Martin den Heijer

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy
    Piet Hein Jongbloet
    Department of Epidemiology, Biostatistics, and Health Technology Assessment, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Exp Clin Assist Reprod 5:5. 2008
  2. ncbi request reprint Homocysteine levels--before and after methionine loading--in 51 Dutch families
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 13:753-62. 2005
  3. ncbi request reprint Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:139-44. 2007
  4. ncbi request reprint Hyperhomocysteinaemia as a risk factor for venous thrombosis: an update of the current evidence
    Martin den Heijer
    Department of Endocrinology 531, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem Lab Med 41:1404-7. 2003
  5. ncbi request reprint Are B vitamins a risk factor for VTE? Perhaps
    M Den Heijer
    Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Thromb Haemost 4:309-11. 2006
  6. ncbi request reprint Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies
    M Den Heijer
    Department of Endocrinology 531, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Thromb Haemost 3:292-9. 2005
  7. ncbi request reprint MTRR 66A>G polymorphism in relation to congenital heart defects
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem Lab Med 44:1317-23. 2006
  8. ncbi request reprint Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thromb Haemost 98:1226-31. 2007
  9. ncbi request reprint Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study
    Anita C Peeters
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Vasc Surg 45:701-5. 2007
  10. ncbi request reprint Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis
    Miranda B A J Keijzer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thromb Haemost 96:492-7. 2006

Detail Information

Publications72

  1. pmc Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy
    Piet Hein Jongbloet
    Department of Epidemiology, Biostatistics, and Health Technology Assessment, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Exp Clin Assist Reprod 5:5. 2008
    ..These high-risk conditions may cause developmental anomalies and defective epigenetic reprogramming in progeny. The interaction between genetic and environmental factors is a plausible mechanism of multifactorial inheritance...
  2. ncbi request reprint Homocysteine levels--before and after methionine loading--in 51 Dutch families
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 13:753-62. 2005
    ..Further studies are needed to identify the genes responsible for the inheritance of postload homocysteine levels...
  3. ncbi request reprint Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:139-44. 2007
    ..65-1.98) in the hyperhomocysteinemic group and 0.58 (95% CI, 0.31-1.07) in the normohomocysteinemic group. The results of our study do not show that homocysteine lowering by B vitamin supplementation prevents recurrent venous thrombosis...
  4. ncbi request reprint Hyperhomocysteinaemia as a risk factor for venous thrombosis: an update of the current evidence
    Martin den Heijer
    Department of Endocrinology 531, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem Lab Med 41:1404-7. 2003
    ..The results of one homocysteine-lowering trial regarding venous thrombosis are awaited at the end of 2003. In this paper the current evidence for hyperhomocysteinaemia as a risk factor for venous thrombosis is being discussed...
  5. ncbi request reprint Are B vitamins a risk factor for VTE? Perhaps
    M Den Heijer
    Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Thromb Haemost 4:309-11. 2006
    ..Because homocysteine levels are strongly influenced by the intake and concentrations of B vitamins, it is worthwhile to assess the role of these vitamins as a risk factor for venous thrombosis...
  6. ncbi request reprint Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies
    M Den Heijer
    Department of Endocrinology 531, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Thromb Haemost 3:292-9. 2005
    ..It has been suggested that elevated total plasma homocysteine levels are associated with the risk of venous thrombosis...
  7. ncbi request reprint MTRR 66A>G polymorphism in relation to congenital heart defects
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem Lab Med 44:1317-23. 2006
    ..In addition, possible interaction between this variant and plasma methylmalonic acid (MMA) concentrations, as an indicator of intracellular vitamin B(12) status, was investigated...
  8. ncbi request reprint Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thromb Haemost 98:1226-31. 2007
    ..61 [95% CI 0.97 to 2.65], p = 0.06) compared to control subjects. We show that the COMT rs4680 variant modulates tHcy, and might be associated with venous thrombosis risk as well...
  9. ncbi request reprint Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study
    Anita C Peeters
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Vasc Surg 45:701-5. 2007
    ....
  10. ncbi request reprint Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis
    Miranda B A J Keijzer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thromb Haemost 96:492-7. 2006
    ..This risk association was stronger for methionine than for homocysteine or cysteine. This supports the hypothesis that impaired methylation may be involved in the pathogenesis of venous thrombosis...
  11. ncbi request reprint No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study
    Miranda B A J Keijzer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6525 GA Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Thromb Haemost 97:32-7. 2007
    ..23 (95%CI 0.72 to 2.11). Both the meta-analyses of published studies and a large case-only study did not show evidence for interaction between factor V Leiden and hyperhomocysteinemia for risk of venous thrombosis...
  12. ncbi request reprint Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk
    Karin J A Lievers
    Department of Pediatrics, PO Box 9101, University Medical Center Nijmegen, 6500 HB, Nijmegen, The Netherlands
    Atherosclerosis 164:269-73. 2002
    ....
  13. ncbi request reprint Methylmalonic acid values in healthy Dutch children
    Marije Hogeveen
    Dept of Paediatrics, Metabolic and Endocrine Diseases, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nutr 47:26-31. 2008
    ..This deficiency can give rise to non-specific but serious symptoms in childhood such as developmental delay, convulsions and failure to thrive and may even lead to irreversible neurological damage...
  14. doi request reprint Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects?
    Annenienke C van de Ven
    Department of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Thyroid 22:1236-43. 2012
    ..Thyrotoxicosis and hypothyroidism are associated with fatigue. Here we studied euthyroid subjects to determine if there was a relationship between serum thyrotropin (TSH), free thyroxine (FT(4)) and thyroperoxidase antibodies and fatigue...
  15. doi request reprint Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects
    Ingrid M van Beynum
    Children s Heart Center, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem Lab Med 46:1369-75. 2008
    ..eNOS-deficient mice have impaired cardiac development resulting in congenital heart defects (CHDs). In humans, a single nucleotide polymorphism in the gene coding for eNOS (894G>T) is associated with birth defects...
  16. ncbi request reprint Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis
    Miranda B A J Keijzer
    Department of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Thromb Haemost 88:723-8. 2002
    ..7 (95% CI: 3.3 to 108). We conclude that hyperhomocysteinemia and factor V Leiden are risk factors for recurrent venous thrombosis. The risk of thrombosis appeared high for individuals who had both risk factors...
  17. ncbi request reprint Cystathionine beta-synthase polymorphisms and hyperhomocysteinaemia: an association study
    Karin J A Lievers
    Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, The Netherlands
    Eur J Hum Genet 11:23-9. 2003
    ..In conclusion, we did not find any indication that genetic variation in the CBS gene is associated with increased homocysteine concentrations...
  18. ncbi request reprint Elevated leptin levels in subjects with familial combined hyperlipidemia are associated with the increased risk for CVD
    Gerly M van der Vleuten
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 183:355-60. 2005
    ..These increased leptin levels are associated with an increased risk for CVD both in FCH patients and non-FCH subjects, independent of BMI, insulin resistance and gender...
  19. pmc A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C
    Judith G M Bergboer
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS ONE 7:e32045. 2012
    ..We aimed to replicate these studies in a large Dutch cohort...
  20. doi request reprint Underestimation of effect of thyroid function parameters on morbidity and mortality due to intra-individual variation
    Annenienke C van de Ven
    Department of Endocrinology 471, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 96:E2014-7. 2011
    ....
  21. ncbi request reprint The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
    Anita C T M Peeters
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem Lab Med 45:54-8. 2007
    ....
  22. doi request reprint Polymorphisms in the H19 gene and the risk of bladder cancer
    Gerald W Verhaegh
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 54:1118-26. 2008
    ..In this study we examined whether sequence variants within the H19 gene are associated with the risk of developing bladder cancer...
  23. ncbi request reprint Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida
    Ivon J M van der Linden
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mol Genet Metab 91:98-103. 2007
    ..73, p=0.09). We did not find evidence for an effect of the DHFR 19-bp deletion or 9-bp repeat on spina bifida risk in mothers and children. An effect of the 6/6 repeat genotype on DHFR expression cannot be ruled out...
  24. ncbi request reprint The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida
    Ivon J M van der Linden
    Laboratory of Pediatrics and Neurology 830, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Mol Med (Berl) 84:1047-54. 2006
    ..96, 95% CI 0.46-2.01). These data show that the MTRR 66GG genotype is a maternal risk factor for spina bifida especially when intracellular vitamin B12 status is low...
  25. ncbi request reprint Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study
    Jan Willem Muntjewerff
    GGz Nijmegen, Mental Health Institute, Nijmegen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 135:69-72. 2005
    ..91-1.8]. Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia. These observations support a causal relation between disturbed homocysteine metabolism and schizophrenia...
  26. doi request reprint Serum hepcidin: reference ranges and biochemical correlates in the general population
    Tessel E Galesloot
    Department of Epidemiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 117:e218-25. 2011
    ..Our study provides age- and sex-specific reference ranges of serum hepcidin concentration and indicates ferritin as the primary correlate of serum hepcidin concentration...
  27. doi request reprint Application and validation of a diagnostic algorithm for the atherogenic apoB dyslipoproteinemias: ApoB dyslipoproteinemias in a Dutch population-based study
    Suzanne Holewijn
    Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Clin Invest 41:423-33. 2011
    ..We also characterized the overall cardiovascular (CV) risk profiles, including arterial structure and function as measured with a panel of noninvasive parameters...
  28. pmc The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk
    Ivon J M van der Linden
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Hum Genet 52:516-20. 2007
    ..55-13.22 and OR 3.38, 95%CI 1.46-7.84, respectively). In our study population, the NOS3 894GT/TT genotype might be a risk factor for having a spina bifida affected child in mothers who already have an impaired homocysteine metabolism...
  29. ncbi request reprint Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors
    Mirian C H Janssen
    Department of General Internal Medicine 591, Radboud University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Thromb Haemost 93:1021-6. 2005
    ..The minor effect of factor V Leiden mutation and the protrombin gene mutation (risk factors for venous thrombosis only) suggests that atherosclerosis might be an important factor in the development of CRVO...
  30. ncbi request reprint Genetic determinants of plasma total homocysteine
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology 424, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Semin Vasc Med 5:98-109. 2005
    ..In the last section, we summarize the polymorphisms, for which the obtained data provides evidence for their involvement in Hhcy at the population level, and discuss how to continue our search for genetic determinants of tHcy...
  31. ncbi request reprint No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease risk
    Miranda B A Keijzer
    Dept of Endocrinology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    Thromb Haemost 95:380-5. 2006
    ..The methionine loading test has no added value next to measuring fasting homocysteine levels for identifying subjects at risk for venous thrombosis or cardiovascular disease and for that reason should not be used in clinical practice...
  32. pmc Neural tube defects and folate: case far from closed
    Henk J Blom
    Laboratory of Pediatrics and Neurology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Neurosci 7:724-31. 2006
    ..Exploring the methylation hypothesis could direct us towards additional strategies to prevent neural tube defects...
  33. doi request reprint Maternal homocysteine and related B vitamins as risk factors for low birthweight
    Marije Hogeveen
    Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Am J Obstet Gynecol 202:572.e1-6. 2010
    ..We designed a large prospective study to explore the relationship between maternal homocysteine concentrations and related B vitamins and birthweight...
  34. doi request reprint Composite reference interval for thyroid-stimulating hormone and free thyroxine, comparison with common cutoff values, and reconsideration of subclinical thyroid disease
    H Alec Ross
    Department of Chemical Endocrinology and Department of Endocrinology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Chem 55:2019-25. 2009
    ..We desired to establish and critically evaluate a composite reference interval for TSH and FT(4) to allow bivariate classification of biochemical thyroid conditions...
  35. doi request reprint An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 85:216-26. 2009
    ..5 to 12 per 1000 births globally. In this article we attempt to identify genes related to folate and its metabolic pathways that are involved in the etiology of spina bifida...
  36. ncbi request reprint Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem Lab Med 45:471-6. 2007
    ..Genetic variation in folate-metabolizing genes may affect folate availability and hence confer a greater risk of venous thrombosis...
  37. doi request reprint Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study
    Tessel E Galesloot
    Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Med Genet 50:593-8. 2013
    ..We report here the second study to investigate the role of hepcidin in the associations between common variants in HFE and TMPRSS6 with iron parameters...
  38. pmc Serum brain-derived neurotrophic factor: determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people
    Boudewijn A A Bus
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    World J Biol Psychiatry 13:39-47. 2012
    ..We explored potential determinants of serum BDNF levels in a community sample of 1230 subjects...
  39. doi request reprint Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    Eur Heart J 31:464-71. 2010
    ..To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations...
  40. doi request reprint Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis
    Judith G M Bergboer
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 130:2057-61. 2010
    ..Subgroup analysis did not reveal an association with concomitant asthma. Our data suggest that the potential roles of skin barrier defects in the pathogenesis of AD and psoriasis are based on distinct genetic causes...
  41. ncbi request reprint Total homocysteine and its predictors in Dutch children
    Ingrid M van Beynum
    Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Am J Clin Nutr 81:1110-6. 2005
    ..Limited data are available about the influence of these factors on tHcy in children...
  42. doi request reprint Adiponectin multimer distribution in patients with familial combined hyperlipidemia
    Tim B Koenen
    Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochem Biophys Res Commun 376:164-8. 2008
    ..2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution...
  43. ncbi request reprint Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, The Netherlands
    Eur J Hum Genet 12:942-8. 2004
    ..27 (95% CI 0.55-2.94), whereas the -34CT genotype confers a risk of 1.25 (95% CI 0.44-3.52) compared with the wild-type genotype at this locus. However, the wide confidence intervals do not allow firm conclusions to be drawn...
  44. ncbi request reprint Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation
    Ingrid M van Beynum
    Children s Heart Centre, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Eur Heart J 27:981-7. 2006
    ..We studied the association between MTHFR 677C > T variants and CHD risk. The interaction with periconceptional folate supplementation was also investigated...
  45. doi request reprint Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight
    Marije Hogeveen
    Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Pediatr Res 73:783-7. 2013
    ..Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development. We examined whether choline, betaine, and dimethylglycine (DMG) concentrations were associated with LBW in Dutch women...
  46. doi request reprint High-sensitive radioimmunoassay for human serum hepcidin
    Nicolai Grebenchtchikov
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Haematol 146:317-25. 2009
    ....
  47. ncbi request reprint Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels
    Henkjan Gellekink
    Laboratory of Paediatrics and Neurology, Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 15:103-9. 2007
    ..The 19-bp del/del genotype was associated with a lower plasma tHcy (-14.4% [95% confidence interval: -23.5 to -4.5], P=0.006) compared with the wild-type genotype. This may suggest that intracellular folate levels are affected...
  48. doi request reprint Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia
    Jan Willem Muntjewerff
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur Neuropsychopharmacol 21:300-5. 2011
    ..There was no evidence for interaction between MTHFR 677TT genotype and winter birth in the development of schizophrenia...
  49. ncbi request reprint The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study
    Edith M Roumen-Klappe
    Department of General Internal Medicine, University Medical Centre, Nijmegen, The Netherlands
    Thromb Haemost 94:825-30. 2005
    ..Moreover, measurement of TS, VOR and reflux three months after DVT could predict, with reasonable accuracy, the risk of PTS after one year of follow-up...
  50. ncbi request reprint Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk?
    Sandra G Heil
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem Lab Med 46:655-9. 2008
    ....
  51. ncbi request reprint Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients
    Karin J A Lievers
    Departments of Pediatrics, Division of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1383-9. 2002
    ....
  52. ncbi request reprint The effect of homocysteine reduction by B-vitamin supplementation on markers of endothelial dysfunction
    Anita C T M Peeters
    Department of Endocrinology, University Medical Centre Nijmegen, The Netherlands
    Thromb Haemost 92:1086-91. 2004
    ..In conclusion, the results of our study show that homocysteine reduction by B-vitamin supplementation has no effect on markers of endothelial dysfunction in healthy volunteers...
  53. doi request reprint The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosis
    Karlijn Peffer
    Department of Donor Studies, Sanquin Research, Nijmegen, The Netherlands
    Transfusion 53:1468-74. 2013
    ..Even within blood donors, differences in stored iron are observed. This study investigates whether increasing lifetime number of donations decreases the extent of subclinical atherosclerosis within blood donors...
  54. doi request reprint Introduction of the CKD-EPI equation to estimate glomerular filtration rate in a Caucasian population
    Jan A J G van den Brand
    Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nephrol Dial Transplant 26:3176-81. 2011
    ..Here, we assess consequences of introducing the CKD-EPI equation in a West European Caucasian population...
  55. pmc Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis
    Calin Popa
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1503-7. 2007
    ..In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients...
  56. doi request reprint Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidism
    Kim Freriks
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Head Neck 32:1328-35. 2010
    ..In renal hyperparathyroidism, it remains unclear whether intraoperative parathyroid hormone (PTH) measurements can predict postoperative outcome and guide the extent of surgical exploration...
  57. doi request reprint The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis
    Suzanne Holewijn
    Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Endocrinol Metab 94:2893-9. 2009
    ..Furthermore, we determined the impact of three different definitions of the MetS...
  58. ncbi request reprint Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer
    Lambertus A Kiemeney
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Cancer 42:3219-27. 2006
    ..We studied the association between both polymorphisms and the risk of bladder cancer...
  59. ncbi request reprint Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X
    Manon C Zweers
    Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Circulation 113:1702-7. 2006
    ..In this study, we investigated whether tenascin-X is present in normal human aorta and abdominal aortic aneurysm (AAA) tissues and whether an association exists between serum tenascin-X levels and AAA...
  60. doi request reprint Inhibition of methylation and changes in gene expression in relation to neural tube defects
    Ivon J M van der Linden
    The Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Birth Defects Res A Clin Mol Teratol 82:676-83. 2008
    ..In the present study, we therefore examined differential gene expression between Adox-treated and control chick embryos, using the Affymetrix Genechip Chicken Genome Array...
  61. ncbi request reprint Sequential balancing: a simple method for treatment allocation in clinical trials
    George Florimond Borm
    Radboud University Nijmegen Medical Centre, Netherlands
    Contemp Clin Trials 26:637-45. 2005
    ..If there are more than four factors, the sequential balancing method may still be an acceptable option, but the advantage of simplicity has to be weighed against the loss of performance compared to other minimisation methods...
  62. doi request reprint Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome
    Kim Freriks
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Eur J Endocrinol 168:91-9. 2013
    ..06) did not, at the cost of deceleration of breast development and mild virilization. The aim of this follow-up study in adult participants of the pediatric trial was to investigate the long-term effects of previous Ox treatment...
  63. doi request reprint Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer
    Ruben G Cremers
    Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Cancer 46:3294-9. 2010
    ..A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages and PC in a large case-control study...
  64. ncbi request reprint Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma
    Henkjan Gellekink
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 51:1487-92. 2005
    ..We aimed to develop a rapid and sensitive method to measure AdoHcy and its precursor S-adenosylmethionine (AdoMet)...
  65. ncbi request reprint Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection
    Chantal A A Van der Graaf
    Department of Internal Medicine 463, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 17:29-34. 2006
    ..These findings show that the TLR4 Asp299Gly/Thr399Ile polymorphisms are associated with an increased susceptibility to Candida bloodstream infections, and an increased production of IL-10 is probably involved in this effect...
  66. doi request reprint Subclinical hypothyroidism after vascular complicated pregnancy
    Moniek van der Zanden
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hypertens Pregnancy 32:1-10. 2013
    ..008). Conclusion. In this cohort, subclinical hypothyroidism is more common after very preterm delivery. It may contribute to the elevated risk of remote cardiovascular disease...
  67. ncbi request reprint Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile
    Gerly M van der Vleuten
    Department of Medicine and Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Lipid Res 46:2398-404. 2005
    ..This finding implies a role of adipose tissue metabolism in the pathophysiology of FCH...
  68. ncbi request reprint Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex
    Elizabeth H Hoogendoorn
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 52:104-11. 2006
    ..We present a large European population-based study of thyroid function, performed in a population with longstanding borderline sufficient iodine intake...
  69. doi request reprint Trends in incidence and mortality of thyroid carcinoma in The Netherlands between 1989 and 2003: correlation with thyroid fine-needle aspiration cytology and thyroid surgery
    Romana T Netea-Maier
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 123:1681-4. 2008
    ..The mortality rates decreased by 2.3% per year (p = 0.01). The decrease in incidence of both follicular and anaplastic TC is assumed to be largely responsible for the decrease in TC mortality rates...
  70. doi request reprint Publication bias was not a good reason to discourage trials with low power
    George F Borm
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Epidemiol 62:47.e1-10. 2009
    ..However, such an analysis may be biased, because trials with low power are likely to have a nonsignificant result and are less likely to be published than trials with a statistically significant outcome...
  71. pmc Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin
    Patrick A M Jansen
    Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4725. 2009
    ....
  72. ncbi request reprint Inflammatory response in the acute phase of deep vein thrombosis
    Edith M Roumen-Klappe
    Department of General Internal Medicine, University Medical Center Nijmegen, The Netherlands
    J Vasc Surg 35:701-6. 2002
    ..Deep vein thrombosis (DVT) is a multifactorial disease. Recently, inflammation has been suggested as a risk factor for DVT. The question is whether inflammation is a cause of venous thrombosis or rather a result of the thrombotic process...