Nicolaus Kroger

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi Autologous-allogeneic tandem stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 46:813-21. 2005
  2. ncbi Autologous and allogeneic stem cell transplantation for myelodysplastic syndrome
    Theo de Witte
    Department of Hematology, University Medical Centre Radboud, Nijmegen, The Netherlands
    Blood Rev 21:49-59. 2007
  3. ncbi Autologous stem cell transplantation in myelodysplastic syndromes
    Theo de Witte
    Department of Hematology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands, and Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Semin Hematol 44:274-7. 2007
  4. ncbi Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG) followed by allografting in patients with advanced multiple myeloma. A phase I/II study of the German Study-group Multiple Myeloma (DSMM)
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Bone Marrow Transplant 31:973-9. 2003
  5. doi Unrelated stem cell transplantation after reduced intensity conditioning for patients with multiple myeloma relapsing after autologous transplantation
    Nicolaus Kroger
    University Hospital Hamburg Eppendorf, Germany
    Br J Haematol 148:323-31. 2010
  6. doi Postallograft lenalidomide induces strong NK cell-mediated antimyeloma activity and risk for T cell-mediated GvHD: Results from a phase I/II dose-finding study
    Christine Wolschke
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Exp Hematol 41:134-142.e3. 2013
  7. doi Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Exp Hematol 36:1047-54. 2008
  8. ncbi Impact of high-risk cytogenetics and achievement of molecular remission on long-term freedom from disease after autologous-allogeneic tandem transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 19:398-404. 2013
  9. doi Second allogeneic stem cell transplantation in myeloid malignancies
    Maite Hartwig
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Acta Haematol 122:185-92. 2009
  10. doi HLA-mismatched unrelated donors as an alternative graft source for allogeneic stem cell transplantation after antithymocyte globulin-containing conditioning regimen
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 15:454-62. 2009

Detail Information

Publications75

  1. ncbi Autologous-allogeneic tandem stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 46:813-21. 2005
    ....
  2. ncbi Autologous and allogeneic stem cell transplantation for myelodysplastic syndrome
    Theo de Witte
    Department of Hematology, University Medical Centre Radboud, Nijmegen, The Netherlands
    Blood Rev 21:49-59. 2007
    ..Further development of accurate prognostic classification systems will allow a risk-adapted strategy for an individual patient...
  3. ncbi Autologous stem cell transplantation in myelodysplastic syndromes
    Theo de Witte
    Department of Hematology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands, and Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Semin Hematol 44:274-7. 2007
    ..Further development of precise prognostic classification systems, including an accurate evaluation of cytogenetic/molecular response to chemotherapy, is needed to develop a risk-adapted strategy for individual patients...
  4. ncbi Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG) followed by allografting in patients with advanced multiple myeloma. A phase I/II study of the German Study-group Multiple Myeloma (DSMM)
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Bone Marrow Transplant 31:973-9. 2003
    ..In vivo T-cell depletion with ATG resulted in a low rate of severe GvHD with low treatment-related mortality, and a substantial number of long-term survivors...
  5. doi Unrelated stem cell transplantation after reduced intensity conditioning for patients with multiple myeloma relapsing after autologous transplantation
    Nicolaus Kroger
    University Hospital Hamburg Eppendorf, Germany
    Br J Haematol 148:323-31. 2010
    ..02). We conclude that optimal donor selection is mandatory for a low non-relapse mortality and high relapse incidence, which remains a major concern, should be improved by including post-transplant strategies to upgrade remission status...
  6. doi Postallograft lenalidomide induces strong NK cell-mediated antimyeloma activity and risk for T cell-mediated GvHD: Results from a phase I/II dose-finding study
    Christine Wolschke
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Exp Hematol 41:134-142.e3. 2013
    ..Study registered under: NCT 00778752.)...
  7. doi Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Exp Hematol 36:1047-54. 2008
    ..Allogeneic HSCT from matched unrelated and mismatched donors carries an increased risk of graft-vs-host disease (GVHD) and transplant-related mortality (TRM)...
  8. ncbi Impact of high-risk cytogenetics and achievement of molecular remission on long-term freedom from disease after autologous-allogeneic tandem transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 19:398-404. 2013
    ..These results suggest that auto-allo tandem SCT may overcome the negative prognostic effect of del(17p13) and/or t(4;14) and that achievement of molecular remission resulted in long-term freedom from disease...
  9. doi Second allogeneic stem cell transplantation in myeloid malignancies
    Maite Hartwig
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Acta Haematol 122:185-92. 2009
    ..Efforts should concentrate on an optimization of conditioning strategies, immunosuppression and post-transplant surveillance for this specific situation...
  10. doi HLA-mismatched unrelated donors as an alternative graft source for allogeneic stem cell transplantation after antithymocyte globulin-containing conditioning regimen
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 15:454-62. 2009
    ..013) (P = .004) and bad-risk disease (HR 1.975) (P < .001) were independent risk factors for DFS. In conclusion, pretransplant ATG allows allogeneic SCT from unrelated donors with HLA disparities...
  11. ncbi Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation
    Francis Ayuk
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistr 52, 20245, Hamburg, Germany
    Ann Hematol 93:855-61. 2014
    ..Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation. ..
  12. doi Donor lymphocyte infusions and second transplantation as salvage treatment for relapsed myelofibrosis after reduced-intensity allografting
    Evgeny Klyuchnikov
    Department of Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany
    Br J Haematol 159:172-81. 2012
    ....
  13. doi Role of interleukin 16 in multiple myeloma
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    J Natl Cancer Inst 104:1005-20. 2012
    ..Interleukin 16 (IL-16) is involved in regulating the migration and proliferation of normal leukocytes. However, the role of IL-16 in human cancers, including multiple myeloma, is unclear...
  14. doi Comparison of two doses of antithymocyte globulin in patients undergoing matched unrelated donor allogeneic stem cell transplantation
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 14:913-9. 2008
    ..A prospective randomized study comparing these 2 doses of ATG-F is warranted...
  15. doi Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia
    Bettina Wiedemann
    Interdisciplinary Clinic for Stem Cell Transplantation, University of Hamburg, Martinistrasse 52, Hamburg, Germany
    Exp Hematol 38:1261-71. 2010
    ..Chimerism is well-established for surveillance of acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (HSCT), but interpretation of the results and techniques is not standardized...
  16. ncbi Unrelated stem cell transplantation in multiple myeloma after a reduced-intensity conditioning with pretransplantation antithymocyte globulin is highly effective with low transplantation-related mortality
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Blood 100:3919-24. 2002
    ....
  17. ncbi Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Transplantation 82:1024-30. 2006
    ....
  18. doi Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 37:791-8. 2009
    ..To investigate post-transplant immunotherapy with escalating donor-lymphocyte infusions (DLI) and novel agents (thalidomide, bortezomib, and lenalidomide) to target complete remission (CR)...
  19. ncbi Bortezomib after dose-reduced allogeneic stem cell transplantation for multiple myeloma to enhance or maintain remission status
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 34:770-5. 2006
    ..3 mg/m(2) intravenously, days 1, 4, 8, and 11) after dose-reduced allogeneic stem cell transplantation (SCT) on toxicity, CD3(+) cells, graft-versus-host disease (GvHD), and response in patients with multiple myeloma...
  20. doi The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients
    Yanran Cao
    Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 38:860-7. 2010
    ..We aimed at answering the question which cytokines, chemokines, and growth factors are typically found in the BM of untreated MM patients as well as in MM patients after allogeneic stem cell transplantation (alloSCT)...
  21. pmc Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma
    Djordje Atanackovic
    Center of Oncology, Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, Hamburg, Germany
    Haematologica 96:1512-20. 2011
    ..We, therefore, investigated functionally relevant immunoreceptors specifically associated with myeloma cells as well as their clonogenic precursors...
  22. ncbi Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Br J Haematol 129:631-43. 2005
    ..0001). We conclude that alemtuzumab produced less acute GvHD, but higher probability of relapse. The data implicated a major role of KIR-ligand mismatched transplantation in multiple myeloma...
  23. ncbi Low-dose thalidomide and donor lymphocyte infusion as adoptive immunotherapy after allogeneic stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 104:3361-3. 2004
    ..The 2-year estimated overall and progression-free survival were 100% and 84%, respectively. Adoptive immunotherapy with low-dose thalidomide and DLI induces a strong antimyeloma effect with low incidence of graft versus host disease...
  24. doi Long-term follow-up of an intensified myeloablative conditioning regimen with in vivo T cell depletion followed by allografting in patients with advanced multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 16:861-4. 2010
    ..Our data indicate that an intensified myeloablative conditioning regimen followed by allogeneic SCT can produce long-term survival and freedom from disease in patients with multiple myeloma who achieve CR...
  25. doi Outcome of allogeneic SCT in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy
    Anthony Oyekunle
    Department for Stem Cell Transplantation, University Cancer Center Hamburg UCCH, Martinistr 52, 20246, Hamburg, Germany
    Ann Hematol 92:487-96. 2013
    ..Therefore, for patients with advanced CML phases, allogeneic SCT provides an acceptable chance of cure. Transplant research should focus on improving conditioning regimens and post-SCT management for this subgroup of CML patients...
  26. doi Purification of CD4+ T cells for adoptive immunotherapy after allogeneic hematopoietic stem cell transplantation
    Evgeny Klyuchnikov
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 17:374-83. 2011
    ..Automated enrichment of CD4(+) by magnetic cell sorting provides an efficient and rapid method for processing donor lymphocytes. Additional studies should further investigate this approach in terms of efficacy and the risk of GVHD...
  27. ncbi An optimized assay for the enumeration of antigen-specific memory B cells in different compartments of the human body
    Yanran Cao
    Department of Internal Medicine II Oncology, Haematology, Stem Cell Transplantation, University Cancer Centre Hamburg Hubertus Wald Tumorzentrum, Hamburg, Germany
    J Immunol Methods 358:56-65. 2010
    ..In the framework of our current study we set out to develop an optimized assay for the quantification of antigen-specific B cells in different compartments of the human body...
  28. doi Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis
    Haefaa Alchalby
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Blood 116:3572-81. 2010
    ..03). We conclude that JAK2V617F-mutated status, but not allele frequency, resulted in an improved survival and rapid clearance after allografting reduces the risk of relapse...
  29. doi Pegfilgrastim compared to lenograstim after allogeneic peripheral blood stem-cell transplantation from unrelated donors
    Sunday Ocheni
    Department for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 50:612-8. 2009
    ..We conclude that Pegfilgrastim ensured rapid neutrophil engraftment after unrelated allogeneic peripheral SCT, which was at least as effective as daily lenograstim...
  30. doi Risk models predicting survival after reduced-intensity transplantation for myelofibrosis
    Haefaa Alchalby
    Department of Stem Cell Transplantation, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Br J Haematol 157:75-85. 2012
    ..In conclusion, a simple model which includes: age, JAK2 V617F-status and constitutional symptoms can clearly separate distinct risk groups and can be used in addition to the Lille model to predict OS after RIC-ASCT for myelofibrosis...
  31. pmc Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation
    Sebastian Kobold
    Department of Internal Medicine II, Oncology Hematology Bone Marrow Transplantation with the Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Dev Immunol 2011:302145. 2011
    ..The questions whether SOX2-specific autoantibodies merely represent an epiphenomenon, are related to graft-versus-host effects or participate in the immune control of myeloma needs to be answered in prospective studies...
  32. pmc Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center, Hamburg Eppendorf, Martinistraße 52 D 20246, Hamburg, Germany
    Haematologica 96:291-7. 2011
    ..Bone marrow fibrosis in patients with myelodysplastic syndrome is associated with a poor outcome, but whether the outcome after allogeneic stem cell transplantation is related to the degree of bone marrow fibrosis is unknown...
  33. doi Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    Nicolaus Kroger
    Center for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 114:5264-70. 2009
    ..70; P = .02) and human leukocyte antigen-mismatched donor (hazard ratio = 3.04; P = .006) remained significant factors for survival. The study was registered at www.clinicaltrials.gov as #NCT 00599547...
  34. ncbi Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia
    Jörg Hessling
    Bone Marrow Transplantation, University Hospital Eppendorf, Hamburg, Germany
    Br J Haematol 119:769-72. 2002
    ..All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation...
  35. doi Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia
    Tim Luetkens
    Department of Oncology and Hematology, Center of Oncology, Hamburg, Germany
    Leuk Res 34:1647-55. 2010
    ..However, a broad picture of the expression of CT antigens and associated humoral immune responses in chronic myeloid leukemia (CML) is still missing...
  36. doi Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma
    Caroline Pabst
    Department of Oncology Hematology Bone Marrow Transplantation with the Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Mol Pathol 89:175-81. 2010
    ..013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes...
  37. ncbi Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 103:4056-61. 2004
    ..48; 95% CI, 1.19-5.17; P =.02), while patients with deletion 13q had a nearly 2 times higher risk of death (HR, 1.94; 95% CI, 0.95-3.98; P =.07) after dose-reduced allogeneic stem cell transplantation...
  38. ncbi Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells
    Lubin Fang
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 79:369-71. 2005
    ..78%-98%). These data show that ATG induces depletion of circulating MDCs and PDCs, which might be in addition to the T-cell depletion a further mechanism to reduce graft-versus-host disease after allogeneic stem-cell transplantation...
  39. doi International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma
    Henk Lokhorst
    Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Oncol 28:4521-30. 2010
    ..To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group...
  40. doi Diagnostic tools in the indications for allogeneic stem cell transplantation in myelodysplastic syndromes
    Ulrike Bacher
    Interdisciplinary Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 16:1-11. 2010
    ..Consequently, in the near future, risk stratification in MDS might incorporate additional diagnostic tools and categorization systems aimed at improving the timing and indication for SCT in this complex disorder...
  41. ncbi Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation
    Natalja Fehse
    Bone Marrow Transplantation, University Hospital Eppendorf, Hamburg, Germany
    J Hematother Stem Cell Res 12:237-42. 2003
    ..We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT...
  42. ncbi Kinetics of plasma-cell chimerism after allogeneic stem cell transplantation by highly sensitive real-time PCR based on sequence polymorphism and its value to quantify minimal residual disease in patients with multiple myeloma
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 34:688-94. 2006
    ....
  43. ncbi Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 12:159-68. 2006
    ..To analyze prognostic and predictive effects of immunohistochemical factors within a randomized study of high-dose versus standard-dose chemotherapy in high-risk breast cancer with >10 involved lymph nodes...
  44. doi NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse following Allogenei
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinstrasse 52, Hamburg, Germany
    Biol Blood Marrow Transplant 16:1187-211. 2010
    ....
  45. doi Comparison of cytogenetic clonal evolution patterns following allogeneic hematopoietic transplantation versus conventional treatment in patients at relapse of AML
    Ulrike Bacher
    Interdisciplinary Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Blood Marrow Transplant 16:1649-57. 2010
    ..001). Thus, higher frequencies of clonal evolution and increasing cytogenetic complexity were observed in the stem cell recipients probably related to the more unfavorable cytogenetic profiles already depicted at diagnosis...
  46. ncbi Randomized trial of single compared with tandem high-dose chemotherapy followed by autologous stem-cell transplantation in patients with chemotherapy-sensitive metastatic breast cancer
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 24:3919-26. 2006
    ..To compare progression-free survival between single and tandem high-dose chemotherapy (HDT) followed by autologous stem-cell transplantation in chemotherapy-sensitive metastatic breast cancer patients...
  47. doi Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation
    Sunday Ocheni
    Clinic for Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany
    Leuk Lymphoma 50:551-8. 2009
    ..Research should focus on prospective studies aiming to improve treatment of extramedullary relapse in stem cell recipients with CML with a special focus on the role of second generation tyrosine kinase inhibitors...
  48. doi Postallogeneic monitoring with molecular markers detected by pretransplant next-generation or Sanger sequencing predicts clinical relapse in patients with myelodysplastic/myeloproliferative neoplasms
    Yuewen Fu
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Haematol 92:189-94. 2014
    ..15%, P = 0.04). In conclusion, pretransplant molecular mutation analysis can help to detect biomarkers in patients with MPN/MDS, which may be subsequently used as minimal residual disease markers after AHSCT. ..
  49. doi Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
    Djordje Atanackovic
    Department of Internal Medicine II, Oncology Hematology Stem Cell Transplantation, Center of Oncology, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, Martinistrasse 52, Hamburg, Germany
    Stress 16:421-8. 2013
    ..We suggest that in the case of frequent stress exposure, this might result in the promotion of, for example, allergic conditions...
  50. doi Cytogenetics of extramedullary manifestations in multiple myeloma
    Lisa Billecke
    Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Cancer Centre, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Br J Haematol 161:87-94. 2013
    ..del(17p13), occurring additional in three of four cases, seems a strong marker for extramedullary progression of myeloma...
  51. doi Challenges for allogeneic hematopoietic stem cell transplantation in chronic myeloid leukemia in the era of tyrosine kinase inhibitors
    Anthony Oyekunle
    Department for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Acta Haematol 126:30-9. 2011
    ..Still, the outcome of patients in advanced CML phases remains guarded, and requires an improvement in current transplant strategies...
  52. pmc Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Haematologica 95:785-93. 2010
    ..Surprisingly, the biological role of cancer-testis genes in myeloma remains poorly understood...
  53. ncbi Kinetics of G-CSF and CD34+ cell mobilization after once or twice daily stimulation with rHu granulocyte-stimulating factor (lenograstim) in healthy volunteers: an intraindividual crossover study
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transfusion 44:104-10. 2004
    ..G-CSF given as split dose increased the harvested number of CD34+ cells in comparison to a once daily schedule, but the mechanism is poorly understood...
  54. doi Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation: a study from the Myeloproliferative Neoplasm Subcommittee of the CMWP of the European Group for Blood and Marrow Transplantation
    Haefaa Alchalby
    Department of Stem Cell Transplantation, University Hospital Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 20:279-81. 2014
    ..008); however, complete remission was achieved only in 8 patients. Allogeneic stem cell transplantation can cure myelofibrosis patients transformed to leukemia. ..
  55. doi Comparative diagnostic performance of ¹⁸F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation
    Thorsten Derlin
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Radiol 23:570-8. 2013
    ....
  56. ncbi Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia
    Ulrike Bacher
    Department for Stem Cell Transplantation, University Cancer Centre Hamburg, Martinistrasse 52, Hamburg, Germany
    Br J Haematol 153:149-67. 2011
    ..This review summarizes the current status of pharmacotherapy and transplantation in CMML and outlines recent results of molecular research for diagnosis of this heterogeneous entity...
  57. doi 18F-FDG PET/CT for detection and localization of residual or recurrent disease in patients with multiple myeloma after stem cell transplantation
    Thorsten Derlin
    Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Nucl Med Mol Imaging 39:493-500. 2012
    ....
  58. doi Caspofungin plus posaconazole as salvage therapy of invasive fungal infections in immunocompromised patients
    Heinrich Lellek
    Clinic for Stem Cell Transplantation, Center of Oncology, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Mycoses 54:39-44. 2011
    ..This study indicates that the combination of caspofungin and posaconazole may provide an effective and tolerable therapy of IA in immunocompromised patients refractory to primary treatment...
  59. pmc Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation
    Nicolaus Kroger
    Dept for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Haematologica 94:542-9. 2009
    ..After successful treatment of malignant diseases, therapy-related myelodysplastic syndrome and acute myeloid leukemia have emerged as significant problems...
  60. doi Complement-dependent and complement-independent cytotoxicity of polyclonal antithymocyte globulins in chronic lymphocytic leukemia
    Francis A Ayuk
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Leuk Res 32:1200-6. 2008
    ..ATGs however, contain antibodies targeting antigens expressed on various hematopoietic cells including B cells...
  61. ncbi Rabbit-IgG levels in patients receiving thymoglobulin as part of conditioning before unrelated donor stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Haematologica 90:869B. 2005
  62. pmc Impact of the NK cell receptor LIR-1 (ILT-2/CD85j/LILRB1) on cytotoxicity against multiple myeloma
    Silke Heidenreich
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Dev Immunol 2012:652130. 2012
    ..To our knowledge, this work provides the first investigation of the inhibitory capability of LIR-1 in NK-92-mediated cytotoxicity against MM and the first functional evaluation of LIR-1 on MM and LBCL...
  63. doi Assessment of physiologic natural killer cell cytotoxicity in vitro
    Heidi Duske
    Transfusion Medicine, HLA Laboratory, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Immunol 72:1007-12. 2011
    ..This assay may help to predict donor NK cell activity in vivo, to reconcile conflicting data about NK cells obtained in transplantation studies...
  64. ncbi Haemopoietic cell transplantation of patients with a history of deep or invasive fungal infection during prophylaxis with liposomal amphotericin B
    William H Krüger
    Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany
    Acta Haematol 113:104-8. 2005
    ..However, fungal infections and transplant-related mortality remain major problems in this often heavily pretreated subgroup of patients...
  65. pmc Minimal residual disease following allogeneic hematopoietic stem cell transplantation
    Nicolaus Kroger
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 17:S94-100. 2011
    ....
  66. doi Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1343-52. 2009
    ....
  67. doi Reduced-intensity conditioning followed by allogeneic hematopoietic stem cell transplantation in myelofibrosis
    Haefaa Alchalby
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Hematol Malig Rep 5:53-61. 2010
    ..Such a tool may optimally include not only clinicomorphologic characteristics but also other potentially relevant factors such as cytogenetics and novel molecular markers...
  68. ncbi High-dose therapy for breast cancer - a case of suspended animation
    Axel R Zander
    University Hospital Hamburg Eppendorf, Hamburg Eppendorf, Germany
    Acta Haematol 114:248-54. 2005
    ..It is further necessary to look at the biology of breast cancer in the context of high-dose chemotherapy studies...
  69. doi Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Blood 119:5632-9. 2012
    ....
  70. doi Unrelated stem cell transplantation for patients with multiple myeloma
    Nicolaus Kroger
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Hematol 17:538-43. 2010
    ....
  71. ncbi Dose and schedule effect of G-GSF for stem cell mobilization in healthy donors for allogeneic transplantation
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 43:1391-4. 2002
    ..A prolonged follow-up of the donors is needed to rule out late toxicity of the donors...
  72. doi Approaches to relapse after allogeneic stem cell transplantation
    Nicolaus Kroger
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Oncol 23:203-8. 2011
    ..In general, prognosis is poor for patients who relapsed to an allograft since effective treatment options are limited. Here, we review the available and upcoming treatment approaches for relapse...
  73. ncbi Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Blood 100:755-60. 2002
    ..The tandem auto-allotransplant protocol is highly active and provides rapid engraftment with complete donor chimerism and tolerable toxicity...
  74. doi Drug dosing and monitoring in obese patients undergoing allogenic stem cell transplantation
    Claudia Langebrake
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246, Hamburg, Germany
    Int J Clin Pharm 33:918-24. 2011
    ..Glomerular filtration rate and renal perfusion appear to be similar in obese and normal weight individuals, thus elimination of hydrophilic and extensively renally cleared drugs mainly depends upon creatinine clearance...
  75. pmc Detection of virulence-associated genes not useful for discriminating between invasive and commensal Staphylococcus epidermidis strains from a bone marrow transplant unit
    Holger Rohde
    Institut für Infektionsmedizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Clin Microbiol 42:5614-9. 2004
    ..epidermidis strains. The dynamics of S. epidermidis populations reveal that detection of icaADBC and mecA is not suitable for discriminating invasive from contaminating S. epidermidis strains...