Research Topics
| Anders KarlsonSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Detail Information
Publications
Absence of a relation between efavirenz plasma concentrations and toxicity-driven efavirenz discontinuations in the EuroSIDA studyMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Antivir Ther 14:75-83. 2009..We aimed to determine whether patients with high EFV plasma concentrations have an increased likelihood of toxicity-driven EFV discontinuations...
Efavirenz dose reduction is safe in patients with high plasma concentrations and may prevent efavirenz discontinuationsMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Acquir Immune Defic Syndr 52:240-5. 2009..To establish whether efavirenz dose reduction in patients with high plasma concentrations prevents toxicity-induced efavirenz discontinuations...
The effect of raltegravir on the glucuronidation of lamotrigineMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
J Clin Pharmacol 49:1220-7. 2009..The mean ratio of the AUC(0-->48) of lamotrigine-2N-glucuronide to lamotrigine was similar when lamotrigine was taken alone (0.35) or when taken with raltegravir (0.36). Raltegravir does not influence the glucuronidation of lamotrigine...
Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavirMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
AIDS 24:1223-6. 2010..Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir...
Drug-drug interactions between raltegravir and pravastatin in healthy volunteersMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Acquir Immune Defic Syndr 55:82-6. 2010..To evaluate the potential drug-drug interaction between raltegravir and pravastatin...
Adherence to HIV therapeutic drug monitoring guidelines in The NetherlandsMatthijs van Luin
Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ther Drug Monit 33:32-9. 2011..Therapeutic drug monitoring (TDM) is recommended in several international HIV treatment guidelines. The adherence of clinicians to these recommendations is unknown. The authors evaluated the adherence to the Dutch TDM guideline of 2005...
