R P Kuiper

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi Germline copy number variation and cancer risk
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Curr Opin Genet Dev 20:282-9. 2010
  2. pmc The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution
    Esmé Waanders
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 8:e1002533. 2012
  3. pmc Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Cancer 12:292. 2012
  4. pmc High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    Maria V Yusenko
    Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 9:152. 2009
  5. doi Recurrence and variability of germline EPCAM deletions in Lynch syndrome
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mutat 32:407-14. 2011
  6. doi IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
    R P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 24:1258-64. 2010
  7. doi The tumor suppressor gene FBXW7 is disrupted by a constitutional t(3;4)(q21;q31) in a patient with renal cell cancer
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Center, and Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 195:105-11. 2009
  8. ncbi Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution
    Roland P Kuiper
    Department of Human Genetics, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 12:1661-9. 2003
  9. doi Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
    E Waanders
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Leukemia 25:254-8. 2011
  10. ncbi Molecular mechanisms underlying the MiT translocation subgroup of renal cell carcinomas
    K Medendorp
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cytogenet Genome Res 118:157-65. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Germline copy number variation and cancer risk
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Curr Opin Genet Dev 20:282-9. 2010
    ..We expect that copy number profiling in unexplained high-risk families will lead to the discovery of additional cancer-predisposing genes and/or mechanisms...
  2. pmc The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution
    Esmé Waanders
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 8:e1002533. 2012
    ..These findings provide further evidence for a complex and multiclonal evolution of ALL...
  3. pmc Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Cancer 12:292. 2012
    ..We assessed the influence of modification of KRAS by gene copy number aberration (CNA) and microRNAs (miRNAs) in correlation to clinical outcome in mCRC patients treated with cetuximab in combination with chemotherapy and bevacizumab...
  4. pmc High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    Maria V Yusenko
    Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 9:152. 2009
    ..The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases...
  5. doi Recurrence and variability of germline EPCAM deletions in Lynch syndrome
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mutat 32:407-14. 2011
    ..We conclude that 3' end EPCAM deletions are a recurrent cause of Lynch syndrome, which should be implemented in routine Lynch syndrome diagnostics...
  6. doi IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
    R P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 24:1258-64. 2010
    ....
  7. doi The tumor suppressor gene FBXW7 is disrupted by a constitutional t(3;4)(q21;q31) in a patient with renal cell cancer
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Center, and Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 195:105-11. 2009
    ..Previous mouse models have suggested that the FBXW7 gene may play a role in the predisposition to tumor development. Here we report that disruption of this gene may predispose to the development of human RCC...
  8. ncbi Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution
    Roland P Kuiper
    Department of Human Genetics, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 12:1661-9. 2003
    ....
  9. doi Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
    E Waanders
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Leukemia 25:254-8. 2011
    ....
  10. ncbi Molecular mechanisms underlying the MiT translocation subgroup of renal cell carcinomas
    K Medendorp
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cytogenet Genome Res 118:157-65. 2007
    ..Hence the name MiT translocation subgroup of RCCs. In this review several features of this RCC subgroup will be discussed, including the molecular mechanisms that may underlie their development...
  11. ncbi High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
    R P Kuiper
    1Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 21:1258-66. 2007
    ....
  12. doi Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanisms
    R Venkatachalam
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cytogenet Genome Res 123:188-94. 2008
    ..Finally, we discuss a novel copy number-associated epigenetic mechanism underlying the predisposition to colorectal cancer...
  13. pmc Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains
    Roland P Kuiper
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Nucleic Acids Res 32:2315-22. 2004
    ..Our data reveal that multiple levels of regulation exist for the MiTF/TFE family of transcription factors, which indicates how these transcription factors may participate in various cellular processes in different tissues...
  14. doi Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1
    Marjolijn J L Ligtenberg
    Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Genet 41:112-7. 2009
    ..Depending on the expression pattern of the neighboring gene that lacks its normal polyadenylation signal, this may cause either generalized or mosaic patterns of epigenetic inactivation...
  15. doi Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma
    Marjolijn C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Genes Chromosomes Cancer 49:635-41. 2010
    ..Sequence analysis of the SOS1 gene in 20 sporadic ERMS tumors failed to reveal any pathogenic mutations, implicating that SOS1 is not a major player in the development of this tumor outside the context of NS...
  16. ncbi No evidence for large-scale germline genomic aberrations in hereditary bladder cancer patients with high-resolution array-based comparative genomic hybridization
    Lambertus A Kiemeney
    Department of Urology, Radboud University Nijmegen Medical Centre, P O Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:180-3. 2006
  17. ncbi Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene
    Anita Bonne
    Department of Human Genetics, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 179:11-8. 2007
    ..KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC...
  18. ncbi Acquired mutations in TET2 are common in myelodysplastic syndromes
    Saskia M C Langemeijer
    Department of Hematology and Central Hematology Laboratory, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Nat Genet 41:838-42. 2009
    ..We conclude that TET2 is the most frequently mutated gene in MDS known so far...
  19. doi The epigenetics of (hereditary) colorectal cancer
    Ramprasath Venkatachalam
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Centre for Oncology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 203:1-6. 2010
    ..In this review, we will focus on DNA methylation events as heritable epimutations predisposing to colorectal cancer development...
  20. ncbi Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    Gorica Nikoloski
    Department of Laboratory Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Genet 42:665-7. 2010
    ..As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS...
  21. doi High-resolution genomic profiling of pediatric lymphoblastic lymphomas reveals subtle differences with pediatric acute lymphoblastic leukemias in the B-lineage
    Margit Schraders
    Department of Pathology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Genet Cytogenet 191:27-33. 2009
    ....
  22. ncbi BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia
    Joost C van Galen
    Department of Pediatrics, Laboratory of Pediatric Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 115:4810-9. 2010
    ..Further characterization of this complex as part of the GR regulatory circuitry could offer novel opportunities for improving the efficacy of GC-based therapies in ALL and other hematologic malignancies...