Leo A B Joosten

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
  2. pmc The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis
    Rieke Alten
    Department of Internal Medicine II, Rheumatology, Schlosspark Klinik Teaching Hospital Charité University Medicine Berlin, Heubnerweg, D 14059 Berlin, Germany
    Arthritis Res Ther 10:R67. 2008
  3. ncbi request reprint Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
  4. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
  5. doi request reprint T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
  6. ncbi request reprint Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3753-64. 2008
  7. ncbi request reprint IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
    Erik Lubberts
    Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 170:2655-62. 2003
  8. ncbi request reprint Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
  9. pmc Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway
    Daniela C Ifrim
    Department of Experimental Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    J Immunol 190:4129-35. 2013
  10. doi request reprint IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1866-72. 2010

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  2. pmc The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis
    Rieke Alten
    Department of Internal Medicine II, Rheumatology, Schlosspark Klinik Teaching Hospital Charité University Medicine Berlin, Heubnerweg, D 14059 Berlin, Germany
    Arthritis Res Ther 10:R67. 2008
    ..IL-1beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production...
  3. ncbi request reprint Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases...
  4. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  5. doi request reprint T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
    ..The present study was undertaken to develop a mouse model of chronic destructive arthritis induced by repeated intraarticular (IA) exposure to bacterial cell wall fragments and to investigate the cytokine dependence of this model...
  6. ncbi request reprint Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3753-64. 2008
    ....
  7. ncbi request reprint IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
    Erik Lubberts
    Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 170:2655-62. 2003
    ..These findings suggest T cell IL-17 to be an important inducer of RANKL expression leading to loss of the RANKL/OPG balance, stimulating osteoclastogenesis and bone erosion in arthritis...
  8. ncbi request reprint Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  9. pmc Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway
    Daniela C Ifrim
    Department of Experimental Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    J Immunol 190:4129-35. 2013
    ..albicans is nevertheless required. In conclusion, C. albicans is able to modify cytokine responses to TLR ligands and colonizing bacteria, which is likely to impact the inflammatory reaction during mucosal diseases...
  10. doi request reprint IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1866-72. 2010
    ..To investigate the potential synergism between interleukin (IL) 32γ and Streptococcus pyogenes cell wall (SCW) fragments in the development of destructive arthritis...
  11. ncbi request reprint Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:3239-47. 2005
    ..To examine the role of interleukin-17 receptor (IL-17R) signaling in cartilage destruction and its interrelationship with synovial IL-1 expression during chronic reactivated streptococcal cell wall (SCW)-induced arthritis...
  12. pmc Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:3651-62. 2009
    ..This study was undertaken to establish the relative importance of caspase 1 and serine proteases in mouse models of acute and chronic inflammatory arthritis...
  13. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010
    ..In fact, it is the excessive consumption of food or alcohol that elicits the inflammation of the acute gout attack. The aim of this study was to identify the precise mechanism that initiates flares of gouty arthritis...
  14. pmc Role of Dectin-2 for host defense against systemic infection with Candida glabrata
    Daniela C Ifrim
    Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
    Infect Immun 82:1064-73. 2014
    ..glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen. ..
  15. pmc Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism
    Marije Oosting
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:172-81. 2011
    ..As IL-17 has been implicated in the pathogenesis of chronic Lyme disease, these data suggest that caspase-1 targeting may represent a new immunomodulatory strategy for the treatment of complications of late stage Lyme disease...
  16. ncbi request reprint Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:3856-65. 2004
    ..To study the expression of Toll-like receptor 2 (TLR-2) and TLR-4 and its association with proinflammatory cytokines in synovial tissue from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and healthy individuals...
  17. pmc Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation
    Shahla Abdollahi-Roodsaz
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Pathol 175:2004-13. 2009
    ..These data emphasize the potential relevance of TLR4 activation in rheumatoid arthritis, particularly with respect to IL-1-mediated joint pathology...
  18. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  19. doi request reprint The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40
    Nozomi Takahashi
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3471-84. 2008
    ..The objective of this study was to identify genes and pathways that determine disease progression based on gene expression profiling in this model...
  20. pmc Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 105:9017-22. 2008
    ..Whether a distorted balance between the function of Nod1 and/or Nod2 is involved in the pathogenesis of human autoinflammatory or autoimmune disease, such as rheumatoid arthritis, remains to be elucidated...
  21. doi request reprint Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1838-47. 2012
    ..The objective of this study was to investigate the specific roles of MyD88 and TRIF in chronic experimental arthritis and the accompanying adaptive immune responses...
  22. doi request reprint Modulation of Toll-like receptor ligands and Candida albicans-induced cytokine responses by specific probiotics
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cytokine 59:159-65. 2012
    ..In conclusion, specific probiotic strains exhibit cross-tolerance effects towards other inflammatory stimuli, especially C. albicans, which might have beneficial effects on gut inflammation...
  23. pmc Inflammasome is a central player in the induction of obesity and insulin resistance
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity, 6525 GA Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:15324-9. 2011
    ..These findings reveal a critical function of the inflammasome in obesity and insulin resistance, and suggest inhibition of the inflammasome as a potential therapeutic strategy...
  24. pmc Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 118:205-16. 2008
    ....
  25. doi request reprint Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction
    Marije Oosting
    Department of Medicine, Nijmegen Institute of Infection, Inflammation, and Immunity, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 201:1849-58. 2010
    ..The interplay between TLR2 and NOD2 might not only be necessary for the induction of a proper immune response but may also contribute to inflammatory-induced pathology...
  26. pmc Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:4962-7. 2011
    ..Splicing of IL-32γ into IL-32β is a safety switch in controlling the effects of IL-32γ and thereby reduces chronic inflammation...
  27. pmc Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models
    Fons A J van de Loo
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 163:1525-37. 2003
    ..This showed that the involvement of NADPH oxidase in arthritis is probably far more complex and that oxygen radicals might also be important in controlling disease severity, and reducing joint inflammation and connective tissue damage...
  28. ncbi request reprint Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:975-83. 2005
    ..To examine the capacity of T cell interleukin-17A (IL-17A; referred to hereinafter as IL-17) to induce cartilage damage during experimental arthritis in the absence of IL-1...
  29. ncbi request reprint Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice
    Alfons S K de Hooge
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Arthritis Rheum 48:1750-61. 2003
    ..To investigate the involvement of proinflammatory and destructive mediators in oncostatin M (OSM)-induced joint pathology, using gene-deficient mice...
  30. doi request reprint Candida albicans dampens host defense by downregulating IL-17 production
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
    J Immunol 185:2450-7. 2010
    ..In addition, we show that these latter 5-hydroxytryptophan metabolites inhibit IL-17 production. In conclusion, live C. albicans inhibits host Th17 responses by modulatory effects on tryptophan metabolism...
  31. doi request reprint Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    Marije I Koenders
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 58:3461-70. 2008
    ..In this study, the role of Th17 cells and the effect of neutralization of IL-17, IL-1, and tumor necrosis factor alpha (TNFalpha) were investigated in this IL-1-driven murine arthritis model...
  32. doi request reprint Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Microbes Infect 13:151-9. 2011
    ..Chitin, on the other hand, did not have significant immunomodulatory capability. The ability of the fungal cell wall to alter the immune signature of the pathogen may contribute to its virulence and the pathogenesis of co-infection...
  33. pmc Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunology 130:46-54. 2010
    ..In conclusion, A. fumigatus does not stimulate production of IL-17 and human host defence against aspergillosis may not rely on potent Th17 responses...
  34. pmc Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)
    Kathrin Buffen
    Department of Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Biol Chem 288:8658-66. 2013
    ..Our results thus demonstrate the induction of autophagy, which, in turn, modulates cytokine production by B. burgdorferi for the first time...
  35. doi request reprint Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:806-14. 2013
    ..In this study, the effect of the insertion/deletion polymorphism in NOD1 on RA susceptibility and severity was assessed...
  36. doi request reprint Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation
    Renoud J Marijnissen
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Nijmegen, The Netherlands
    Arthritis Rheum 63:2939-48. 2011
    ....
  37. pmc Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Biol Chem 287:5733-43. 2012
    ..This study demonstrates for the first time that IL-32 binds to the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting a dual role for IL-32 in integrin signaling...
  38. pmc Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 60:517-24. 2011
    ..In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance...
  39. pmc Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease
    Marije Oosting
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    Infect Immun 79:4681-7. 2011
    ..burgdorferi-induced IL-17 production in vitro and that an IL-23R gene SNP leads to impaired IL-17 production. However, the IL-23R gene polymorphism is not crucial for the pathogenesis of chronic Lyme...
  40. doi request reprint Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 70:660-7. 2011
    ..To investigate the interplay between IL-32 and tumour necrosis factor alpha (TNFα) during the chronic inflammation of rheumatoid arthritis (RA) and to assess whether anti-TNFα treatment of RA patients modulates synovial IL-32 expression...
  41. ncbi request reprint Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 56:2957-67. 2007
    ..The objective of this study was to investigate the involvement of TLR-4 activation in the development and progression of autoimmune destructive arthritis...
  42. doi request reprint Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:1087-96. 2009
    ..The aim of the present study was to investigate the pathways of IL-1beta production induced by Candida albicans in human monocytes...
  43. pmc STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e29248. 2011
    ..The challenge for the future is to translate this knowledge into novel strategies for the treatment of this severe immunodeficiency...
  44. pmc Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis
    Renoud J Marijnissen
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e38889. 2012
    ..We investigated whether exposure to a minute amount of C. albicans in the arthritic joint altered the local cytokine environment, leading to enhanced Th17 expansion and resulting in a more destructive arthritis...
  45. doi request reprint Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients
    Diana C Rosentul
    Department of Internal Medicine, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, Nijmegen, The Netherlands
    Immunol Invest 40:735-50. 2011
    ..These results suggest a role of dectin-1 in the host defense against respiratory bacterial infections, and future studies are warranted to confirm this association...
  46. pmc TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes
    Marije Oosting
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e25998. 2011
    ..TLR6 polymorphisms lead to a minor modified cytokine production. This study indicates a dominant role for TLR1/TLR2 heterodimers in the induction of the early inflammatory response by Borrelia spirochetes in humans...
  47. doi request reprint Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 42:993-1004. 2012
    ..These findings reveal a central role of anaphylatoxin C5a in augmenting host proinflammatory cytokine production upon contact with C. albicans, and define the role of the complement system in anti-Candida host defense in humans...
  48. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
    ..These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans...
  49. pmc Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 204:1138-45. 2011
    ..The role of genetic variation of DECTIN-1 and CARD9 genes on the susceptibility to candidemia is unknown...
  50. doi request reprint Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 34:407-11. 2010
    ..These data demonstrate that IL-17 does not have a major contribution to the inflammatory pathology leading to organ failure in fungal sepsis and support the concept that the IL-17 pathway is protective in antifungal host defense...
  51. doi request reprint The anti-CD20 antibody rituximab reduces the Th17 cell response
    Frank L van de Veerdonk
    Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Arthritis Rheum 63:1507-16. 2011
    ..The present study was undertaken to investigate the mechanism of action of rituximab in RA...
  52. ncbi request reprint Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis
    Leo A B Joosten
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 46:1379-89. 2002
    ....
  53. pmc Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response
    Johanneke Kleinnijenhuis
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunology 134:341-8. 2011
    ....
  54. doi request reprint A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis
    Heleen D de Koning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 130:2611-20. 2010
    ..In conclusion, upregulation of dectin-1 in psoriatic lesions seems to be under control of psoriasis-associated cytokines. Its role in the biology of skin inflammation and infection remains to be explored...
  55. ncbi request reprint Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:339-47. 2003
    ....
  56. pmc Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e7818. 2009
    ..714T>G (p.Y238X) polymorphism is associated with lower disease susceptibility or severity in IBD and to investigate the level of dectin-1 expression in inflamed and non-inflamed colon tissue of IBD patients...
  57. ncbi request reprint The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 35:558-61. 2008
    ..To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA)...
  58. pmc Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis
    Jeroen Geurts
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Ther 17:1877-87. 2009
    ..These results demonstrate the value of bioinformatics for guiding the selection of endogenous promoters for transcriptionally targeted gene therapy...
  59. pmc Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors
    Daniela C Ifrim
    Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
    Clin Vaccine Immunol 21:534-45. 2014
    ..Trained immunity and tolerance are two distinct and opposing functional programs induced by the specific microbial ligands engaging the monocytes. ..
  60. pmc Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype
    Arjan van Laarhoven
    Department of Medicine and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, Radboud University Medical Centre, Nijmegen, The Netherlands
    Infect Immun 81:3750-6. 2013
    ..The observed differences in cytokine induction point to a reduction in proinflammatory cytokine response as a possible contributing factor to the evolutionary success of modern Beijing strains. ..
  61. doi request reprint The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses
    Mark S Gresnigt
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Eur J Immunol 43:416-26. 2013
    ..These data describe that IL-36-dependent signals are a novel cytokine pathway that regulates Th responses induced by A. fumigatus, and demonstrate a role for TLR4 and dectin-1 in the induction of IL-36γ...
  62. doi request reprint Human genetic susceptibility to Candida infections
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 50:785-94. 2012
    ..This review provides an overview of the current insights in genetic susceptibility to Candida infections and their consequences for the immune response against Candida...
  63. doi request reprint Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death
    Bas Heinhuis
    Department of Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Cytokine 60:321-7. 2012
    ..Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions...
  64. doi request reprint High variability of TLR4 gene in different ethnic groups in Iran
    Mihai Ioana
    Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Department of Medicine, Nijmegen, The Netherlands
    Innate Immun 18:492-502. 2012
    ..These findings suggest a weak, or absent, selection pressure on TLR4 polymorphisms in the Middle-East that does not support the assumption of an important role of these polymorphisms in the host defense against local pathogens...
  65. pmc Polymorphisms in autophagy genes and susceptibility to tuberculosis
    Mário Songane
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e41618. 2012
    ..This first examination of a broad set of polymorphisms in autophagy genes fails to show a clear association with TB, with M. tuberculosis Beijing genotype infection or with ex-vivo pro-inflammatory cytokine production...
  66. doi request reprint T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization
    Marije I Koenders
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1762-70. 2012
    ....
  67. doi request reprint The evolutionary history of TLR4 polymorphisms in Europe
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Innate Immun 4:168-75. 2012
    ..In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis...
  68. doi request reprint The macrophage mannose receptor induces IL-17 in response to Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Host Microbe 5:329-40. 2009
    ..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...
  69. doi request reprint The classical CD14⁺⁺ CD16⁻ monocytes, but not the patrolling CD14⁺ CD16⁺ monocytes, promote Th17 responses to Candida albicans
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:2915-24. 2011
    ..In conclusion, both monocyte subsets have potent innate antifungal properties, but only CD14(++) CD16(-) monocytes are capable of inducing a potent Th17 response to C. albicans, an important component of antifungal host defense...
  70. ncbi request reprint Citrullination of synovial proteins in murine models of rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:2489-500. 2003
    ....
  71. doi request reprint The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Endocrinology 152:3769-78. 2011
    ..The increased intrinsic caspase-1 activity in VAT represents a novel and specific inflammatory pathway that may determine the proinflammatory character of this specific depot...
  72. doi request reprint Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 48:897-903. 2010
    ..This suggests a heavier reliance of in vivo antifungal host defense on lectin receptors than on TLRs, a notion compatible with the clinical picture in individuals deficient in MyD88/TLRs or dectin-1/CARD9...
  73. doi request reprint Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    Marije I Koenders
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
    Arthritis Rheum 63:2329-39. 2011
    ....
  74. doi request reprint The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation
    Edwin J P van Asseldonk
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Obesity (Silver Spring) 18:2234-6. 2010
    ..Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine...
  75. doi request reprint The inflammasome puts obesity in the danger zone
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
    Cell Metab 15:10-8. 2012
    ..These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes...
  76. doi request reprint Cytokine production from stimulated whole blood cultures in rheumatoid arthritis patients treated with various TNF blocking agents
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Cytokine Netw 20:88-93. 2009
    ..As a possible mechanism contributing to that, we assessed the modulation of cytokine production induced by TNF neutralization...
  77. doi request reprint Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study
    Edwin J P van Asseldonk
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 96:2119-26. 2011
    ..Obesity induces low-grade inflammation that may promote the development of insulin resistance. IL-1 is one of the key inflammatory factors...
  78. pmc Inflammasome-independent modulation of cytokine response by autophagy in human cells
    Tania O Crişan
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e18666. 2011
    ..In conclusion, autophagy modulates the secretion of proinflammatory cytokines in human cells through an inflammasome-independent pathway, and this is a novel mechanism that may be targeted in inflammatory diseases...
  79. doi request reprint TREM-1 interaction with the LPS/TLR4 receptor complex
    Rob J W Arts
    Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    Eur Cytokine Netw 22:11-4. 2011
    ..These data are in line with the TLR4-TREM1 co-localization in human neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with the TLR4/LPS-receptor complex...
  80. doi request reprint NOD2 engagement induces proinflammatory cytokine production, but not apoptosis, in leukocytes isolated from patients with Crohn's disease
    Evelien Bodar
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur Cytokine Netw 19:185-9. 2008
    ..NLR proteins modulate inflammation and apoptosis, and several studies have implicated NOD2 in the induction of cytokines and inflammatory reactions. However, only scarce data are available regarding its role in apoptosis...
  81. ncbi request reprint Absence of citrulline-specific autoantibodies in animal models of autoimmunity
    Erik R Vossenaar
    University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2370-2. 2004
  82. pmc Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection
    Mihai G Netea
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e4237. 2009
    ..Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines...
  83. ncbi request reprint Th17 responses and host defense against microorganisms: an overview
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    BMB Rep 42:776-87. 2009
    ..It has become evident that the type of microorganisms and the setting in which they trigger the Th17 response determines the outcome of the delicate balance that exists between Th17 induced protection and immunopathogenesis...
  84. ncbi request reprint The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  85. ncbi request reprint Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 46:3055-64. 2002
    ..This study was undertaken to identify in vivo the hitherto-unknown origin and localization of RANK-expressing osteoclast precursor cells at sites of bone erosion in arthritis...
  86. ncbi request reprint Murine antigen-induced arthritis
    Wim B van den Berg
    Radboud University Nijmegen Medical Centre, The Netherlands
    Methods Mol Med 136:243-53. 2007
    ..Concomitant boosting of the immune response with Bordetella pertussis adds to this. T-cell mediated flares can be induced by local or systemic rechallenge with low dose antigen, and display a strong erosive phenotype...
  87. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ....
  88. pmc IL-1beta processing in host defense: beyond the inflammasomes
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen Center for Infections, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    PLoS Pathog 6:e1000661. 2010
    ..In conclusion, IL-1beta/IL-18 processing during infection is a complex process in which the inflammasomes are only one of several activation mechanisms...
  89. pmc Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Infect Immun 75:4831-7. 2007
    ..Because of the role of TLR4 in inflammation, B. quintana LPS may prove useful as a potent anti-TLR4 agent with therapeutic potential in both infections and autoimmune inflammation...
  90. pmc Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mol Med 17:391-6. 2011
    ..In an in vitro bone destruction assay, ITF2357 was highly effective at a dose of 100 nmol/L. In conclusion, inhibition of HDAC prevents joint inflammation and cartilage and bone destruction in experimental arthritis...
  91. pmc Caspase-12 and the inflammatory response to Yersinia pestis
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e6870. 2009
    ..In African-Americans, it has been shown that caspase-12 inhibits the pro-inflammatory cytokine production...
  92. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  93. pmc The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    Rinke Stienstra
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen 6525 GA, The Netherlands
    Cell Metab 12:593-605. 2010
    ....
  94. pmc Amplifying elements of arthritis and joint destruction
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 66:iii45-8. 2007
    ..Spontaneous T cell-dependent arthritis in IL1Ra-/- mice is absent under germ-free conditions, and markedly suppressed in TLR4-deficient mice. Moreover, TLR4 blocking with a receptor antagonist suppresses erosive arthritis...
  95. pmc Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    Marije I Koenders
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, 189, Geert Grooteplein Zuid 26 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 167:141-9. 2005
    ..These data indicate that IL-17 is an important upstream mediator in joint pathology during flare-up of experimental arthritis...
  96. doi request reprint Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  97. ncbi request reprint Interleukin-17 acts independently of TNF-alpha under arthritic conditions
    Marije I Koenders
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:6262-9. 2006
    ..These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions...
  98. ncbi request reprint Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology Research and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, The Netherlands
    J Immunol 176:7021-7. 2006
    ..These findings suggest a role for HSPB8 during the inflammatory process in autoimmune diseases such as RA...
  99. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  100. doi request reprint Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Immunol 39:1914-22. 2009
    ..In conclusion, we have dissected the molecular mechanisms responsible for IL-1beta production by M. tuberculosis, and that may contribute to a deeper knowledge of the mechanisms of cell activation by M. tuberculosis...