Bastiaan R Bloem

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Falls in Parkinson's disease
    Yvette A M Grimbergen
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands and Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Curr Opin Neurol 17:405-15. 2004
  2. ncbi request reprint Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:871-84. 2004
  3. ncbi request reprint Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease
    Maaike Bakker
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:1092-9. 2004
  4. ncbi request reprint The "posture second" strategy: a review of wrong priorities in Parkinson's disease
    Bastiaan R Bloem
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurol Sci 248:196-204. 2006
  5. doi request reprint Gait disorders and balance disturbances in Parkinson's disease: clinical update and pathophysiology
    Tjitske A Boonstra
    Department of Neurology, Donders Center for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Neurol 21:461-71. 2008
  6. pmc Move for change part I: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's disease
    B R Bloem
    Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Neurol 19:402-10. 2012
  7. pmc Too hot to handle: heat stroke in multiple system atrophy
    Carla C P Verstappen
    J Neurol 254:664-5. 2007
  8. pmc Prevalence and definition of drooling in Parkinson's disease: a systematic review
    J G Kalf
    Department of Rehabilitation, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurol 256:1391-6. 2009
  9. pmc Connectedness of healthcare professionals involved in the treatment of patients with Parkinson's disease: a social networks study
    Michel Wensing
    Scientific Institute for Quality of Healthcare IQ Healthcare, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, Nijmegen, Netherlands
    Implement Sci 6:67. 2011
  10. doi request reprint Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait
    Anke H Snijders
    Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Brain 134:59-72. 2011

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Falls in Parkinson's disease
    Yvette A M Grimbergen
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands and Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Curr Opin Neurol 17:405-15. 2004
    ..To summarize the latest insights into the clinical significance, assessment, pathophysiology and treatment of falls in Parkinson's disease...
  2. ncbi request reprint Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:871-84. 2004
    ....
  3. ncbi request reprint Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease
    Maaike Bakker
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:1092-9. 2004
    ..Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase...
  4. ncbi request reprint The "posture second" strategy: a review of wrong priorities in Parkinson's disease
    Bastiaan R Bloem
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurol Sci 248:196-204. 2006
    ..Instead, Parkinson patients use a "posture second" strategy and treat all elements of a complex task with equal priority, which in daily life may go at the expense of maintaining balance and lead to falls...
  5. doi request reprint Gait disorders and balance disturbances in Parkinson's disease: clinical update and pathophysiology
    Tjitske A Boonstra
    Department of Neurology, Donders Center for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Neurol 21:461-71. 2008
    ..Here, we discuss the latest findings regarding epidemiology, assessment, pathophysiology and treatment of gait and balance impairments in Parkinson's disease...
  6. pmc Move for change part I: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's disease
    B R Bloem
    Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Neurol 19:402-10. 2012
    ..Move for Change is a three-part series of pan-European patient surveys based on this Charter...
  7. pmc Too hot to handle: heat stroke in multiple system atrophy
    Carla C P Verstappen
    J Neurol 254:664-5. 2007
  8. pmc Prevalence and definition of drooling in Parkinson's disease: a systematic review
    J G Kalf
    Department of Rehabilitation, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurol 256:1391-6. 2009
    ..In about a quarter of PD patients, drooling appears to be a frequently occurring problem. We recommend to report drooling in future studies with more detailed consideration of severity, frequency and nocturnal versus diurnal complaints...
  9. pmc Connectedness of healthcare professionals involved in the treatment of patients with Parkinson's disease: a social networks study
    Michel Wensing
    Scientific Institute for Quality of Healthcare IQ Healthcare, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, Nijmegen, Netherlands
    Implement Sci 6:67. 2011
    ..We aimed to describe and analyze connectedness in a regional network of health professionals involved in ambulatory treatment of patients with Parkinson's disease (PD)...
  10. doi request reprint Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait
    Anke H Snijders
    Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Brain 134:59-72. 2011
    ..These limitations might become particularly evident during challenging events that require precise regulation of step length and gait timing, such as turning or initiating walking, which are known triggers for freezing of gait...
  11. ncbi request reprint An update on falls
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Curr Opin Neurol 16:15-26. 2003
    ..In addition, falls pose high costs to the public health service. For these reasons, falls remain a popular topic for research. Here, we review several interesting developments that have been published during the past year...
  12. doi request reprint StartReact restores reaction time in HSP: evidence for subcortical release of a motor program
    Jorik Nonnekes
    Nijmegen Centre for Evidence Based Practice, Department of Rehabilitation and Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands, and Sint Maartenskliniek Research, Development and Education, 6500 GM Nijmegen, The Netherlands
    J Neurosci 34:275-81. 2014
    ..These delayed onsets in HSP were normalized when the imperative stimulus was combined with a SAS, presumably through release of a subcortically stored motor program conveyed by the preserved reticulospinal tract. ..
  13. doi request reprint Nonmotor symptoms in nursing home residents with Parkinson's disease: prevalence and effect on quality of life
    Nico J Weerkamp
    Department of Neurology, Atrium Medical Center, Heerlen, The Netherlands Department of Neurology, Nijmegen Center for Evidence Based Practice, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Geriatr Soc 61:1714-21. 2013
    ..To determine the prevalence of nonmotor symptoms (NMS) in nursing home (NH) residents with Parkinson's disease (PD) and to establish the association with quality of life...
  14. doi request reprint The ParkinsonNet trial: design and baseline characteristics
    Samyra H J Keus
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Mov Disord 25:830-7. 2010
    ..Baseline characteristics of participants in the ParkinsonNet and control clusters were comparable. With 699 participating patients, this is the largest allied health study in PD to date...
  15. pmc Promotion of physical activity and fitness in sedentary patients with Parkinson's disease: randomised controlled trial
    Marlies van Nimwegen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Nijmegen, Netherlands
    BMJ 346:f576. 2013
    ..To evaluate whether a multifaceted behavioural change programme increases physical activities in patients with Parkinson's disease...
  16. doi request reprint Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism
    Bart F L Van Nuenen
    Department of Neurology 935, Radboud University Nijmegen Medical Centre, PO Box 9 101, 6500 HB Nijmegen, The Netherlands
    Brain 135:3687-98. 2012
    ..These functional cerebral changes open the possibility to use a prospective study to test their relevance as early markers of Parkinson's disease...
  17. ncbi request reprint Cerebral white matter lesions and lacunar infarcts contribute to the presence of mild parkinsonian signs
    Karlijn F de Laat
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Stroke 43:2574-9. 2012
    ..To identify subjects at early stages of the disease, we investigated whether the presence of MPS was dependent on the severity and location of small-vessel disease, including white matter lesions and lacunar infarcts...
  18. pmc Assessment of dual tasking has no clinical value for fall prediction in Parkinson’s disease
    Katrijn Smulders
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognitionand Behaviour, Internal Code 935, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Neurol 259:1840-7. 2012
    ..These results did not change after correction for baseline group differences. Deterioration of gait or Stroop performance under dual task conditions was not associated with prospective falls in this large sample of patients with PD...
  19. pmc Effectiveness of occupational therapy in Parkinson's disease: study protocol for a randomized controlled trial
    Ingrid H W M Sturkenboom
    Nijmegen Centre of Evidence Based Practice, Department of Rehabilitation Occupational Therapy 898, Radboud University Nijmegen Medical Centre, Reinier Postlaan 2, 6525GC, PO Box 9101 6500HB, Nijmegen, The Netherlands
    Trials 14:34. 2013
    ..Evidence for this added value is inconclusive due to a lack of rigorous studies. The aim of this trial is to evaluate the (cost) effectiveness of occupational therapy in improving daily functioning of patients with Parkinson's disease...
  20. doi request reprint Increased dependence of action selection on recent motor history in Parkinson's disease
    Rick C Helmich
    Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Neurosci 29:6105-13. 2009
    ..The enhanced MFC activity may result either from reduced focusing abilities of the basal ganglia or from compensatory processes...
  21. doi request reprint Involvement of specific executive functions in mobility in Parkinson's disease
    Katrijn Smulders
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Parkinsonism Relat Disord 19:126-8. 2013
    ..In order to fully interpret gait and postural stability of PD patients in everyday situations, the role of impairments in working memory and response generation should be taken into account...
  22. doi request reprint The possible price of auditory cueing: influence on obstacle avoidance in Parkinson's disease
    Wandana Nanhoe-Mahabier
    Department of Neurology and Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 27:574-8. 2012
    ..We primarily examined whether concurrent auditory cueing interferes with an obstacle avoidance task in patients with PD. The secondary aim was to study differences between patients with and without freezing of gait...
  23. doi request reprint How might physical activity benefit patients with Parkinson disease?
    Arlène D Speelman
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Neurol 7:528-34. 2011
    ....
  24. doi request reprint Timed motor tests can detect subtle motor dysfunction in early Parkinson's disease
    Charlotte A Haaxma
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 25:1150-6. 2010
    ..Therefore, it may be worth evaluating as a diagnostic tool in everyday clinical practice to assess patients with early symptomatic PD, or as part of a more elaborate screening battery in a defined population at risk...
  25. doi request reprint Integrated multidisciplinary care in Parkinson's disease: a non-randomised, controlled trial (IMPACT)
    Marjolein A van der Marck
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Neurol 12:947-56. 2013
    ..To address this gap in knowledge, we assessed the effectiveness of an integrated multidisciplinary approach compared with usual care...
  26. pmc Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
    Rick C Helmich
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands, The Netherlands
    Brain 135:3206-26. 2012
    ....
  27. pmc Physical inactivity in Parkinson's disease
    Marlies van Nimwegen
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol 258:2214-21. 2011
    ..Because physical inactivity has many adverse consequences, work is needed to develop safe and enjoyable exercise programs for patients with PD...
  28. doi request reprint Spatial remapping of cortico-striatal connectivity in Parkinson's disease
    Rick C Helmich
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    Cereb Cortex 20:1175-86. 2010
    ..These alterations of network properties may underlie abnormal sensorimotor integration in PD...
  29. doi request reprint The ParkinsonNet concept: development, implementation and initial experience
    Maarten J Nijkrake
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Mov Disord 25:823-9. 2010
    ..We describe the procedures for developing a ParkinsonNet network. Our initial experience with this new concept is promising, showing an increase in PD-specific and a steady rise in the patient volume of individual therapists...
  30. doi request reprint Clinimetrics of freezing of gait
    Anke H Snijders
    Department of Neurology and Parkinson Center Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 23:S468-74. 2008
    ..Various quantitative gait assessments have been proposed, but these methods have not proven value for clinical practice...
  31. doi request reprint The impact of occupational therapy in Parkinson's disease: a randomized controlled feasibility study
    Ingrid H Sturkenboom
    Department of Rehabilitation, Nijmegen Centre of Evidence Based Practice, Radboud University Nijmegen Medical Centre, The Netherlands
    Clin Rehabil 27:99-112. 2013
    ..To evaluate the feasibility of a randomized controlled trial including process and potential impact of occupational therapy in Parkinson's disease...
  32. pmc Contribution of routine brain MRI to the differential diagnosis of parkinsonism: a 3-year prospective follow-up study
    Frederick J A Meijer
    Department of Radiology, Radboud University Nijmegen Medical Centre, Postbus 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol 259:929-35. 2012
    ..Routine brain MRI has limited added value for differentiating between PD and AP when clinical certainty is already high, but has some diagnostic value when the clinical diagnosis is still uncertain...
  33. doi request reprint Compensatory activity in the extrastriate body area of Parkinson's disease patients
    Bart F L Van Nuenen
    Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, 6500 HB Nijmegen, The Netherlands
    J Neurosci 32:9546-53. 2012
    ..These findings suggest that the right extrastriate body area plays a compensatory role in PD by supporting a function that is no longer performed by the dorsal premotor cortex...
  34. doi request reprint Pathophysiology of diurnal drooling in Parkinson's disease
    Johanna G Kalf
    Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands
    Mov Disord 26:1670-6. 2011
    ..These findings can provide a rationale for behavioral approaches to treat drooling...
  35. doi request reprint Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale-III in Parkinson's disease
    Charlotte A Haaxma
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 23:1707-17. 2008
    ..Compared to the UPDRS-III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. (c) 2008 Movement Disorder Society...
  36. doi request reprint Efficacy of community-based physiotherapy networks for patients with Parkinson's disease: a cluster-randomised trial
    Marten Munneke
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Neurol 9:46-54. 2010
    ..We aimed to assess the efficacy of this approach for improving health-care outcomes...
  37. ncbi request reprint Cerebral compensation during motor imagery in Parkinson's disease
    Rick C Helmich
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Neuropsychologia 45:2201-15. 2007
    ..These findings characterize the cerebral bases of the increased dependence on visual information processing during the generation of motor plans in PD, pointing to its compensatory role...
  38. doi request reprint Effectiveness of multidisciplinary care for Parkinson's disease: a randomized, controlled trial
    Marjolein A van der Marck
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Department of Neurology, Nijmegen, The Netherlands
    Mov Disord 28:605-11. 2013
    ..Further research is required to assess teams involving additional disciplines and to evaluate cost-effectiveness of integrated approaches. © 2012 Movement Disorder Society...
  39. doi request reprint Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor
    Rick C Helmich
    Donders Institute for Brain, Cognition, and Behavior, Center for Cognitive NeuroImaging, Radboud University Nijmegen, The Netherlands
    Ann Neurol 69:269-81. 2011
    ..Instead, resting tremor is associated with increased activity in a distinct cerebellothalamic circuit. To date, it remains unknown how the interplay between basal ganglia and the cerebellothalamic circuit can result in resting tremor...
  40. doi request reprint Obstacle avoidance to elicit freezing of gait during treadmill walking
    Anke H Snijders
    Department of Neurology and Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HBNijmegen, The Netherlands
    Mov Disord 25:57-63. 2010
    ..However, the moving treadmill and the obstacle both act as cues, which apparently help to immediately overcome the provoked FOG episode. This may limit the ecological validity of this new approach...
  41. doi request reprint The clinical utility of posturography
    Jasper E Visser
    Department of Neurology, Parkinson Center Nijmegen ParC, Donders Center for Neuroscience, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Neurophysiol 119:2424-36. 2008
    ..We critically review the shortcomings of posturography as it is presently used, and conclude with several recommendations for future research...
  42. doi request reprint First trial postural reactions to unexpected balance disturbances: a comparison with the acoustic startle reaction
    Lars B Oude Nijhuis
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Neurophysiol 104:2704-12. 2010
    ..Acoustic startle reactions may also be partially triggered by vestibular inputs. Similar muscle activation driven by vestibular inputs may be the common element of first trial postural responses and acoustic startle reactions...
  43. doi request reprint Motor imagery evokes increased somatosensory activity in Parkinson's disease patients with tremor
    Rick C Helmich
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Hum Brain Mapp 33:1763-79. 2012
    ..We conclude that parkinsonian tremor influences motor imagery by modulating central somatosensory processing through the VIM. This mechanism may explain clinical differences between PD patients with and without tremor...
  44. doi request reprint Freezer or non-freezer: clinical assessment of freezing of gait
    Anke H Snijders
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, The Netherlands
    Parkinsonism Relat Disord 18:149-54. 2012
    ..Given the known difficulties to elicit FOG when examining patients, we aimed to investigate which simple clinical test would be the most sensitive to provoke FOG objectively...
  45. doi request reprint Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss
    Esther Aarts
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behavior, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands
    Neuroimage 59:3339-46. 2012
    ..The present results concur with observations that low baseline dopamine states predispose to drug and other addictions...
  46. doi request reprint Falls and gait disturbances in Huntington's disease
    Yvette A M Grimbergen
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Mov Disord 23:970-6. 2008
    ..These factors should be considered as future targets for therapies that aim to reduce falls in Huntington's disease...
  47. doi request reprint Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease
    Jasper E Visser
    Dept of Neurology HP 935, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurol 255:205-10. 2008
    ..Of note, marked levodopa- resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease...
  48. doi request reprint Reproducibility and validity of patient-rated assessment of speech, swallowing, and saliva control in Parkinson's disease
    Johanna G Kalf
    Department of Rehabilitation, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arch Phys Med Rehabil 92:1152-8. 2011
    ....
  49. pmc Using online health communities to deliver patient-centered care to people with chronic conditions
    Martijn van der Eijk
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Department of Neurology 935, Nijmegen, Netherlands
    J Med Internet Res 15:e115. 2013
    ..Our health care system faces major threats as the number of people with multiple chronic conditions rises dramatically...
  50. pmc Design and baseline characteristics of the ParkFit study, a randomized controlled trial evaluating the effectiveness of a multifaceted behavioral program to increase physical activity in Parkinson patients
    Marlies van Nimwegen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Nijmegen, The Netherlands
    BMC Neurol 10:70. 2010
    ..However, because of physical and cognitive impairments, patients with PD require specific support to increase their level of physical activity...
  51. ncbi request reprint Quantification of trunk rotations during turning and walking in Parkinson's disease
    Jasper E Visser
    Department of Neurology, Radboud University Nijmegen Medical Centre, Parkinson Center Nijmegen, Nijmegen, The Netherlands
    Clin Neurophysiol 118:1602-6. 2007
    ..To develop a reliable, objective and sensitive measure of axial trunk rotations in PD, which can be applied in an ambulatory setting...
  52. ncbi request reprint Trunk sway in patients with spinocerebellar ataxia
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Mov Disord 20:1006-13. 2005
    ..The postural instability in SCA was found to be multidirectional, although there is generally more pitch than roll instability corresponding with predominant involvement of the spinocerebellum...
  53. doi request reprint Cueing for freezing of gait: a need for 3-dimensional cues?
    Anke H Snijders
    Department of Neurology 935, Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Neurologist 18:404-5. 2012
    ..Here, we describe a patient with severe freezing of gait, who responded well to 3-dimensional cues, but not to 2-dimensional visual cues. We discuss the potential implications of this phenomenon...
  54. doi request reprint Improving the diagnostic accuracy in parkinsonism: a three-pronged approach
    Marjolein B Aerts
    Department of Neurology, Parkinson Center Nijmegen ParC, and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Pract Neurol 12:77-87. 2012
    ....
  55. doi request reprint Nocturnal hypokinesia and sleep quality in Parkinson's disease
    Maartje Louter
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Am Geriatr Soc 60:1104-8. 2012
    ..To study the relationship between nocturnal hypokinesia and sleep quality in Parkinson's disease (PD)...
  56. doi request reprint CSF tau, Aβ42, and MHPG differentiate dementia with Lewy bodies from Alzheimer's disease
    Marjolein B Aerts
    Radboud University Nijmegen Medical Centre, Department of Neurology and Parkinson Center Nijmegen, Nijmegen, The Netherlands
    J Alzheimers Dis 27:377-84. 2011
    ....
  57. doi request reprint Mapping preclinical compensation in Parkinson's disease: an imaging genomics approach
    Bart F L Van Nuenen
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 24:S703-10. 2009
    ..This will help to determine how "generically" the human brain compensates for a preclinical dopaminergic dysfunction...
  58. doi request reprint Bicycling breaks the ice for freezers of gait
    Anke H Snijders
    Department of Neurology and Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    Mov Disord 26:367-71. 2011
    ..Finally, we provide some directions for future research stimulated by this fascinating observation...
  59. ncbi request reprint CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease
    W Farid Abdo
    Department of Neurology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 28:742-7. 2007
    ..In early disease stages it can be clinically difficult to differentiate idiopathic Parkinson's disease (IPD) from patients with multiple system atrophy predominated by parkinsonism (MSA-P)...
  60. ncbi request reprint Impact of drooling in Parkinson's disease
    Johanna G Kalf
    Dept of Allied Health Occupations, Speech Language Therapy, Nijmegen, The Netherlands
    J Neurol 254:1227-32. 2007
    ..History taking ought to be detailed and specific to understand the full impact of drooling for an individual patient. Therapeutic options should be evaluated more intensively...
  61. doi request reprint A simple method for calculating power based on a prior trial
    George F Borm
    Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, Nijmegen, The Netherlands
    J Clin Epidemiol 63:992-7. 2010
    ..The objective was to develop a method to determine the power of a trial, based on minimal information from a previous (reference) trial...
  62. doi request reprint Parkinson disease and comorbid cerebrovascular disease
    Wandana Nanhoe-Mahabier
    Donders Institute for Brain, Cognition and Behavior, Centre for Neuroscience, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Neurol 5:533-41. 2009
    ..Finding comorbid CVD in such patients could have prognostic implications, and could necessitate treatment to arrest further progression of CVD...
  63. ncbi request reprint Online maintenance of sensory and motor representations: effects on corticospinal excitability
    Paul van den Hurk
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Kapittelweg 29, 6500 HB Nijmegen, The Netherlands
    J Neurophysiol 97:1642-8. 2007
    ..We infer that short-term storage of sensory information and preparation of motor responses have differential and specific access to the output stage of the motor system...
  64. doi request reprint Patient-centeredness in PD care: development and validation of a patient experience questionnaire
    Martijn van der Eijk
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    Parkinsonism Relat Disord 18:1011-6. 2012
    ..Here we describe the development and validation of the Patient-Centered Questionnaire for PD (PCQ-PD), and its initial application in a large patient sample...
  65. doi request reprint Body mass index in Parkinson's disease: a meta-analysis
    Marjolein A van der Marck
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Department of Neurology, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 18:263-7. 2012
    ..1-7.7, P<0.05). Disease duration was not associated with BMI. Because a low body weight is associated with negative health effects and a poorer prognosis, monitoring weight and nutritional status should be part of PD management...
  66. pmc Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol
    Anouk Gw van Norden
    Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Neurol 11:29. 2011
    ..Diffusion tensor imaging (DTI) provides alternative information on microstructural white matter integrity. The association between SVD, its microstructural integrity, and incident dementia and parkinsonism has never been investigated...
  67. doi request reprint Evaluation of the falls telephone: an automated system for enduring assessment of falls
    Marjolein A van der Marck
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Am Geriatr Soc 59:340-4. 2011
    ..To evaluate the reliability and user experiences of an automated telephone system to monitor falls during a prolonged period of time...
  68. pmc Choice reaction times for human head rotations are shortened by startling acoustic stimuli, irrespective of stimulus direction
    Lars B Oude Nijhuis
    Department of Neurology, Radboud University Nijmegen Medical Centre, 935, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Physiol 584:97-109. 2007
    ....
  69. doi request reprint Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease
    Bart F L Van Nuenen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 23:2404-6. 2008
    ..Further systematic studies are required to pinpoint the clinical and surgical determinants of this late gait deterioration...
  70. doi request reprint Physical therapy in Parkinson's disease: evolution and future challenges
    Samyra H J Keus
    Parkinson Center Nijmegen ParC, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 24:1-14. 2009
    ..We provide some recommendations for future research, and discuss innovative strategies to improve the organization of allied health care in PD, making evidence-based care available to all PD patients...
  71. doi request reprint Motor profile and drug treatment of nursing home residents with Parkinson's disease
    Nico J Weerkamp
    Department of Neurology, Atrium Medical Center, Heerlen, The Netherlands
    J Am Geriatr Soc 60:2277-82. 2012
    ..To examine the clinical characteristics, motor impairments, and drug treatments of nursing home residents with Parkinson's disease (PD)...
  72. doi request reprint Allied health care in Parkinson's disease: referral, consultation, and professional expertise
    Maarten J Nijkrake
    Parkinson Center Nijmegen, Department of Neurology, Donders Center for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 24:282-6. 2009
    ..Current referral to and delivery of allied health care in PD are suboptimal. Evidence-based guidelines for allied health care in PD and active implementation of these guidelines are needed...
  73. ncbi request reprint Falls in degenerative cerebellar ataxias
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Mov Disord 20:497-500. 2005
    ..Clinicians should be aware of this problem in ataxia patients and should try to prevent falls...
  74. ncbi request reprint Neurological gait disorders in elderly people: clinical approach and classification
    Anke H Snijders
    Department of Neurology and Parkinson Center Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Neurol 6:63-74. 2007
    ..We conclude by proposing a practical three-step approach to categorise gait disorders and we present a simplified classification system based on clinical signs and symptoms...
  75. doi request reprint The dynamic regulation of cortical excitability is altered in episodic ataxia type 2
    Rick C Helmich
    Radboud University Nijmegen Medical Center, Department of Neurology, Nijmegen, The Netherlands
    Brain 133:3519-29. 2010
    ..We argue that this deficient control of cortical excitability may set the stage for the emergence of paroxysmal neural dysfunction in this disorder...
  76. doi request reprint Postural instability in Parkinson's disease: the adrenergic hypothesis and the locus coeruleus
    Yvette A M Grimbergen
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Expert Rev Neurother 9:279-90. 2009
    ....
  77. doi request reprint A weak balance: the contribution of muscle weakness to postural instability and falls
    Corinne G C Horlings
    Department of Neurology, Donders Centre for Neuroscience, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Clin Pract Neurol 4:504-15. 2008
    ....
  78. doi request reprint Atypical dystonic shoulder movements following neuralgic amyotrophy
    William F Abdo
    Institute of Neurology and Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 24:293-6. 2009
    ..The nature of the involuntary movements, which did not easily comply with classic descriptions of hyperkinetic movement disorders, is probably best referred to as dystonia...
  79. ncbi request reprint A more efficient enzyme-linked immunosorbent assay for measurement of alpha-synuclein in cerebrospinal fluid
    Wieneke J A van Geel
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    J Neurosci Methods 168:182-5. 2008
    ....
  80. ncbi request reprint Secondary parkinsonism in childhood: A rare complication after radiotherapy
    Nicol C Voermans
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Pediatr Neurol 34:495-8. 2006
    ..We suggest that focal encephalopathy resulting from postradiation edema secondary to microangiopathy led to dysfunction of the globus pallidus and thalamus...
  81. doi request reprint A toxic shot from the hip
    Judith W P M Oomen
    Department of Orthopedic Surgery 357, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    J Neurol Neurosurg Psychiatry 82:353-4. 2011
    ..Treatment with excision of the femoral head and debridement of the hip followed by a total hip, in combination with chelating therapy, led to a remarkable remission...
  82. doi request reprint The treatment of early Parkinson's disease: levodopa rehabilitated
    Annemarie Vlaar
    Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Nijmegen Medical Centre, Radboud University, Nijmegen, The Netherlands
    Pract Neurol 11:145-52. 2011
    ..A 'phobia' for levodopa—or, indeed, for any other antiparkinsonian medication—is unacceptable according to current evidence...
  83. pmc Levodopa is not a useful treatment for Lesch-Nyhan disease
    Jasper E Visser
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 26:746-9. 2011
    ..All 6 study participants discontinued levodopa early, due to lack of effect and sometimes worsening of motor function. The results provide important clues for pathophysiological mechanisms and suggestions for future treatment options...
  84. ncbi request reprint Botulinum toxin A for drooling in Parkinson's disease: a pilot study to compare submandibular to parotid gland injections
    Johanna G Kalf
    Department of Allied Health Occupations, Speech Language Therapy, Radboud University Nijmegen Medical Centre, The Netherlands
    Parkinsonism Relat Disord 13:532-4. 2007
    ..Between-group differences showed a trend towards superiority for the submandibular group. Injecting the submandibular glands instead of the parotid glands seems a promising approach, and larger studies are justified...
  85. ncbi request reprint Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease
    Rick C Helmich
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurol Sci 248:84-96. 2006
    ..We finally propose future directions of research that may help to improve the therapeutic efficacy of rTMS in PD...
  86. pmc Role of the basal ganglia in balance control
    Jasper E Visser
    Department of Neurology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Neural Plast 12:161-74; discussion 263-72. 2005
    ....
  87. doi request reprint Nordic walking improves mobility in Parkinson's disease
    Frank J M van Eijkeren
    Department of Neurology, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Mov Disord 23:2239-43. 2008
    ..These preliminary findings suggest that Nordic walking could provide a safe, effective, and enjoyable way to reduce physical inactivity in PD and to improve the quality of life. A large randomized clinical trial now appears justified...
  88. ncbi request reprint Executive functions are associated with gait and balance in community-living elderly people
    Marianne B van Iersel
    Radboud University Nijmegen Medical Centre, Department of Geriatrics, 6500 HB Nijmegen, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:1344-9. 2008
    ..We extend this prior work by examining the association between two different executive functions and measures of both gait and balance, with and without two different cognitive dual tasks...
  89. ncbi request reprint PRKCG mutation (SCA-14) causing a Ramsay Hunt phenotype
    Jasper E Visser
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mov Disord 22:1024-6. 2007
    ..We suggest that SCA-14 should be considered in the differential diagnosis of progressive myoclonic ataxia...
  90. doi request reprint Moving towards patient-centered healthcare for patients with Parkinson's disease
    Martijn van der Eijk
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Parkinsonism Relat Disord 17:360-4. 2011
    ..As a first step towards patient-centered care in Parkinson's disease (PD), we explored the unmet needs of PD patients and their informal caregivers...
  91. ncbi request reprint [Insufficient medication compliance in Parkinson's disease]
    Marjolein B Aerts
    Universitair Medisch Centrum St Radboud, Nijmegen, The Netherlands
    Ned Tijdschr Geneeskd 155:A3031. 2011
    ..Modern methods of communication (text message reminders) and 'smart' pill dispensers may be beneficial, but the advantages of such interventions have not yet been scientifically studied...
  92. doi request reprint The clinical approach to movement disorders
    Wilson F Abdo
    Parkinson Centre Nijmegen ParC, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Neurol 6:29-37. 2010
    ..We illustrate this diagnostic process for the most common types of movement disorder, namely, akinetic-rigid syndromes and the various types of hyperkinetic disorders (myoclonus, chorea, tics, dystonia and tremor)...
  93. ncbi request reprint Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease
    W Farid Abdo
    Department of Neurology, University Medical Center, Nijmegen, The Netherlands
    Mov Disord 19:571-9. 2004
    ..We propose that CSF analysis may become part of the diagnostic work-up of patients with parkinsonian syndromes...
  94. doi request reprint Hitting a support surface at unexpected height during walking induces loading transients
    Marleen H van der Linden
    Department of Rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Gait Posture 29:255-60. 2009
    ..These characteristics deserve further study in the context of the frequent falls induced by uneven surfaces during walking...
  95. pmc Gender differences in Parkinson's disease
    Charlotte A Haaxma
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 78:819-24. 2007
    ..To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD)...
  96. doi request reprint Gait in elderly with cerebral small vessel disease
    Karlijn F de Laat
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Stroke 41:1652-8. 2010
    ..The aim of our study was to investigate the effect of both the severity and location of both WMLs and lacunar infarcts on gait...
  97. doi request reprint Falls in spinocerebellar ataxias: Results of the EuroSCA Fall Study
    Ella M R Fonteyn
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Cerebellum 9:232-9. 2010
    ....
  98. ncbi request reprint "Recumbent" gait: relationship to the phenotype of "astasia-abasia"?
    Hieronymus D Boogaarts
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Mov Disord 22:2121-2. 2007
    ..Here, we describe one such patient with a very unusual gait disturbance that might be regarded as a variant of astasia-abasia. The patient characteristics are described and discussed in a historical context...
  99. ncbi request reprint Clinical tests for the evaluation of postural instability in patients with parkinson's disease
    Martine Visser
    Departmentof Neurology, Leiden University Medical Center, The Netherlands
    Arch Phys Med Rehabil 84:1669-74. 2003
    ..To determine which test for postural instability in Parkinson's disease (PD) is reliable, valid, and easy to perform in a clinical setting...
  100. ncbi request reprint Incorporating voluntary knee flexion into nonanticipatory balance corrections
    Lars B Oude Nijhuis
    Department of Otorhinolaryngology, University Hospital, Basel, Switzerland
    J Neurophysiol 98:3047-59. 2007
    ..These findings highlight the flexibility of the human balance repertoire and underscore both the advantages and limitations of using trained voluntary movements to aid balance corrections in man...
  101. ncbi request reprint Postural responses to multidirectional stance perturbations in cerebellar ataxia
    Maaike Bakker
    Department of ORL, University Hospital, Basel, Switzerland
    Exp Neurol 202:21-35. 2006
    ..The observed pathophysiology is very different from that seen in other patient populations...