Research Topics
| Wietske KievitSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
The relationship between change in subjective outcome and change in disease: a potential paradoxWietske Kievit
Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Qual Life Res 19:985-94. 2010..Therefore, if health deteriorates, the former health state will receive a better rating, whereas if it improves, the former health state will receive a worse rating...
Long-term effectiveness and safety of TNF-blocking agents in daily clinical practice: results from the Dutch Rheumatoid Arthritis Monitoring registerWietske Kievit
Department of Rheumatic Diseases 470, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Rheumatology (Oxford) 50:196-203. 2011..The objective of this article is to describe drug survival, disease activity, daily functioning, quality of life and adverse events of TNF-blocking agents in daily clinical practice after 5 years of follow-up...
Factors that influence rheumatologists' decisions to escalate care in rheumatoid arthritis: results from a choice-based conjoint analysisWietske Kievit
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Care Res (Hoboken) 62:842-7. 2010..Our objective was to determine the influence of specific attributes relative to a validated measure of disease activity (the Disease Activity Score [DAS]) on rheumatologists' decisions to escalate care...
The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practiceW Kievit
Department of Rheumatology 470, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Ann Rheum Dis 66:1473-8. 2007..Randomised controlled trials (RCTs) evaluating the efficacy of antagonists to tumour necrosis factor alpha (TNFalpha) showed high response percentages in the groups treated with active drugs...
The effectiveness and medication costs of three anti-tumour necrosis factor alpha agents in the treatment of rheumatoid arthritis from prospective clinical practice dataW Kievit
Department of Rheumatology 470, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Ann Rheum Dis 67:1229-34. 2008..Aim: to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design...
Evaluating guidelines on continuation of anti-tumour necrosis factor treatment after 3 months: clinical effectiveness and costs of observed care and different alternative strategiesW Kievit
Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
Ann Rheum Dis 68:844-9. 2009..The secondary objective was to evaluate alternatives to the present guidelines with regard to the percentage of responders and costs...
The reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent does not influence the effect of a second TNF blocking agent in patients with rheumatoid arthritisMarlies Blom
Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, H 470, 6500 HB Nijmegen, The Netherlands
J Rheumatol 36:2171-7. 2009..To investigate whether the reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent influences the effect of a second TNF blocking agent...
The prevalence of clinical remission in RA patients treated with anti-TNF: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registryYvonne M R de Punder
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Rheumatology (Oxford) 51:1610-7. 2012..6 and minimal disease activity (MDA) criteria, and to compare the extent of residual disease activity with disability in RA patients after 6 months of treatment with anti-TNF...
Effectiveness of a third tumor necrosis factor-α-blocking agent compared with rituximab after failure of 2 TNF-blocking agents in rheumatoid arthritisMarlies Blom
Department of Rheumatology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
J Rheumatol 38:2355-61. 2011..To compare the effectiveness of a third tumor necrosis factor-α (TNF-α)-blocking agent with rituximab after failure of 2 TNF-blocking agents in patients with rheumatoid arthritis (RA) in daily clinical practice...
Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effectiveLydia G Schipper
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Sint Maartenskliniek Nijmegen, Nijmegen, The Netherlands
Rheumatology (Oxford) 50:1320-30. 2011....
Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort studyAatke van der Maas
Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, Postbus 9011, Nijmegen 6500 GM, The Netherlands
Ann Rheum Dis 71:1849-54. 2012..Therefore, our local treatment protocol includes tapering infliximab dose. This observational study describes the prevalence of successful down-titration in daily clinical practice and its effect on costs and quality of life (QoL)...
Cost effectiveness of a new strategy to identify HNPCC patientsW Kievit
Department of Medical Technology, University Medical Centre Nijmegen, 417 Human Genetics, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Gut 54:97-102. 2005..CONCLUSIONS: MSI testing in a selection of newly diagnosed CRC patients was shown to be cost effective and a feasible method to identify patients at risk for HNPCC who are not recognised by family history...
Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcomeMarieke J H Coenen
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Institute for Genetic and Metabolic Disease IGMD, Nijmegen, The Netherlands
PLoS ONE 5:e14326. 2010..We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication...
[More hereditary intestinal cancer can be detected if patients with colorectal carcinoma that are selected by the pathologist are examined for microsatellite instability]J H F M de Bruin
Universitair Medisch Centrum St Radboud, Postbus 9IoI, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 149:1792-8. 2005....
Frequency and effectiveness of dose increase of adalimumab, etanercept, and infliximab in daily clinical practiceM Blom
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Care Res (Hoboken) 62:1335-41. 2010..To describe the frequency and effectiveness of dose increase of adalimumab, etanercept, and infliximab in the treatment of rheumatoid arthritis (RA) in daily clinical practice...
Comment on the use of self-reporting instruments to assess patients with rheumatoid arthritis: the longitudinal association between the DAS28 and the VAS general healthW Kievit
Department of Medical Technology Assessment, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 55:745-50. 2006..The objective was to explore the association (in time) between disease activity and patient perception of general health, disease activity, pain, and functional disability in patients with RA...
The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritisE J M Toonen
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Rheum Dis 67:1174-7. 2008....
Influence of age on the outcome of antitumour necrosis factor alpha therapy in rheumatoid arthritisB J Radovits
Radboud University Nijmegen Medical Centre, Department of Rheumatology, PO Box 9101, HP 470, Nijmegen 6500 HB, The Netherlands
Ann Rheum Dis 68:1470-3. 2009..To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA)...
Results of three analytical approaches on long-term efficacy of etanercept for psoriasis in daily practicePaula P M van Lümig
Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Am Acad Dermatol 68:57-63. 2013..The method used to account for missing observations for the therapy under analysis has a great influence on the inference of efficacy...
Current clinical selection strategies for identification of hereditary non-polyposis colorectal cancer families are inadequate: a meta-analysisW Kievit
Department of Medical Technology Assessment, University Medical Center Nijmegen, Nijmegen, The Netherlands
Clin Genet 65:308-16. 2004..Therefore, a new strategy is needed for the identification of HNPCC...
Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritisErik J M Toonen
Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 7:e33199. 2012..Our results confirm that gene expression profiling prior to treatment is a useful tool to predict anti-TNF (non) response...
Tumour necrosis factor-alpha antagonists in the management of rheumatoid arthritis in the elderly: a review of their efficacy and safetyBeáta J Radovits
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Drugs Aging 26:647-64. 2009....
