Nicoline Hoogerbrugge

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Focusing on patient needs and preferences may improve genetic counseling for colorectal cancer
    Simone Salemink
    Department of Human Genetics 836, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Genet Couns 22:118-24. 2013
  2. pmc Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
    Ingrid P Vogelaar
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500HB, The Netherlands
    Hered Cancer Clin Pract 10:18. 2012
  3. ncbi request reprint [Tumour examination to detect hereditary colorectal cancer]
    Nicoline Hoogerbrugge
    Afd Genetica, UMC St Radboud, Nijmegen, The Netherlands
    Ned Tijdschr Geneeskd 156:A4982. 2012
  4. pmc Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation
    Marjolijn C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Hum Genet 19:870-4. 2011
  5. ncbi request reprint Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors
    Arjen R Mensenkamp
    Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Electronic address
    Gastroenterology 146:643-646.e8. 2014
  6. ncbi request reprint Can we test for hereditary cancer at 18 years when we start surveillance at 25? Patient reported outcomes
    Aisha S Sie
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Fam Cancer 12:675-82. 2013
  7. doi request reprint Female BRCA mutation carriers with a preference for prophylactic mastectomy are more likely to participate an educational-support group and to proceed with the preferred intervention within 2 years
    Karin M Landsbergen
    Department of Human Genetics, Raboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
    Fam Cancer 9:213-20. 2010
  8. pmc Adequacy of family history taking in ovarian cancer patients: a population-based study
    Anne M van Altena
    Department of Obstetrics and Gynecology, Radboud University Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Fam Cancer 11:343-9. 2012
  9. ncbi request reprint In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response
    Tineke W H Meijer
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 55:414-22. 2009
  10. doi request reprint Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
    Ramprasath Venkatachalam
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 129:1635-42. 2011

Detail Information

Publications41

  1. pmc Focusing on patient needs and preferences may improve genetic counseling for colorectal cancer
    Simone Salemink
    Department of Human Genetics 836, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Genet Couns 22:118-24. 2013
    ..Our data suggest that focusing on familial CRC risk and surveillance options, in combination with sensitive communication may lead to better satisfaction with genetic counseling...
  2. pmc Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
    Ingrid P Vogelaar
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500HB, The Netherlands
    Hered Cancer Clin Pract 10:18. 2012
    ..Future research should focus on identifying new genetic predisposing factors for all types of familial gastric cancer...
  3. ncbi request reprint [Tumour examination to detect hereditary colorectal cancer]
    Nicoline Hoogerbrugge
    Afd Genetica, UMC St Radboud, Nijmegen, The Netherlands
    Ned Tijdschr Geneeskd 156:A4982. 2012
    ..For family members and patients diagnosed with CRC more than a year ago, a digital test can be used to determine whether genetic counselling by a geneticist is indicated (www.umcn.nl/verwijzers)...
  4. pmc Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation
    Marjolijn C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Hum Genet 19:870-4. 2011
    ..In conclusion, this study provides first evidence of an increased risk of cancer in patients with NS and a PTPN11 mutation, compared with that in the general population. Our data do not warrant specific cancer surveillance...
  5. ncbi request reprint Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors
    Arjen R Mensenkamp
    Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Electronic address
    Gastroenterology 146:643-646.e8. 2014
    ..We conclude that 2 acquired events explain the MMR-deficiency in more than 50% of the MMR-deficient tumors without causal germline mutations or promoter methylation. ..
  6. ncbi request reprint Can we test for hereditary cancer at 18 years when we start surveillance at 25? Patient reported outcomes
    Aisha S Sie
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Fam Cancer 12:675-82. 2013
    ..These patients may benefit from decisional support and personalized information...
  7. doi request reprint Female BRCA mutation carriers with a preference for prophylactic mastectomy are more likely to participate an educational-support group and to proceed with the preferred intervention within 2 years
    Karin M Landsbergen
    Department of Human Genetics, Raboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
    Fam Cancer 9:213-20. 2010
    ..The study provides presumptive evidence that educational-support group participants decide to undergo prophylactic mastectomy earlier than non-attendees...
  8. pmc Adequacy of family history taking in ovarian cancer patients: a population-based study
    Anne M van Altena
    Department of Obstetrics and Gynecology, Radboud University Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Fam Cancer 11:343-9. 2012
    ..These data urge for better uptake of hereditary cancer risk assessment. Different strategies for this assessment like improved family history taking and genetic testing in EOC patients should be explored...
  9. ncbi request reprint In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response
    Tineke W H Meijer
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 55:414-22. 2009
    ..The aim was to investigate this hypothesis by correlating loss of mismatch repair proteins and infiltration of lymphocytes in Lynch syndrome-associated adenomas and hyperplastic polyps...
  10. doi request reprint Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
    Ramprasath Venkatachalam
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 129:1635-42. 2011
    ..Since several of these newly identified candidate genes may be functionally linked to CRC development, our results illustrate the potential of this approach for the identification of novel candidate genes involved in CRC predisposition...
  11. doi request reprint Recurrence and variability of germline EPCAM deletions in Lynch syndrome
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mutat 32:407-14. 2011
    ..We conclude that 3' end EPCAM deletions are a recurrent cause of Lynch syndrome, which should be implemented in routine Lynch syndrome diagnostics...
  12. doi request reprint Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts
    Ingrid P Vogelaar
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
    Hum Mol Genet 22:919-26. 2013
    ..This finding opens a new pathway to reveal the molecular basis of non-syndromic OFC. Cancer risk among carriers of these mutations needs to be defined...
  13. doi request reprint The epigenetics of (hereditary) colorectal cancer
    Ramprasath Venkatachalam
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Centre for Oncology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 203:1-6. 2010
    ..In this review, we will focus on DNA methylation events as heritable epimutations predisposing to colorectal cancer development...
  14. ncbi request reprint More breast cancer patients prefer BRCA-mutation testing without prior face-to-face genetic counseling
    Aisha S Sie
    Department of Human Genetics 836, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Fam Cancer 13:143-51. 2014
    ..In conclusion, more BC patients preferred DNA-direct over intake consultation prior to BRCA-mutation testing, the majority being strongly to moderately satisfied with the procedure followed, without increased distress...
  15. pmc Compound heterozygosity for two MSH2 mutations suggests mild consequences of the initiation codon variant c.1A>G of MSH2
    Carolien M Kets
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 17:159-64. 2009
    ..Met1?) should not be considered as a regular pathogenic mutation that leads to a strongly increased cancer risk, though it possibly contributes to a more severe phenotype when combined with a truncating mutation on the other allele...
  16. pmc DNA-testing for BRCA1/2 prior to genetic counselling in patients with breast cancer: design of an intervention study, DNA-direct
    Aisha S Sie
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Womens Health 12:12. 2012
    ....
  17. doi request reprint EPCAM deletion carriers constitute a unique subgroup of Lynch syndrome patients
    Marjolijn J L Ligtenberg
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fam Cancer 12:169-74. 2013
    ....
  18. doi request reprint Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis
    Rachel S van der Post
    Department of Human Genetics 849, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Virchows Arch 454:25-9. 2009
    ..At present, IHC cannot be used in clinical practice to differentiate between colorectal tissue with and without germline MUTYH mutations...
  19. doi request reprint The tumor suppressor gene FBXW7 is disrupted by a constitutional t(3;4)(q21;q31) in a patient with renal cell cancer
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Center, and Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 195:105-11. 2009
    ..Previous mouse models have suggested that the FBXW7 gene may play a role in the predisposition to tumor development. Here we report that disruption of this gene may predispose to the development of human RCC...
  20. doi request reprint Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1
    Marjolijn J L Ligtenberg
    Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Genet 41:112-7. 2009
    ..Depending on the expression pattern of the neighboring gene that lacks its normal polyadenylation signal, this may cause either generalized or mosaic patterns of epigenetic inactivation...
  21. ncbi request reprint Added value of family history in counseling about risk of BRCA1/2 mutation in early-onset epithelial ovarian cancer
    Marieke Arts-de Jong
    Departments of Obstetrics and Gynaecology, Internal Medicine, Human Genetics, and Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Int J Gynecol Cancer 23:1406-10. 2013
    ..We evaluated clinical data, family history, and risk of identifying BRCA1/2 mutations in women with early-onset epithelial ovarian cancer...
  22. doi request reprint Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are risk factors for colorectal cancer
    Richarda M de Voer
    Department of Human Genetics, Radboud University Medical Centre and Research Institute for Oncology, Nijmegen, The Netherlands
    Gastroenterology 145:544-7. 2013
    ..These results indicate that mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age...
  23. pmc Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS ONE 8:e55734. 2013
    ..Our data also support the emerging view that non-BRCA1/2 hereditary breast cancer families have a very heterogeneous genetic basis...
  24. doi request reprint Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer
    Anika Nagelkerke
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Radiother Oncol 101:39-45. 2011
    ..Here, we quantified expression of endogenous γ-H2AX and its downstream factor 53BP1 in a large number of breast cancer cell lines (n=54) and a node-negative breast cancer cohort that had not received adjuvant systemic treatment (n=122)...
  25. pmc Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
    Marlies J E Kempers
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Oncol 12:49-55. 2011
    ..We aim to establish the risk of cancer associated with such EPCAM deletions...
  26. ncbi request reprint Germline copy number variation and cancer risk
    Roland P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Curr Opin Genet Dev 20:282-9. 2010
    ..We expect that copy number profiling in unexplained high-risk families will lead to the discovery of additional cancer-predisposing genes and/or mechanisms...
  27. pmc Most patients with colorectal tumors at young age do not visit a cancer genetics clinic
    Lucia I H Overbeek
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
    Dis Colon Rectum 51:1249-54. 2008
    ..This study examined the referral process for genetic counseling at a cancer genetics clinic in patients with colorectal cancer and to search for determinants of variation in this referral process...
  28. doi request reprint Rare variants in XRCC2 as breast cancer susceptibility alleles
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    J Med Genet 49:618-20. 2012
    ..However, the breast cancer risk associated with these variants needs further evaluation...
  29. pmc Revertant somatic mosaicism by mitotic recombination in dyskeratosis congenita
    Marjolijn C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Am J Hum Genet 90:426-33. 2012
    ..This shows that revertant mosaicism is a recurrent event in DC. This finding has important implications for improving diagnostic testing and understanding the variable phenotype of DC...
  30. ncbi request reprint Interpretation of immunohistochemistry for mismatch repair proteins is only reliable in a specialized setting
    Lucia I H Overbeek
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
    Am J Surg Pathol 32:1246-51. 2008
    ..An indefinite or aberrant staining result has to be followed by molecular microsatellite instability analysis to confirm the presence of a defective DNA MMR system...
  31. ncbi request reprint [Familial history of ovarian carcinoma: policy]
    Joanne A De Hullu
    Universitair Medisch Centrum St Radboud, afd Obstetrie en Gynaecologie, Nijmegen, The Netherlands
    Ned Tijdschr Geneeskd 155:A2392. 2011
    ..In these families the lifetime risk for ovarian cancer is considered to be well below 10%...
  32. pmc Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome
    Lotte H M Gerritzen
    Department of Obstetrics and Gynaecologic Oncology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Fam Cancer 8:391-7. 2009
    ....
  33. ncbi request reprint Unfavorable pathological characteristics in familial colorectal cancer with low-level microsatellite instability
    Carolien M Kets
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mod Pathol 19:1624-30. 2006
    ..However, tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with no and tumors with high-level MSI. These differences suggest a distinct underlying biology of CRC with low-level MSI...
  34. pmc Improving calculation, interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trial
    Nicky Dekker
    Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Implement Sci 5:6. 2010
    ..Our results may also be useful in improving healthcare in other diseases. TRIAL REGISTRATION: ClinicalTrials.gov NCT00929097...
  35. doi request reprint Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer
    Marie Luise Klauke
    Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
    Virchows Arch 461:425-31. 2012
    ..Our results show that the overall PARP expression in familial breast cancer is higher than in sporadic breast cancer which might suggest they might respond better to treatment with PARP inhibitors...
  36. pmc Group medical visits in the follow-up of women with a BRCA mutation: design of a randomized controlled trial
    Annemiek Visser
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Womens Health 11:39. 2011
    ..However, it should be noted that group sessions may increase fear in some patients or influence their decision making...
  37. pmc Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact
    Karin M Landsbergen
    Department of Human Genetics, Raboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    Fam Cancer 8:325-37. 2009
    ..We found presumptive evidence that specific subgroups of patients with CRC are more vulnerable for genetic-testing-related distress...
  38. doi request reprint Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma
    Marjolijn C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Genes Chromosomes Cancer 49:635-41. 2010
    ..Sequence analysis of the SOS1 gene in 20 sporadic ERMS tumors failed to reveal any pathogenic mutations, implicating that SOS1 is not a major player in the development of this tumor outside the context of NS...
  39. ncbi request reprint Genetic uptake in BRCA-mutation families is related to emotional and behavioral communication characteristics of index patients
    Karin Landsbergen
    Department of Human Genetics, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Fam Cancer 4:115-9. 2005
    ..This study is aimed at determining the number of relatives tested for a BRCA mutation, and the exploration of facilitating and debilitating factors in the transmission of genetic information from index patient to relatives...
  40. doi request reprint Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome
    Juul T Wijnen
    Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    Gastroenterology 136:131-7. 2009
    ..To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variants in a large series of proven mutation carriers...
  41. ncbi request reprint Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene
    Anita Bonne
    Department of Human Genetics, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Genet Cytogenet 179:11-8. 2007
    ..KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC...