B Franke

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc The genetics of attention deficit/hyperactivity disorder in adults, a review
    B Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 17:960-87. 2012
  2. pmc Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury
    Bart P Ramakers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R3. 2011
  3. pmc The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Behav Brain Funct 4:48. 2008
  4. ncbi Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation
    Barbara Franke
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 67:979-84. 2003
  5. pmc Genome-wide association studies in ADHD
    Barbara Franke
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Genet 126:13-50. 2009
  6. ncbi Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals
    Barbara Franke
    Department of Human Genetics, Institute for Genetic and Metabolic Disorders, Center for Neuroscience, Radboud University Nijmegen Medical Center, The Netherlands
    Biol Psychiatry 68:586-8. 2010
  7. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
  8. doi An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 85:216-26. 2009
  9. doi Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD
    B Franke
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1576-9. 2008
  10. ncbi Analysis of the embryonic phenotype of Bent tail, a mouse model for X-linked neural tube defects
    Barbara Franke
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Anat Embryol (Berl) 207:255-62. 2003

Detail Information

Publications78

  1. pmc The genetics of attention deficit/hyperactivity disorder in adults, a review
    B Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 17:960-87. 2012
    ..Progress in identifying aADHD risk genes may provide us with tools for the prediction of disease progression in the clinic and better treatment, and ultimately may help to prevent persistence of ADHD into adulthood...
  2. pmc Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury
    Bart P Ramakers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R3. 2011
    ..In addition, we studied whether subjects with the common 34C > T nonsense variant (rs17602729) of adenosine monophosphate deaminase (AMPD1), which predicts increased adenosine formation, have less inflammation-induced injury...
  3. pmc The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Behav Brain Funct 4:48. 2008
    ..abstract:..
  4. ncbi Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation
    Barbara Franke
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 67:979-84. 2003
    ..These nutrients are thought to be involved in the etiology of NTDs, in combination with a genetic predisposition...
  5. pmc Genome-wide association studies in ADHD
    Barbara Franke
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Genet 126:13-50. 2009
    ..Many more (much larger studies) will be needed. For this, collaboration between researchers as well as standardized protocols for phenotyping and DNA-collection will become increasingly important...
  6. ncbi Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals
    Barbara Franke
    Department of Human Genetics, Institute for Genetic and Metabolic Disorders, Center for Neuroscience, Radboud University Nijmegen Medical Center, The Netherlands
    Biol Psychiatry 68:586-8. 2010
    ..To elucidate the mechanisms by which such effects on psychiatric disease are brought about by genetic factors, we investigated the influence of CACNA1C polymorphisms on brain structure...
  7. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
    ..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD...
  8. doi An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 85:216-26. 2009
    ..5 to 12 per 1000 births globally. In this article we attempt to identify genes related to folate and its metabolic pathways that are involved in the etiology of spina bifida...
  9. doi Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD
    B Franke
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1576-9. 2008
    ..If confirmed in other studies, the differential association of the gene with ADHD in children and in adults might imply that SLC6A3 plays a role in modulating the ADHD phenotype, rather than causing it...
  10. ncbi Analysis of the embryonic phenotype of Bent tail, a mouse model for X-linked neural tube defects
    Barbara Franke
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Anat Embryol (Berl) 207:255-62. 2003
    ..Other phenotypic features described in this study also occur in the wild type genetic background of the Bent tail strain. Apparently, the genetic background contains elements conducive to these developmental abnormalities...
  11. doi CDH13 is associated with working memory performance in attention deficit/hyperactivity disorder
    A Arias-Vasquez
    Department of Psychiatry 966, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Genes Brain Behav 10:844-51. 2011
    ..As such, our study may be viewed as exploratory, with the results presented providing interesting hypotheses for further testing...
  12. ncbi A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects
    R Klootwijk
    Department of Human Genetics, University Medical Centre Nijmegen, The Netherlands
    Hum Mol Genet 9:1615-22. 2000
    ..These patients occasionally also show spina bifida, indicating that genetic variation in human ZIC3 may contribute to other congenital malformations, including neural tube defects...
  13. pmc Effects of maternal and paternal smoking on attentional control in children with and without ADHD
    Marieke E Altink
    Department of Psychiatry, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, P O Box 9101, HP 966, Nijmegen 6500 HB, The Netherlands
    Eur Child Adolesc Psychiatry 18:465-75. 2009
    ..Future studies should examine if the results can be generalized to other cognitive domains...
  14. ncbi The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  15. doi Gene expression profiling in rheumatoid arthritis: current concepts and future directions
    E J M Toonen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 67:1663-9. 2008
    ..We suggest that both sets of genes include interesting candidate genes for further study in RA...
  16. ncbi Further characterization of the genetic defect of the Bent tail mouse, a mouse model for human neural tube defects
    Riko Klootwijk
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 70:880-4. 2004
    ..More than 100 mouse models for human neural tube defects exist; Bent tail is one of them. The mouse mutant is caused by a submicroscopic deletion on Xq that completely encompasses the Zic3 gene...
  17. ncbi Spina bifida and genetic factors related to myo-inositol, glucose, and zinc
    P M W Groenen
    Department of Epidemiology and Biostatistics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Mol Genet Metab 82:154-61. 2004
    ..We investigated the biochemical concentrations of these nutrients and polymorphisms in the myo-inositol transporter SLC5A11, myo-inositol synthase ISYNA1, and zinc transporter SLC39A4 in association with spina bifida risk...
  18. doi Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
    M Verhagen
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 15:260-71. 2010
    ..Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. Future research into gender issues will be of interest...
  19. ncbi Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjects
    L Gerritsen
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Psychol Med 42:335-43. 2012
    ..Here, we studied whether memory bias is related to amygdala and hippocampal volume, two structures that are critical for emotional memory processes and that show consistent volume alterations in depression...
  20. doi The 22G>A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo
    Niels P Riksen
    Departments of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Pharmacogenet Genomics 18:843-6. 2008
    ..We hypothesized that the 22G>A polymorphism in the ADA gene inhibits its catalytic activity, and potentiates the protective effects of adenosine...
  21. ncbi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..We confirmed two known loci and identified four novel ones for shared CD-RA genetic risk. Most of the shared loci further emphasize a role for adaptive and innate immunity in these diseases...
  22. pmc AKAPs integrate genetic findings for autism spectrum disorders
    G Poelmans
    Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transl Psychiatry 3:e270. 2013
    ..In addition, our results point towards the AKAPs as promising targets for developing novel ASD treatments...
  23. doi BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects
    L Gerritsen
    Department of Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Psychiatry 17:597-603. 2012
    ..Given the key role of the subgenual ACC in emotion regulation, this finding provides an important mechanistic link between stress and BDNF on one hand and mood impairments on the other hand...
  24. doi The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study
    L Wouts
    Department of Psychiatry, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, The Netherlands
    Int J Geriatr Psychiatry 26:702-10. 2011
    ..In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life...
  25. doi The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus
    Bas J Schouwenberg
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Pharmacogenet Genomics 18:369-72. 2008
    ..Future studies are required to confirm these results in larger, independent populations...
  26. doi Differential association between MAOA, ADHD and neuropsychological functioning in boys and girls
    Nanda N J Rommelse
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1524-30. 2008
    ..01). These findings suggest that the genetic and neuropsychological mechanisms underlying ADHD may be different in boys and girls and underline the importance of taking into account sex effects when studying ADHD...
  27. doi A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD
    Nanda N J Rommelse
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1536-46. 2008
    ....
  28. pmc The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interaction
    Marieke E Altink
    Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, The Netherlands
    J Child Psychol Psychiatry 49:1053-60. 2008
    ....
  29. doi ADHD and poor motor performance from a family genetic perspective
    Ellen Fliers
    Bavo Europoort Youth Department, Twentestraat 52, 3083 BD Rotterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 48:25-34. 2009
    ....
  30. pmc Actual motor performance and self-perceived motor competence in children with attention-deficit hyperactivity disorder compared with healthy siblings and peers
    Ellen A Fliers
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Dev Behav Pediatr 31:35-40. 2010
    ..In this cross-sectional study, the relationship between actual motor performance and perceived motor competence was examined...
  31. ncbi Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans
    Riko Klootwijk
    Department of Human Genetics, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    Am J Med Genet A 124:40-7. 2004
    ..Neither mutations nor polymorphisms were found in the coding region or flanking sequences of ZIC1. Our data indicate that ZIC1, ZIC2, and ZIC3 are not major risk factors for NTD in humans...
  32. ncbi Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida
    Pascal M Groenen
    Department of Epidemiology and Biostatistics, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Obstet Gynecol 189:1713-9. 2003
    ..The purpose of this study was to investigate the maternal and children's myo-inositol, glucose, and zinc status in association with spina bifida risk...
  33. ncbi NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 34:2052-9. 2004
    ..In conclusion, defective NOD2 function results in a pro-inflammatory cytokine bias after stimulation of mononuclear cells with TLR2 stimuli, and this could contribute to the overwhelming inflammation seen in Crohn's disease...
  34. ncbi Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene
    Niels P Riksen
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Heart J 28:1085-91. 2007
    ..We hypothesized that in subjects with this variant allele, ischaemia-induced intracellular adenosine formation is increased, augmenting reactive hyperaemia and ischaemic tolerance...
  35. ncbi Cyclin D1 genotype and expression in sporadic hemangioblastomas
    Johanna M M Gijtenbeek
    Department of Neurology, Radboud University, Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Neurooncol 74:261-6. 2005
    ..We conclude that, whereas variable but sometimes high cyclin D1 expression is a feature of sporadic hemangioblastomas, CCND1 genotype is unlikely to be an important genetic modifier in the oncogenesis of these tumors...
  36. ncbi Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
    ..To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA)...
  37. pmc Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans
    Chantal A A Van der Graaf
    Department of Medicine, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Vaccine Immunol 13:423-5. 2006
    ..Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans...
  38. ncbi The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo
    Niels P Riksen
    Department of Pharmacology, Radboud University Nijmegen Medical Center, The Netherlands
    Pharmacogenet Genomics 17:551-4. 2007
    ..Therefore, this polymorphism does not contribute to the variation in the effects of adenosine receptor stimulation...
  39. ncbi The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 54:3828-37. 2006
    ..The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function...
  40. ncbi Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis
    Marieke J H Coenen
    Radboud University, Nijmegen Medical Centre, Department of Human Genetics, Internal Mail 855, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pharmacogenomics 8:761-73. 2007
    ..Nevertheless, replication and large prospective studies will be needed to demonstrate the validity of the identified genetic markers before implementation into daily clinical practice...
  41. pmc Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
    Nanda N J Rommelse
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen, The Netherlands
    Eur Child Adolesc Psychiatry 19:281-95. 2010
    ..Multivariate multi-level models are probably best suited for the statistical analysis...
  42. pmc Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome
    Marieke J H Coenen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Institute for Genetic and Metabolic Disease IGMD, Nijmegen, The Netherlands
    PLoS ONE 5:e14326. 2010
    ..We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication...
  43. ncbi No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease
    Dirk J de Jong
    Department of Gastroenterology and Hepatology, University Medical Center Nijmegen, The Netherlands
    Eur J Hum Genet 11:884-7. 2003
    ..From this we conclude that IL-4R and CD11B in the IBD1 region and STAT6 in the IBD2 region are not involved in Crohn's disease in this Dutch cohort...
  44. doi Cognitive flexibility depends on white matter microstructure of the basal ganglia
    M R van Schouwenburg
    Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, PO Box 9101, 6500 HB Nijmegen, The Netherlands Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, PO Box 9104, 6500 HE Nijmegen, The Netherlands Department of Neurology, University of California, San Francisco, CA 94158, USA Electronic address
    Neuropsychologia 53:171-7. 2014
    ..Our findings highlight the crucial role of the basal ganglia and the fronto-striato-thalamic circuit for cognitive flexibility. ..
  45. doi Attention deficit hyperactivity disorder (ADHD) and executive functioning in affected and unaffected adolescents and their parents: challenging the endophenotype construct
    A J A M Thissen
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands
    Psychol Med 44:881-92. 2014
    ....
  46. doi DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task
    D B Spronk
    Department of Psychiatry 966, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Neurophysiol 124:909-15. 2013
    ..The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and latency in an auditory oddball task...
  47. doi Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction
    C S van der Zwaluw
    Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Psychiatry 15:727-35. 2010
    ..The DRD2 genotype may pose an increased risk for alcohol use and abuse, depending on the presence of environmental risk factors, such as alcohol-specific parenting...
  48. doi The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis
    E J M Toonen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 67:1174-7. 2008
    ....
  49. ncbi Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Lambertus A Kiemeney
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Cancer 42:3219-27. 2006
    ..We studied the association between both polymorphisms and the risk of bladder cancer...
  50. ncbi Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a Dutch sib-pair collection
    Carolien G F de Kovel
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:294-300. 2008
    ..Comparison of our results and literature data shows that loci link to different phenotypes in different samples. The mutual connections of these traits and their relation to developmental dyslexia remain elusive...
  51. ncbi Motor coordination problems in children and adolescents with ADHD rated by parents and teachers: effects of age and gender
    E Fliers
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neural Transm 115:211-20. 2008
    ..Furthermore, we assessed whether the association between ADHD and motor coordination problems was comparable across ages and was similar for both genders...
  52. ncbi Familiality of major depressive disorder and gender differences in comorbidity
    M Verhagen
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Psychiatr Scand 118:130-8. 2008
    ..Gender differences exist in the prevalence and psychiatric comorbidity of major depressive disorder (MDD). This study investigates whether familiality of MDD contributes to observed gender differences in comorbidity...
  53. doi Depressive symptom clusters are differentially associated with atherosclerotic disease
    B A A Bus
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychol Med 41:1419-28. 2011
    ..While taking into account the differentiation between somatic-affective and cognitive-affective symptoms of depression, we examined the association between depression and atherosclerosis in a community-based sample...
  54. doi A theoretical molecular network for dyslexia: integrating available genetic findings
    G Poelmans
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 16:365-82. 2011
    ....
  55. doi The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuli
    Guido van Wingen
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Neuroimage 50:1212-8. 2010
    ..Furthermore, the sex-specific genotype effects may contribute to sex-specific effects of BDNF Val66Met on depression vulnerability...
  56. pmc Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging
    Esther Aarts
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:1943-51. 2010
    ..These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control...
  57. doi Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?
    Loes F M van der Zanden
    Department of Epidemiology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 95:2384-90. 2010
    ..Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in studies of small sample size. Most of these associations have not been replicated...
  58. doi Familiality of major depressive disorder and patterns of lifetime comorbidity. The NEMESIS and GenMood studies. A comparison of three samples
    Maaike Verhagen
    Department of Psychiatry 966, Radboud University Nijmegen Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    Eur Arch Psychiatry Clin Neurosci 258:505-12. 2008
    ..This study examined whether familiality of MDD is associated with the presence of specific comorbid disorders, which might be an important factor to be taken into account in MDD treatment and research into MDD etiology...
  59. doi Effect of the 5-HTTLPR polymorphism in the serotonin transporter gene on major depressive disorder and related comorbid disorders
    Maaike Verhagen
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychiatr Genet 19:39-44. 2009
    ..This could be because of the phenotypic heterogeneity of MDD, as it often presents with comorbid disorders such as generalized anxiety disorder (GAD), alcohol-related disorders, and dysthymia...
  60. doi Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review
    Carmen S van der Zwaluw
    Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    Pharmacogenomics 10:853-66. 2009
    ..We discuss shortcomings, such as lack of power and disregarding moderating variables, as well as future challenges of gene association studies...
  61. ncbi Allelic imbalance analysis using a single-nucleotide polymorphism microarray for the detection of bladder cancer recurrence
    Marieke J H Coenen
    Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 14:8198-204. 2008
    ..We investigated whether this method is suitable to detect allelic imbalance as an indicator of recurrences in non-muscle-invasive bladder cancer follow-up...
  62. pmc Acute stress modulates genotype effects on amygdala processing in humans
    Helena Cousijn
    Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 107:9867-72. 2010
    ..Our results demonstrate that genetic effects on brain operations can be state dependent, such that they only become apparent under specific, often environmentally controlled, conditions...
  63. ncbi Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida
    Ivon J M van der Linden
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mol Genet Metab 91:98-103. 2007
    ..73, p=0.09). We did not find evidence for an effect of the DHFR 19-bp deletion or 9-bp repeat on spina bifida risk in mothers and children. An effect of the 6/6 repeat genotype on DHFR expression cannot be ruled out...
  64. ncbi Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test
    Jessica Lasky-Su
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Biol Psychiatry 62:985-90. 2007
    ..We sought to replicate this finding by using the same methodology in an independent sample of ADHD individuals...
  65. ncbi Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice
    Jun Aruga
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 20:2159-67. 2004
    ..These findings may have some clinical implications in relation to disorders characterized by cerebellar dysgenesis, such as Joubert syndrome...
  66. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  67. ncbi Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis
    Behrooz Z Alizadeh
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 16:2552-9. 2007
    ..If replicated, our findings would suggest FcgRIIa*519G as a common risk factor for auto-immune diseases. This may have clinical implications with regard to efficacy or safety of antibody-based immuno-modulator therapies...
  68. ncbi Population differences in the International Multi-Centre ADHD Gene Project
    Benjamin M Neale
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genet Epidemiol 32:98-107. 2008
    ..Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations...
  69. pmc Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11
    Nanda N J Rommelse
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Hum Genet 83:99-105. 2008
    ..3 (LOD score: 2.878) overlapped with the region significantly linked to Motor Timing. Endophenotype approaches may increase power to detect susceptibility loci in ADHD and possibly in other complex disorders...
  70. ncbi Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
    Edmund J S Sonuga-Barke
    School of Psychology, University of Southampton, Southampton, UK
    Am J Med Genet B Neuropsychiatr Genet 147:316-9. 2008
    ..We also observed no association of other SNPs with IQ in ADHD...
  71. pmc Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases
    Alexandra Zhernakova
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 81:1284-8. 2007
    ..72 [95% CI 0.61-0.86]). Our results replicate and extend the association found in the KIAA1109/Tenr/IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases...
  72. ncbi Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia
    Chaidir A Mochtar
    Department of Urology G4 105 1, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    BJU Int 97:852-5. 2006
    ..There was a small effect on perceived quality of life but this was not reflected in other variables that measured the treatment response more directly...
  73. ncbi Many sequence variants affecting diversity of adult human height
    Daniel F Gudbjartsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:609-15. 2008
    ..Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene...
  74. ncbi Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans
    Carmen S van der Zwaluw
    Radboud University Nijmegen, Behavioural Science Institute, PO Box 9104, 6500 HE Nijmegen, The Netherlands
    Pharmacogenomics 8:1427-36. 2007
    ..Factors that complicate genetic research on alcohol dependence, such as gene-environment interaction, and genetic and clinical heterogeneity, are discussed...
  75. ncbi Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
    Philip Asherson
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, SE5 8AF UK
    Am J Psychiatry 164:674-7. 2007
    ....
  76. ncbi Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)
    J Sandra Kooij
    PsyQ, Psycho Medical Programs, The Hague, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:201-8. 2008
    ..The polymorphisms in DRD4 and the SLC6A2 were not associated with treatment response. This study supports a role of the SLC6A3 genotype in determining the response to MPH in the treatment of adults with ADHD...
  77. ncbi An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD
    A Marije Boonstra
    Department of Child Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:397-402. 2008
    ..Interestingly, the presence of the risk alleles in DRD4 and SLC6A3 was related to better cognitive performance. Our findings contribute to an improved understanding of the functional implications of risk genes for ADHD...
  78. ncbi The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia
    Hans Mulder
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Clin Psychopharmacol 27:338-43. 2007
    ..00-6.85]; OR, 4.09 [95% CI, 1.41-11.89]; and OR, 3.12 [95% CI, 1.13-8.16]), respectively. Our findings suggest that HTR2C genotypes are associated with antincreased risk of metabolic syndrome in patients taking antipsychotics...