortic aneurysms
    Lina J Leurs
    EUROSTAR Data Registry Centre, Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Endovasc Ther 12:288-96. 2005
    ..To investigate the influence of diabetes mellitus on outcome after endovascular abdominal aortic aneurysm (AAA) repair...
  57. ncbi request reprint Short mucin 6 alleles are associated with H pylori infection
    Thai V Nguyen
    Department of Gastroenterology, Can Tho University of Medicine and Pharmacy, Viet Nam
    World J Gastroenterol 12:6021-5. 2006
    ..To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection...
  58. ncbi request reprint Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis
    Mariette Verlaan
    Department of Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Alcohol Alcohol 39:20-4. 2004
    ..Therefore we determined whether polymorphisms in the genes for alcohol dehydrogenase 3 (ADH3) or cytochrome p450 2E1 (CYP2E1) predispose to the development of CP...
  59. ncbi request reprint Outcome of endovascular abdominal aortic aneurysm repair in patients with conditions considered unfit for an open procedure: a report on the EUROSTAR experience
    Jacob Buth
    EUROSTAR Data Registry Center, Catharina Hospital, Eindhoven, The Netherlands
    J Vasc Surg 35:211-21. 2002
    ..This study involves the evaluation of preoperative risk classification and an assessment of the outcome of interventions...
  60. ncbi request reprint Statin use is associated with reduced all-cause mortality after endovascular abdominal aortic aneurysm repair
    Lina J Leurs
    EUROSTAR Data Registry Center, Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
    Vascular 14:1-8. 2006
    ..However, when adjusted for age and medical risk factors, the use of statin in patients who underwent EVAR was still independently associated with reduced overall mortality...