Erwin H J M Kemna

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Novel urine hepcidin assay by mass spectrometry
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:3268-70. 2005
  2. ncbi request reprint Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1864-6. 2005
  3. ncbi request reprint Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:620-8. 2007
  4. ncbi request reprint Nitric oxide does not contribute to inflammation-induced hypoferremia in humans
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Haematol 118:149-52. 2007
  5. doi request reprint Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways
    Apriliana E R Kartikasari
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochim Biophys Acta 1784:2029-37. 2008
  6. pmc Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry
    Dorine W Swinkels
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e2706. 2008
  7. doi request reprint Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
    Apriliana E R Kartikasari
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Cell Mol Med 13:3091-102. 2009
  8. pmc Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization
    Joyce J C Kroot
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Haematologica 94:1748-52. 2009
  9. ncbi request reprint Regulation of hepcidin: insights from biochemical analyses on human serum samples
    Erwin H J M Kemna
    Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood Cells Mol Dis 40:339-46. 2008
  10. doi request reprint Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:253-62. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Novel urine hepcidin assay by mass spectrometry
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:3268-70. 2005
    ..In conclusion, this novel MS urine hepcidin assay is easy to perform and available to a wide audience. This enables the implementation of hepcidin measurements in large clinical studies...
  2. ncbi request reprint Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1864-6. 2005
    ..These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system...
  3. ncbi request reprint Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:620-8. 2007
    ..Recent reports on the measurement of urine and serum hepcidin by surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) necessitate analytical and clinical evaluation of MS-based methodologies...
  4. ncbi request reprint Nitric oxide does not contribute to inflammation-induced hypoferremia in humans
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Haematol 118:149-52. 2007
  5. doi request reprint Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways
    Apriliana E R Kartikasari
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochim Biophys Acta 1784:2029-37. 2008
    ..The study underscores hepcidin-25 quantification as a valuable tool to unravel regulatory pathways in iron metabolism...
  6. pmc Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry
    Dorine W Swinkels
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e2706. 2008
    ....
  7. doi request reprint Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
    Apriliana E R Kartikasari
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Cell Mol Med 13:3091-102. 2009
    ..This study therefore shows a crucial role for HO-1 in maintaining body iron balance...
  8. pmc Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization
    Joyce J C Kroot
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Haematologica 94:1748-52. 2009
    ..The round robin results inform the scientific and medical community on the status and agreement of the current hepcidin methods. Ongoing initiatives should facilitate standardization by exchanging calibrators and representative samples...
  9. ncbi request reprint Regulation of hepcidin: insights from biochemical analyses on human serum samples
    Erwin H J M Kemna
    Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood Cells Mol Dis 40:339-46. 2008
    ..Future studies are needed to validate the combined utility of this predictive algorithm together with actual measured hepcidin levels in clinical diagnosis...
  10. doi request reprint Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:253-62. 2009
    ..We conclude that high concentrations of hepcidin explain the observed disturbances in host iron homeostasis associated with malaria and may contribute to malarial anemia and an impaired erythropoietic response to iron supplementation...
  11. doi request reprint Hepcidin: from discovery to differential diagnosis
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, P O Box 9101 6500 HB Nijmegen, The Netherlands
    Haematologica 93:90-7. 2008
    ..Ongoing studies in humans should provide us with more information on the etiology of iron metabolism disorders in order to create new therapeutic strategies and improve differential diagnosis protocols for these diseases...
  12. doi request reprint (Pre)analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies
    Joyce J C Kroot
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anal Biochem 389:124-9. 2009
    ..Transferrin saturation did not correlate with hepcidin levels. To minimize variability, we recommend (i) standardizing for sampling time and (ii) measuring serum hepcidin levels...
  13. ncbi request reprint Effect of the new HJV-L165X mutation on penetrance of HFE
    Boukje A C van Dijk
    Blood 109:5525-6. 2007