Research Topics
Genomes and Genes | Lambertus A KiemeneySummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Publications
Urologists' and GPs' knowledge of hereditary prostate cancer is suboptimal for prostate cancer counseling: a nation-wide survey in The NetherlandsRuben Cremers
Department of Epidemiology, Biostatistics and HTA 133, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Fam Cancer 11:195-200. 2012..Hence, PCa counseling might not be optimal for men with a positive family history. Multidisciplinary guidelines on this topic should be developed to optimize personalized counseling...- Health inequalities in the Netherlands: a cross-sectional study of the role of Type D (distressed) personalityMarja J H van Bon-Martens
Academic Collaborative Centre Public Health Brabant, Tranzo, Tilburg School of Social and Behavioral Sciences, University of Tilburg, Tilburg, The Netherlands
BMC Public Health 12:46. 2012..From the perspective of the 'indirect selection hypothesis', this study was designed to expand our understanding of the role of Type D personality as an explanation of health inequalities... - Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancerDieuwertje E G Kok
Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
World J Urol 29:695-701. 2011..To determine the effect of body mass index (BMI) on clinical and pathological characteristics at time of diagnosis and on risk of biochemical recurrence after radical prostatectomy among Dutch men diagnosed with prostate cancer... - Glenohumeral joint injection: a comparative study of ultrasound and fluoroscopically guided techniques before MR arthrographyMatthieu J C M Rutten
Department of Radiology, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
Eur Radiol 19:722-30. 2009..US-guided injections and especially the anterior approach are significantly less time consuming, more successful on the first attempt, cause less patient discomfort and obviate the need for radiation and iodine contrast... 
[The risk of cancer in the Netherlands]L A L M Kiemeney
Universitair Medisch Centrum St Radboud, afd Epidemiologie, Biostatistiek en HTA, Huispost 133 EBH, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 152:2233-41. 2008..Calculation of valid and detailed risks of cancer from, and up to, specific ages for inhabitants of the Netherlands...
Genome-wide association studies in bladder cancer: first results and potential relevanceLambertus A Kiemeney
Department of Epidemiology, Biostatistics and HTA, The Netherlands
Curr Opin Urol 19:540-6. 2009..All GWASs have been published in high-impact journals and the strengths of the design are acknowledged by all experts, but there is criticism about the relevance of the results. Late 2008, the first GWAS in bladder cancer was published...- A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancerLambertus A Kiemeney
Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
Nat Genet 42:415-9. 2010..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC... - Gene expression analysis for the prediction of recurrence in patients with primary Ta urothelial cell carcinomaIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Urol 51:416-22; discussion 422-3. 2007..This study aims at discriminating between patients with primary Ta UCC and long or short recurrence-free periods... - Polymorphisms in the H19 gene and the risk of bladder cancerGerald W Verhaegh
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Urol 54:1118-26. 2008..In this study we examined whether sequence variants within the H19 gene are associated with the risk of developing bladder cancer... - Sequence variant on 8q24 confers susceptibility to urinary bladder cancerLambertus A Kiemeney
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Nat Genet 40:1307-12. 2008..A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7))... - The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression in patients with urothelial cell carcinomaIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Anticancer Res 27:1025-30. 2007..The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression was investigated in patients with urothelial cell carcinoma (UCC)... - Impact of obesity on surgical outcomes following open radical prostatectomyJoep G H van Roermund
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Urol Int 82:256-61. 2009..It is unknown whether obesity affects the surgical and oncological outcomes following open radical retropubic prostatectomy (RRP). Knowledge concerning this issue is relevant when counselling obese patients with PCa for RRP... - Prediction of recurrence in Ta urothelial cell carcinoma by real-time quantitative PCR analysis: a microarray validation studyIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Cancer 119:1915-9. 2006..In conclusion, we were not able to confirm the microarray gene expression pattern of the 26 genes shown by Dyrskjøt et al. The discovery of accurate recurrence predictive markers, therefore, remains a challenge... - A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"I M van Oort
Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Urol Oncol 27:509-13. 2009..5 cc and Gleason scores <7, InsigPC) are considered clinically insignificant by some investigators. The aim of this study is to determine the biochemical recurrence rate (BCR) of svPC and InsigPC in prostatectomy specimens... - Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects?Annenienke C van de Ven
Department of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Thyroid 22:1236-43. 2012..Thyrotoxicosis and hypothyroidism are associated with fatigue. Here we studied euthyroid subjects to determine if there was a relationship between serum thyrotropin (TSH), free thyroxine (FT(4)) and thyroperoxidase antibodies and fatigue... - Clinical epidemiology of nonurothelial bladder cancer: analysis of the Netherlands Cancer RegistryMartine Ploeg
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Urol 183:915-20. 2010..Nonurothelial malignancies represent a small fraction of bladder malignancies and are less extensively studied, resulting in sparse empirical data on these tumors. We sought insight into tumor characteristics and survival... - Screening for prostate cancer in Dutch hereditary prostate cancer familiesLambertus A Kiemeney
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Cancer 122:871-6. 2008..We suggest that the same PSA testing guidelines should apply to HPC families and the general population. A more aggressive screening policy in HPC families does not seem to be justified... - CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomasIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Cancer 116:282-4. 2005..Our results suggest, in contrast to those of Guo et al. (Nat Med 2004;10:374-81), that the oncogene CDC91L1 is not overexpressed at the mRNA level in urothelial cell carcinomas and cannot be used to predict the course of the disease... - Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancerRuben G Cremers
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands
Eur J Cancer 46:3294-9. 2010..A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages and PC in a large case-control study... - Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancerLambertus A Kiemeney
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur J Cancer 42:3219-27. 2006..We studied the association between both polymorphisms and the risk of bladder cancer... - Segregation analysis of urothelial cell carcinomaKatja K H Aben
Dept. of Epidemiology and Biostatistics, Radboud University, Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Eur J Cancer 42:1428-33. 2006..The 'no major gene' (or sporadic) model appeared to be the most parsimonious one to describe the occurrence of UCC in these families... - No evidence for large-scale germline genomic aberrations in hereditary bladder cancer patients with high-resolution array-based comparative genomic hybridizationLambertus A Kiemeney
Department of Urology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands
Cancer Epidemiol Biomarkers Prev 15:180-3. 2006 - The present and future burden of urinary bladder cancer in the worldMartine Ploeg
Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
World J Urol 27:289-93. 2009..But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to global changes in exposure to risk factors for UBC and growth and aging of the world population... - Personal hair dye use and the risk of bladder cancer: a case-control study from The NetherlandsMartine M Ros
Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, The Netherlands
Cancer Causes Control 23:1139-48. 2012..There has also been concern about a possible increased risk of bladder cancer among users of hair dyes. However, the association between personal hair dye use and bladder cancer risk remains inconclusive... - Trends in therapy and survival of advanced stage epithelial ovarian cancer patients in the NetherlandsAnne M van Altena
Department of Obstetrics and Gynecology, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Gynecol Oncol 125:649-54. 2012..The aim of this study was to describe trends in survival and therapy in advanced stage epithelial ovarian cancer (EOC) in the Netherlands and to determine if changes in therapy affected survival... - Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomasIman J Schultz
Department of Clinical Chemistry, University Medical Center Nijmegen, Nijmegen, The Netherlands
Clin Chem 50:1425-8. 2004 - Germline genetic markers for urinary bladder cancer risk, prognosis and treatment responseAnne J Grotenhuis
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Future Oncol 6:1433-60. 2010.... - Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and NutritionMartine M Ros
Centre for Nutrition and Health, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
Eur J Cancer 48:3267-77. 2012..Therefore, we examined the relation between fruit and vegetable consumption and the risk of aggressive and non-aggressive UCC in the European Prospective Investigation into Cancer and Nutrition (EPIC)... - The efficacy of different follow-up strategies in clinical stage I Non-seminomatous Germ Cell Cancer: a Markov simulation studyJesse Roan Spermon
Department of Urology, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Urol 48:258-67; discussion 267-8. 2005..In this study, we constructed a Markov model to evaluate the impact of different follow-up strategies on disease-specific mortality (DSM) and life expectancy (LE) of patients with CS I NSGCT... - Ultrasound-guided transrectal implantation of gold markers for prostate localization during external beam radiotherapy: complication rate and risk factorsJohan F Langenhuijsen
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Radiat Oncol Biol Phys 69:671-6. 2007..To report the complication rate and risk factors of transrectally implanted gold markers, used for prostate position verification and correction procedures... - DD3(PCA3), a very sensitive and specific marker to detect prostate tumorsJacques B de Kok
Department of Clinical Chemistry, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
Cancer Res 62:2695-8. 2002..Consequently, DD3 measurements may be used for clinical application in prostate needle biopsies or bodily fluids such as blood, ejaculate, urine, or prostate massage fluid... - Underestimation of effect of thyroid function parameters on morbidity and mortality due to intra-individual variationAnnenienke C van de Ven
Department of Endocrinology 471, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
J Clin Endocrinol Metab 96:E2014-7. 2011.... - Spouse controls in family case-control studies: a methodological considerationBas A J Verhage
Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands
Fam Cancer 2:101-8. 2003..Using a simulation study it is illustrated that even strong assortative mating on a factor, which is strongly correlated with a true risk factor under study, will have a negligible effect on the observed extent of familial aggregation... - DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancerDaphne Hessels
Department of Experimental Urology, Nijmegen Center for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Urol 44:8-15; discussion 15-6. 2003..DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed... - Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHDBarbara Franke
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Neuropsychopharmacology 35:656-64. 2010..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD... - Phenotypic characteristics of male subfertility and its familial occurrenceRon J T van Golde
Department of Obstetrics and Gynecology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Androl 25:819-23. 2004..Furthermore, examination of the data suggests that subfertile men with a familial occurrence of male subfertility more often have normal levels of FSH and LH and a lower percentage of motile sperm... - The prevalence of urinary incontinence in community-dwelling married women: a matter of definitionVera Vandoninck
Department of Urology, University Medical Center, Nijmegen, The Netherlands
BJU Int 94:1291-5. 2004..CONCLUSIONS: Up to 46% of the married female population had some degree of UI, and severe UI significantly compromised their quality of life... - Underestimation of subfertility among relatives when using a family history: taboo biasIrene A M van der Avoort
Department of Obstetrics and Gynaecology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
J Androl 24:285-8. 2003..Therefore, researchers and clinicians should be aware that an inquiry of family history is likely to lead to underestimation of subfertility among relatives... - Baseline prostatic specific antigen does not predict the outcome of high energy transurethral microwave thermotherapyM Pilar Laguna
Department of Urology, University Medical Centre St. Radboud, Nijmegen, The Netherlands
J Urol 167:1727-30. 2002..Receiver operating characteristics curves failed to distinguish more or less favorable outcomes in all evaluated parameters. CONCLUSIONS: Pretreatment PSA cannot predict the clinical outcome after high energy transurethral thermotherapy...