M I Koenders

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    Marije I Koenders
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
    Arthritis Rheum 63:2329-39. 2011
  2. pmc Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis
    M I Koenders
    Radboud University Nijmegen Medical Center, Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, 272, Geert Grooteplein 26, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:iii29-33. 2006
  3. ncbi Interleukin-17 acts independently of TNF-alpha under arthritic conditions
    Marije I Koenders
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:6262-9. 2006
  4. doi Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    Marije I Koenders
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 58:3461-70. 2008
  5. pmc Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    Marije I Koenders
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, 189, Geert Grooteplein Zuid 26 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 167:141-9. 2005
  6. ncbi Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:975-83. 2005
  7. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
  8. doi Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis
    Lilyanne C Grevers
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:396-407. 2009
  9. ncbi Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:3239-47. 2005
  10. ncbi Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice
    Alfons S K de Hooge
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2014-23. 2004

Detail Information

Publications22

  1. doi Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    Marije I Koenders
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
    Arthritis Rheum 63:2329-39. 2011
    ....
  2. pmc Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis
    M I Koenders
    Radboud University Nijmegen Medical Center, Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, 272, Geert Grooteplein 26, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:iii29-33. 2006
    ..On the basis of these studies, the authors propose IL-17 as an interesting additional target in the treatment of RA...
  3. ncbi Interleukin-17 acts independently of TNF-alpha under arthritic conditions
    Marije I Koenders
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:6262-9. 2006
    ..These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions...
  4. doi Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    Marije I Koenders
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 58:3461-70. 2008
    ..In this study, the role of Th17 cells and the effect of neutralization of IL-17, IL-1, and tumor necrosis factor alpha (TNFalpha) were investigated in this IL-1-driven murine arthritis model...
  5. pmc Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    Marije I Koenders
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, 189, Geert Grooteplein Zuid 26 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 167:141-9. 2005
    ..These data indicate that IL-17 is an important upstream mediator in joint pathology during flare-up of experimental arthritis...
  6. ncbi Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:975-83. 2005
    ..To examine the capacity of T cell interleukin-17A (IL-17A; referred to hereinafter as IL-17) to induce cartilage damage during experimental arthritis in the absence of IL-1...
  7. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  8. doi Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis
    Lilyanne C Grevers
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:396-407. 2009
    ..This study was undertaken to determine the role of IL-17 in FcgammaR-mediated cartilage destruction in IC-mediated arthritis and to compare its effect with that of IFNgamma...
  9. ncbi Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:3239-47. 2005
    ..To examine the role of interleukin-17 receptor (IL-17R) signaling in cartilage destruction and its interrelationship with synovial IL-1 expression during chronic reactivated streptococcal cell wall (SCW)-induced arthritis...
  10. ncbi Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice
    Alfons S K de Hooge
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2014-23. 2004
    ..The present study was undertaken to investigate synovial STAT-1 and STAT-3 activation in an experimental animal model of arthritis...
  11. doi IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1866-72. 2010
    ..To investigate the potential synergism between interleukin (IL) 32γ and Streptococcus pyogenes cell wall (SCW) fragments in the development of destructive arthritis...
  12. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010
    ..In fact, it is the excessive consumption of food or alcohol that elicits the inflammation of the acute gout attack. The aim of this study was to identify the precise mechanism that initiates flares of gouty arthritis...
  13. pmc Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:3651-62. 2009
    ..This study was undertaken to establish the relative importance of caspase 1 and serine proteases in mouse models of acute and chronic inflammatory arthritis...
  14. pmc Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation
    Shahla Abdollahi-Roodsaz
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Pathol 175:2004-13. 2009
    ..These data emphasize the potential relevance of TLR4 activation in rheumatoid arthritis, particularly with respect to IL-1-mediated joint pathology...
  15. doi Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3753-64. 2008
    ....
  16. doi T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
    ..The present study was undertaken to develop a mouse model of chronic destructive arthritis induced by repeated intraarticular (IA) exposure to bacterial cell wall fragments and to investigate the cytokine dependence of this model...
  17. pmc Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 118:205-16. 2008
    ....
  18. pmc Amplifying elements of arthritis and joint destruction
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 66:iii45-8. 2007
    ..Spontaneous T cell-dependent arthritis in IL1Ra-/- mice is absent under germ-free conditions, and markedly suppressed in TLR4-deficient mice. Moreover, TLR4 blocking with a receptor antagonist suppresses erosive arthritis...
  19. pmc The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models
    Erik Lubberts
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:29-37. 2005
    ..Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy...
  20. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  21. ncbi Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases...
  22. pmc Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?
    M I Koenders
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Exp Immunol 159:131-6. 2010
    ..Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction...