D M Burger

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi request reprint Clinical management of drug-drug interactions in HCV therapy: challenges and solutions
    David Burger
    Department of Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Hepatol 58:792-800. 2013
  2. ncbi request reprint Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children
    David M Burger
    University Medical Centre Nijmegen, Nijmegen University Centre for Infectious Diseases, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    J Pediatr 145:403-5. 2004
  3. pmc Drug-drug interactions with raltegravir
    David M Burger
    Department of Clinical Pharmacy, 864 Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Eur J Med Res 14:17-21. 2009
  4. pmc Effect of rifampin on steady-state pharmacokinetics of atazanavir with ritonavir in healthy volunteers
    D M Burger
    Department of Clinical Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 50:3336-42. 2006
  5. ncbi request reprint The role of therapeutic drug monitoring in pediatric HIV/AIDS
    David M Burger
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ther Drug Monit 32:269-72. 2010
  6. doi request reprint The effect of atazanavir and atazanavir/ritonavir on UDP-glucuronosyltransferase using lamotrigine as a phenotypic probe
    D M Burger
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Pharmacol Ther 84:698-703. 2008
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients
    David Burger
    Department of Clinical Pharmacy, 533 University Medical Centre Nijmegen, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    J Antimicrob Chemother 51:1231-8. 2003
  8. ncbi request reprint Limited sampling models to predict the pharmacokinetics of nevirapine, stavudine, and lamivudine in HIV-infected children treated with pediatric fixed-dose combination tablets
    David Burger
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 32:369-72. 2010
  9. ncbi request reprint Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals
    David Burger
    Department of Clinical Pharmacy, University Medical Centre, Nijmegen, The Netherlands
    AIDS 17:1157-65. 2003
  10. doi request reprint Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies
    David M Burger
    Department of Pharmacy, 864 Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Expert Opin Drug Metab Toxicol 6:1151-60. 2010

Detail Information

Publications120 found, 100 shown here

  1. doi request reprint Clinical management of drug-drug interactions in HCV therapy: challenges and solutions
    David Burger
    Department of Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Hepatol 58:792-800. 2013
    ..g., dose adjustments, safe alternatives and therapeutic drug monitoring) is of equal importance. This review provides a practical overview of the safe and effective management of these clinical challenges...
  2. ncbi request reprint Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children
    David M Burger
    University Medical Centre Nijmegen, Nijmegen University Centre for Infectious Diseases, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    J Pediatr 145:403-5. 2004
    ..8 mg/L. Virologic response at week 48 was observed in 29% of children with subtherapeutic nelfinavir troughs versus 80% in children with therapeutic nelfinavir troughs (P=.02)...
  3. pmc Drug-drug interactions with raltegravir
    David M Burger
    Department of Clinical Pharmacy, 864 Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Eur J Med Res 14:17-21. 2009
    ..To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir...
  4. pmc Effect of rifampin on steady-state pharmacokinetics of atazanavir with ritonavir in healthy volunteers
    D M Burger
    Department of Clinical Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 50:3336-42. 2006
    ..Coadministration of ATV with RIF was safe and generally well tolerated. Since ATV exposures were reduced in all regimens, ATV and RIF should not be coadministered at the dosing regimens studied...
  5. ncbi request reprint The role of therapeutic drug monitoring in pediatric HIV/AIDS
    David M Burger
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ther Drug Monit 32:269-72. 2010
    ..There is a need for more descriptive studies on the usefulness of TDM in HIV-infected children to convince pediatricians worldwide to let more children benefit from TDM...
  6. doi request reprint The effect of atazanavir and atazanavir/ritonavir on UDP-glucuronosyltransferase using lamotrigine as a phenotypic probe
    D M Burger
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Pharmacol Ther 84:698-703. 2008
    ..45 for lamotrigine to 0.71 for ATV/RTV + lamotrigine. ATV alone does not significantly influence glucuronidation of lamotrigine. In contrast, ATV/RTV results in moderately decreased exposure to lamotrigine...
  7. ncbi request reprint Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients
    David Burger
    Department of Clinical Pharmacy, 533 University Medical Centre Nijmegen, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    J Antimicrob Chemother 51:1231-8. 2003
    ..To describe the pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in human immunodeficiency virus (HIV)-infected Thai patients...
  8. ncbi request reprint Limited sampling models to predict the pharmacokinetics of nevirapine, stavudine, and lamivudine in HIV-infected children treated with pediatric fixed-dose combination tablets
    David Burger
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 32:369-72. 2010
    ..0 to +0.7; rmse%: 3.4%; r: 0.99). A limited sampling model using three time points (1, 2, 6 hours) can be used to predict nevirapine, stavudine, and lamivudine AUC accurately and precisely in HIV-infected African children...
  9. ncbi request reprint Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals
    David Burger
    Department of Clinical Pharmacy, University Medical Centre, Nijmegen, The Netherlands
    AIDS 17:1157-65. 2003
    ..Therapeutic drug monitoring (TDM) offers the possibility to detect patients with drug concentrations outside therapeutic ranges, who can subsequently benefit from dose modifications...
  10. doi request reprint Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies
    David M Burger
    Department of Pharmacy, 864 Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Expert Opin Drug Metab Toxicol 6:1151-60. 2010
    ..Raltegravir is the first HIV-integrase inhibitor licensed by the FDA...
  11. ncbi request reprint A once-daily HAART regimen containing indinavir + ritonavir plus one or two nucleoside reverse transcriptase inhibitors (PIPO study)
    David M Burger
    Department of Clinical Pharmacy, University Medical Center Nijmegen, The Netherlands
    Antivir Ther 8:455-61. 2003
    ..A Phase II study was conducted to investigate the pharmacokinetics, and short-term safety and efficacy of an indinavir/ritonavir combination as part of a once-daily regimen...
  12. pmc Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism
    David Burger
    Radboud University Medical Center Nijmegen, The Netherlands
    Br J Clin Pharmacol 61:148-54. 2006
    ..To characterize the demographic and pharmacogenetic factors that influence interpatient variability in the plasma concentrations of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz...
  13. doi request reprint The International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma: a global proficiency testing program
    David Burger
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nigmegen, The Netherlands
    Ther Drug Monit 33:239-43. 2011
    ..Laboratories should put more effort in adequately analyzing concentrations of antiretroviral drugs with low minimum effective concentrations...
  14. ncbi request reprint Therapeutic drug monitoring of nelfinavir in pregnancy: a case report
    David M Burger
    Department of Clinical Pharmacy, University Medical Center, Nijmegen, The Netherlands
    Ther Drug Monit 26:576-8. 2004
    ..Although a causal relationship cannot be proven, viral load became undetectable after our interventions. A healthy uninfected daughter was born...
  15. ncbi request reprint Age-dependent pharmacokinetics of lamivudine in HIV-infected children
    D M Burger
    Department of Clinical Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands
    Clin Pharmacol Ther 81:517-20. 2007
    ..In conclusion, further investigation of the relationship between decreased lamivudine exposure and treatment outcome and long-term resistance development in younger children with HIV infection is warranted...
  16. ncbi request reprint Simultaneous determination of the HIV-protease inhibitors indinavir, nelfinavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography
    P W Hugen
    Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands
    J Chromatogr B Biomed Sci Appl 727:139-49. 1999
    ..The method was validated extensively and stability tests under various conditions were performed. The assay is now in use to analyse plasma samples from patients treated with (combinations of) HIV-protease inhibitors...
  17. ncbi request reprint Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapy
    D M Burger
    Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands
    Antivir Ther 3:215-20. 1998
    ..0) were independent factors related to virological treatment failure. Monitoring of indinavir plasma concentrations may be an important tool for the optimization of triple drug combination therapy...
  18. pmc Effect of efavirenz treatment on the pharmacokinetics of nelfinavir boosted by ritonavir in healthy volunteers
    C J L la Porte
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Clin Pharmacol 58:632-40. 2004
    ..In the present study the effect of efavirenz on the pharmacokinetics and tolerability of once-daily nelfinavir/ritonavir was evaluated in healthy subjects...
  19. pmc Pharmacokinetics of adjusted-dose lopinavir-ritonavir combined with rifampin in healthy volunteers
    C J L la Porte
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1553-60. 2004
    ..5 mg/liter (day 24) and was similar between the two arms. Adjusted-dose regimens of lopinavir-ritonavir in combination with therapeutic drug monitoring and monitoring of liver function may allow concomitant use of rifampin...
  20. ncbi request reprint Clinically relevant drug interactions with antiretroviral agents
    D M Burger
    Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands
    Antivir Ther 2:149-65. 1997
    ..It must be emphasized, however, that in many cases these proposals are not backed up by authoritative clinical consensus panels and that clinical experience with many of these combinations is limited...
  21. ncbi request reprint Simultaneous determination of the HIV nucleoside analogue reverse transcriptase inhibitors lamivudine, didanosine, stavudine, zidovudine and abacavir in human plasma by reversed phase high performance liquid chromatography
    C P W G M Verweij-van Wissen
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 816:121-9. 2005
    ..5% and extraction recoveries were higher than 97%. This method proved to be simple, accurate and precise, and is currently in use in our laboratory for the quantitative analysis of NRTIs in plasma...
  22. ncbi request reprint Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography
    J A H Droste
    Deparment of Clinical Pharmacy, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Ther Drug Monit 25:393-9. 2003
    ..This method proved to be simple, accurate, and precise and is useful for the therapeutic drug monitoring of protease inhibitors and the nonnucleoside reverse transcriptase inhibitor nevirapine on a routine basis...
  23. pmc Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children
    A S Bergshoeff
    University Medical Center, Department of Clinical Pharmacy, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1904-7. 2004
    ..1 (0.87 to 1.3), 0.96 (0.60 to 1.5), and 0.80 (0.68 to 0.94), respectively...
  24. pmc Pharmacokinetic study of tenofovir disoproxil fumarate combined with rifampin in healthy volunteers
    J A H Droste
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, P O Box 9101, 533 KF, 6500 HB Nijmegen, The Netherlands
    Antimicrob Agents Chemother 49:680-4. 2005
    ..In conclusion, adaptation of either the rifampin or the tenofovir DF dose for the simultaneous treatment of tuberculosis and human immunodeficiency virus (HIV) infection in HIV-infected patients is probably not required...
  25. ncbi request reprint Carbamazepine--indinavir interaction causes antiretroviral therapy failure
    P W Hugen
    Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands
    Ann Pharmacother 34:465-70. 2000
    ..To report a case of antiretroviral therapy failure caused by an interaction between carbamazepine and indinavir...
  26. ncbi request reprint A retrospective, cohort-based survey of patients using twice-daily indinavir + ritonavir combinations: pharmacokinetics, safety, and efficacy
    D M Burger
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 26:218-24. 2001
    ..To describe the pharmacokinetics, safety, and efficacy of twice-daily indinavir + ritonavir regimens..
  27. ncbi request reprint The influence of efavirenz on the pharmacokinetics of a twice-daily combination of indinavir and low-dose ritonavir in healthy volunteers
    Rob E Aarnoutse
    Department of Clinical Pharmacy, University Medical Centre, Nijmegen, The Netherlands
    Clin Pharmacol Ther 71:57-67. 2002
    ....
  28. doi request reprint Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets
    Rafaëlla F A L'homme
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    AIDS 22:557-65. 2008
    ..We determined whether this ratio results in optimal exposure in the target population...
  29. pmc Pharmacokinetics of the protease inhibitor indinavir in human immunodeficiency virus type 1-infected children
    D M Burger
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 45:701-5. 2001
    ..It would even be better to adjust the indinavir dose based on an AUC of greater than 20 mg/liter. h...
  30. ncbi request reprint Therapeutic drug monitoring of the HIV protease inhibitor atazanavir in clinical practice
    R M M Cleijsen
    Department of Clinical Pharmacy, Radboud University Medical Centre Nijmegen, The Netherlands
    J Antimicrob Chemother 60:897-900. 2007
    ..Therapeutic drug monitoring (TDM) is being applied for a number of antiretroviral agents. Little is known about the use of TDM for atazanavir...
  31. ncbi request reprint Increased dose of lopinavir/ritonavir compensates for efavirenz-induced drug-drug interaction in HIV-1-infected children
    Alina S Bergshoeff
    Department of Clinical Pharmacy, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 39:63-8. 2005
    ..In children, the extent of the pharmacokinetic interaction between efavirenz and lopinavir/ritonavir has not yet been studied...
  32. doi request reprint Clinical experience with the combined use of lopinavir/ritonavir and rifampicin
    Rafaëlla Fa L'homme
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    AIDS 23:863-5. 2009
    ..Combined use of lopinavir/ritonavir and rifampicin is challenging as it implies balancing between suboptimal efficacy and toxicity...
  33. doi request reprint Pharmacokinetics of two generic co-formulations of lopinavir/ritonavir for HIV-infected children: a pilot study of paediatric Lopimune versus the branded product in healthy adult volunteers
    C T M M de Kanter
    Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Antimicrob Chemother 65:538-42. 2010
    ....
  34. ncbi request reprint HIV-1 RNA levels in the cerebrospinal fluid may increase owing to damage to the blood-brain barrier
    D M Burger
    Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 2:113-7. 1997
    ..This study indicates that increased levels of HIV-1 RNA in the CSF of neurologically symptomatic patients are the result of damage to the blood-brain barrier...
  35. ncbi request reprint Lopinavir/ritonavir plus saquinavir in salvage therapy; pharmacokinetics, tolerability and efficacy
    Charles J L la Porte
    Department of Clinical Pharmacy, University Medical Centre, Nijmegen, The Netherlands
    AIDS 17:1700-2. 2003
    ..The tolerability of the regimen was good and efficacy was encouraging...
  36. doi request reprint High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets
    Hanneke M J Nijland
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, The Netherlands
    AIDS 22:931-5. 2008
    ..Our objective was to study the combined use of rifampicin and the newly introduced lopinavir/ritonavir tablets...
  37. ncbi request reprint Rifampicin reduces plasma concentrations of moxifloxacin in patients with tuberculosis
    H M J Nijland
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 45:1001-7. 2007
    ..Rifampicin induces the phase II metabolic enzymes that are involved in the biotransformation of moxifloxacin. Therefore, the interaction between rifampicin and moxifloxacin should be investigated...
  38. ncbi request reprint Plasma levels of zidovudine twice daily compared with three times daily in six HIV-1-infected children
    Alina S Bergshoeff
    Department of Clinical Pharmacy, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Antimicrob Chemother 54:1152-4. 2004
    ..We have evaluated the plasma pharmacokinetics of zidovudine administered every 8 h versus every 12 h in HIV-1-infected children...
  39. ncbi request reprint The genotypic inhibitory quotient and the (cumulative) number of mutations predict the response to lopinavir therapy
    Jolanda G M Hoefnagel
    Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, The Netherlands
    AIDS 20:1069-71. 2006
    ..Furthermore, the predictive value of the GIQ was no different from that of the number of mutations alone...
  40. ncbi request reprint Pros and cons of therapeutic drug monitoring of antiretroviral agents
    David M Burger
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
    Curr Opin Infect Dis 15:17-22. 2002
    ..In addition, therapeutic drug monitoring may be used as a direct and objective instrument to measure non-adherence. This review describes possibilities and limitations of therapeutic drug monitoring in HIV treatment...
  41. ncbi request reprint Assessment of adherence to HIV protease inhibitors: comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring
    Patricia W H Hugen
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 30:324-34. 2002
    ..Adherence to protease inhibitor-containing antiretroviral therapy is crucial, but difficult to measure...
  42. pmc International interlaboratory quality control program for measurement of antiretroviral drugs in plasma
    Rob E Aarnoutse
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 46:884-6. 2002
    ..The results demonstrate the need for and utility of an ongoing quality control program in this area of bioanalysis...
  43. ncbi request reprint Pharmacokinetics of indinavir/ritonavir (800/100 mg twice a day) combined with efavirenz in HIV-infected patients
    Rob E Aarnoutse
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    AIDS 18:565-7. 2004
    ..The pharmacokinetic data suggest that indinavir/ritonavir plus efavirenz (without dose modifications) should be effective in treatment-naive patients, and this was supported by the treatment response of the participants...
  44. ncbi request reprint Treatment of hepatitis C monoinfection in adults--Dutch national guidelines
    M H Lamers
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, The Netherlands
    Neth J Med 71:377-85. 2013
    ....
  45. ncbi request reprint High-performance liquid chromatography of HIV protease inhibitors in human biological matrices
    R E Aarnoutse
    Department of Clinical Pharmacy, University Medical Center Nijmegen, The Netherlands
    J Chromatogr B Biomed Sci Appl 764:363-84. 2001
    ..Participation in an interlaboratory quality control program is recommended for every laboratory engaged in the bioanalysis of PIs...
  46. pmc Pharmacokinetics, food intake requirements and tolerability of once-daily combinations of nelfinavir and low-dose ritonavir in healthy volunteers
    R E Aarnoutse
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Clin Pharmacol 55:115-25. 2003
    ..This study was performed to evaluate the steady-state pharmacokinetics, food intake requirements and short-term tolerability of once-daily combinations of nelfinavir and low-dose ritonavir...
  47. ncbi request reprint Antiretroviral therapy in HIV patients: aspects of metabolic complications and mitochondrial toxicity
    H J M ter Hofstede
    Department of Internal Medicine, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 61:393-403. 2003
  48. doi request reprint Therapeutic drug monitoring of voriconazole
    Roger J M Bruggemann
    Department of Clinical Pharmacy, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 30:403-11. 2008
    ..We provide a summary of the problem so that further research can be conducted to address this are of clinical need...
  49. ncbi request reprint Pharmacokinetics of two generic fixed-dose combinations for HIV-infected children (Pedimune Baby & Pedimune Junior) are similar to the branded products in healthy adults
    Rafaëlla F A L'homme
    Department of Clinical Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Antimicrob Chemother 59:92-6. 2007
    ..We determined the pharmacokinetic profiles of stavudine, lamivudine and nevirapine in Pedimune and compared these with the branded products...
  50. doi request reprint The effect of raltegravir on the glucuronidation of lamotrigine
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Clin Pharmacol 49:1220-7. 2009
    ..35) or when taken with raltegravir (0.36). Raltegravir does not influence the glucuronidation of lamotrigine...
  51. ncbi request reprint A retrospective TDM database analysis of interpatient variability in the pharmacokinetics of lopinavir in HIV-infected adults
    Martijn R van der Leur
    Department of Clinical Pharmacy, Radboud University Medical Center Nijmegen, The Netherlands
    Ther Drug Monit 28:650-3. 2006
    ....
  52. ncbi request reprint Brief report: enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women
    Rafaëlla F A L'homme
    Department of Clinical Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 43:193-6. 2006
    ..The objective of this study was to find enzyme inducers to reduce the NVP half-life...
  53. ncbi request reprint Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects
    Manon J van der Lee
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Pharmacol Ther 80:159-68. 2006
    ..Limited data are available about the effect of lopinavir and low-dose ritonavir on glucuronidation. Lamotrigine undergoes glucuronidation. We studied the effect of lopinavir/ritonavir on the pharmacokinetics of lamotrigine and vice versa...
  54. doi request reprint Pharmacokinetics and safety of 14 days intravenous voriconazole in allogeneic haematopoietic stem cell transplant recipients
    Roger J M Bruggemann
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, The Netherlands
    J Antimicrob Chemother 65:107-13. 2010
    ..Little is known about the pharmacokinetics (PK) of voriconazole in this population, who also receive cyclosporine A...
  55. doi request reprint Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of Tanzanian plant extracts traditionally used for treatment of fungal infections
    Carolien J P van den Bout-van den Beukel
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Basic Clin Pharmacol Toxicol 102:515-26. 2008
    ..africana significantly induced CYP3A4 mRNA levels. These results indicate the possibility of potential medicinal plant-antiretroviral interactions...
  56. doi request reprint Efavirenz dose reduction is safe in patients with high plasma concentrations and may prevent efavirenz discontinuations
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 52:240-5. 2009
    ..To establish whether efavirenz dose reduction in patients with high plasma concentrations prevents toxicity-induced efavirenz discontinuations...
  57. doi request reprint Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents
    Roger J M Bruggemann
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 48:1441-58. 2009
    ..This article provides an overview of all published drug-drug interactions in humans (either healthy volunteers or patients), and on the basis of these findings, we have developed recommendations for managing the specific interactions...
  58. pmc Interaction study of the combined use of paroxetine and fosamprenavir-ritonavir in healthy subjects
    Manon J van der Lee
    Department of Clinical Pharmacy, Radboud University Medical Centre Nijmegen, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:4098-104. 2007
    ..This is partly explained by protein displacement of paroxetine. We think that this interaction is clinically relevant and that titration to a higher dose of paroxetine may be necessary to accomplish the needed antidepressant effect...
  59. pmc International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations
    Roger J M Bruggemann
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 53:303-5. 2009
    ..The results demonstrate the need for and utility of an ongoing proficiency testing program to further improve the analytical methods for routine patient management and clinical research...
  60. ncbi request reprint Absence of a relation between efavirenz plasma concentrations and toxicity-driven efavirenz discontinuations in the EuroSIDA study
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Antivir Ther 14:75-83. 2009
    ..We aimed to determine whether patients with high EFV plasma concentrations have an increased likelihood of toxicity-driven EFV discontinuations...
  61. ncbi request reprint Therapeutic drug monitoring of voriconazole in a child with invasive aspergillosis requiring extracorporeal membrane oxygenation
    Roger J M Bruggemann
    Department of Clinical Pharmacy, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 30:643-6. 2008
    ..We describe a patient with invasive pulmonary aspergillosis on extracorporeal membrane oxygenation therapy in which therapeutic drug monitoring and individualization of therapy by measuring voriconazole plasma concentrations were performed...
  62. doi request reprint Stavudine plasma concentrations and lipoatrophy
    Hadewych J M ter Hofstede
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Antimicrob Chemother 61:933-8. 2008
    ..The objective of this study was to determine the correlation between plasma stavudine concentrations and lipoatrophy (LA), one of the major adverse events in patients on stavudine and one of the major reasons to discontinue stavudine...
  63. ncbi request reprint Possible drug-metabolism interactions of medicinal herbs with antiretroviral agents
    Carolien J P van den Bout-van den Beukel
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Drug Metab Rev 38:477-514. 2006
    ..Further pharmacokinetic studies to unveil potential Western and especially African herb-antiretroviral drug interactions are urgently required, and the clinical significance of these interactions should be assessed...
  64. ncbi request reprint Evaluation of antiretroviral drug measurements by an interlaboratory quality control program
    Jacqueline A H Droste
    Department of Clinical Pharmacy, University Medical Center, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 32:287-91. 2003
    ..This variability may have important implications for therapeutic drug monitoring of these drugs and for pharmacokinetic studies. Interlaboratory testing is useful to alert laboratories to previously undetected analytical problems...
  65. doi request reprint The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus
    Douwe Dekker
    Radboud University Nijmegen Medical Centre, Nijimegen Center for Molecular Life Sciences, Departments of Pharmacology and Toxicology, and Orthodontics and Oral Biology, Nijmegen, The Netherlands
    Arterioscler Thromb Vasc Biol 31:458-63. 2011
    ..We thus hypothesized that treatment with atazanavir would ameliorate oxidative stress and vascular inflammation and improve endothelial function in T2DM...
  66. doi request reprint Adherence to HIV therapeutic drug monitoring guidelines in The Netherlands
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 33:32-9. 2011
    ..Therapeutic drug monitoring (TDM) is recommended in several international HIV treatment guidelines. The adherence of clinicians to these recommendations is unknown. The authors evaluated the adherence to the Dutch TDM guideline of 2005...
  67. doi request reprint Interaction between antiretroviral drugs and acenocoumarol
    Marieke E B Welzen
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Antivir Ther 16:249-52. 2011
    ..This is the first report of a possible drug interaction between efavirenz and atazanavir/ritonavir with acenocoumarol and also of the uncomplicated concurrent use of raltegravir with acenocoumarol...
  68. doi request reprint Rhabdomyolysis in an HIV-infected patient with impaired renal function concomitantly treated with rosuvastatin and lopinavir/ritonavir
    Clara T M M de Kanter
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, The Netherlands
    Antivir Ther 16:435-7. 2011
    ..Knowledge of these interactions is important to provide patients with the best possible care...
  69. ncbi request reprint Administration of indinavir and low-dose ritonavir (800/100 mg twice daily) with food reduces nephrotoxic peak plasma levels of indinavir
    Rob E Aarnoutse
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, The Netherlands
    Antivir Ther 8:309-14. 2003
    ..High indinavir Cmax values have been associated with indinavir-related nephrotoxicity...
  70. ncbi request reprint Pharmacokinetics of nelfinavir in children: influencing factors and dose implications
    Alina S Bergshoeff
    University Medical Centre, Department of Clinical Pharmacy, Nijmegen, The Netherlands
    Antivir Ther 8:215-22. 2003
    ..The study describes the pharmacokinetics (PK) of the protease inhibitor nelfinavir and its active metabolite M8 in children and evaluates the influence of patient-related factors on nelfinavir plasma levels...
  71. ncbi request reprint TDM: therapeutic drug measuring or therapeutic drug monitoring?
    Jacqueline A H Droste
    Department of Clinical Pharmacy, University Medical Centre, Nijmegen, The Netherlands
    Ther Drug Monit 27:412-6. 2005
    ..Almost half of the recommendations (44%) given were satisfactory. Levels of knowledge regarding HIV treatment appeared to be variable among the respondents and for this reason were partly incomparable...
  72. doi request reprint Effect of posaconazole on the pharmacokinetics of fosamprenavir and vice versa in healthy volunteers
    Roger J M Bruggemann
    Radboud University Nijmegen Medical Centre, Department of Clinical Pharmacy, Nijmegen, The Netherlands
    J Antimicrob Chemother 65:2188-94. 2010
    ....
  73. ncbi request reprint Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers
    Rob E Aarnoutse
    Departments of Clinical Pharmacy and General Internal Medicine, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Clin Pharmacol Ther 78:664-74. 2005
    ..When applied in a therapeutic dose (600 mg twice daily), ritonavir also inhibits CYP2D6. The effect of low-dose ritonavir on CYP2D6 is unknown and was investigated in this study...
  74. ncbi request reprint Assessment of drug-drug interactions between tenofovir disoproxil fumarate and the nonnucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients
    Jacqueline A H Droste
    Department of Clinical Pharmacy, Radboud University, Nijmegen Medical Centre, The Netherlands
    J Acquir Immune Defic Syndr 41:37-43. 2006
    ..Furthermore, the combination of efavirenz 600 mg and tenofovir DF 300 mg once daily was compared with use of efavirenz 600 mg once daily only...
  75. doi request reprint Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    AIDS 24:1223-6. 2010
    ..Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir...
  76. ncbi request reprint Ritonavir-enhanced pharmacokinetics of nelfinavir/M8 during rifampin use
    Alina S Bergshoeff
    Department of Clinical Pharmacy, University Medical Center, Nijmegen, The Netherlands
    Ann Pharmacother 37:521-5. 2003
    ..To describe a case of successful protease inhibitor-based highly active antiretroviral therapy (HAART) concomitant with rifampin...
  77. doi request reprint Drug-drug interactions between raltegravir and pravastatin in healthy volunteers
    Matthijs van Luin
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 55:82-6. 2010
    ..To evaluate the potential drug-drug interaction between raltegravir and pravastatin...
  78. ncbi request reprint Therapeutic drug monitoring: an aid to optimising response to antiretroviral drugs?
    Rob E Aarnoutse
    Department of Clinical Pharmacy, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Drugs 63:741-53. 2003
    ..Additional clinical trials are needed before routine TDM can be adopted as standard of care in the treatment of HIV infection...
  79. ncbi request reprint Role of the inhibitory quotient in HIV therapy
    Jolando G M Hoefnagel
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, The Netherlands
    Antivir Ther 10:879-92. 2005
    ..As the IQ can be modified by adjustment of the drug dosage, it may be of clinical value. Its application in patient care should therefore be further investigated...
  80. doi request reprint Ribavirin plasma concentration measurements in patients with hepatitis C: early ribavirin concentrations predict steady-state concentrations
    Serena Slavenburg
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Ther Drug Monit 33:40-4. 2011
    ..Monitoring ribavirin concentration is suggested in the literature, but it is unclear at what time point during treatment plasma ribavirin concentrations should be monitored...
  81. pmc Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs
    R W F van Leeuwen
    Department of Pharmacy, Erasmus University Medical Center, Rotterdam 3015CE, The Netherlands
    Br J Cancer 108:1071-8. 2013
    ..We assessed the prevalence and seriousness of potential PDDIs among ambulatory cancer patients on oral anticancer treatment...
  82. doi request reprint Simultaneous determination of the azoles voriconazole, posaconazole, isavuconazole, itraconazole and its metabolite hydroxy-itraconazole in human plasma by reversed phase ultra-performance liquid chromatography with ultraviolet detection
    C P W G M Verweij van Wissen
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 887:79-84. 2012
    ..This method proved to be simple, accurate, precise and fast and is currently in use in our laboratory for the quantitative analysis of these azoles for Therapeutic Drug Monitoring and pharmacokinetic research...
  83. doi request reprint The effect of cholecalciferol supplementation on vitamin D levels and insulin sensitivity is dose related in vitamin D-deficient HIV-1-infected patients
    C J P van den Bout-van den Beukel
    Departments of General Internal Medicine, Radbound University Nijmegen Medical Center, Nijmegen, The Netherlands
    HIV Med 9:771-9. 2008
    ..The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, bone mineral density (BMD), body fat distribution and insulin sensitivity in vitamin D-deficient HIV-1-infected patients...
  84. doi request reprint Vitamin D deficiency among HIV type 1-infected individuals in the Netherlands: effects of antiretroviral therapy
    Carolien J P van den Bout-van den Beukel
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    AIDS Res Hum Retroviruses 24:1375-82. 2008
    ..Evaluation of 25(OH)D(3) and PTH levels, especially in NNRTI-treated and dark skinned HIV-1-infected patients, is necessary to detect and treat vitamin D deficiency early...
  85. ncbi request reprint Treatment failure of nelfinavir-containing triple therapy can largely be explained by low nelfinavir plasma concentrations
    David M Burger
    Department of Clinical Pharmacy, University Medical Center, Nijmegen, The Netherlands
    Ther Drug Monit 25:73-80. 2003
    ..014). Virologic failure of nelfinavir-containing triple therapy can be explained, to a large extent, by low plasma levels of nelfinavir...
  86. doi request reprint Therapeutic drug monitoring of nevirapine in resource-limited settings
    Rafaëlla F A L'homme
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 47:1339-44. 2008
    ..We developed a simple and inexpensive thin-layer chromatography (TLC) assay for semiquantitative detection of saliva concentrations of nevirapine in resource-limited settings. The method was validated in an African target population...
  87. ncbi request reprint Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications
    Charles J L la Porte
    Department of Clinical Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands
    AIDS 19:1105-7. 2005
    ..Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study...
  88. ncbi request reprint Cyclosporine short infusion and C2 monitoring in haematopoietic stem cell transplant recipients
    M P Hendriks
    Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Bone Marrow Transplant 38:521-5. 2006
    ..Therefore, we recommend CsA infusions in 2 h during transplant and perform C2 monitoring to obtain therapeutic C2 levels >or=800 microg/l...
  89. pmc A phase I dose-escalation study to evaluate safety and tolerability of sorafenib combined with sirolimus in patients with advanced solid cancer
    I M E Desar
    Department of Medical Oncology 452, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500 HB, The Netherlands
    Br J Cancer 103:1637-43. 2010
    ..The combination of sorafenib (vascular endothelial growth factor receptor 2 inhibitor) and sirolimus (mammalian target of rapamycin inhibitor) might work synergistically...
  90. ncbi request reprint Saquinavir soft-gel capsules (Fortovase) give lower exposure than expected, even after a high-fat breakfast
    P W H Hugen
    Department of Clinical Pharmacy, University Medical Centre Nijmegen, 533 Dept Clinical Pharmacy, 6500 HB Nijmegen, The Netherlands
    Pharm World Sci 24:83-6. 2002
    ..However, in a Dutch study population using saquinavir-sgc plasma levels were lower than expected. We hypothesised that this was caused by differences in the amount of fat in the meals of the study populations...
  91. ncbi request reprint Therapeutic drug monitoring of HIV-protease inhibitors to assess noncompliance
    Patricia W H Hugen
    Department of Clinical Pharmacy, University Medical Nijmegen, Nijmegen, The Netherlands
    Ther Drug Monit 24:579-87. 2002
    ..In the absence of a gold standard for measuring compliance and to avoid complex techniques, measuring plasma concentrations may be an objective and easy way to check noncompliance...
  92. ncbi request reprint Therapeutic drug monitoring of indinavir and nelfinavir to assess adherence to therapy in human immunodeficiency virus-infected children
    Annemarie M van Rossum
    Department of Pediatrics, Sophia Children s Hospital Erasmus University Medical Center, Rotterdam, The Netherlands
    Pediatr Infect Dis J 21:743-7. 2002
    ..We studied during a 2-year follow-up period routinely taken plasma protease inhibitor concentrations to assess adherence to antiretroviral therapy in HIV-1-infected children...
  93. doi request reprint Toxic lopinavir concentrations in an HIV-1 infected patient taking herbal medications
    Carolien J P Beukel van den Bout-van den
    AIDS 22:1243-4. 2008
  94. ncbi request reprint Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients
    Reshma Saskia Autar
    The HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, 104 Rajdumri Road, 10330 Pathumwan, Bangkok, Thailand
    J Antimicrob Chemother 56:908-13. 2005
    ..Differential exposure to saquinavir/ritonavir may lead to therapy failure. The objective was to identify factors that influence variability of saquinavir/ritonavir plasma concentrations...
  95. ncbi request reprint The pharmacology of antiretroviral nucleoside and nucleotide reverse transcriptase inhibitors: implications for once-daily dosing
    David J Back
    Department of Pharmacology, University of Liverpool, Liverpool, UK
    J Acquir Immune Defic Syndr 39:S1-23, quiz S24-25. 2005
    ....
  96. ncbi request reprint Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi
    Joep J van Oosterhout
    Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
    Trop Med Int Health 10:464-70. 2005
    ..The only ART was a fixed drug combination of stavudine, lamivudine and nevirapine...
  97. ncbi request reprint Nelfinavir plasma concentrations are low during pregnancy
    Jeannine F J B Nellen
    Academic Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS, Amsterdam, The Netherlands
    Clin Infect Dis 39:736-40. 2004
    ..After we adjusted for confounders, we found that the mean nelfinavir CR was 34% lower in pregnant women (P=.02). With targeted interventions, subsequent CRs in pregnant women showed a significant increase (median increase, 0.31; P=.01)...
  98. ncbi request reprint Therapeutic drug monitoring in children with HIV/AIDS
    Pieter L A Fraaij
    Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
    Ther Drug Monit 26:122-6. 2004
    ..We conclude that TDM is a useful tool in the treatment of HIV-1-infected children. Additional data are needed to establish child-specific reference values and to assess the optimal method of TDM...
  99. ncbi request reprint Safety and efficacy of a NRTI-sparing HAART regimen of efavirenz and lopinavir/ritonavir in HIV-1-infected children
    Pieter L A Fraaij
    Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
    Antivir Ther 9:297-9. 2004
    ..Observed side effects were transient with the exception of dyslipidaemia...
  100. ncbi request reprint Comparison of two reduced-dose regimens of indinavir (600 mg vs 400 mg twice daily) and ritonavir (100 mg twice daily) in healthy volunteers (COREDIR)
    Jan Christian Wasmuth
    Department of Internal Medicine I, University of Bonn, Germany
    Antivir Ther 9:213-20. 2004
    ..To assess the pharmacokinetics and tolerability of reduced dosages of twice daily indinavir (IDV) boosted by low-dose ritonavir (RTV) in healthy volunteers...
  101. ncbi request reprint The effect of nevirapine on the pharmacokinetics of indinavir/ritonavir 800/100 mg BID
    David M Burger
    J Acquir Immune Defic Syndr 35:97-8. 2004