Affiliation: Radboud University Nijmegen
Country: The Netherlands
- Identification of novel bacterial M.SssI DNA methyltransferase inhibitorsMarlinda Hupkes
Department of Cell and Applied Biology, Radboud University Nijmegen, Nijmegen, 6525 AJ, Netherlands
J Biomol Screen 18:348-55. 2013..Our set of novel M.SssI DNMT inhibitors, once confirmed in an orthogonal DNMT assay, may thus serve as a starting point to identify and characterize suitable lead candidates for further drug optimization...
- DNA methylation restricts spontaneous multi-lineage differentiation of mesenchymal progenitor cells, but is stable during growth factor-induced terminal differentiationMarlinda Hupkes
Department of Cell and Applied Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
Biochim Biophys Acta 1813:839-49. 2011..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
- Epigenetics: DNA demethylation promotes skeletal myotube maturationMarlinda Hupkes
Department of Cell and Applied Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
FASEB J 25:3861-72. 2011..Our data suggest that genomic demethylation induced by 5AC overcomes an epigenetic barrier that prevents untreated C2C12 myotubes from reaching full maturity...