Judith R Homberg

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Eur J Neurosci 26:2066-73. 2007
  2. doi request reprint New perspectives on the neurodevelopmental effects of SSRIs
    Judith R Homberg
    Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Trends Pharmacol Sci 31:60-5. 2010
  3. pmc Genetic and pharmacological manipulations of the serotonergic system in early life: neurodevelopmental underpinnings of autism-related behavior
    Karsten Kinast
    Behavioural Neurogenetics, Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre Nijmegen, Netherlands
    Front Cell Neurosci 7:72. 2013
  4. ncbi request reprint The attribution of incentive salience to an appetitive conditioned cue is not affected by knockout of the serotonin transporter in rats
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, The Netherlands Electronic address
    Behav Brain Res 259:268-73. 2014
  5. doi request reprint Serotonin and decision making processes
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, UMC St Radboud, 6525 EZ Nijmegen, The Netherlands
    Neurosci Biobehav Rev 36:218-36. 2012
  6. doi request reprint Measuring behaviour in rodents: towards translational neuropsychiatric research
    Judith R Homberg
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands
    Behav Brain Res 236:295-306. 2013
  7. doi request reprint Genetic sensitivity to the environment, across lifetime
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, 6525 EZ Nijmegen, The Netherlands
    Behav Brain Sci 35:368. 2012
  8. doi request reprint The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behavior, Centre for Neuroscience, Dept of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands
    Prog Neurobiol 99:117-27. 2012
  9. doi request reprint The stress-coping (mis)match hypothesis for nature × nurture interactions
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21 route 126, 6525 EZ Nijmegen, The Netherlands
    Brain Res 1432:114-21. 2012
  10. pmc Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats
    Judith Homberg
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    BMC Genet 11:37. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Eur J Neurosci 26:2066-73. 2007
    ....
  2. doi request reprint New perspectives on the neurodevelopmental effects of SSRIs
    Judith R Homberg
    Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Trends Pharmacol Sci 31:60-5. 2010
    ..Here, we review the existing evidence on the long-term effects of developmental SSRI exposure...
  3. pmc Genetic and pharmacological manipulations of the serotonergic system in early life: neurodevelopmental underpinnings of autism-related behavior
    Karsten Kinast
    Behavioural Neurogenetics, Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre Nijmegen, Netherlands
    Front Cell Neurosci 7:72. 2013
    ..Here, we review and compare the neurodevelopmental and behavioral consequences of serotonin transporter gene variation, and prenatal SSRI and VPA exposure in the context of ASD...
  4. ncbi request reprint The attribution of incentive salience to an appetitive conditioned cue is not affected by knockout of the serotonin transporter in rats
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, The Netherlands Electronic address
    Behav Brain Res 259:268-73. 2014
    ..Rather, 5-HTT(-/-) rats may be more sensitive to the motivational properties of the unconditioned stimulus. ..
  5. doi request reprint Serotonin and decision making processes
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, UMC St Radboud, 6525 EZ Nijmegen, The Netherlands
    Neurosci Biobehav Rev 36:218-36. 2012
    ..5-HT(2A) agonists and 5-HT2c antagonists decrease compulsivity, whereas 5-HT(2A) antagonists and 5-HT(2C) agonists decrease impulsivity. 5-HT(6) antagonists univocally affect decision making processes...
  6. doi request reprint Measuring behaviour in rodents: towards translational neuropsychiatric research
    Judith R Homberg
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands
    Behav Brain Res 236:295-306. 2013
    ..Finally, I will touch upon behavioural tasks for rodents that are currently lacking and needed to catch up neuropsychiatric research...
  7. doi request reprint Genetic sensitivity to the environment, across lifetime
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, 6525 EZ Nijmegen, The Netherlands
    Behav Brain Sci 35:368. 2012
    ..I argue that real life is even more complex because (1) genotype influences sensitivity to environmental stimuli, and (2) the genome continues to be modified throughout life...
  8. doi request reprint The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behavior, Centre for Neuroscience, Dept of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands
    Prog Neurobiol 99:117-27. 2012
    ..e. reflecting 5-HTT×E×E interactions...
  9. doi request reprint The stress-coping (mis)match hypothesis for nature × nurture interactions
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21 route 126, 6525 EZ Nijmegen, The Netherlands
    Brain Res 1432:114-21. 2012
    ..The potential role of the prefrontal-amygdala circuit and the therapeutic implications of the SCM hypothesis will also be discussed...
  10. pmc Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats
    Judith Homberg
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    BMC Genet 11:37. 2010
    ..To gain insight into serotonin transporter (SERT)-specific genetic modifiers, we studied an intercross between the Wistar SERT-/- rat and the behaviorally and genetically divergent Brown Norway rat, and performed a QTL analysis...
  11. doi request reprint Serotonin transporter dosage modulates long-term decision-making in rat and human
    Judith R Homberg
    Department of Cognitive Neuroscience, Donders Centre for Neuroscience, UMC St Radboud, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Neuropharmacology 55:80-4. 2008
    ....
  12. pmc Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat
    Judith R Homberg
    Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e16646. 2011
    ....
  13. doi request reprint Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring
    Jocelien D A Olivier
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21 route 126, 6525, EZ, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 217:419-32. 2011
    ..Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially neurodevelopmental changes in the fetus...
  14. doi request reprint Serotonin transporter genotype x construction stress interaction in rats
    Pieter Schipper
    Department of Anatomy, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Behav Brain Res 223:169-75. 2011
    ..These data importantly contribute to the understanding of 5-HTT gene x environment interactions and show the risk of losing genotype effects by construction stress...
  15. doi request reprint Improved cognitive flexibility in serotonin transporter knockout rats is unchanged following chronic cocaine self-administration
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, The Netherlands
    Addict Biol 18:434-40. 2013
    ..As 5-HTT(-/-) rodents model the low activity s-allele of the human serotonin transporter-linked polymorphic region, these findings may have heuristic value in the treatment of s-allele cocaine addicts...
  16. ncbi request reprint The reciprocal interaction between serotonin and social behaviour
    Dominik Kiser
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, UMC St Radboud, Nijmegen, The Netherlands
    Neurosci Biobehav Rev 36:786-98. 2012
    ..Simultaneously, these behavioural responses influence the serotonergic system, leading to highly complex bidirectional serotonin×environment interaction...
  17. doi request reprint A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats
    Pieter Schipper
    Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Behav Pharmacol 22:324-34. 2011
    ..We suggest that such a mixed diet may serve as an attractive adjuvant to treat anxiety in 5-HTT length polymorphic region short-allele carriers...
  18. doi request reprint Looking on the bright side of serotonin transporter gene variation
    Judith R Homberg
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biol Psychiatry 69:513-9. 2011
    ..This notion may not only explain the modest effect size of the 5-HTTLPR and inconsistent reports but may also lead to a more refined appreciation of allelic variation in 5-HTT function...
  19. pmc Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Psychiatry Neurosci 37:224-30. 2012
    ..Given that s-allele carriers also show improved adaptive responding when exposed to positive stimuli, we hypothesized that this trait could be used to offset impaired fear extinction...
  20. ncbi request reprint Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, 6525 EZ, The Netherlands
    Learn Mem 19:190-3. 2012
    ..Results indicate that 5-HTT(-/-) rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism...
  21. doi request reprint The genetics of selective serotonin reuptake inhibitors
    Yvet Kroeze
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, 6525 EZ Nijmegen, The Netherlands
    Pharmacol Ther 136:375-400. 2012
    ..So far little is known about the epigenetic and age-dependent molecular effects of SSRIs, which might give more insights in the working mechanism(s) of SSRIs...
  22. ncbi request reprint Individual differences in cocaine addiction: maladaptive behavioural traits
    Judith R Homberg
    Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands
    Addict Biol 19:517-28. 2014
    ..This 'behavioural (mal)adaptation view' on individual differences in vulnerability to cocaine addiction may help to improve therapies for addiction. ..
  23. pmc Impaired fear extinction as displayed by serotonin transporter knockout rats housed in open cages is disrupted by IVC cage housing
    Ling Shan
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e91472. 2014
    ..Our findings also underline the possibility that housing conditions confound the interpretation of anxiety-related behaviours in rodents. ..
  24. doi request reprint Perseverative instrumental and Pavlovian responding to conditioned stimuli in serotonin transporter knockout rats
    Lourens J P Nonkes
    Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurobiol Learn Mem 100:48-55. 2013
    ..These findings complement earlier findings showing that 5-HTT knockout animals' behavior is heavily influenced by environmental stimuli and indicate that this extends to the instrumental domain...
  25. doi request reprint The interplay between brain 5-hydroxytryptamine levels and cocaine addiction
    Lourens J P Nonkes
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Behav Pharmacol 22:723-38. 2011
    ..In addition, 5-HT mediates, to some extent, the aversive effects of cocaine. Difficulties with data interpretation are discussed...
  26. ncbi request reprint Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats
    Jocelien D A Olivier
    Department Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Pharmacol 590:190-7. 2008
    ..It is concluded that the SERT knockout rat reveals that 5-HT(1A) receptors modulating stress-induced hyperthermia belong to a population of receptors that differs from that involved in hypothermia...
  27. pmc Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats
    Judith R Homberg
    Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Psychopharmacology (Berl) 195:175-82. 2007
    ....
  28. ncbi request reprint Molecular reactivity of mesocorticolimbic brain areas of high and low grooming rats after elevated plus maze exposure
    Eisuke Koya
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Free University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    Brain Res Mol Brain Res 137:184-92. 2005
    ....
  29. ncbi request reprint Individual differences in sensitivity to factors provoking reinstatement of cocaine-seeking behavior
    Judith R Homberg
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Behav Brain Res 152:157-61. 2004
    ..In conclusion, the present findings indicate that the therapeutic efficacy of relapse prevention strategies may depend on individual sensitivity to distinct relapse provoking stimuli...