Research Topics
Genomes and GenesSpecies | Jan BuitelaarSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Detail Information
Publications
A randomized, double-blind study of continuation treatment for attention-deficit/hyperactivity disorder after 1 yearJan K Buitelaar
University Medical Center St Radboud, Nijmegen, The Netherlands
Biol Psychiatry 61:694-9. 2007..The efficacy of atomoxetine in maintaining symptom response following 1 year of treatment was assessed in children and adolescents (n = 163) with DSM-IV defined attention-deficit/hyperactivity disorder (ADHD)...
Does maternal prenatal stress adversely affect the child's learning and memory at age six?Barbara M Gutteling
Department of Child and Adolescent Psychiatry, Utrecht University Medical Center and the Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
J Abnorm Child Psychol 34:789-98. 2006..No associations were found between prenatal maternal cortisol and the offspring's learning and memory...
Stability and change of IQ scores in preschool children diagnosed with autistic spectrum disorderClaudine Dietz
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O 85500, 3508 GA, Utrecht, The Netherlands
Eur Child Adolesc Psychiatry 16:405-10. 2007....
Finding effective screening instruments for autism using bayes theoremWouter B Groen
Child and Adolescent Psychiatry, University Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
Arch Pediatr Adolesc Med 161:415-6. 2007
Treating attention-deficit/hyperactivity disorder beyond symptom control alone in children and adolescents: a review of the potential benefits of long-acting stimulantsJan Buitelaar
Department of Psychiatry, UMC St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 19:325-40. 2010..Concerns of long-term stimulant treatment are also discussed...
Conduct disordersJan K Buitelaar
Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, P O Box 9101, 204 6500 HB, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 22:49-54. 2013..There is a role for medication in the treatment of comorbid syndromes and/or in case of insufficient response to psychosocial interventions and severe and dangerous aggressive and violent behaviours...
Predictors of placebo response in adults with attention-deficit/hyperactivity disorder: data from 2 randomized trials of osmotic-release oral system methylphenidateJan K Buitelaar
Department of Cognitive Neuroscience, University Medical Center, St Radboud and Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands
J Clin Psychiatry 73:1097-102. 2012..To find potential correlates of placebo response in adults with attention-deficit/hyperactivity disorder (ADHD) and gain insights into why placebo response may be high in clinical trials...
A pilot study of abnormal growth in autism spectrum disorders and other childhood psychiatric disordersNanda N J Rommelse
Karakter, Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands
J Autism Dev Disord 41:44-54. 2011..Thus abnormal growth appears to be related to psychiatric disorders in general and is mainly expressed as an accelerated growth of height not matched by an increase in weight or head circumference...
Predictive value of subclinical autistic traits at age 14-15 months for behavioural and cognitive problems at age 3-5 yearsEsmé Möricke
Department of Psychiatry 966, Nijmegen Centre for Evidence Based Practice NCEBP, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 19:659-68. 2010..The practical implications bear on the early recognition of children at risk for behavioural problems and for language and cognitive problems...
Effects of maternal and paternal smoking on attentional control in children with and without ADHDMarieke E Altink
Department of Psychiatry, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, P O Box 9101, HP 966, Nijmegen 6500 HB, The Netherlands
Eur Child Adolesc Psychiatry 18:465-75. 2009..Future studies should examine if the results can be generalized to other cognitive domains...
Relationship between endophenotype and phenotype in ADHDNanda Nj Rommelse
Department of Clinical Neuropsychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Behav Brain Funct 4:4. 2008..abstract:..
The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysisRobert D Oades
Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
Behav Brain Funct 4:48. 2008..abstract:..
The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligenceUeli C Muller
Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland
BMC Psychiatry 11:55. 2011..In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures...
The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patternsUeli C Muller
Department of Child and Adolescent Psychiatry, University of Zurich, Switzerland
BMC Psychiatry 11:54. 2011..A particular focus was on the effects of the study design and the diagnostic procedure on the homogeneity of the sample in terms of symptom-based behavioural data, and potential consequences for further analyses based on these data...
Predictors of treatment outcome in adults with ADHD treated with OROS® methylphenidateJan K Buitelaar
UMC St Radboud, Department of Cognitive Neuroscience, Nijmegen, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 35:554-60. 2011....
Foreword -- ADHD in the scientific and political contextJan K Buitelaar
Dept of Psychiatry 333, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 13:I1-6. 2004..Not only a European perspective" underlines this perspective and reflects a broad spectrum of ADHD-related activities currently underway in Europe while having the worldwide development of the field in mind...
Comparison of symptomatic versus functional changes in children and adolescents with ADHD during randomized, double-blind treatment with psychostimulants, atomoxetine, or placeboJan K Buitelaar
Department of Psychiatry, Radboud University Nijmegen Medical Centre and Karakter University Centre for Child and Adolescent Psychiatry, Nijmegen, The Netherlands
J Child Psychol Psychiatry 50:335-42. 2009....
A comparison of North American versus non-North American ADHD study populationsJan K Buitelaar
Dept of Psychiatry, Academic Centre for Child and Adolescent Psychiatry, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 15:177-81. 2006..This supports the practice of generalizing results from treatment studies across geographies...
Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidateJ K Buitelaar
Department of Cognitive Neuroscience, University Medical Centre, St Radboud and Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
Psychol Med 42:195-204. 2012..Daily functioning was assessed as part of an open-label extension, and associations with symptom scores were evaluated...
Motor flexibility problems as a marker for genetic susceptibility to attention-deficit/hyperactivity disorderDorine Slaats-Willemse
Academic Center for Child and Adolescent Psychiatry Oost Nederland, University Medical Center St Radboud, Reinier Postlaan 12, 6525 GC Nijmegen, The Netherlands
Biol Psychiatry 58:233-8. 2005..We hypothesized that if fine motor problems may be a marker for genetic susceptibility to ADHD, nonaffected siblings of ADHD probands would experience motor problems similar to those of their ADHD siblings...
Contributions of the medial temporal lobe to declarative memory retrieval: manipulating the amount of contextual retrievalIndira Tendolkar
Department of Psychiatry, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands
Learn Mem 15:611-7. 2008..If one assumes departure from linearity, however, our results can also be explained by one-dimensional modulation of memory strength...
Exceptions and anomalies: an ERP study on context sensitivity in autismJudith Pijnacker
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
Neuropsychologia 48:2940-51. 2010..Because sentence context had a modulating effect in a later phase, semantic integration is perhaps less automatic in HFA, and presumably more elaborate processes are needed to arrive at a sentence interpretation...
The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuliGuido van Wingen
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
Neuroimage 50:1212-8. 2010..Furthermore, the sex-specific genotype effects may contribute to sex-specific effects of BDNF Val66Met on depression vulnerability...
Amygdala responsivity related to memory of emotionally neutral stimuli constitutes a trait factor for depressionPhilip van Eijndhoven
Radboud University Nijmegen Medical Centre, Department of Psychiatry, Nijmegen, The Netherlands
Neuroimage 54:1677-84. 2011..These findings represent initial evidence for a neurocognitive trait or vulnerability marker of depression-amygdala involvement in episodic memory formation of neutral stimuli...
DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch familiesSteven C Bakker
Department of Psychiatry, A 00 241, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 132:50-2. 2005..These data suggest that DAT1, DRD4, and DRD5 do not contribute substantially to ADHD in the Dutch population...
Current self-reported symptoms of attention deficit/hyperactivity disorder are associated with total brain volume in healthy adultsMartine Hoogman
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
PLoS ONE 7:e31273. 2012..In order to get a better understanding of the neurobiology of ADHD, we take the first step in studying the dimensionality of current self-reported adult ADHD symptoms, by looking at its relation with total brain volume...
Reasoning with exceptions: an event-related brain potentials studyJudith Pijnacker
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
J Cogn Neurosci 23:471-80. 2011..Possible accounts for the observed effect are discussed...
How useful is the Social Communication Questionnaire in toddlers at risk of autism spectrum disorder?Iris Oosterling
Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, Nijmegen, The Netherlands
J Child Psychol Psychiatry 51:1260-8. 2010..Indices of diagnostic accuracy have been shown to be strong in school-aged samples; however, relatively little is known about the performance of the SCQ in toddlers at risk of autism spectrum disorder (ASD)...
Familiality of major depressive disorder and patterns of lifetime comorbidity. The NEMESIS and GenMood studies. A comparison of three samplesMaaike Verhagen
Department of Psychiatry 966, Radboud University Nijmegen Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
Eur Arch Psychiatry Clin Neurosci 258:505-12. 2008..This study examined whether familiality of MDD is associated with the presence of specific comorbid disorders, which might be an important factor to be taken into account in MDD treatment and research into MDD etiology...
The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interactionMarieke E Altink
Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, The Netherlands
J Child Psychol Psychiatry 49:1053-60. 2008....
Impaired task switching performance in children with dyslexia but not in children with autismEdita Poljac
Radboud University Nijmegen, Nijmegen, The Netherlands
Q J Exp Psychol (Hove) 63:401-16. 2010..The implications of our data are further discussed in relation to the interpretation of the Wisconsin Card Sorting Test...
Neural basis of recollection in first-episode major depressionPhilip van Eijndhoven
Department of Psychiatry, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
Hum Brain Mapp 34:283-94. 2013..Here, we used an event-related fMRI design, to dissociate hippocampal and prefrontal contributions to the neural processes involved in recollection success and recollection attempt early in the course of MDD...
Nitric oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjectsMartine Hoogman
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
Am J Psychiatry 168:1099-106. 2011..In the present study, the authors investigated the effect of a functional variable number of tandem repeats (VNTR) polymorphism in NOS1 (NOS1 exon 1f-VNTR) on the processing of rewards, one of the cognitive deficits in ADHD...
Head circumference and height abnormalities in autism revisited: the role of pre- and perinatal risk factorsMargo Schrieken
Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 22:35-43. 2013..However, prospective studies measuring growth and ASD characteristics in both premature/low birth weight and a terme children are necessary to support this conclusion...
Amygdala and hippocampus enlargement during adolescence in autismWouter Groen
Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
J Am Acad Child Adolesc Psychiatry 49:552-60. 2010..Although some studies in children with autism suggest that there is an enlargement of amygdala and hippocampal volume, findings in adolescence are sparse...
Lifespan attention deficit/hyperactivity disorder and borderline personality disorder symptoms in female patients: a latent class approachFiona van Dijk
Department of Psychiatry, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
Psychiatry Res 190:327-34. 2011..ADHD classification subtypes may not be permanent over time, and different developmental pathways to adult ADHD and BPD should therefore be investigated...
Atomoxetine for attention-deficit/hyperactivity disorder symptoms in children with pervasive developmental disorders: a pilot studyPieter W Troost
Department of Psychiatry, University Medical Center Groningen, University of Groningen, The Netherlands
J Child Adolesc Psychopharmacol 16:611-9. 2006..This pilot study examined the effects of atomoxetine on attention-deficit/hyperactivity disorder (ADHD) symptoms and autistic features in children with pervasive developmental disorders (PDD)...
Psychomotor planning is deficient in recent-onset schizophreniaKoen P Grootens
Department of Psychiatry, University Medical Center St Radboud, and Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
Schizophr Res 107:294-302. 2009..The aim of the present study is to test the hypothesis that such deficits are already present in patients with recent-onset schizophrenia...
Medically unexplained physical symptoms in elderly people: a pilot study of psychiatric geriatric characteristicsPeter H Hilderink
GGz Nijmegen, Department of Old Age Psychiatry, Radboud Univeristy Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Nijmegen, The Netherlands
Am J Geriatr Psychiatry 17:1085-8. 2009..To examine the somatic complaints, functional impairment, and psychiatric comorbidity in elderly patients with medically unexplained symptoms (MUSs)...
Testosterone reduces amygdala-orbitofrontal cortex couplingGuido van Wingen
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands
Psychoneuroendocrinology 35:105-13. 2010..Because interhemispheric amygdala coupling is lower in men than in women, this result suggests that circulating testosterone may contribute to this sexual dimorphism...
Severe fatigue in narcolepsy with cataplexyHal A Droogleever Fortuyn
Department of Psychiatry, Radboud University Nijmegen Medical Center, The Netherlands
J Sleep Res 21:163-9. 2012..In conclusion, a majority of patients with narcolepsy suffer from severe fatigue, which can be distinguished from daytime sleepiness, and results in severe functional impairment...
The crown of love: intimate relations and alcohol use in adolescenceCarmen S van der Zwaluw
Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 18:407-17. 2009..In the current study, we examined associations between adolescent alcohol use and romantic partners' drinking behavior...
ADHD and poor motor performance from a family genetic perspectiveEllen Fliers
Bavo Europoort Youth Department, Twentestraat 52, 3083 BD Rotterdam, The Netherlands
J Am Acad Child Adolesc Psychiatry 48:25-34. 2009....
Family-genetic study of executive functioning in attention-deficit/hyperactivity disorder: Evidence for an endophenotype?Dorine I E Slaats-Willemse
Rudolph Magnus Center for Neurosciences, University Medical Center Utrecht, The Netherlands
Neuropsychology 21:751-60. 2007..These results suggest that these executive functions may be suitable endophenotypes of ADHD...
Inhibition errors in borderline personality disorder with psychotic-like symptomsKoen P Grootens
Radboud University Nijmegen Medical Center, Dept of Psychiatry, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 32:267-73. 2008..Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms...
Early and late components of error monitoring in violent offenders with psychopathyInti A Brazil
Department of Psychiatry, Donders Centre for Neurosciences, University Medical Center St Radboud, Nijmegen, The Netherlands Pompestichting, Nijmegen, The Netherlands
Biol Psychiatry 65:137-43. 2009..One of the most recognizable features of psychopathy is the reduced ability to successfully learn and adapt overt behavior. This might be due to deficient processing of error information indicating the need to adapt controlled behavior...
Increased p50 gating but intact prepulse inhibition in borderline personality disorderKoen P Grootens
CW2 Hospital Nijmegen, Department of Psychiatry A15, P O Box 9015, 6500 GS Nijmegen, The Netherlands
J Neuropsychiatry Clin Neurosci 20:348-56. 2008..The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication...
The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controlsArnt F A Schellekens
Department of Psychiatry, University Medical Centre St Radboud, Nijmegen, The Netherlands
Eur Neuropsychopharmacol 19:68-73. 2009..Little is known on functional changes in the fronto-striatal-thalamic dopaminergic neurocircuitry in these patients. The objective of this study was to assess sensitivity of prefrontal dopamine receptors in alcohol dependent patients...
Attention-deficit/hyperactivity disorder and social dysfunctioningJudith S Nijmeijer
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
Clin Psychol Rev 28:692-708. 2008..Future research should address the exact nature and long-term consequences of social dysfunctioning in children with ADHD, and focus on development of effective treatment strategies...
A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHDNanda N J Rommelse
Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 147:1536-46. 2008....
Externalizing behaviors in preadolescents: familial risk to externalizing behaviors, prenatal and perinatal risks, and their interactionsCathelijne J M Buschgens
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 18:65-74. 2009..We investigated whether familial risk (FR) to externalizing behaviors and prenatal and perinatal risk factors, separately or in interaction with each other, predicted externalizing behaviors...
Psychotic symptoms in narcolepsy: phenomenology and a comparison with schizophreniaHal A Droogleever Fortuyn
Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Gen Hosp Psychiatry 31:146-54. 2009..We also compared the prevalence of formal psychotic disorders between narcolepsy patients and controls...
The phenotype and neural correlates of language in autism: an integrative reviewWouter B Groen
Karakter, Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
Neurosci Biobehav Rev 32:1416-25. 2008....
Cardiac disease, depressive symptoms, and incident stroke in an elderly populationLonneke Wouts
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arch Gen Psychiatry 65:596-602. 2008..However, the reliability of much research is limited by the lack of documentation on the presence of preexistent cardiovascular disease and by the use of limited measures of depression or stroke...
Gender in voice perception in autismWouter B Groen
Karakter, Child and Adolescent Psychiatry University Center, 6500 HB, Nijmegen, The Netherlands
J Autism Dev Disord 38:1819-26. 2008..The differences in response times suggest that individuals with HFA use different perceptual approaches from those used by typically developing individuals...
Effect of the 5-HTTLPR polymorphism in the serotonin transporter gene on major depressive disorder and related comorbid disordersMaaike Verhagen
Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Psychiatr Genet 19:39-44. 2009..This could be because of the phenotypic heterogeneity of MDD, as it often presents with comorbid disorders such as generalized anxiety disorder (GAD), alcohol-related disorders, and dysthymia...
Neuropsychological measures probably facilitate heritability research of ADHDNanda N J Rommelse
Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
Arch Clin Neuropsychol 23:579-91. 2008..These findings suggest heritability research in ADHD will probably be facilitated by including neuropsychological measures...
Differential association between MAOA, ADHD and neuropsychological functioning in boys and girlsNanda N J Rommelse
Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 147:1524-30. 2008..01). These findings suggest that the genetic and neuropsychological mechanisms underlying ADHD may be different in boys and girls and underline the importance of taking into account sex effects when studying ADHD...
Intact spectral but abnormal temporal processing of auditory stimuli in autismWouter B Groen
Karakter, Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands
J Autism Dev Disord 39:742-50. 2009..008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account...
Prenatal stress and mixed-handednessBarbara M Gutteling
Department of Psychiatry, Radboud University Medical Center St Radboud, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Pediatr Res 62:586-90. 2007..In conclusion, reported and physiologic measures of prenatal stress in a moderately stressed pregnant population were only partly related to offspring mixed-handedness...
Comorbid problems in ADHD: degree of association, shared endophenotypes, and formation of distinct subtypes. Implications for a future DSMNanda N J Rommelse
Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
J Abnorm Child Psychol 37:793-804. 2009..No such results were found for oppositional defiant behaviors and anxiety. ADHD in co-occurrence with comorbid problems may not be best seen as a distinct subtype of ADHD, but further research is warranted...
Actual motor performance and self-perceived motor competence in children with attention-deficit hyperactivity disorder compared with healthy siblings and peersEllen A Fliers
Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Dev Behav Pediatr 31:35-40. 2010..quot; In this cross-sectional study, the relationship between actual motor performance and perceived motor competence was examined...
Anxiety and mood disorders in narcolepsy: a case-control studyH A Droogleever Fortuyn
Department of Psychiatry, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Gen Hosp Psychiatry 32:49-56. 2010..Although many authors suggest an overrepresentation of mood disorders, few systematic studies have been performed and conflicting results have been reported. Anxiety disorders in narcolepsy have only received little attention...
The effect of ondansetron, a 5-HT3 receptor antagonist, in chronic fatigue syndrome: a randomized controlled trialGerard K H The
Radboud University Nijmegen Medical Centre, Department of Psychiatry, 966, Reinier Postlaan 10, 6525 GC Nijmegen, The Netherlands
J Clin Psychiatry 71:528-33. 2010..In this randomized controlled clinical trial, the effect of ondansetron, a 5-HT(3) receptor antagonist, was assessed on fatigue severity and functional impairment in adult patients with chronic fatigue syndrome...
A controlled study of formal thought disorder in children with autism and multiple complex developmental disordersRutger J van der Gaag
University Medical Centre St Radboud Nijmegen Academic Centre for Child and Adolescent Psychiatry, Nijmegen, The Netherlands
J Child Adolesc Psychopharmacol 15:465-76. 2005....
Maternal prenatal stress and 4-6 year old children's salivary cortisol concentrations pre- and post-vaccinationBarbara M Gutteling
Department of Psychiatry, Radboud University Nijmegen, Medical Center, The Netherlands
Stress 7:257-60. 2004..Furthermore, more daily hassles and a higher level of fear of bearing a handicapped child during pregnancy were associated with higher concentrations of cortisol in the children...
Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)Marieke M Lansbergen
Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Psychopharmacology (Berl) 213:745-56. 2011..Typical users of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") are polydrug users, combining MDMA with alcohol or cannabis [most active compound: delta-9-tetrahydrocannabinol (THC)]...
Pervasive microstructural abnormalities in autism: a DTI studyWouter B Groen
Karakter, Child and Adolescent Psychiatry University Center, P O Box 9101, 6500 HB Nijmegen, TheNetherlands
J Psychiatry Neurosci 36:32-40. 2011..Since autism is a developmental disorder, we aim to investigate the nature and location of decreases in white and grey matter integrity in an adolescent sample while accounting for age...
Prenatal exposure to testosterone and functional cerebral lateralization: a study in same-sex and opposite-sex twin girlsCelina C C Cohen-Bendahan
Department of Psychiatry, University Medical Center St Radboud, Nijmegen, The Netherlands
Psychoneuroendocrinology 29:911-6. 2004..Secondly, as predicted OS girls had a more masculine pattern of cerebral lateralization, than SS girls. These findings support the notion of an influence of prenatal T on early brain organization in girls...
Facilitated attentional disengagement from negative information in relation to self-reported depressive symptoms of Dutch female undergraduate studentsPatricia A M Van Deurzen
Donders Institute for Brain, Cognition, and Behavior, Department of Psychiatry, Radboud University Nijmegen Medical Centre, Karakter Child and Adolescent Psychiatry, University Centre Nijmegen, The Netherlands
Psychol Rep 108:252-62. 2011..An explanation for the discrepancy with findings from Koster, et al. may be the different stimulus presentation time (1000 msec. instead of 500 or 1500 msec.)...
Externalizing behaviors in preadolescents: familial risk to externalizing behaviors and perceived parenting stylesCathelijne J M Buschgens
Department of Psychiatry, Radboud University, Nijmegen Medical Centre, PO Box 9101, HP 966, 6500 HB, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 19:567-75. 2010....
Hyperactive night and day? Actigraphy studies in adult ADHD: a baseline comparison and the effect of methylphenidateA Marije Boonstra
University Medical Center Utrecht, Department of Psychiatry, Utrecht, The Netherlands
Sleep 30:433-42. 2007..To investigate parameters of sleep, activity, and circadian rhythm, as well as the effects of methylphenidate on these variables, in adults with ADHD...
HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS studyRianne Marsman
Department of Psychiatry, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Psychoneuroendocrinology 33:789-98. 2008..It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity...
Problem behavior in a community sample of 14- and 19-month-old children: common versus uncommon behaviors, structure, and stabilityAnne Claire E Beernink
Dept of Psychiatry, University Medical Center St Radboud, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 16:271-80. 2007..These results will facilitate the recognition of psychopathology at very early age and the study of its development over time...
Prenatal stress and children's cortisol reaction to the first day of schoolBarbara M Gutteling
Department of Psychiatry 333, Radbond University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Psychoneuroendocrinology 30:541-9. 2005..In addition, the circadian rhythm of cortisol on school days appeared to have a steeper slope as compared to that of the circadian curve on a weekend day...
Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS studyRianne Marsman
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 18:565-73. 2009..Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems...
Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHDBarbara Franke
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Neuropsychopharmacology 35:656-64. 2010..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD...
Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorderNanda N J Rommelse
Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 19:281-95. 2010..Multivariate multi-level models are probably best suited for the statistical analysis...
Neural state and trait bases of mood-incongruent memory formation and retrieval in first-episode major depressionGuido A van Wingen
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
J Psychiatr Res 44:527-34. 2010..These distinct neural mechanisms may respectively constitute symptom maintenance and cognitive vulnerability factors for depression...
The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequencyMarieke M Lansbergen
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 35:47-52. 2011..Future research should elucidate the functional role of resting-state brain oscillations by investigating neurophysiological subgroups, which may have a clearer relation to cognitive functions than single frequency bands...
Familial clustering of executive functioning in affected sibling pair families with ADHDDorine Slaats-Willemse
Department of Psychiatry, Radboud University Medical Center, and The Academic Center for Child and Adolescent Psychiatry Oost Nederland, Nijmegen, The Netherlands
J Am Acad Child Adolesc Psychiatry 44:385-91. 2005..To investigate familial clustering of executive functioning (i.e., response inhibition, fine visuomotor functioning, and attentional control) in attention-deficit/hyperactivity disorder (ADHD)-affected sibling pairs...
Physiological stress reactivity in human pregnancy--a reviewCarolina de Weerth
Department of Psychiatry, University Medical Center Nijmegen, HP 333, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Neurosci Biobehav Rev 29:295-312. 2005..These methodological points are general and can therefore also be of use for researchers studying human stress reactivity in other populations and ages...
Unification of speaker and meaning in language comprehension: an FMRI studyCathelijne M J Y Tesink
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
J Cogn Neurosci 21:2085-99. 2009....
Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblingsSarah Durston
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 43:332-40. 2004..To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology...
A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHDJan K Buitelaar
Department of Psychiatry, University Medical Center Nijmegen, 9101, 6500, HB Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 13:249-57. 2004..CONCLUSION: These open-label data, gathered in an international setting, add to our knowledge of the value of atomoxetine in treating ADHD symptoms, as well as its safety and tolerability...
Neuropsychological effects of risperidone in children with pervasive developmental disorders: a blinded discontinuation studyPieter W Troost
Department of Psychiatry, University Medical Center Groningen, University of Groningen, The Netherlands
J Child Adolesc Psychopharmacol 16:561-73. 2006..Little is known about the neuropsychological effects of risperidone in children with pervasive developmental disorders...
Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic reviewCarmen S van der Zwaluw
Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
Pharmacogenomics 10:853-66. 2009..We discuss shortcomings, such as lack of power and disregarding moderating variables, as well as future challenges of gene association studies...
Pragmatic inferences in high-functioning adults with autism and Asperger syndromeJudith Pijnacker
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
J Autism Dev Disord 39:607-18. 2009..Moreover, our results suggest that verbal intelligence is a constraint for task performance in autistic disorder but not in Asperger syndrome...
Amygdala volume marks the acute state in the early course of depressionPhilip van Eijndhoven
Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Biol Psychiatry 65:812-8. 2009..It remains unclear how much structural and functional changes of amygdala and hippocampus reflect the acute state of depression or an underlying neurobiological trait marker of depression...
Probing the neural correlates of associative memory formation: a parametrically analyzed event-related functional MRI studyIndira Tendolkar
Department of Psychiatry, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
Brain Res 1142:159-68. 2007..In contrast, if associations have to be formed across widely distributed neocortical representations, the hippocampus may provide a binding operation in order to establish a coherent memory...
Parental compliance after screening social development in toddlersClaudine Dietz
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Arch Pediatr Adolesc Med 161:363-8. 2007....
Long-term effects of risperidone in children with autism spectrum disorders: a placebo discontinuation studyPieter W Troost
Department of Psychiatry, University Medical Center Groningen, University of Groningen, The Netherlands
J Am Acad Child Adolesc Psychiatry 44:1137-44. 2005..The short-term benefit of risperidone in ameliorating severe disruptive behavior in pediatric patients with autism spectrum disorders is well established; however, only one placebo-controlled, long-term study of efficacy is available...
Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorderMartine van Dongen-Boomsma
Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
Neurosci Lett 469:102-6. 2010..These findings were interpreted vis-à-vis a biophysical model assuming that the hypo-arousal in ADHD is due to an overdrive of the nucleus coeruleus resulting in inhibitory activity of the thalamic reticular nucleus...
Randomized controlled trial of the focus parent training for toddlers with autism: 1-year outcomeIris Oosterling
Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, Nijmegen, The Netherlands
J Autism Dev Disord 40:1447-58. 2010....
High prevalence of eating disorders in narcolepsy with cataplexy: a case-control studyHal A Droogleever Fortuyn
Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Sleep 31:335-41. 2008..To study the prevalence of and symptoms of eating disorders in patients with narcolepsy...
Behaviour problems in childhood and adolescence in psychotic offenders: an exploratory studyKris Goethals
Pompe Foundation, Nijmegen, The Netherlands
Crim Behav Ment Health 18:153-65. 2008..It is less clear whether such problems follow a particular pattern in such patients...
Childbirth complications affect young infants' behaviorCarolina de Weerth
Developmental Psychology, Radboud University Nijmegen, P O Box 9104, 6500 HE, Nijmegen, The Netherlands
Eur Child Adolesc Psychiatry 16:379-88. 2007..In this study, we examine how mode of delivery and delivery complications are related to the behavior and cortisol reactivity of infants during the first 2 months...
Is pregnancy anxiety a distinctive syndrome?Anja C Huizink
Department of Child and Adolescent Psychiatry and Rudolf Magnus Institute, University Medical Centre Utrecht, The Netherlands
Early Hum Dev 79:81-91. 2004..Therefore, a questionnaire on pregnancy anxieties was used to test their structure, and to examine their associations with general anxiety and depression...
Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adultsJ J Sandra Kooij
Parnassia, Psycho-Medical Centre, Den Haag, The Netherlands
Psychol Med 35:817-27. 2005..ADHD is not merely a child psychiatric disorder that persists into young adulthood, but an important and unique manifestation of psychopathology across the lifespan...
Cortisol awakening response in pregnant womenCarolina de Weerth
Department of Developmental Psychology, Radboud University Nijmegen, The Netherlands
Psychoneuroendocrinology 30:902-7. 2005..non-working day. In conclusion, the free cortisol awakening response is present during pregnancy, and is potentially a useful marker to study the association between prenatal psychosocial stress and offspring development...
Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?A Marije Boonstra
Department of Child Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Exp Neuropsychol 27:278-98. 2005..Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD...
