J Fransen

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Design and analysis of a randomized controlled trial testing the effects of clinical decision support on the management of rheumatoid arthritis
    Jaap Fransen
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 51:124-7. 2004
  2. pmc High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study
    Elke Arts
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 14:R116. 2012
  3. doi request reprint Predictors for the 5-year risk of serious infections in patients with rheumatoid arthritis treated with anti-tumour necrosis factor therapy: a cohort study in the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
    Sanne A A van Dartel
    Department of Rheumatology, University Nijmegen Medical Centre, Huispost 470, Postbus 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:1052-7. 2013
  4. doi request reprint A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 71:845-50. 2012
  5. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
  6. pmc Time to achieve remission determines time to be in remission
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 12:R97. 2010
  7. pmc Outcome measures in inflammatory rheumatic diseases
    Jaap Fransen
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, 6500HB Nijmegen, The Netherlands
    Arthritis Res Ther 11:244. 2009
  8. doi request reprint The Disease Activity Score and the EULAR response criteria
    Jaap Fransen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Rheum Dis Clin North Am 35:745-57, vii-viii. 2009
  9. pmc Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors
    J Fransen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:1373-8. 2006
  10. doi request reprint Clinical prediction of 5-year survival in systemic sclerosis: validation of a simple prognostic model in EUSTAR centres
    J Fransen
    Correspondence to J Fransen, Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ann Rheum Dis 70:1788-92. 2011

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Design and analysis of a randomized controlled trial testing the effects of clinical decision support on the management of rheumatoid arthritis
    Jaap Fransen
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 51:124-7. 2004
  2. pmc High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study
    Elke Arts
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 14:R116. 2012
    ..In this study, we investigated whether HDL2-chol and HDL3-chol concentrations differ between RA patients and healthy controls, and whether these levels are related to the level of RA disease activity...
  3. doi request reprint Predictors for the 5-year risk of serious infections in patients with rheumatoid arthritis treated with anti-tumour necrosis factor therapy: a cohort study in the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
    Sanne A A van Dartel
    Department of Rheumatology, University Nijmegen Medical Centre, Huispost 470, Postbus 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:1052-7. 2013
    ..The objective of this study was to identify which factors are predictive of the increased risk of serious infections in RA patients treated with TNF inhibiting therapy...
  4. doi request reprint A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 71:845-50. 2012
    ..However, the question is whether these results can be translated into daily clinical practice and clinical remission is a reachable target indeed...
  5. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  6. pmc Time to achieve remission determines time to be in remission
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 12:R97. 2010
    ..The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice...
  7. pmc Outcome measures in inflammatory rheumatic diseases
    Jaap Fransen
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, 6500HB Nijmegen, The Netherlands
    Arthritis Res Ther 11:244. 2009
    ..The objective of this review is to describe recent developments in outcome measures for inflammatory rheumatic diseases for trials and clinical practice, with an emphasis on rheumatoid arthritis...
  8. doi request reprint The Disease Activity Score and the EULAR response criteria
    Jaap Fransen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Rheum Dis Clin North Am 35:745-57, vii-viii. 2009
    ..This article summarizes the development and validation of the DAS and DAS28 and their use in clinical trials and practice for the clinician...
  9. pmc Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors
    J Fransen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:1373-8. 2006
    ..In recent clinical trials in patients with psoriatic arthritis (PsA), the response criteria and disease activity measures that have been used were those developed for rheumatoid arthritis. However, these have not yet been validated in PsA...
  10. doi request reprint Clinical prediction of 5-year survival in systemic sclerosis: validation of a simple prognostic model in EUSTAR centres
    J Fransen
    Correspondence to J Fransen, Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ann Rheum Dis 70:1788-92. 2011
    ..A study was undertaken to validate the prognostic model to predict 5-year survival in SSc in other centres throughout Europe...
  11. pmc Effectiveness of systematic monitoring of rheumatoid arthritis disease activity in daily practice: a multicentre, cluster randomised controlled trial
    J Fransen
    Department of Rheumatology, University Medical Centre Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, Netherlands
    Ann Rheum Dis 64:1294-8. 2005
    ..To test the efficacy of standardised monitoring using the disease activity index DAS28 versus usual care on disease modifying antirheumatic drug (DMARD) prescription and disease activity in rheumatoid arthritis...
  12. pmc Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis
    J Fransen
    Department of Rheumatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, Netherlands
    Ann Rheum Dis 63:1222-6. 2004
    ..To study the influence of rheumatologists' adherence to a methotrexate guideline on efficacy and toxicity in the treatment of rheumatoid arthritis...
  13. ncbi request reprint Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria
    J Fransen
    Department of Rheumatology, University Medical Centre Nijmegen, P O Box 9101, NL 6500HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 43:1252-5. 2004
    ..To determine which cut-off point in the RA disease activity score (DAS28) corresponds to fulfilment of the ARA criteria for clinical remission...
  14. ncbi request reprint Are better endpoints and better design of clinical trials needed?
    Jaap Fransen
    University Medical Centre Nijmegen, Department of Rheumatology, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Best Pract Res Clin Rheumatol 18:97-109. 2004
    ..When it can be measured truly and feasible, the marker would be useful as an endpoint in trials and for supporting treatment decisions in clinical practice...
  15. doi request reprint The effectiveness and medication costs of three anti-tumour necrosis factor alpha agents in the treatment of rheumatoid arthritis from prospective clinical practice data
    W Kievit
    Department of Rheumatology 470, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 67:1229-34. 2008
    ..Aim: to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design...
  16. doi request reprint Evaluating guidelines on continuation of anti-tumour necrosis factor treatment after 3 months: clinical effectiveness and costs of observed care and different alternative strategies
    W Kievit
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 68:844-9. 2009
    ..The secondary objective was to evaluate alternatives to the present guidelines with regard to the percentage of responders and costs...
  17. doi request reprint Influence of age on the outcome of antitumour necrosis factor alpha therapy in rheumatoid arthritis
    B J Radovits
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, PO Box 9101, HP 470, Nijmegen 6500 HB, The Netherlands
    Ann Rheum Dis 68:1470-3. 2009
    ..To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA)...
  18. doi request reprint The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis
    E J M Toonen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 67:1174-7. 2008
    ....
  19. pmc The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice
    W Kievit
    Department of Rheumatology 470, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 66:1473-8. 2007
    ..Randomised controlled trials (RCTs) evaluating the efficacy of antagonists to tumour necrosis factor alpha (TNFalpha) showed high response percentages in the groups treated with active drugs...
  20. doi request reprint Association between fatigue and pain in rheumatoid arthritis: does pain precede fatigue or does fatigue precede pain?
    S A A van Dartel
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Care Res (Hoboken) 65:862-9. 2013
    ..Therefore, the objective of this study was to investigate the longitudinal relationship between fatigue and pain in patients with RA using time-lag models...
  21. ncbi request reprint Influence of age and gender on the 28-joint Disease Activity Score (DAS28) in rheumatoid arthritis
    B J Radovits
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, PO Box 9101, HP 470, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 67:1127-31. 2008
    ....
  22. doi request reprint Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritis
    B J Radovits
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
    Arthritis Care Res (Hoboken) 62:362-70. 2010
    ....
  23. ncbi request reprint DAS remission cut points
    J Fransen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Rheumatol 24:S-29-32. 2006
    ..Values of DAS %lt;1.6 and DAS28 %lt; 2.6 correspond with an increased likelihood of being in remission. This review presents development of the DAS and DAS28 remission cut points and their interpretation...
  24. doi request reprint Disease activity as a risk factor for myocardial infarction in rheumatoid arthritis
    B J Radovits
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, P O Box 9101, H470, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 68:1271-6. 2009
    ..Systemic inflammation may contribute to this risk. This study investigated whether the level of disease activity is associated with the risk of developing myocardial infarction (MI) in patients with RA...
  25. ncbi request reprint The use of different methods for rapid determination of the ESR induces DAS28 misclassification in clinical practice
    A van der Maas
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Clin Exp Rheumatol 28:477-82. 2010
    ..Monitoring of disease activity using DAS28 is more effective than routine RA care, but the ESR measurement is time consuming. Alternative rapid ESR determination methods can be used but effects on DAS28 classification are unknown...
  26. doi request reprint Development of quality indicators for monitoring of the disease course in rheumatoid arthritis
    L T C van Hulst
    Department of Rheumatology 470, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 68:1805-10. 2009
    ..The objective of this study was to develop a set of quality indicators to evaluate RA disease course monitoring of rheumatologists in daily clinical practice...
  27. ncbi request reprint Established rheumatoid arthritis: clinical assessments
    Piet L C M van Riel
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Best Pract Res Clin Rheumatol 21:807-25. 2007
    ..For the evaluation of interventions, 'core sets' of valid measures to assess disease activity, outcome and specific criteria for improvement are used; these can, to some extent, be useful in clinical practice...
  28. doi request reprint The effect of anti-TNF-α vs. DMARDs on fatigue in rheumatoid arthritis patients
    D van Hoogmoed
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Scand J Rheumatol 42:15-9. 2013
    ..The aim of our study was to analyse whether, in patients with RA, the effect of anti-TNF on fatigue is greater than the effect of DMARD treatment...
  29. ncbi request reprint The Disease Activity Score and the EULAR response criteria
    J Fransen
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Clin Exp Rheumatol 23:S93-9. 2005
    ..The EULAR response criteria classify individual patients as non-, moderate, or good responders, dependent on the extent of change and the level of disease activity reached...
  30. doi request reprint Oesophageal dilatation on high-resolution computed tomography scan of the lungs as a sign of scleroderma
    M C Vonk
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 67:1317-21. 2008
    ..The objective of this study is to evaluate the predictive value of oesophageal dilatation on the HRCT scan for the diagnosis of SSc...
  31. ncbi request reprint Risk factors for surgical site infections and other complications in elective surgery in patients with rheumatoid arthritis with special attention for anti-tumor necrosis factor: a large retrospective study
    Alfons A den Broeder
    Department of Rheumatology and Orthopaedic Surgery, Sint Maartenskliniek, The Netherlands
    J Rheumatol 34:689-95. 2007
    ..To identify risk factors for surgical site infection (SSI) in patients with rheumatoid arthritis (RA) with special attention for anti-tumor necrosis factor (anti-TNF) treatment...
  32. ncbi request reprint Gap between short- and long-term effects of patient education in rheumatoid arthritis patients: a systematic review
    Karin Niedermann
    Department of Rheumatology and Institute for Physical Medicine, University Hospital Zurich, Zurich, Switzerland
    Arthritis Rheum 51:388-98. 2004
    ..To systematically review educational or psychoeducational interventions for patients with rheumatoid arthritis focusing on long-term effects, especially health status...
  33. ncbi request reprint Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis
    Paco M J Welsing
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:2616-24. 2005
    ..This study was undertaken to investigate whether the course of disease activity and functional disability in patients with RA has become milder over the past several years...
  34. ncbi request reprint Minimal disease activity for rheumatoid arthritis: a preliminary definition
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 32:2016-24. 2005
    ..This set of 2 definitions gained approval of 73% of the attendees. These (and other) definitions will now be subject to further validation in other databases...
  35. ncbi request reprint Persistent severe fatigue in patients with rheumatoid arthritis
    Han Repping-Wuts
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Nurs 16:377-83. 2007
    ..To determine whether persistent severe fatigue in patients with rheumatoid arthritis can be predicted by inflammation and disability...
  36. pmc DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis
    Piet L C M van Riel
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Res Ther 7:189-90. 2005
    ..This result once more confirms the validity of the DAS28 to monitor disease activity in patients with rheumatoid arthritis and to titrate treatment with biologicals...
  37. pmc Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1525-30. 2007
    ..Therefore, the question of whether two functional variants in MIF are associated with the response to tumour necrosis factor (TNF)alpha-neutralising and GC treatments in RA was investigated...
  38. pmc Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 66:1334-8. 2007
    ..CCL18 and CXCL16 are two chemokines that facilitate T cell attraction by APC, of which a role in the pathogenesis of RA has been suggested...
  39. ncbi request reprint A simple sample size formula for analysis of covariance in randomized clinical trials
    George F Borm
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    J Clin Epidemiol 60:1234-8. 2007
    ..Randomized clinical trials that compare two treatments on a continuous outcome can be analyzed using analysis of covariance (ANCOVA) or a t-test approach. We present a method for the sample size calculation when ANCOVA is used...
  40. ncbi request reprint Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials
    Ruud Knols
    Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    J Clin Oncol 23:3830-42. 2005
    ....