Research Topics
Genomes and Genes
| Martin den HeijerSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathyPiet Hein Jongbloet
Department of Epidemiology, Biostatistics, and Health Technology Assessment, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
J Exp Clin Assist Reprod 5:5. 2008..These high-risk conditions may cause developmental anomalies and defective epigenetic reprogramming in progeny. The interaction between genetic and environmental factors is a plausible mechanism of multifactorial inheritance...
Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studiesM Den Heijer
Department of Endocrinology 531, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Thromb Haemost 3:292-9. 2005..It has been suggested that elevated total plasma homocysteine levels are associated with the risk of venous thrombosis...- Are B vitamins a risk factor for VTE? PerhapsM Den Heijer
Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Thromb Haemost 4:309-11. 2006..Because homocysteine levels are strongly influenced by the intake and concentrations of B vitamins, it is worthwhile to assess the role of these vitamins as a risk factor for venous thrombosis... - Homocysteine levels--before and after methionine loading--in 51 Dutch familiesMartin den Heijer
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Hum Genet 13:753-62. 2005..Further studies are needed to identify the genes responsible for the inheritance of postload homocysteine levels... - Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trialMartin den Heijer
Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Blood 109:139-44. 2007..65-1.98) in the hyperhomocysteinemic group and 0.58 (95% CI, 0.31-1.07) in the normohomocysteinemic group. The results of our study do not show that homocysteine lowering by B vitamin supplementation prevents recurrent venous thrombosis... - Hyperhomocysteinaemia as a risk factor for venous thrombosis: an update of the current evidenceMartin den Heijer
Department of Endocrinology 531, University Medical Center Nijmegen, Nijmegen, The Netherlands
Clin Chem Lab Med 41:1404-7. 2003..The results of one homocysteine-lowering trial regarding venous thrombosis are awaited at the end of 2003. In this paper the current evidence for hyperhomocysteinaemia as a risk factor for venous thrombosis is being discussed... - MTRR 66A>G polymorphism in relation to congenital heart defectsIngrid M van Beynum
Children s Heart Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Chem Lab Med 44:1317-23. 2006..In addition, possible interaction between this variant and plasma methylmalonic acid (MMA) concentrations, as an indicator of intracellular vitamin B(12) status, was investigated... - Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis riskHenkjan Gellekink
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Thromb Haemost 98:1226-31. 2007..61 [95% CI 0.97 to 2.65], p = 0.06) compared to control subjects. We show that the COMT rs4680 variant modulates tHcy, and might be associated with venous thrombosis risk as well... - Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control studyAnita C Peeters
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Vasc Surg 45:701-5. 2007.... - Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosisMiranda B A J Keijzer
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Thromb Haemost 96:492-7. 2006..This risk association was stronger for methionine than for homocysteine or cysteine. This supports the hypothesis that impaired methylation may be involved in the pathogenesis of venous thrombosis... - No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only studyMiranda B A J Keijzer
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6525 GA Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Thromb Haemost 97:32-7. 2007..23 (95%CI 0.72 to 2.11). Both the meta-analyses of published studies and a large case-only study did not show evidence for interaction between factor V Leiden and hyperhomocysteinemia for risk of venous thrombosis... - Methylmalonic acid values in healthy Dutch childrenMarije Hogeveen
Dept of Paediatrics, Metabolic and Endocrine Diseases, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur J Nutr 47:26-31. 2008..This deficiency can give rise to non-specific but serious symptoms in childhood such as developmental delay, convulsions and failure to thrive and may even lead to irreversible neurological damage... - Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease riskKarin J A Lievers
Department of Pediatrics, PO Box 9101, University Medical Center Nijmegen, 6500 HB, Nijmegen, The Netherlands
Atherosclerosis 164:269-73. 2002.... - Elevated leptin levels in subjects with familial combined hyperlipidemia are associated with the increased risk for CVDGerly M van der Vleuten
Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Atherosclerosis 183:355-60. 2005..These increased leptin levels are associated with an increased risk for CVD both in FCH patients and non-FCH subjects, independent of BMI, insulin resistance and gender... - Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defectsIngrid M van Beynum
Children s Heart Center, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Chem Lab Med 46:1369-75. 2008..eNOS-deficient mice have impaired cardiac development resulting in congenital heart defects (CHDs). In humans, a single nucleotide polymorphism in the gene coding for eNOS (894G>T) is associated with birth defects... - Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosisMiranda B A J Keijzer
Department of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
Thromb Haemost 88:723-8. 2002..7 (95% CI: 3.3 to 108). We conclude that hyperhomocysteinemia and factor V Leiden are risk factors for recurrent venous thrombosis. The risk of thrombosis appeared high for individuals who had both risk factors... - Cystathionine beta-synthase polymorphisms and hyperhomocysteinaemia: an association studyKarin J A Lievers
Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, The Netherlands
Eur J Hum Genet 11:23-9. 2003..In conclusion, we did not find any indication that genetic variation in the CBS gene is associated with increased homocysteine concentrations... - Underestimation of Effect of Thyroid Function Parameters on Morbidity and Mortality due to Intra-Individual VariationAnnenienke C van de Ven
Department of Endocrinology 471, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
J Clin Endocrinol Metab 96:E2014-7. 2011..The true association will be about 33% (1/0.75) higher for studies with a follow-up time of 2-4 yr... - The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markersAnita C T M Peeters
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Chem Lab Med 45:54-8. 2007.... - Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifidaIvon J M van der Linden
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Mol Genet Metab 91:98-103. 2007..73, p=0.09). We did not find evidence for an effect of the DHFR 19-bp deletion or 9-bp repeat on spina bifida risk in mothers and children. An effect of the 6/6 repeat genotype on DHFR expression cannot be ruled out... - Polymorphisms in the H19 gene and the risk of bladder cancerGerald W Verhaegh
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Urol 54:1118-26. 2008..In this study we examined whether sequence variants within the H19 gene are associated with the risk of developing bladder cancer... - A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3CJudith G M Bergboer
Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
PLoS ONE 7:e32045. 2012..We aimed to replicate these studies in a large Dutch cohort... - The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifidaIvon J M van der Linden
Laboratory of Pediatrics and Neurology 830, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Mol Med (Berl) 84:1047-54. 2006..96, 95% CI 0.46-2.01). These data show that the MTRR 66GG genotype is a maternal risk factor for spina bifida especially when intracellular vitamin B12 status is low... - No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease riskMiranda B A Keijzer
Dept. of Endocrinology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
Thromb Haemost 95:380-5. 2006..The methionine loading test has no added value next to measuring fasting homocysteine levels for identifying subjects at risk for venous thrombosis or cardiovascular disease and for that reason should not be used in clinical practice... - Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factorsMirian C H Janssen
Department of General Internal Medicine 591, Radboud University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Thromb Haemost 93:1021-6. 2005..The minor effect of factor V Leiden mutation and the protrombin gene mutation (risk factors for venous thrombosis only) suggests that atherosclerosis might be an important factor in the development of CRVO... 
The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida riskIvon J M van der Linden
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Hum Genet 52:516-20. 2007..55-13.22 and OR 3.38, 95%CI 1.46-7.84, respectively). In our study population, the NOS3 894GT/TT genotype might be a risk factor for having a spina bifida affected child in mothers who already have an impaired homocysteine metabolism...
Application and validation of a diagnostic algorithm for the atherogenic apoB dyslipoproteinemias: ApoB dyslipoproteinemias in a Dutch population-based studySuzanne Holewijn
Department of General Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Clin Invest 41:423-33. 2011..We also characterized the overall cardiovascular (CV) risk profiles, including arterial structure and function as measured with a panel of noninvasive parameters...- Serum hepcidin: reference ranges and biochemical correlates in the general populationTessel E Galesloot
Department of Epidemiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Blood 117:e218-25. 2011..Our study provides age- and sex-specific reference ranges of serum hepcidin concentration and indicates ferritin as the primary correlate of serum hepcidin concentration... - Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control studyJan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute, Nijmegen, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 135:69-72. 2005..91-1.8]. Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia. These observations support a causal relation between disturbed homocysteine metabolism and schizophrenia... - Genetic determinants of plasma total homocysteineHenkjan Gellekink
Laboratory of Pediatrics and Neurology (424, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Semin Vasc Med 5:98-109. 2005..In the last section, we summarize the polymorphisms, for which the obtained data provides evidence for their involvement in Hhcy at the population level, and discuss how to continue our search for genetic determinants of tHcy... - Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects?Annenienke C van de Ven
1 Department of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Thyroid 22:1236-43. 2012..The reasons for this are unclear, but subtle abnormalities in the dynamics of thyroid hormone secretion should be considered... - An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)Barbara Franke
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Birth Defects Res A Clin Mol Teratol 85:216-26. 2009..5 to 12 per 1000 births globally. In this article we attempt to identify genes related to folate and its metabolic pathways that are involved in the etiology of spina bifida... - Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis Henkjan Gellekink
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Chem Lab Med 45:471-6. 2007..Genetic variation in folate-metabolizing genes may affect folate availability and hence confer a greater risk of venous thrombosis... - Neural tube defects and folate: case far from closedHenk J Blom
Laboratory of Pediatrics and Neurology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, The Netherlands
Nat Rev Neurosci 7:724-31. 2006..Exploring the methylation hypothesis could direct us towards additional strategies to prevent neural tube defects... - Composite reference interval for thyroid-stimulating hormone and free thyroxine, comparison with common cutoff values, and reconsideration of subclinical thyroid diseaseH Alec Ross
Department of Chemical Endocrinology and Department of Endocrinology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Clin Chem 55:2019-25. 2009..We desired to establish and critically evaluate a composite reference interval for TSH and FT(4) to allow bivariate classification of biochemical thyroid conditions... - Maternal homocysteine and related B vitamins as risk factors for low birthweightMarije Hogeveen
Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Am J Obstet Gynecol 202:572.e1-6. 2010..We designed a large prospective study to explore the relationship between maternal homocysteine concentrations and related B vitamins and birthweight... - Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern NetherlandsIngrid M van Beynum
Children s Heart Centre, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
Eur Heart J 31:464-71. 2010..To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations... - Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementationIngrid M van Beynum
Children s Heart Centre, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Eur Heart J 27:981-7. 2006..We studied the association between MTHFR 677C > T variants and CHD risk. The interaction with periconceptional folate supplementation was also investigated... - Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitisJudith G M Bergboer
Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Invest Dermatol 130:2057-61. 2010..Subgroup analysis did not reveal an association with concomitant asthma. Our data suggest that the potential roles of skin barrier defects in the pathogenesis of AD and psoriasis are based on distinct genetic causes... - Total homocysteine and its predictors in Dutch childrenIngrid M van Beynum
Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Am J Clin Nutr 81:1110-6. 2005..Limited data are available about the influence of these factors on tHcy in children... - Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosisHenkjan Gellekink
Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, The Netherlands
Eur J Hum Genet 12:942-8. 2004..27 (95% CI 0.55-2.94), whereas the -34CT genotype confers a risk of 1.25 (95% CI 0.44-3.52) compared with the wild-type genotype at this locus. However, the wide confidence intervals do not allow firm conclusions to be drawn... - Adiponectin multimer distribution in patients with familial combined hyperlipidemiaTim B Koenen
Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Biochem Biophys Res Commun 376:164-8. 2008..2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution... - Effects of season of birth and a common MTHFR gene variant on the risk of schizophreniaJan Willem Muntjewerff
Department of Psychiatry, Radboud University Nijmegen Medical Centre, The Netherlands
Eur Neuropsychopharmacol 21:300-5. 2011..There was no evidence for interaction between MTHFR 677TT genotype and winter birth in the development of schizophrenia... - The effect of homocysteine reduction by B-vitamin supplementation on markers of endothelial dysfunctionAnita C T M Peeters
Department of Endocrinology, University Medical Centre Nijmegen, The Netherlands
Thromb Haemost 92:1086-91. 2004..In conclusion, the results of our study show that homocysteine reduction by B-vitamin supplementation has no effect on markers of endothelial dysfunction in healthy volunteers... - High-sensitive radioimmunoassay for human serum hepcidinNicolai Grebenchtchikov
Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Br J Haematol 146:317-25. 2009.... - Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patientsKarin J A Lievers
Departments of Pediatrics, Division of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
Clin Chem 48:1383-9. 2002.... - Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk?Sandra G Heil
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Chem Lab Med 46:655-9. 2008.... - Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levelsHenkjan Gellekink
Laboratory of Paediatrics and Neurology, Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Hum Genet 15:103-9. 2007..The 19-bp del/del genotype was associated with a lower plasma tHcy (-14.4% [95% confidence interval: -23.5 to -4.5], P=0.006) compared with the wild-type genotype. This may suggest that intracellular folate levels are affected... - The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up studyEdith M Roumen-Klappe
Department of General Internal Medicine, University Medical Centre, Nijmegen, The Netherlands
Thromb Haemost 94:825-30. 2005..Moreover, measurement of TS, VOR and reflux three months after DVT could predict, with reasonable accuracy, the risk of PTS after one year of follow-up... - Introduction of the CKD-EPI equation to estimate glomerular filtration rate in a Caucasian populationJan A J G van den Brand
Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Nephrol Dial Transplant 26:3176-81. 2011..Here, we assess consequences of introducing the CKD-EPI equation in a West European Caucasian population... - Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidismKim Freriks
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Head Neck 32:1328-35. 2010..In renal hyperparathyroidism, it remains unclear whether intraoperative parathyroid hormone (PTH) measurements can predict postoperative outcome and guide the extent of surgical exploration... - Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-XManon C Zweers
Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
Circulation 113:1702-7. 2006..In this study, we investigated whether tenascin-X is present in normal human aorta and abdominal aortic aneurysm (AAA) tissues and whether an association exists between serum tenascin-X levels and AAA... - Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancerLambertus A Kiemeney
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur J Cancer 42:3219-27. 2006..We studied the association between both polymorphisms and the risk of bladder cancer... - The metabolic syndrome and its traits as risk factors for subclinical atherosclerosisSuzanne Holewijn
Department of General Internal Medicine 463, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Clin Endocrinol Metab 94:2893-9. 2009..Furthermore, we determined the impact of three different definitions of the MetS... - Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritisCalin Popa
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Rheum Dis 66:1503-7. 2007..In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients... - Inhibition of methylation and changes in gene expression in relation to neural tube defectsIvon J M van der Linden
The Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Birth Defects Res A Clin Mol Teratol 82:676-83. 2008..In the present study, we therefore examined differential gene expression between Adox-treated and control chick embryos, using the Affymetrix Genechip Chicken Genome Array... - Sequential balancing: a simple method for treatment allocation in clinical trialsGeorge Florimond Borm
Radboud University Nijmegen Medical Centre, Netherlands
Contemp Clin Trials 26:637-45. 2005..If there are more than four factors, the sequential balancing method may still be an acceptable option, but the advantage of simplicity has to be weighed against the loss of performance compared to other minimisation methods... - Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasmaHenkjan Gellekink
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Chem 51:1487-92. 2005..The SPE columns enable simple cleanup, and no metabolite derivatization is needed. The instability of AdoMet is a serious problem and can be prevented easily by immediate acidification of samples... - Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancerRuben G Cremers
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands
Eur J Cancer 46:3294-9. 2010..A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages and PC in a large case-control study... - Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infectionChantal A A Van der Graaf
Department of Internal Medicine 463, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Cytokine Netw 17:29-34. 2006..These findings show that the TLR4 Asp299Gly/Thr399Ile polymorphisms are associated with an increased susceptibility to Candida bloodstream infections, and an increased production of IL-10 is probably involved in this effect... - Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sexElizabeth H Hoogendoorn
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Chem 52:104-11. 2006..We present a large European population-based study of thyroid function, performed in a population with longstanding borderline sufficient iodine intake... - Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profileGerly M van der Vleuten
Department of Medicine and Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Lipid Res 46:2398-404. 2005..This finding implies a role of adipose tissue metabolism in the pathophysiology of FCH... - Trends in incidence and mortality of thyroid carcinoma in The Netherlands between 1989 and 2003: correlation with thyroid fine-needle aspiration cytology and thyroid surgeryRomana T Netea-Maier
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Cancer 123:1681-4. 2008..The mortality rates decreased by 2.3% per year (p = 0.01). The decrease in incidence of both follicular and anaplastic TC is assumed to be largely responsible for the decrease in TC mortality rates... - Publication bias was not a good reason to discourage trials with low powerGeorge F Borm
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Clin Epidemiol 62:47.e1-10. 2009..However, such an analysis may be biased, because trials with low power are likely to have a nonsignificant result and are less likely to be published than trials with a statistically significant outcome... - Inflammatory response in the acute phase of deep vein thrombosisEdith M Roumen-Klappe
Department of General Internal Medicine, University Medical Center Nijmegen, The Netherlands
J Vasc Surg 35:701-6. 2002..Deep vein thrombosis (DVT) is a multifactorial disease. Recently, inflammation has been suggested as a risk factor for DVT. The question is whether inflammation is a cause of venous thrombosis or rather a result of the thrombotic process... - Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skinPatrick A M Jansen
Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 4:e4725. 2009....