Research Topics
Genomes and Genes | Hans J P M KoenenSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Publications
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cellsHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, The Netherlands
Blood 112:2340-52. 2008..Thus, the data suggest that epigenetic modification underlies the phenomenon of Treg plasticity here described...
IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppressionHans J P M Koenen
Department for Blood Transfusion and Transplantation Immunology, University Medical Center, Nijmegen, The Netherlands
J Immunol 171:6431-41. 2003..In conclusion, IL-15-expanded, de novo-induced human anergic regulatory CD4(+) T cells are of interest in Ag-specific immunotherapy...- A novel bispecific antihuman CD40/CD86 fusion protein with t-cell tolerizing potentialHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology ABTI OV603, University Medical Center Nijmegen, P Box 9101, 6500 HB Nijmegen, The Netherlands
Transplantation 78:1429-38. 2004..These data provide proof of concept in successfully combining the antagonistic activity of two humanized mAb with great clinical potential in transplantation and autoimmunity, in one single molecule... - Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantityHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
Hum Immunol 67:665-75. 2006..Accordingly, ex vivoselection procedures to induce and isolate highly suppressive antigen-specific Treg (subsets) are needed. This subject, as well as the Treg-facilitating potential of immunosuppressive agents, is discussed... - CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cellsHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Immunol 174:7573-83. 2005..Summarizing, the described procedure enables induction, expansion, and especially selection of highly suppressive, Ag-specific Treg subsets, which are crucial in Ag-specific, Treg-based immunotherapy... - Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitroHans J P M Koenen
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Transplantation 80:522-9. 2005..T-cell anergy is crucial in transplantation tolerance... - The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cellsEllen Kreijveld
Radboud University Nijmegen Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Blood 109:244-52. 2007..The cells revealed delayed p27(kip1) degradation and enhanced phosphorylation of STAT3. In conclusion, the new drug FK778 shows tolerizing potential through the induction of a regulatory T-cell subset in CD4+ CD25- T cells... - CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockadeJeroen J A Coenen
Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
J Immunol 176:5240-6. 2006..We conclude that CTLA-4 signaling and T(REG) independently cooperate in the inhibition of CD8(+) T cell expansion under costimulation blockade... - Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cellsJeroen J A Coenen
Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Blood 107:1018-23. 2006..This differential effect of rapamycin and CsA on the CD27+ T(REG) subset dominance may favor the use of rapamycin in tolerance-inducing strategies... 
Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimusEllen Kreijveld
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 3:e2711. 2008..In a case-control design, the results were compared between patients with (n = 15) and without (n = 28) acute rejection after tacrolimus withdrawal...- Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartmentAi Leng Khoo
Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
PLoS ONE 7:e29250. 2012..Given that the current observations are limited to healthy adult males, larger population-based studies would be useful to validate these findings... - Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservationJorieke H Peters
Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 3:e3161. 2008..To obtain sufficient Treg for immunotherapy, subsequent ex vivo expansion might be needed... - Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivityJeroen J A Coenen
Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Transpl Immunol 17:237-42. 2007..We propose that selectively favoring the effects of alloreactive T(REG) is a pivotal element in inducing graft acceptance... - 1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cellsAi Leng Khoo
Department of Laboratory Medicine, Laboratory Medical Immunology, Nijmegen, The Netherlands
Immunology 134:459-68. 2011.... - Immunotherapy with regulatory T cells in transplantationJorieke H Peters
Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Immunotherapy 1:855-71. 2009..In the following years, we expect exciting new data regarding the clinical application of Treg immunotherapy in transplantation to be released... - 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responsesAi Leng Khoo
Department of Laboratory Medicine, Radboud University Nijmegen Medical Center 3Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
J Infect Dis 203:122-30. 2011..Our interest in immunological effects produced by vitamin D(3) (1,25(OH)(2)D(3)) and its therapeutic potential prompted us to examine the role of 1,25(OH)(2)D(3) on cytokine production by Candida albicans... - Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin productionAi Leng Khoo
Department of Laboratory Medicine, Laboratory Medical Immunology, Nijmegen, The Netherlands
Cytokine 55:294-300. 2011..These two effects may have beneficial consequences, by reducing the collateral tissue damage induced by proinflammatory cytokines, while the antibacterial effects of cathelicidin are enhanced... - Ex vivo expansion of human CD4+ CD25high regulatory T cells from transplant recipients permits functional analysis of small blood samplesEllen Kreijveld
Department of Blood Transfusion and Transplantation Immunology, Internal Postal Code 469, Radboud University Nijmegen, Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Immunol Methods 314:103-13. 2006..This protocol will facilitate the monitoring of Treg function in patients in order to address the role of Treg in transplantation tolerance... - Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosisHans J P M Koenen
Department for Blood Transfusion and Transplantation Immunology, University Medical Center Nijmegen, The Netherlands
Transplantation 75:1581-90. 2003..The ability of Rap to promote apoptosis, which contributes to T-cell suppression, remained unaffected upon combination with FK506 or CsA. These data support the combined use of FK506+Rap over CsA+Rap for immunosuppressive therapy... - Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapyJorieke H Peters
Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 3:e2233. 2008..For the human setting, information is lacking on how to generate Treg with direct antigen-specificity ex vivo to be used for immunotherapy... - Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cellsJeroen J A Coenen
Department of Bloodtransfusion and Transplantation Immunology ABTI OV603, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
Transplantation 79:147-56. 2005..This induced suppressive capacity was found to be dependent on the presence of CD4CD25 T cells at the start of MLR... - High-dose vitamin D(3) supplementation is a requisite for modulation of skin-homing markers on regulatory T cells in HIV-infected patientsAi Leng Khoo
Department of Laboratory Medicine, Laboratory Medical Immunology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
AIDS Res Hum Retroviruses 29:299-306. 2013..At a standard dose of 800 IU/day, vitamin D(3) is not effective in achieving an optimal 25(OH)D(3) concentration in patients with an underlying T cell dysfunction and is unable to exert any immunomodulatory effects... - Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skinH Jorn Bovenschen
Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Invest Dermatol 131:1853-60. 2011..These data stress the clinical relevance of Treg differentiation for the perpetuation of chronic inflammatory disease and may pave novel ways for immunotherapy... - Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cellsVivian L de Oliveira
Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 7:e45509. 2012..This combined approach will gain our understanding of the dermal immunopathology in humans and benefit the development of novel therapeutics for controlling inflammatory skin diseases... - Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populationsJorieke H Peters
Department of Laboratory Medicine Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands
J Dermatol Sci 69:44-53. 2013..Both keratinocytes and T-cells are crucial players in cutaneous immune responses. We hypothesized that direct interactions between keratinocytes and T-cell subsets could shape the nature or strength of the local immune response... - The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent diseaseMark H Wenink
Department of Rheumatology, Nijmegen Centre of Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, The Netherlands
J Immunol 183:4509-20. 2009..This TLR4-FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway... - The macrophage mannose receptor induces IL-17 in response to Candida albicansFrank L van de Veerdonk
Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Cell Host Microbe 5:329-40. 2009..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...