Bart Ferwerda

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
    Oliver Kumpf
    Department of Anesthesiology, Intensive Care Medicine and Pain Management, HANSE Klinikum Stralsund, Grosse Parower Strasse 47 53, Stralsund 18435, Germany
    Crit Care 14:R103. 2010
  2. pmc Caspase-12 and the inflammatory response to Yersinia pestis
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e6870. 2009
  3. pmc Functional consequences of toll-like receptor 4 polymorphisms
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mol Med 14:346-52. 2008
  4. pmc Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 55:87-94. 2010
  5. pmc Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
    Bart Ferwerda
    Department of Internal Medicine and Nijmegen Institute for Infectious Inflammation and Immunity, Radboud University Nijmegen Medical Center, HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 106:10272-7. 2009
  6. ncbi Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Cytokine Netw 21:77-83. 2010
  7. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
  8. doi High variability of TLR4 gene in different ethnic groups in Iran
    Mihai Ioana
    Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Department of Medicine, Nijmegen, The Netherlands
    Innate Immun 18:492-502. 2012
  9. pmc TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 104:16645-50. 2007
  10. ncbi ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 80:492-8. 2009

Detail Information

Publications12

  1. pmc Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
    Oliver Kumpf
    Department of Anesthesiology, Intensive Care Medicine and Pain Management, HANSE Klinikum Stralsund, Grosse Parower Strasse 47 53, Stralsund 18435, Germany
    Crit Care 14:R103. 2010
    ....
  2. pmc Caspase-12 and the inflammatory response to Yersinia pestis
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e6870. 2009
    ..In African-Americans, it has been shown that caspase-12 inhibits the pro-inflammatory cytokine production...
  3. pmc Functional consequences of toll-like receptor 4 polymorphisms
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mol Med 14:346-52. 2008
    ..In addition, we review the geographical distribution of TLR4 polymorphisms and present a model for evolutionary pressures on the TLR4 genetic make-up...
  4. pmc Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 55:87-94. 2010
    ..We investigated whether genetic variations in the innate immune genes DECTIN-1, TLR2, TLR4, TIRAP, and CASPASE-12 are associated with the presence of OPC in HIV-infected subjects from East Africa...
  5. pmc Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
    Bart Ferwerda
    Department of Internal Medicine and Nijmegen Institute for Infectious Inflammation and Immunity, Radboud University Nijmegen Medical Center, HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 106:10272-7. 2009
    ..This combination of functional and genetic data provides unique insights to our understanding of the pathogenesis of sepsis...
  6. ncbi Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Cytokine Netw 21:77-83. 2010
    ..Strikingly, the L-allele is still widely prevalent in African populations, presumably due to a counterbalancing selective force specific to this continent, for which malaria is a prime candidate...
  7. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ....
  8. doi High variability of TLR4 gene in different ethnic groups in Iran
    Mihai Ioana
    Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Department of Medicine, Nijmegen, The Netherlands
    Innate Immun 18:492-502. 2012
    ..These findings suggest a weak, or absent, selection pressure on TLR4 polymorphisms in the Middle-East that does not support the assumption of an important role of these polymorphisms in the host defense against local pathogens...
  9. pmc TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 104:16645-50. 2007
    ....
  10. ncbi ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 80:492-8. 2009
    ....
  11. ncbi Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients
    Theo S Plantinga
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 49:724-32. 2009
    ....
  12. ncbi The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania
    Bart Ferwerda
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    AIDS 21:1375-7. 2007
    ..We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism...