Hans J P M Koenen

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    Hum Immunol 67:665-75. 2006
  2. doi request reprint Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 112:2340-52. 2008
  3. ncbi request reprint Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transplantation 80:522-9. 2005
  4. ncbi request reprint CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 174:7573-83. 2005
  5. ncbi request reprint A novel bispecific antihuman CD40/CD86 fusion protein with t-cell tolerizing potential
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology ABTI OV603, University Medical Center Nijmegen, P Box 9101, 6500 HB Nijmegen, The Netherlands
    Transplantation 78:1429-38. 2004
  6. ncbi request reprint IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression
    Hans J P M Koenen
    Department for Blood Transfusion and Transplantation Immunology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 171:6431-41. 2003
  7. ncbi request reprint The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells
    Ellen Kreijveld
    Radboud University Nijmegen Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:244-52. 2007
  8. ncbi request reprint CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:5240-6. 2006
  9. ncbi request reprint Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production
    Xuehui He
    Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 134:975-83. 2014
  10. ncbi request reprint Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 107:1018-23. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    Hum Immunol 67:665-75. 2006
    ..Accordingly, ex vivoselection procedures to induce and isolate highly suppressive antigen-specific Treg (subsets) are needed. This subject, as well as the Treg-facilitating potential of immunosuppressive agents, is discussed...
  2. doi request reprint Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 112:2340-52. 2008
    ..Thus, the data suggest that epigenetic modification underlies the phenomenon of Treg plasticity here described...
  3. ncbi request reprint Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transplantation 80:522-9. 2005
    ..T-cell anergy is crucial in transplantation tolerance...
  4. ncbi request reprint CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 174:7573-83. 2005
    ..Summarizing, the described procedure enables induction, expansion, and especially selection of highly suppressive, Ag-specific Treg subsets, which are crucial in Ag-specific, Treg-based immunotherapy...
  5. ncbi request reprint A novel bispecific antihuman CD40/CD86 fusion protein with t-cell tolerizing potential
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology ABTI OV603, University Medical Center Nijmegen, P Box 9101, 6500 HB Nijmegen, The Netherlands
    Transplantation 78:1429-38. 2004
    ..These data provide proof of concept in successfully combining the antagonistic activity of two humanized mAb with great clinical potential in transplantation and autoimmunity, in one single molecule...
  6. ncbi request reprint IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression
    Hans J P M Koenen
    Department for Blood Transfusion and Transplantation Immunology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 171:6431-41. 2003
    ..In conclusion, IL-15-expanded, de novo-induced human anergic regulatory CD4(+) T cells are of interest in Ag-specific immunotherapy...
  7. ncbi request reprint The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells
    Ellen Kreijveld
    Radboud University Nijmegen Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:244-52. 2007
    ..The cells revealed delayed p27(kip1) degradation and enhanced phosphorylation of STAT3. In conclusion, the new drug FK778 shows tolerizing potential through the induction of a regulatory T-cell subset in CD4+ CD25- T cells...
  8. ncbi request reprint CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:5240-6. 2006
    ..We conclude that CTLA-4 signaling and T(REG) independently cooperate in the inhibition of CD8(+) T cell expansion under costimulation blockade...
  9. ncbi request reprint Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production
    Xuehui He
    Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 134:975-83. 2014
    ..Thus, pharmacological inhibition of PKC may serve as a powerful tool to concurrently inhibit effector T cells and to facilitate Treg, thereby showing therapeutic potential for the treatment of psoriasis. ..
  10. ncbi request reprint Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 107:1018-23. 2006
    ..This differential effect of rapamycin and CsA on the CD27+ T(REG) subset dominance may favor the use of rapamycin in tolerance-inducing strategies...
  11. doi request reprint Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases
    Ellen H van den Bogaard
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 134:719-27. 2014
    ..We propose that our T cell-driven inflammatory skin equivalent model has potential to study the pathogenesis of inflammatory skin diseases and may serve as a preclinical screening tool for anti-inflammatory drugs. ..
  12. doi request reprint High-dose vitamin D3 supplementation is a requisite for modulation of skin-homing markers on regulatory T cells in HIV-infected patients
    Ai Leng Khoo
    Department of Laboratory Medicine, Laboratory Medical Immunology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    AIDS Res Hum Retroviruses 29:299-306. 2013
    ..At a standard dose of 800 IU/day, vitamin D(3) is not effective in achieving an optimal 25(OH)D(3) concentration in patients with an underlying T cell dysfunction and is unable to exert any immunomodulatory effects...
  13. pmc Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus
    Ellen Kreijveld
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e2711. 2008
    ..In a case-control design, the results were compared between patients with (n = 15) and without (n = 28) acute rejection after tacrolimus withdrawal...
  14. doi request reprint Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations
    Jorieke H Peters
    Department of Laboratory Medicine Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Dermatol Sci 69:44-53. 2013
    ..Both keratinocytes and T-cells are crucial players in cutaneous immune responses. We hypothesized that direct interactions between keratinocytes and T-cell subsets could shape the nature or strength of the local immune response...
  15. pmc Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment
    Ai Leng Khoo
    Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 7:e29250. 2012
    ..Given that the current observations are limited to healthy adult males, larger population-based studies would be useful to validate these findings...
  16. pmc 1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells
    Ai Leng Khoo
    Department of Laboratory Medicine, Laboratory Medical Immunology, Nijmegen, The Netherlands
    Immunology 134:459-68. 2011
    ....
  17. ncbi request reprint Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivity
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Transpl Immunol 17:237-42. 2007
    ..We propose that selectively favoring the effects of alloreactive T(REG) is a pivotal element in inducing graft acceptance...
  18. pmc Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation
    Jorieke H Peters
    Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e3161. 2008
    ..To obtain sufficient Treg for immunotherapy, subsequent ex vivo expansion might be needed...
  19. doi request reprint Immunotherapy with regulatory T cells in transplantation
    Jorieke H Peters
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Immunotherapy 1:855-71. 2009
    ..In the following years, we expect exciting new data regarding the clinical application of Treg immunotherapy in transplantation to be released...
  20. ncbi request reprint In Vivo Induction of Cutaneous Inflammation Results in the Accumulation of Extracellular Trap-Forming Neutrophils Expressing RORγt and IL-17
    Romy R M C Keijsers
    1 Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands 2 Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands 3 Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    J Invest Dermatol 134:1276-84. 2014
    ..Surprisingly, T cells represented a minority of the IL-17-expressing cell population. These observations challenge the classical opinion that IL-17 is predominantly associated with T cells in skin inflammation. ..
  21. doi request reprint Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells
    Jorieke H Peters
    Department of Laboratory Medicine Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Blood 122:2213-23. 2013
    ..This knowledge may be exploited for further optimization of Treg immunotherapy, for example, by ex vivo selection of Tregs with capacity to migrate to lymphoid organs providing an in vivo platform for further Treg expansion. ..
  22. pmc 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses
    Ai Leng Khoo
    Department of Laboratory Medicine, Radboud University Nijmegen Medical Center 3Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
    J Infect Dis 203:122-30. 2011
    ..Our interest in immunological effects produced by vitamin D(3) (1,25(OH)(2)D(3)) and its therapeutic potential prompted us to examine the role of 1,25(OH)(2)D(3) on cytokine production by Candida albicans...
  23. ncbi request reprint Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cells
    Jeroen J A Coenen
    Department of Bloodtransfusion and Transplantation Immunology ABTI OV603, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Transplantation 79:147-56. 2005
    ..This induced suppressive capacity was found to be dependent on the presence of CD4CD25 T cells at the start of MLR...
  24. ncbi request reprint Ex vivo expansion of human CD4+ CD25high regulatory T cells from transplant recipients permits functional analysis of small blood samples
    Ellen Kreijveld
    Department of Blood Transfusion and Transplantation Immunology, Internal Postal Code 469, Radboud University Nijmegen, Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Immunol Methods 314:103-13. 2006
    ..This protocol will facilitate the monitoring of Treg function in patients in order to address the role of Treg in transplantation tolerance...
  25. pmc Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy
    Jorieke H Peters
    Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e2233. 2008
    ..For the human setting, information is lacking on how to generate Treg with direct antigen-specificity ex vivo to be used for immunotherapy...
  26. ncbi request reprint Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis
    Hans J P M Koenen
    Department for Blood Transfusion and Transplantation Immunology, University Medical Center Nijmegen, The Netherlands
    Transplantation 75:1581-90. 2003
    ..The ability of Rap to promote apoptosis, which contributes to T-cell suppression, remained unaffected upon combination with FK506 or CsA. These data support the combined use of FK506+Rap over CsA+Rap for immunosuppressive therapy...
  27. doi request reprint Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production
    Ai Leng Khoo
    Department of Laboratory Medicine, Laboratory Medical Immunology, Nijmegen, The Netherlands
    Cytokine 55:294-300. 2011
    ..These two effects may have beneficial consequences, by reducing the collateral tissue damage induced by proinflammatory cytokines, while the antibacterial effects of cathelicidin are enhanced...
  28. ncbi request reprint Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin
    H Jorn Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 131:1853-60. 2011
    ..These data stress the clinical relevance of Treg differentiation for the perpetuation of chronic inflammatory disease and may pave novel ways for immunotherapy...
  29. pmc Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells
    Vivian L de Oliveira
    Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e45509. 2012
    ..This combined approach will gain our understanding of the dermal immunopathology in humans and benefit the development of novel therapeutics for controlling inflammatory skin diseases...
  30. doi request reprint The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease
    Mark H Wenink
    Department of Rheumatology, Nijmegen Centre of Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, The Netherlands
    J Immunol 183:4509-20. 2009
    ..This TLR4-FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway...
  31. doi request reprint The macrophage mannose receptor induces IL-17 in response to Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Host Microbe 5:329-40. 2009
    ..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...