Research Topics
Species | N HoogerbruggeSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Detail Information
Publications
Improving calculation, interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trialNicky Dekker
Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Implement Sci 5:6. 2010..Our results may also be useful in improving healthcare in other diseases. TRIAL REGISTRATION: ClinicalTrials.gov NCT00929097...- A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family historyEncarna B Gomez Garcia
Department of Clinical Genetics, University Hospital Maastricht, Maastricht, The Netherlands
Breast Cancer Res 11:R8. 2009..The aim of the present study was to identify which is the best combination of clinical parameters that can predict whether a UV is deleterious, to be used for the classification of UVs... - Group medical visits in the follow-up of women with a BRCA mutation: design of a randomized controlled trialAnnemiek Visser
Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
BMC Womens Health 11:39. 2011..However, it should be noted that group sessions may increase fear in some patients or influence their decision making... - Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studiesAnna Gonzalez-Neira
Genotyping Unit, CeGen, Human Cancer Genetics Programme, Spanish National Cancer Centre, Spain
BMC Genomics 8:299. 2007.... - A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an exampleLeila Mohammadi
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
BMC Cancer 9:211. 2009..Statistical methods have been described in literature but these methods are not always easy to apply in a diagnostic setting... 
[Preventive resection of hereditary diffuse gastric cancer]N Hoogerbrugge
Universitair Medisch Centrum St Radboud, polikliniek Familiaire Tumoren, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 150:2417-20. 2006..It is recommended that the supervision, screening and possible preventative gastrectomy for hereditary diffuse gastric cancers are handled by a multidisciplinary team in a specialised centre...- The impact of a false-positive MRI on the choice for mastectomy in BRCA mutation carriers is limitedN Hoogerbrugge
Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Oncol 19:655-9. 2008..To assess the false-positive rate of breast cancer surveillance by magnetic resonance imaging (MRI) in BRCA mutation carriers and the impact of an abnormal mammography or breast MRI on the patients' decision for prophylactic mastectomy... - Numerous high-risk epithelial lesions in familial breast cancerN Hoogerbrugge
Department of Human Genetics, Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur J Cancer 42:2492-8. 2006..To assess the occurrence of high-risk epithelial lesions in women of breast cancer families with and without a BRCA mutation... - [Recognition of congenital endometrial carcinoma: the importance of family history and investigation of microsatellite instability in the tumour]N Hoogerbrugge
Universitair Medisch Centrum St Radboud, Klinische Genetica, Postbus 9101, 65oo HB Nijmegen
Ned Tijdschr Geneeskd 151:1441-4. 2007.... - [More hereditary intestinal cancer can be detected if patients with colorectal carcinoma that are selected by the pathologist are examined for microsatellite instability]J H F M de Bruin
Universitair Medisch Centrum St Radboud, Postbus 9IoI, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 149:1792-8. 2005.... - Randomized trial of a shared decision-making intervention consisting of trade-offs and individualized treatment information for BRCA1/2 mutation carriersM S van Roosmalen
Department of Radiotherapy 341, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Clin Oncol 22:3293-301. 2004..To evaluate a shared decision-making intervention (SDMI) for BRCA1/2 mutation carriers who have to make a choice between screening and prophylactic surgery for breasts and/or ovaries... - Patients with an unexplained microsatellite instable tumour have a low risk of familial cancerL I H Overbeek
Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Br J Cancer 96:1605-12. 2007..Patients with an as yet unexplained microsatellite instable tumour likely carry a different type of mutation that confers a lower risk of cancer for relatives... - Impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancerMariëlle S van Roosmalen
Department of Radiotherapy 341, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Am J Med Genet A 124:346-55. 2004..Disclosure of a positive test result had a negative impact on well-being. Affected women, especially those who have been recently diagnosed with cancer, experienced the worst well-being and could benefit from psychosocial support... 
Young age and a positive family history of colorectal cancer are complementary selection criteria for the identification of Lynch syndromeP Manders
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Cancer 47:1407-13. 2011..Families from patients selected by individual criteria more often harbour extracolonic Lynch syndrome associated malignancies...- Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instabilityC M Kets
Department of Human Genetics, Radboud University Nijmegen Medical Centre, 849 Human Genetics, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Cancer 95:1678-82. 2006..The prevalence of a germline MSH6 mutation is very low in HNPCC suspected patients with non-MSI-high CRC. Microsatellite instability analysis in CRCs is highly sensitive to select patients for MSH6 germline mutation analysis... - Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriersR S van der Post
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Med Genet 47:464-70. 2010..The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer... - [Recognising hereditary non-polyposis colorectal cancer without a clear family history]J H F M de Bruin
afd Antropogenetica, Universitair Medisch Centrum St Radboud, Postbus 91o1, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 148:2053-7. 2004..The following individual criteria can help to recognize a patient at risk for HNPCC: (a) colorectal cancer diagnosed below 50 years of age, (b) second colorectal cancer, (c) a combination of colorectal and endometrial cancer... - Is early-onset microsatellite and chromosomally stable colorectal cancer a hallmark of a genetic susceptibility syndrome?C M Kets
Department of Human Genetics, Radboud University Nijmegen Medical Centre, The Netherlands
Int J Cancer 122:796-801. 2008..We find no evidence that early-onset microsatellite and chromosomally stable colorectal cancer is a hallmark of a hereditary colorectal cancer syndrome... - Cost effectiveness of a new strategy to identify HNPCC patientsW Kievit
Department of Medical Technology, University Medical Centre Nijmegen, 417 Human Genetics, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Gut 54:97-102. 2005..CONCLUSIONS: MSI testing in a selection of newly diagnosed CRC patients was shown to be cost effective and a feasible method to identify patients at risk for HNPCC who are not recognised by family history... - [In cases of familial ovarian cancer, always consider the risk of breast cancer]C M Kets
afd Antropogenetica, sectie Klinische Genetica, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 148:1709-11. 2004..Because the patients and their family members can benefit from regular surveillance and prophylactic surgery, it is of great importance to identify the high breast cancer risks as well as the high ovarian cancer risks in these families... - Surveillance of women at high risk for hereditary ovarian cancer is inefficientA L Oei
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Cancer 94:814-9. 2006..For prevention of advanced stage ovarian cancer, prophylactic BSO from age 35-40 years is a more efficient alternative... - Educational-support groups for BRCA mutation carriers satisfy need for information but do not affect emotional distressK M Landsbergen
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Genet Couns 21:423-37. 2010..The aim of this study is to evaluate educational-support groups, which are offered to facilitate mutual support between BRCA mutation carriers and to provide adequate information... - High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancerN Hoogerbrugge
Hereditary Cancer Clinic, Department of Human Genetics, University Medical Center Nijmegen, The Netherlands
J Clin Oncol 21:41-5. 2003..The use of prophylactic mastectomy is still debated. Identification of frequent premalignant lesions in mastectomy specimens would support the preventive concept of prophylactic mastectomy... - Deficient mismatch repair system in patients with sporadic advanced colorectal cancerM Koopman
Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Br J Cancer 100:266-73. 2009..The low incidence of dMMR does not allow drawing meaningful conclusions about the outcome of treatment in these patients... - Genetic testing offered directly after the diagnosis of colorectal cancer: a pilot study on the reactions of patientsK M Landsbergen
Department of Human Genetics, University Nijmegen Medical Centre, The Netherlands
Genet Couns 20:317-25. 2009..Genetic testing offered directly after the diagnosis of colorectal cancer: a pilot study on the reactions of patients:.. - Current clinical selection strategies for identification of hereditary non-polyposis colorectal cancer families are inadequate: a meta-analysisW Kievit
Department of Medical Technology Assessment, University Medical Center Nijmegen, Nijmegen, The Netherlands
Clin Genet 65:308-16. 2004..Therefore, a new strategy is needed for the identification of HNPCC... - Optimal selection for BRCA1 and BRCA2 mutation testing using a combination of 'easy to apply' probability modelsD Bodmer
Department of Human Genetics, Radboud University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Cancer 95:757-62. 2006..The efficiency of the selection of families for mutation testing of BRCA1 and BRCA2 can be optimised by using a combination of available easy to apply risk assessment models... - Psychological distress in newly diagnosed colorectal cancer patients following microsatellite instability testing for Lynch syndrome on the pathologist's initiativeK M Landsbergen
849 Department of Human Genetics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Fam Cancer 11:259-67. 2012..Immediately after result disclosure, high cancer-specific distress was observed in 40% of the MSI-positive patients... - Shortened time interval between colorectal cancer diagnosis and risk testing for hereditary colorectal cancer is not related to higher psychological distressK M Landsbergen
Department of Human Genetics, Raboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Fam Cancer 10:51-7. 2011..Females, religious persons, those having low social support and those reporting difficulties communicating hereditary colorectal cancer with relatives are at higher risk for psychological distress... - Electronic reminders for pathologists promote recognition of patients at risk for Lynch syndrome: cluster-randomised controlled trialL I Overbeek
Department of Human Genetics 849, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Virchows Arch 456:653-9. 2010..2 (95% CI 1.7-10.1). An electronic reminder system for pathologists appeared effective for adherence to a new complex guideline and will enhance the recognition of Lynch syndrome... - Adding familial risk assessment to faecal occult blood test can increase the effectiveness of population-based colorectal cancer screeningN Dekker
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Cancer 47:1571-7. 2011..Individuals at an increased familial CRC risk (≥ 2 times population risk) should be identified at a younger age, so they and their relatives can receive earlier, more intensive surveillance instead of FOBT... - Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutationM S van Roosmalen
Joint Center for Radiation Oncology Arnhem Nijmegen RADIAN, University Medical Center Nijmegen, Nijmegen, The Netherlands
Br J Cancer 90:333-42. 2004..In conclusion, women being tested for a BRCA1/2 mutation benefit from the DA on information related outcomes. Because timing had no effect, the DA is considered useful either before or after the test result... - Very low incidence of microsatellite instability in rectal cancers from families at risk for HNPCCN Hoogerbrugge
Department of Human Genetics, University Medical Center Nijmegen, The Netherlands
Clin Genet 63:64-70. 2003..01). In families with multiple cases of colorectal cancer, the rectal cancers are only rarely MSI-positive. This indicates that even in families with multiple colorectal cancers, rectal cancers are most commonly of sporadic origin... - A substantial part of the fallopian tube is left after standard prophylactic bilateral salpingo-oophorectomyL H M Gerritzen
Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Gynecol Cancer 16:1940-4. 2006..A substantial part of the fallopian tube remains in situ after prophylactic BSO and is covered with tubal type ciliated epithelium. More research is necessary to investigate the role of this remnant part of the tube for BRCA carriers... - Familial colorectal cancer risk assessment needs improvement for more effective cancer prevention in relativesN Dekker
Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Colorectal Dis 15:e175-85. 2013..Assessment of familial risk of CRC and referral rates for these preventive measures were determined 1 year after the introduction of new guidelines... - Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanismsR Venkatachalam
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
Cytogenet Genome Res 123:188-94. 2008..Finally, we discuss a novel copy number-associated epigenetic mechanism underlying the predisposition to colorectal cancer... - Incidence of cancer in first-degree relatives of basal cell carcinoma patientsM M van Rossum
Department of Dermatology, Radboud University Nijmegen Medical Centre, P O Box 9101, Nijmegen 6500 HB, The Netherlands
Arch Dermatol Res 301:295-9. 2009..These findings may indicate a genetic predisposition to both skin and visceral malignancies in this patient group... - Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRIJ Veltman
430 Department of Radiology, University Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Radiol 18:931-8. 2008..This applies for both mammography and MRI. However the possibility of MRI to evaluate the enhancement pattern and kinetics enables the detection of characteristics suggestive for a malignancy... - Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)M Nielsen
J Med Genet 42:e54. 2005..The frequent occurrence of additional extraintestinal manifestations, such as breast cancer among female MAP patients, should be thoroughly investigated... - Cancer risks in BRCA2 families: estimates for sites other than breast and ovaryC J van Asperen
J Med Genet 42:711-9. 2005..Larger databases with extended follow up are needed to provide insight into mutation specific risks of selected carriers in BRCA2 families... - Tumor characteristics and detection method in the MRISC screening program for the early detection of hereditary breast cancerM Kriege
Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC Daniel den Hoed Cancer Centre, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
Breast Cancer Res Treat 102:357-63. 2007.... - Phenotypic expression of double heterozygosity for BRCA1 and BRCA2 germline mutationsB Leegte
Department of Clinical Genetics, Groningen University Medical Centre, Groningen, The Netherlands
J Med Genet 42:e20. 2005 - Detecting Lynch syndrome by pathologistsJ H van Krieken
Department for Pathology, Radboud University Nijmegen Medical Centre
Verh Dtsch Ges Pathol 91:104-11. 2007..We propose a cost-effective and ethically correct approach for detecting Lynch syndrome by pathologists...