H L Claahsen-van der Grinten

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint [From gene to disease: adrenogenital syndrome and the CYP21A2 gene]
    H L Claahsen-van der Grinten
    Universitair Medisch Centrum St Radboud, Postbus 90ioi, 6500o HB Nijmegen
    Ned Tijdschr Geneeskd 151:1174-7. 2007
  2. ncbi request reprint Ovarian adrenal rest tissue in congenital adrenal hyperplasia--a patient report
    H L Claahsen-van der Grinten
    Department of Metabolic and Endocrine Disease and Radboud University, Nijmegen Medical Center, The Netherlands
    J Pediatr Endocrinol Metab 19:177-82. 2006
  3. pmc Testicular adrenal rest tumours in congenital adrenal hyperplasia
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology 833, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Int J Pediatr Endocrinol 2009:624823. 2009
  4. pmc Physical, social and societal functioning of children with congenital adrenal hyperplasia (CAH) and their parents, in a Dutch population
    Sarita A Sanches
    Netherlands Institute for Health Services Research NIVEL, P, O, Box 1568, 3500 BN Utrecht, The Netherlands
    Int J Pediatr Endocrinol 2012:2. 2012
  5. ncbi request reprint Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology 833, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Eur J Endocrinol 157:339-44. 2007
  6. doi request reprint Testicular adrenal rest tumours in congenital adrenal hyperplasia
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands
    Best Pract Res Clin Endocrinol Metab 23:209-20. 2009
  7. doi request reprint Congenital adrenal hyperplasia--pharmacologic interventions from the prenatal phase to adulthood
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands
    Pharmacol Ther 132:1-14. 2011
  8. doi request reprint An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Endocrinol 159:489-91. 2008
  9. ncbi request reprint Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue
    Hedi L Claahsen-van der Grinten
    Radboud University Nijmegen Medical Centre, Department of Paediatric Endocrinology 833, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 92:3674-80. 2007
  10. ncbi request reprint Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fertil Steril 89:597-601. 2008

Detail Information

Publications20

  1. ncbi request reprint [From gene to disease: adrenogenital syndrome and the CYP21A2 gene]
    H L Claahsen-van der Grinten
    Universitair Medisch Centrum St Radboud, Postbus 90ioi, 6500o HB Nijmegen
    Ned Tijdschr Geneeskd 151:1174-7. 2007
    ..The severity of the disease depends on the degree of CYP21 deficiency. The diagnosis can be made by measuring levels of 17-hydroxyprogesterone and androstenedione in serum...
  2. ncbi request reprint Ovarian adrenal rest tissue in congenital adrenal hyperplasia--a patient report
    H L Claahsen-van der Grinten
    Department of Metabolic and Endocrine Disease and Radboud University, Nijmegen Medical Center, The Netherlands
    J Pediatr Endocrinol Metab 19:177-82. 2006
    ..This is a very rare complication in female patients with CAH with only two previously reported cases...
  3. pmc Testicular adrenal rest tumours in congenital adrenal hyperplasia
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology 833, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Int J Pediatr Endocrinol 2009:624823. 2009
    ..These tumours can be already found in childhood and puberty. In this paper, we review the embryological, histological, biochemical, and clinical features of TART and discuss treatment options...
  4. pmc Physical, social and societal functioning of children with congenital adrenal hyperplasia (CAH) and their parents, in a Dutch population
    Sarita A Sanches
    Netherlands Institute for Health Services Research NIVEL, P, O, Box 1568, 3500 BN Utrecht, The Netherlands
    Int J Pediatr Endocrinol 2012:2. 2012
    ..abstract:..
  5. ncbi request reprint Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology 833, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Eur J Endocrinol 157:339-44. 2007
    ..The aim of our study was to determine the presence of TART and their influence on gonadal function in childhood...
  6. doi request reprint Testicular adrenal rest tumours in congenital adrenal hyperplasia
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands
    Best Pract Res Clin Endocrinol Metab 23:209-20. 2009
    ..Furthermore, we propose a new five-stage classification of TART, based on sonographic, clinical and biochemical parameters, that may lead to a better follow up and treatment of patients with TART...
  7. doi request reprint Congenital adrenal hyperplasia--pharmacologic interventions from the prenatal phase to adulthood
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands
    Pharmacol Ther 132:1-14. 2011
    ..Also prenatal therapy, to prevent congenital virilization of a female CAH newborn, is discussed. Furthermore, an overview of alternative pharmacological treatment options in the future is given...
  8. doi request reprint An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Endocrinol 159:489-91. 2008
    ..Here, we report on an adult patient with CAH due to 3beta-hydroxysteroid dehydrogenase (HSD) deficiency with bilateral TART and additionally a large perirenal adrenal rest tumour...
  9. ncbi request reprint Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue
    Hedi L Claahsen-van der Grinten
    Radboud University Nijmegen Medical Centre, Department of Paediatric Endocrinology 833, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 92:3674-80. 2007
    ..In male patients with congenital adrenal hyperplasia (CAH), testicular adrenal rest tumors are frequently found that may interfere with gonadal function...
  10. ncbi request reprint Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fertil Steril 89:597-601. 2008
    ..To evaluate the histological features of testicular tumors and residual testicular parenchyma in male patients with congenital adrenal hyperplasia (CAH) and longstanding bilateral testicular adrenal rest tumors (TART)...
  11. ncbi request reprint Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fertil Steril 88:705.e5-8. 2007
    ..To report repeated successful induction of fertility in an adult male patient with congenital adrenal hyperplasia (CAH) and testicular adrenal rest tumors (TART)...
  12. ncbi request reprint Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 92:612-5. 2007
    ..Intensifying glucocorticoid therapy does not always lead to tumor regression and improvement of testicular function. Recently, testis-sparing surgery was introduced for treatment of TART...
  13. ncbi request reprint Absence of increased height velocity in the first year of life in untreated children with simple virilizing congenital adrenal hyperplasia
    Hedi L Claahsen-van der Grinten
    Department of Metabolic and Endocrine Diseases 435, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 91:1205-9. 2006
    ..In congenital adrenal hyperplasia (CAH), elevation of adrenal androgens leads to accelerated growth and bone maturation with compromised adult height...
  14. ncbi request reprint Puberty and fertility in congenital adrenal hyperplasia
    B J Otten
    Department of Pediatric Endocrinology, University Hospital St Radboud, Nijmegen, The Netherlands
    Endocr Dev 8:54-66. 2005
    ..Therefore prevention of subfertility has to be implemented as a treatment goal in paediatric endocrinology from the start of puberty...
  15. ncbi request reprint Fertility in patients with congenital adrenal hyperplasia
    H L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Pediatr Endocrinol Metab 19:677-85. 2006
    ..Subfertility in CAH can have its origin already in the peripubertal years and is therefore of interest to the paediatric endocrinologist...
  16. doi request reprint Prevalence of testicular adrenal rest tissue in neonates
    A Bouman
    Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Horm Res Paediatr 75:90-3. 2011
    ..TART are already present in childhood and early infancy in CAH patients. The incidence of TART in neonates without CAH has not yet been described in detail before...
  17. pmc CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome
    M C J Jongmans
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Genet 75:65-71. 2009
    ..If such features are present, particularly deafness, dysmorphic ears and/or hypoplasia or aplasia of the semicircular canals, CHD7 sequencing is recommended...
  18. ncbi request reprint Perinatal rupture of the uropoietic system
    H L Claahsen-van der Grinten
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Clin Nephrol 57:432-8. 2002
    ..The diagnosis is often delayed and the prognosis is related to the degree of renal damage. There is discussion about possible protective mechanisms of the rupture for renal function in patients with obstructive uropathy...
  19. ncbi request reprint Ectopic adrenal rests in congenital adrenal hyperplasia as a cause of androgen excess after adrenalectomy detected by pelvic venous sampling
    H L Claahsen-van der Grinten
    Department of Pediatric Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Horm Res Paediatr 80:293-8. 2013
    ..In female CAH patients ovarian adrenal rests are not commonly detected by conventional radiological techniques...
  20. doi request reprint Inactivating PAPSS2 mutations in a patient with premature pubarche
    Cees Noordam
    Department of Pediatrics Metabolic and Endocrine Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 360:2310-8. 2009
    ..In vitro coincubation of human SULT2A1 and wild-type or mutant PAPSS2 proteins confirmed the inactivating nature of the mutations. These observations indicate that PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess...