Peter Friedl

Summary

Affiliation: Radboud University
Country: The Netherlands

Publications

  1. pmc Nuclear mechanics during cell migration
    Peter Friedl
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O 9101, 6500 HB Nijmegen, The Netherlands
    Curr Opin Cell Biol 23:55-64. 2011
  2. doi request reprint Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
  3. doi request reprint New dimensions in cell migration
    Peter Friedl
    Radboud University Nijmegen Medical Centre, 6500HC Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 13:743-7. 2012
  4. doi request reprint Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
  5. doi request reprint Tube travel: the role of proteases in individual and collective cancer cell invasion
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Cancer Res 68:7247-9. 2008
  6. doi request reprint Proteolytic interstitial cell migration: a five-step process
    Peter Friedl
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O 9101, 6500 HB, Nijmegen, The Netherlands
    Cancer Metastasis Rev 28:129-35. 2009
  7. pmc Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Cell Biol 188:11-9. 2010
  8. doi request reprint Interstitial leukocyte migration and immune function
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525GA Nijmegen, 6500 HB Nijmegen, The Netherlands
    Nat Immunol 9:960-9. 2008
  9. ncbi request reprint Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Exp Med 207:11-9. 2010
  10. doi request reprint Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
    Stephanie Alexander
    Department of Dermatology, Venerology, and Allergology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Histochem Cell Biol 130:1147-54. 2008

Collaborators

Detail Information

Publications55

  1. pmc Nuclear mechanics during cell migration
    Peter Friedl
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O 9101, 6500 HB Nijmegen, The Netherlands
    Curr Opin Cell Biol 23:55-64. 2011
    ..Understanding the regulation of nuclear biomechanics has important implications for cell migration during tissue regeneration, immune defence and cancer...
  2. doi request reprint Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
    ..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination...
  3. doi request reprint New dimensions in cell migration
    Peter Friedl
    Radboud University Nijmegen Medical Centre, 6500HC Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 13:743-7. 2012
    ....
  4. doi request reprint Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
    ..Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research...
  5. doi request reprint Tube travel: the role of proteases in individual and collective cancer cell invasion
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Cancer Res 68:7247-9. 2008
    ..These findings develop our understanding of invasive processes in cancer and how to attack them by interfering with MMP-14 activity...
  6. doi request reprint Proteolytic interstitial cell migration: a five-step process
    Peter Friedl
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O 9101, 6500 HB, Nijmegen, The Netherlands
    Cancer Metastasis Rev 28:129-35. 2009
    ..Pericellular proteolysis is thus integral to the migration cycle and serves to widen ECM gaps and thereby lowers physical stress upon the cell body, which ultimately leads to aligned higher-oder ECM patterns...
  7. pmc Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Cell Biol 188:11-9. 2010
    ..The tuning model provides a matrix of parameters that control cell movement as an adaptive and interconvertible process with relevance to different physiological and pathological contexts...
  8. doi request reprint Interstitial leukocyte migration and immune function
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525GA Nijmegen, 6500 HB Nijmegen, The Netherlands
    Nat Immunol 9:960-9. 2008
    ..Here, we review mechanisms of leukocyte migration and sensing involved in diapedesis, tissue-based interstitial migration and egress, immune cell positioning in inflammation, and emerging therapeutic interference strategies...
  9. ncbi request reprint Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Exp Med 207:11-9. 2010
    ..The tuning model provides a matrix of parameters that control cell movement as an adaptive and interconvertible process with relevance to different physiological and pathological contexts...
  10. doi request reprint Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
    Stephanie Alexander
    Department of Dermatology, Venerology, and Allergology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Histochem Cell Biol 130:1147-54. 2008
    ..This modified window model will be suited to address mechanisms of cancer invasion and metastasis, and related experimental therapy...
  11. ncbi request reprint Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    Katarina Wolf
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Nat Cell Biol 9:893-904. 2007
    ..Thus, invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macropatterning and, consequently, individual and collective cell migration...
  12. doi request reprint A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling
    Julian Storim
    Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Eur J Immunol 40:2741-50. 2010
    ..Thus a dynamic immunological synapse with distinct signaling sectors enables moving T cells to serially sample resident tissue cells and acquire molecular information "en passant"...
  13. ncbi request reprint Collective cell migration in morphogenesis and cancer
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, 97089 Würzburg, Germany
    Int J Dev Biol 48:441-9. 2004
    ..This review highlights cellular and molecular principles of collective migration in the context of morphogenic tissue patterning and tumor cell invasion...
  14. ncbi request reprint Release of cell fragments by invading melanoma cells
    Christian Mayer
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Eur J Cell Biol 83:709-15. 2004
    ..The deposition of cell fragments may further represent a disregulated detachment strategy with implications for neoplastic cell behavior, such as the paracrine effects on neighbor cells or a negative impact on immune effector cells...
  15. doi request reprint Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: filopod-mediated extension-relaxation cycles and force anisotropy
    Josefine Starke
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 87080 Würzburg, Germany
    Exp Cell Res 319:2424-33. 2013
    ..Combined live-cell fluorescence and reflection microscopy of the leading edge thus reveals step-wise caterpillar-like extension-retraction cycles that underlie mesenchymal migration in 3D tissue. ..
  16. pmc Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force
    Katarina Wolf
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands
    J Cell Biol 201:1069-84. 2013
    ..The limits of interstitial cell migration thus depend upon scaffold porosity and deformation of the nucleus, with pericellular collagenolysis and mechanocoupling as modulators...
  17. doi request reprint Determinants of leader cells in collective cell migration
    Antoine A Khalil
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Integr Biol (Camb) 2:568-74. 2010
    ..We here classify molecular and mechanical mechanisms of leading function in collective cell migration during morphogenesis and wound repair and discuss how these are recapitulated during collective invasion of cancer cells...
  18. ncbi request reprint Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Blood 102:3262-9. 2003
    ..Together, amoeboid shape change and contact guidance provide constitutive protease-independent mechanisms for leukocyte trafficking through interstitial tissues that are insensitive toward pharmacologic protease inhibitors...
  19. pmc Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 160:267-77. 2003
    ....
  20. doi request reprint Interstitial guidance of cancer invasion
    Pavlo G Gritsenko
    Microscopical Imaging of the Cell, Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Pathol 226:185-99. 2012
    ....
  21. doi request reprint Collagen-based cell migration models in vitro and in vivo
    Katarina Wolf
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Semin Cell Dev Biol 20:931-41. 2009
    ..Future in-depth comparison of structure and physical properties between 3D ECM-based models in vitro and in vivo are mandatory to better understand the mechanisms and limits of interstitial cell movements in distinct tissue environments...
  22. doi request reprint Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion
    Olga Ilina
    Microscopical Imaging of the Cell, Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Groote Plein 26 28, Nijmegen, HB 6500, The Netherlands
    Phys Biol 8:015010. 2011
    ..Thus, two-photon laser ablation is useful to generate barrier-free microtracks in a 3D ECM which guide collective invasion independently of pericellular proteolysis...
  23. pmc Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms
    Samuel Schmidt
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, The Netherlands
    Cell Tissue Res 339:83-92. 2010
    ..We further discuss the hierarchy of these concurrent adhesion systems, their specific tasks in cell migration and their contribution to migration in three-dimensional multi-ligand tissue environments...
  24. pmc MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation
    Svenja Meierjohann
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany
    Mol Cancer 9:201. 2010
    ..The purpose of this study was to examine RTK-driven three-dimensional migration of melanocytes and the pro-tumorigenic role of matrix metalloproteases for melanocytes and melanoma cells...
  25. doi request reprint Extracellular matrix determinants of proteolytic and non-proteolytic cell migration
    Katarina Wolf
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    Trends Cell Biol 21:736-44. 2011
    ..These concepts call for therapeutic targeting of proteases to prevent invasion-associated tissue destruction rather than the migration process per se...
  26. doi request reprint Mapping proteolytic cancer cell-extracellular matrix interfaces
    Katarina Wolf
    Department of Cell Biology 283, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Metastasis 26:289-98. 2009
    ..Through their combined action these proteolytic surface structures cleave, remove, and realign ECM barriers, support rear end retraction, generate tube-like matrix defects and laterally widen existing tracks during 3D tissue invasion...
  27. doi request reprint Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity
    Gert Jan Bakker
    Microscopical Imaging of the Cell, Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Methods Enzymol 504:109-25. 2012
    ....
  28. ncbi request reprint Molecular mechanisms of cancer cell invasion and plasticity
    Katarina Wolf
    Rudolf Virchow Centre, DFG Centre for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Br J Dermatol 154:11-5. 2006
    ..These adaptation responses show an unexpected degree of plasticity resulting in migratory 'escape' strategies after pharmacotherapeutic intervention by prompting alternative mechanisms of cancer cell dissemination in tissues...
  29. doi request reprint A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes
    Bettina Weigelin
    Department of Cell Biology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biochem Pharmacol 80:2087-91. 2010
    ..Thus, the organotypic assay is useful to monitor spatiotemporal control mechanisms of cytotoxic immune effector functions...
  30. ncbi request reprint Tumour-cell invasion and migration: diversity and escape mechanisms
    Peter Friedl
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Nat Rev Cancer 3:362-74. 2003
    ..Learning more about the cellular and molecular basis of these different migration/invasion programmes will help us to understand how cancer cells disseminate and lead to new treatment strategies...
  31. ncbi request reprint Biological second and third harmonic generation microscopy
    Peter Friedl
    University of Wurzburg, Wurzburg, Germany
    Curr Protoc Cell Biol . 2007
    ..Multimodal multiphoton microscopy using HHGM together with two-photon excited fluorescence will develop into a key approach to real-time imaging of cell dynamics in the context of live tissues...
  32. doi request reprint Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization
    Andrea Imle
    Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Universtiy Würzburg, Germany
    Cytometry A 75:562-8. 2009
    ..Thus, single-cell selection of defined nuclear states is amenable to single-cell CGH and here provides first insight into the aberration drift and genomic diversity in cancer cells with and without micronuclei...
  33. ncbi request reprint Prespecification and plasticity: shifting mechanisms of cell migration
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Curr Opin Cell Biol 16:14-23. 2004
    ....
  34. ncbi request reprint Confocal reflection imaging of 3D fibrin polymers
    Anke Hartmann
    Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Blood Cells Mol Dis 36:191-3. 2006
    ..In conclusion, confocal reflection microscopy is a valuable technique for real-time monitoring of the remodeling of fibrin matrices, such as during thrombus formation, wound healing, and tumor formation...
  35. ncbi request reprint Dynamic imaging of cellular interactions with extracellular matrix
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Germany
    Histochem Cell Biol 122:183-90. 2004
    ..Dynamic 3D imaging has revealed an unexpected degree of dynamics and turnover of cell adhesion and migration as well as basic mechanisms that lead to proteolytic remodeling of connective tissue by stromal cells and invading tumor cells...
  36. doi request reprint Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier
    Anke Hartmann
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Dermatol Surg 34:922-9. 2008
    ..Parallel in vitro culture was used to validate keratinocyte survival and apoptosis in fibrin compared to collagen matrix carrier...
  37. doi request reprint Classifying collective cancer cell invasion
    Peter Friedl
    Department of Cell Biology, NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Cell Biol 14:777-83. 2012
    ....
  38. doi request reprint Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment
    Bettina Weigelin
    Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands
    Immunol Lett 138:19-21. 2011
    ..All these steps of effector function are interdependent and require the amoeboid migration of CTL through tissue to reach, engage with and leave encountered cells...
  39. ncbi request reprint Tuning immune responses: diversity and adaptation of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg 97080, Germany
    Nat Rev Immunol 5:532-45. 2005
    ..These diverse interaction modes might define a molecular code, in which the differences in timing, spacing and molecular composition of the signalling platform determine the outcome of T-cell-APC interactions...
  40. ncbi request reprint Diversity in immune-cell interactions: states and functions of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Trends Cell Biol 14:557-67. 2004
    ....
  41. ncbi request reprint Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies
    Yael Hegerfeldt
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    Cancer Res 62:2125-30. 2002
    ..The conversion from beta1-integrin-dependent collective movement to beta1-integrin-independent single-cell motility suggests efficient cellular and molecular plasticity in tumor cell migration strategies...
  42. doi request reprint Twenty-third annual Pezcoller Symposium: engineering influences in cancer research
    Peter Friedl
    Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Res 72:841-4. 2012
    ....
  43. doi request reprint Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery
    Daniel Kampik
    Department of Ophthalmology, University of Wurzburg, Wurzburg, Germany
    Invest Ophthalmol Vis Sci 51:3929-34. 2010
    ..This study was conducted to investigate whether CXL influences ablation rate, flap thickness, and refractive results of excimer laser procedures ex vivo...
  44. ncbi request reprint Impaired induction of adhesion molecule expression in immortalized endothelial cells leads to functional defects in dynamic interactions with lymphocytes
    Gertie J Oostingh
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 127:2253-8. 2007
    ..The immortalized endothelial cells tested here have lost functions that are required for dynamic interactions with immune cells and that are common to primary endothelial cells...
  45. ncbi request reprint Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition
    Andreas Fischer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Circ Res 100:856-63. 2007
    ..Thus, the Hey gene family shows overlap in controlling Notch induced endocardial epithelial to mesenchymal transition, a process critical for valve and septum formation...
  46. doi request reprint Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging
    Volker Andresen
    University of Wurzburg, Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Venerology, and Allergology, Wurzburg, Germany
    Curr Opin Biotechnol 20:54-62. 2009
    ..Furthermore, it still provides subcellular resolution at depths of several hundred micrometers and thus will enhance long-term live cell and deep tissue microscopy...
  47. ncbi request reprint p53 family members in myogenic differentiation and rhabdomyosarcoma development
    Hakan Cam
    Molecular Tumor Biology Group, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    Cancer Cell 10:281-93. 2006
    ..DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family...
  48. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
    ..Our results indicate that stathmin plays a significant role in tumor metastasis formation, a finding that could lead to exploitation of stathmin as a target of new antimetastatic drugs...
  49. ncbi request reprint Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking
    Peter Friedl
    Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
    Methods Mol Biol 239:77-90. 2004
  50. ncbi request reprint Dynamic imaging of the immune system
    Peter Friedl
    Curr Opin Immunol 16:389-93. 2004
  51. ncbi request reprint Functional imaging of pericellular proteolysis in cancer cell invasion
    Katarina Wolf
    Department of Dermatology, Rudolf Virchow Center, DFG Center for Experimental Biomedicine, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Biochimie 87:315-20. 2005
    ....
  52. ncbi request reprint The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism
    Katharina Uhlenbrock
    Department of Structural Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Cell Sci 117:4863-71. 2004
    ..The reverse transition from mesenchymal invasive to a resident epithelial-like phenotype implicates a role for Tiam1/Rac signaling in the control of cell-cell contacts through a novel ALCAM-mediated mechanism...
  53. ncbi request reprint TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells
    Peter Friedl
    Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
    Immunol Rev 186:83-9. 2002
    ..Herein we develop a model on scanning encounters between T cells and APCs that includes the simultaneous engagement of T-cell leading edge and uropod and implicates a serial receptor triggering mode in cell-cell recognition...
  54. ncbi request reprint CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment
    Michelle J Muessel
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    J Immunol 180:8354-60. 2008
    ....
  55. ncbi request reprint Cell fusion: new mechanisms of plasticity in cancer?
    Peter Friedl
    Lancet Oncol 6:916-8. 2005