Willeke Am M Blokx

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma
    Willeke A M Blokx
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Surg Pathol 31:637-41. 2007
  2. ncbi request reprint INK4-ARF and p53 mutations in metastatic cutaneous squamous cell carcinoma: case report and archival study on the use of Ink4a-ARF and p53 mutation analysis in identification of the corresponding primary tumor
    Willeke A M Blokx
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Surg Pathol 29:125-30. 2005
  3. ncbi request reprint P16 and p53 expression in (pre)malignant epidermal tumors of renal transplant recipients and immunocompetent individuals
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Mod Pathol 16:869-78. 2003
  4. doi request reprint Molecular cytogenetics of cutaneous melanocytic lesions - diagnostic, prognostic and therapeutic aspects
    Willeke Am M Blokx
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 56:121-32. 2010
  5. doi request reprint Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis
    Heidi V N Küsters-Vandevelde
    Department of Pathology C66, Canisius Wilhelmina Hospital, P O Box 9015, 6500 GS Nijmegen, The Netherlands
    Virchows Arch 452:331-6. 2008
  6. doi request reprint Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Cell Mol Med 13:2148-57. 2009
  7. pmc Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung
    Charlotte T A H Wetzels
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4958. 2009
  8. pmc Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Acta Neuropathol 120:755-64. 2010
  9. doi request reprint HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features
    A C H van Engen-van Grunsven
    Departments of Pathology, Radboud University Nijmegen Medical Center, The Netherlands
    Am J Surg Pathol 34:1436-41. 2010
  10. ncbi request reprint Fluorescence diagnosis in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 57:824-31. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma
    Willeke A M Blokx
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Surg Pathol 31:637-41. 2007
    ..This case illustrates that molecular analysis can contribute to the sometimes-difficult differentiation between a second primary melanoma and a melanoma metastasis...
  2. ncbi request reprint INK4-ARF and p53 mutations in metastatic cutaneous squamous cell carcinoma: case report and archival study on the use of Ink4a-ARF and p53 mutation analysis in identification of the corresponding primary tumor
    Willeke A M Blokx
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Surg Pathol 29:125-30. 2005
    ..The major limitation was formed by insufficient DNA quality in archival tissue...
  3. ncbi request reprint P16 and p53 expression in (pre)malignant epidermal tumors of renal transplant recipients and immunocompetent individuals
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Mod Pathol 16:869-78. 2003
    ..Furthermore, HKIN lesions express significantly more p16 than LKINs and SCCs...
  4. doi request reprint Molecular cytogenetics of cutaneous melanocytic lesions - diagnostic, prognostic and therapeutic aspects
    Willeke Am M Blokx
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 56:121-32. 2010
    ..These targeted treatments all need careful evaluation, but might be a promising adjunct for treatment of metastatic melanoma patients, in which other therapies have not brought important survival advantages yet...
  5. doi request reprint Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis
    Heidi V N Küsters-Vandevelde
    Department of Pathology C66, Canisius Wilhelmina Hospital, P O Box 9015, 6500 GS Nijmegen, The Netherlands
    Virchows Arch 452:331-6. 2008
    ..238C>T, p.Arg80X, (p14) c.404C>T, p.Pro135Leu)) in the tumor samples, but not in the normal control tissue of the patient. We concluded that the uveal melanoma is a metastasis from the cutaneous melanoma removed 13 years before...
  6. doi request reprint Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Cell Mol Med 13:2148-57. 2009
    ..P14, p16 and p53 expressions are independent of immune status. Our data indicate that in immunosuppressed patients, beta-PV together with ultraviolet radiation act synergetic in promoting carcinogenesis...
  7. pmc Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung
    Charlotte T A H Wetzels
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4958. 2009
    ..So far the actual presence of the virus in MCC tumour cells on a morphological level has not been demonstrated, and the presence of MCPyV in other small cell neuroendocrine carcinomas has not been studied yet...
  8. pmc Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Acta Neuropathol 120:755-64. 2010
    ..We conclude that a detailed analysis of morphology combined with GNAQ mutational analysis can aid in the differential diagnosis of melanotic schwannoma with leptomeningeal melanocytic lesions...
  9. doi request reprint HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features
    A C H van Engen-van Grunsven
    Departments of Pathology, Radboud University Nijmegen Medical Center, The Netherlands
    Am J Surg Pathol 34:1436-41. 2010
    ..Moreover, this might be a first step toward a more reproducible classification of Spitz tumors combining histological and genetic data...
  10. ncbi request reprint Fluorescence diagnosis in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 57:824-31. 2007
    ..As different tissue types have distinct capabilities to accumulate protoporphyrin-IX, fluorescence diagnosis with aminolevulinic acid-induced porphyrin (FDAP) could be used to discriminate between different tissue types...
  11. doi request reprint Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma
    Marloes M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Photodermatol Photoimmunol Photomed 26:297-302. 2010
    ..Previous results demonstrated higher fluorescence ratios in squamous cell carcinoma (SCC) compared with actinic keratoses (AKs)...
  12. ncbi request reprint Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Exp Dermatol 16:81-6. 2007
    ..Ki67 expression appears a valuable marker in the classification of KINs...
  13. ncbi request reprint Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma
    Leon C L T van Kempen
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    J Pathol 204:333-9. 2004
    ..These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC...
  14. ncbi request reprint Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects
    Jurgen V Smit
    Departments of Dermatology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 50:189-96. 2004
    ..However, no histologic and immunohistochemical studies have been performed to further substantiate these observations...
  15. ncbi request reprint High-dose long wave visible light induces perinuclear vacuolization in vivo but does not result in early photoageing and apoptosis
    Milan Tjioe
    Department of Dermatology, University Medical Centre Nijmegen, The Netherlands
    Exp Dermatol 12:610-4. 2003
    ..High-dose visible light induces a significant increase in perinuclear vacuolization, but does not result in apoptosis, photodamage or early induction of skin ageing...
  16. doi request reprint CDKN2A but not TP53 mutations nor HPV presence predict poor outcome in metastatic squamous cell carcinoma of the skin
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Canisius Wilhelmina Hospital, 6500 GS Nijmegen, The Netherlands
    Int J Cancer 126:2123-32. 2010
    ..In most cases, CDKN2A and TP53 mutations are early genetic events in CSCC tumorigenesis. The possible role of HPV in metastatic CSCC needs further exploration...
  17. ncbi request reprint Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoprolife
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherland
    Am J Dermatopathol 24:414-22. 2002
    ....
  18. ncbi request reprint Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arch Dermatol 138:61-5. 2002
    ..To compare the expression of keratin (K) 13 and K19 in cutaneous warts of renal transplant recipients (RTRs) and immunocompetent individuals (ICIs)...
  19. ncbi request reprint Immunohistochemical effects of temporary cessation of long-term acitretin treatment in keratinocytic intraepidermal neoplasia of renal transplant recipients
    Willeke A M Blokx
    Arch Dermatol 139:671-3. 2003