J Alfred Witjes

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Pharmacokinetics of intravesical gemcitabine: a preclinical study in pigs
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:615-9. 2003
  2. ncbi request reprint Intravesical pharmacotherapy for non-muscle-invasive bladder cancer: a critical analysis of currently available drugs, treatment schedules, and long-term results
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 53:45-52. 2008
  3. doi request reprint EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Electronic address
    Eur Urol 65:778-92. 2014
  4. doi request reprint Intracutaneous and intravesical immunotherapy with keyhole limpet hemocyanin compared with intravesical mitomycin in patients with non-muscle-invasive bladder cancer: results from a prospective randomized phase III trial
    Rianne J M Lammers
    CuraTrial Site Management Organisation and Research, Arnhem, The Netherlands
    J Clin Oncol 30:2273-9. 2012
  5. pmc Two-year follow-up of the phase II marker lesion study of intravesical apaziquone for patients with non-muscle invasive bladder cancer
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Inter Mail 659, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    World J Urol 27:337-42. 2009
  6. ncbi request reprint Review pathology in a diagnostic bladder cancer trial: effect of patient risk category
    J A Witjes
    Department of Urology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Urology 67:751-5. 2006
  7. doi request reprint A multicenter, double-blind, randomized, parallel group study comparing polyvinyl chloride and polyvinyl chloride-free catheter materials
    J A Witjes
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 182:2794-8. 2009
  8. ncbi request reprint Intravesical chemotherapy for superficial bladder cancer
    J Alfred Witjes
    Department of Urology at University Medical Center Nijmegen, The Netherlands
    Nat Clin Pract Urol 1:56-7. 2004
  9. pmc Intravesical hyperthermia and mitomycin-C for carcinoma in situ of the urinary bladder: experience of the European Synergo working party
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    World J Urol 27:319-24. 2009
  10. ncbi request reprint [In favour of open versus laparoscopic prostatectomy]
    J A Witjes
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:139. 2006

Detail Information

Publications83

  1. ncbi request reprint Pharmacokinetics of intravesical gemcitabine: a preclinical study in pigs
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:615-9. 2003
    ..It has been shown to be effective and well tolerated when given systemically. We investigated the use of this agent administered intravesically in pigs for histological studies of the bladder and pharmacokinetic research...
  2. ncbi request reprint Intravesical pharmacotherapy for non-muscle-invasive bladder cancer: a critical analysis of currently available drugs, treatment schedules, and long-term results
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 53:45-52. 2008
    ..Review adjuvant intravesical pharmacotherapy for non-muscle-invasive bladder cancer (NMIBC), emphasising treatment schedules and long-term results...
  3. doi request reprint EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Electronic address
    Eur Urol 65:778-92. 2014
    ..This updated summary provides a synthesis of the 2013 guidelines document, with emphasis on the latest developments...
  4. doi request reprint Intracutaneous and intravesical immunotherapy with keyhole limpet hemocyanin compared with intravesical mitomycin in patients with non-muscle-invasive bladder cancer: results from a prospective randomized phase III trial
    Rianne J M Lammers
    CuraTrial Site Management Organisation and Research, Arnhem, The Netherlands
    J Clin Oncol 30:2273-9. 2012
    ..Keyhole limpet hemocyanin (KLH) was beneficial in earlier studies. In this study, safety and efficacy of KLH were compared with that of mitomycin (MM)...
  5. pmc Two-year follow-up of the phase II marker lesion study of intravesical apaziquone for patients with non-muscle invasive bladder cancer
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Inter Mail 659, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    World J Urol 27:337-42. 2009
    ..To study the time-to-recurrence and duration of response in non-muscle invasive bladder cancer (NMIBC) patients, with a complete ablative response after intravesical apaziquone instillations...
  6. ncbi request reprint Review pathology in a diagnostic bladder cancer trial: effect of patient risk category
    J A Witjes
    Department of Urology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Urology 67:751-5. 2006
    ..Review pathology might be an answer, but appears to be of limited value. We studied the effect of patients' risk profile on the value of review pathology...
  7. doi request reprint A multicenter, double-blind, randomized, parallel group study comparing polyvinyl chloride and polyvinyl chloride-free catheter materials
    J A Witjes
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 182:2794-8. 2009
    ....
  8. ncbi request reprint Intravesical chemotherapy for superficial bladder cancer
    J Alfred Witjes
    Department of Urology at University Medical Center Nijmegen, The Netherlands
    Nat Clin Pract Urol 1:56-7. 2004
  9. pmc Intravesical hyperthermia and mitomycin-C for carcinoma in situ of the urinary bladder: experience of the European Synergo working party
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    World J Urol 27:319-24. 2009
    ..To study the results of chemotherapy combined with intravesical hyperthermia in patients with mainly BCG-failing carcinoma in situ (CIS)...
  10. ncbi request reprint [In favour of open versus laparoscopic prostatectomy]
    J A Witjes
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:139. 2006
    ..Postoperatively, many patients appear to have T3 tumours, which cannot be optimally detected with current imaging techniques. Therefore, an open operation remains preferable...
  11. ncbi request reprint Current practice in the management of superficial bladder cancer in the Netherlands and Belgian Flanders: a survey
    J A Witjes
    Dept of Urology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur Urol 49:478-84. 2006
    ..The purpose of this study is to get insight in the current way urologists diagnose, treat and follow patients with superficial bladder cancer...
  12. ncbi request reprint The role of hexaminolevulinate fluorescence cystoscopy in bladder cancer
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
    Nat Clin Pract Urol 4:542-9. 2007
    ..Long-term studies in this area with HAL are ongoing. The technique is well tolerated and is a useful adjunct to white-light cystoscopy...
  13. doi request reprint Hexaminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: review of the evidence and recommendations
    J Alfred Witjes
    UMC St Radboud, Netherlands, Nijmegen, The Netherlands
    Eur Urol 57:607-14. 2010
    ..There is currently no overall European consensus outlining specifically where hexaminolevulinate is or is not indicated...
  14. ncbi request reprint Management of BCG failures in superficial bladder cancer: a review
    Johannes A Witjes
    Department of Urology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 49:790-7. 2006
    ..Review management of bacillus Calmette-Guérin (BCG) failures in superficial bladder cancer...
  15. ncbi request reprint Apaziquone for non-muscle invasive bladder cancer: a critical review
    J Alfred Witjes
    Radboud University Nijmegen Medical Centre, Department of Urology 659, PO Box 9101, 6500 H B Nijmegen, The Netherlands
    Expert Opin Investig Drugs 17:1085-96. 2008
    ..To describe clinical needs in non-muscle invasive bladder cancer (NMIBC) and review the potential of apaziquone in this respect...
  16. ncbi request reprint Prognosis of muscle-invasive bladder cancer: difference between primary and progressive tumours and implications for therapy
    Barthold Ph Schrier
    Department of Urology 426, University Medical Centre, St Radboud, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 45:292-6. 2004
    ..To evaluate the difference in prognosis between progressive and primary muscle-invasive bladder cancer...
  17. doi request reprint Management of the first recurrence of T1G3 bladder cancer: does intravesical chemotherapy deserve a chance?
    J Alfred Witjes
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Urol Oncol 27:322-4. 2009
    ..Is there a role for intravesical chemotherapy in a patient who has a first recurrence of a T1G3 bladder cancer?..
  18. doi request reprint Contemporary management of low-risk bladder cancer
    Johannes Falke
    Radboud University Nijmegen Medical Center, Department of Urology 659, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Urol 8:42-9. 2011
    ..In the future this profiling will play an important role in the timing and the choice of treatment, as well as guiding follow-up procedures...
  19. ncbi request reprint The impact of obesity on prostate cancer
    Joep G H van Roermund
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    World J Urol 25:491-7. 2007
    ..Obesity is a growing problem, however, the exact role in the development and progression of PC has not been elucidated. Regarding the optimal treatment of PC in obese patients, comparative prospective studies are needed...
  20. doi request reprint Choice between prostatectomy and radiotherapy when men are eligible for both: a randomized controlled trial of usual care vs decision aid
    Julia J van Tol-Geerdink
    Department of Radiation Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands
    BJU Int 111:564-73. 2013
    ..Across the participating hospitals, the decision aid consistently led to fewer patients remaining undecided on their treatment preference and more patients choosing brachytherapy...
  21. ncbi request reprint DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer
    Daphne Hessels
    Department of Experimental Urology, Nijmegen Center for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:8-15; discussion 15-6. 2003
    ..DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed...
  22. doi request reprint MRI with a lymph-node-specific contrast agent as an alternative to CT scan and lymph-node dissection in patients with prostate cancer: a prospective multicohort study
    Roel A M Heesakkers
    Department of Radiology, Radboud University Medical Centre, Nijmegen, Netherlands
    Lancet Oncol 9:850-6. 2008
    ..In this prospective, multicentre cohort study, we aimed to compare the diagnostic accuracy of MRL with up-to-date multidetector CT (MDCT), and test the hypothesis that a negative MRL finding obviates the need for a PLND...
  23. doi request reprint Impact of obesity on surgical outcomes following open radical prostatectomy
    Joep G H van Roermund
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Urol Int 82:256-61. 2009
    ..It is unknown whether obesity affects the surgical and oncological outcomes following open radical retropubic prostatectomy (RRP). Knowledge concerning this issue is relevant when counselling obese patients with PCa for RRP...
  24. doi request reprint The orthotopic Fischer/AY-27 rat bladder urothelial cell carcinoma model to test the efficacy of different apaziquone formulations
    Harm C Arentsen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Urol Oncol 30:64-8. 2012
    ..The objective of this study was to assess antitumor activity and safety of 3 different formulations of intravesical apaziquone in an orthotopic rat bladder cancer model...
  25. pmc Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer
    Dieuwertje E G Kok
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    World J Urol 29:695-701. 2011
    ..To determine the effect of body mass index (BMI) on clinical and pathological characteristics at time of diagnosis and on risk of biochemical recurrence after radical prostatectomy among Dutch men diagnosed with prostate cancer...
  26. doi request reprint Body mass index as a prognostic marker for biochemical recurrence in Dutch men treated with radical prostatectomy
    Joep G H van Roermund
    Department of Urology, University Medical Center Utrecht, The Netherlands
    BJU Int 104:321-5. 2009
    ....
  27. ncbi request reprint Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response
    Antoine G van der Heijden
    University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Urol 176:1349-53; discussion 1353. 2006
    ..We studied the ablative activity of intravesical apaziquone (EOquin) on a papillary marker tumor and determined the incidence of side effects...
  28. doi request reprint Molecular markers for detection, surveillance and prognostication of bladder cancer
    Olaf P J Vrooman
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Urol 16:234-43. 2009
    ..Currently, there are not clinically usable molecular markers that can guide us in diagnosis or surveillance, nor guide us in lowering the frequency of urethrocystoscopy in bladder cancer...
  29. ncbi request reprint Molecular PCA3 diagnostics on prostatic fluid
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 67:881-7. 2007
    ..In this study, we evaluated the PCA3 test on prostatic fluid and compared this with the PCA3 test on urine in a clinical research setting...
  30. doi request reprint Computerized whole slide quantification shows increased microvascular density in pT2 prostate cancer as compared to normal prostate tissue
    Cornelis G van Niekerk
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 69:62-9. 2009
    ..Aim of this study was to investigate whether microvascularity is increased in prostate confined cancer (pT2)...
  31. doi request reprint Changes in prostate shape and volume and their implications for radiotherapy after introduction of endorectal balloon as determined by MRI at 3T
    Stijn W T P J Heijmink
    Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 73:1446-53. 2009
    ..To determine the changes in prostate shape and volume after the introduction of an endorectal coil (ERC) by means of magnetic resonance imaging (MRI) at 3T...
  32. pmc Is increasing physical activity necessary to diminish fatigue during cancer treatment? Comparing cognitive behavior therapy and a brief nursing intervention with usual care in a multicenter randomized controlled trial
    Martine M Goedendorp
    Expert Centre for Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Oncologist 15:1122-32. 2010
    ..The aim of this multicenter randomized controlled trial (RCT) with three conditions was to demonstrate the efficacy and to determine the contribution of physical activity...
  33. doi request reprint A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Urol Oncol 27:509-13. 2009
    ..5 cc and Gleason scores <7, InsigPC) are considered clinically insignificant by some investigators. The aim of this study is to determine the biochemical recurrence rate (BCR) of svPC and InsigPC in prostatectomy specimens...
  34. doi request reprint Body mass index is not a prognostic marker for prostate-specific antigen failure and survival in Dutch men treated with brachytherapy
    Joep G H van Roermund
    Department of Urology, University Medical Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
    BJU Int 105:42-8. 2010
    ....
  35. doi request reprint Detailed analysis of histopathological parameters in radical prostatectomy specimens and PCA3 urine test results
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 68:1215-22. 2008
    ..PCA3 has proven to be of value in the diagnosis of PCa. However, so far few attempts have been made to investigate the prognostic value of PCA3. Our objective was to further investigate the prognostic value of PCA3...
  36. doi request reprint Quantitative analysis of lymph vessel characteristics in organ confined prostate cancer
    Cornelis G van Niekerk
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 71:91-7. 2011
    ..The objective of this study was to analyze the characteristics of lymphatic vasculature in normal and (peri)tumoral prostate tissue, applying accurate and objective quantification techniques based on digital image analysis...
  37. doi request reprint Thirty-two-channel coil 3T magnetic resonance-guided biopsies of prostate tumor suspicious regions identified on multimodality 3T magnetic resonance imaging: technique and feasibility
    Thomas Hambrock
    Department of Radiology, University Medical Centre Nijmegen, Nijmegen, Netherlands
    Invest Radiol 43:686-94. 2008
    ..Furthermore, to evaluate the practicability of MR-guided biopsy on a 3T MR scanner using a 32-channel coil and a MR-compatible biopsy device...
  38. doi request reprint High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies
    Jack J A van Asten
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    MAGMA 21:435-42. 2008
    ..Here, we demonstrate the use of non-destructive high resolution magic angle spinning (HRMAS) proton NMR Spectroscopy for the assessment of metabolic profiles of prostate tissue in PNBs as commonly obtained in standard clinical practice...
  39. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
    ..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC...
  40. doi request reprint Feasibility of 3T dynamic contrast-enhanced magnetic resonance-guided biopsy in localizing local recurrence of prostate cancer after external beam radiation therapy
    Derya Yakar
    Department of Radiology, Nijmegen Medical Centre, Radboud University, Nijmegen, The Netherlands
    Invest Radiol 45:121-5. 2010
    ....
  41. pmc Experimental rat bladder urothelial cell carcinoma models
    Harm C Arentsen
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    World J Urol 27:313-7. 2009
    ..In the second part of the paper the development of a potential new orthotopic rat bladder tumor model is described...
  42. doi request reprint Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen
    Thomas Hambrock
    University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Urol 183:520-7. 2010
    ..We compared results to those in a matched transrectal ultrasound guided prostate biopsy population. Also, we determined the clinical significance of detected tumors...
  43. doi request reprint Predictive value of PCA3 in urinary sediments in determining clinico-pathological characteristics of prostate cancer
    Daphne Hessels
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:10-6. 2010
    ..In this study, PCA3 was correlated with clinical stage, biopsy Gleason score (GS), radical prostatectomy GS, tumor volume, and pathological stage to assess its potential as predictor of PCa aggressiveness...
  44. doi request reprint The prognostic role of the pathological T2 subclassification for prostate cancer in the 2002 Tumour-Nodes-Metastasis staging system
    Inge M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 102:438-41. 2008
    ..To evaluate the prognostic role of the 2002 Tumour-Nodes-Metastasis (TNM) pT2 subclassification for biochemical recurrence (BCR) after radical prostatectomy (RP) for prostate cancer...
  45. ncbi request reprint Site-specific familial aggregation of prostate cancer
    Bas A J Verhage
    Center for Prevention and Health Services Research PZO, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Cancer 109:611-7. 2004
    ..5; 95% CI = 1.7-3.6). Cancers at other sites did not coaggregate with PC. Our data suggest that familial PC, at least in this Western European population, is site-specific, not part of an inherited cancer syndrome...
  46. ncbi request reprint Standardized threshold approach using three-dimensional proton magnetic resonance spectroscopic imaging in prostate cancer localization of the entire prostate
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
    Invest Radiol 42:116-22. 2007
    ..We sought to determine the localization accuracy using 3-dimensional (3D) proton magnetic resonance spectroscopic imaging (MRSI) of the entire prostate with a standardized thresholds approach in prostate cancer patients...
  47. ncbi request reprint Urinary bladder cancer: preoperative nodal staging with ferumoxtran-10-enhanced MR imaging
    Willem M L L G Deserno
    Department of Radiology, University Medical Center Sint Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Radiology 233:449-56. 2004
    ..To prospectively evaluate ferumoxtran-10-enhanced magnetic resonance (MR) imaging for nodal staging in patients with urinary bladder cancer...
  48. ncbi request reprint Prostate cancer: comparison of local staging accuracy of pelvic phased-array coil alone versus integrated endorectal-pelvic phased-array coils. Local staging accuracy of prostate cancer using endorectal coil MR imaging
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur Radiol 17:1055-65. 2007
    ..Overstaging is reduced significantly with equal sensitivity when an endorectal-pelvic phased-array coil is used...
  49. ncbi request reprint Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 241:449-58. 2006
    ....
  50. ncbi request reprint Initial experience of 3 tesla endorectal coil magnetic resonance imaging and 1H-spectroscopic imaging of the prostate
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Nijmegen The Netherlands
    Invest Radiol 39:671-80. 2004
    ..We sought to explore the feasibility of magnetic resonance imaging (MRI) of the prostate at 3T, with the knowledge of potential drawbacks of MRI at high field strengths...
  51. ncbi request reprint The effect of an endorectal balloon and off-line correction on the interfraction systematic and random prostate position variations: a comparative study
    Emile N J Th van Lin
    Department of Radiation Oncology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 61:278-88. 2005
    ..To investigate the effect of an endorectal balloon (ERB) and an off-line correction protocol on the day-to-day, interfraction prostate gland motion, in patients receiving external beam radiotherapy for prostate cancer...
  52. ncbi request reprint IMRT boost dose planning on dominant intraprostatic lesions: gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI
    Emile N J T van Lin
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 65:291-303. 2006
    ....
  53. ncbi request reprint Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, The Netherlands
    Radiology 237:541-9. 2005
    ....
  54. ncbi request reprint Prostate cancer: local staging at 3-T endorectal MR imaging--early experience
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 238:184-91. 2006
    ..To prospectively investigate the local staging accuracy of 3-T endorectal magnetic resonance (MR) imaging for prostate cancer by using whole-mount-section histopathologic analysis as the standard of reference...
  55. ncbi request reprint No evidence for large-scale germline genomic aberrations in hereditary bladder cancer patients with high-resolution array-based comparative genomic hybridization
    Lambertus A Kiemeney
    Department of Urology, Radboud University Nijmegen Medical Centre, P O Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:180-3. 2006
  56. ncbi request reprint The time-resolved fluorescence-based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Cancer Res 13:939-43. 2007
    ..In a previous single institution study, the PCA3 urine test clearly proved to be of diagnostic value. Therefore, the diagnostic performance of the PCA3 urine test was validated in a multicenter study...
  57. ncbi request reprint A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer
    Stijn W T P J Heijmink
    Department of Radiology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur Radiol 16:927-38. 2006
    ..Performing colour or contrast-enhanced Doppler biopsy or adding these techniques to systematic biopsies improves diagnostic performance, particularly by increasing sensitivity...
  58. doi request reprint Comparison of three schedules of intravesical epirubicin in patients with non-muscle-invasive bladder cancer
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 53:984-91. 2008
    ....
  59. ncbi request reprint CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomas
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Cancer 116:282-4. 2005
    ..Our results suggest, in contrast to those of Guo et al. (Nat Med 2004;10:374-81), that the oncogene CDC91L1 is not overexpressed at the mRNA level in urothelial cell carcinomas and cannot be used to predict the course of the disease...
  60. ncbi request reprint Three-dimensional proton MR spectroscopy of human prostate at 3 T without endorectal coil: feasibility
    Tom W J Scheenen
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands
    Radiology 245:507-16. 2007
    ....
  61. ncbi request reprint Applicability of biomarkers in the early diagnosis of prostate cancer
    Daphne Hessels
    Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Expert Rev Mol Diagn 4:513-26. 2004
    ..This could subsequently lead to a reduction of the number of unnecessary biopsies...
  62. ncbi request reprint Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomas
    Iman J Schultz
    Department of Clinical Chemistry, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1425-8. 2004
  63. ncbi request reprint Ultrasound-guided transrectal implantation of gold markers for prostate localization during external beam radiotherapy: complication rate and risk factors
    Johan F Langenhuijsen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 69:671-6. 2007
    ..To report the complication rate and risk factors of transrectally implanted gold markers, used for prostate position verification and correction procedures...
  64. ncbi request reprint Prostate cancer: body-array versus endorectal coil MR imaging at 3 T--comparison of image quality, localization, and staging performance
    Stijn W T P J Heijmink
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 244:184-95. 2007
    ....
  65. ncbi request reprint Simultaneous proteomic and genomic analysis of primary Ta urothelial cell carcinomas for the prediction of tumor recurrence
    Iman J Schultz
    Departments of Clinical Chemistry, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 27:1051-8. 2007
    ..The prediction of tumor recurrence in patients with Ta urothelial cell carcinoma is inaccurate and new prognostic markers are desirable...
  66. doi request reprint The effect of photochemical internalization of bleomycin in the treatment of urothelial carcinoma of the bladder: an in vitro study
    Harm C Arentsen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Electronic address
    Urol Oncol 32:49.e1-6. 2014
    ..In this in vitro study, we determined whether meso-tetraphenyl chlorin disulphonate (TPCS2a)-based photochemical delivery of bleomycin was able to potentiate the cytotoxicity of bleomycin on bladder cancer cells...
  67. doi request reprint Geographical distribution of lymph node metastases on MR lymphography in prostate cancer patients
    Hanneke J M Meijer
    Department of Radiation Oncology, Radbound University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Radiother Oncol 106:59-63. 2013
    ....
  68. doi request reprint Efficacy and tolerance of salvage radiotherapy after radical prostatectomy, with emphasis on high-risk patients suited for adjuvant radiotherapy
    Ruben G H M Cremers
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre, The Netherlands
    Radiother Oncol 97:467-73. 2010
    ....
  69. doi request reprint Long-term cancer-specific survival in patients with high-risk, non-muscle-invasive bladder cancer and tumour progression: a systematic review
    Sven van den Bosch
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 60:493-500. 2011
    ..Some studies report that tumour progression in patients with non-muscle-invasive bladder cancer (NMIBC) is associated with a poor prognosis. However, no systematic evidence is available...
  70. doi request reprint Neoadjuvant androgen deprivation for prostate volume reduction: the optimal duration in prostate cancer radiotherapy
    Johan F Langenhuijsen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Urol Oncol 29:52-7. 2011
    ..The optimal duration of hormonal treatment, however, is unknown. The endpoint of this study is the optimal duration of androgen deprivation for prostate volume reduction in a cohort of patients scheduled for external beam radiotherapy...
  71. doi request reprint Clinical epidemiology of nonurothelial bladder cancer: analysis of the Netherlands Cancer Registry
    Martine Ploeg
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 183:915-20. 2010
    ..Nonurothelial malignancies represent a small fraction of bladder malignancies and are less extensively studied, resulting in sparse empirical data on these tumors. We sought insight into tumor characteristics and survival...
  72. doi request reprint Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues
    Paul N Span
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 102:177-82. 2008
    ....
  73. ncbi request reprint Current strategies for first and second line intravesical therapy for nonmuscle invasive bladder cancer
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Urol 17:352-7. 2007
    ..We discuss options for first-line and second-line adjuvant therapy for nonmuscle invasive bladder cancer...
  74. ncbi request reprint Gene expression analysis for the prediction of recurrence in patients with primary Ta urothelial cell carcinoma
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 51:416-22; discussion 422-3. 2007
    ..This study aims at discriminating between patients with primary Ta UCC and long or short recurrence-free periods...
  75. ncbi request reprint Intravesical gemcitabine: an update of clinical results
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Urol 16:361-6. 2006
    ..In search for efficacy improvement and side effect reduction, we reviewed the promising properties of the relatively new intravesical drug, gemcitabine...
  76. ncbi request reprint Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: an in vitro study
    Antoine G van der Heijden
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Urol 173:1375-80. 2005
    ..However, the working mechanism of this combination therapy is not fully understood. In the current in vitro study we investigated the differences in cytotoxicity of 4 chemotherapeutic agents at 37C or 43C...
  77. ncbi request reprint Computerized three-dimensional localization of prostate cancer using contrast-enhanced power Doppler and clustering analysis
    Hilco van Moerkerk
    Department of Urology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur Urol 50:762-8; discussion 768-9. 2006
    ..To evaluate the potential benefit of semiautomated localization of prostate cancer using clustering analysis on three-dimensional (3-D) contrast-enhanced power Doppler images...
  78. ncbi request reprint Bladder cancer diagnosis and recurrence prognosis: comparison of markers with emphasis on survivin
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin Chim Acta 368:20-32. 2006
    ..Also, important requirements for a successful implementation of such markers in a hospital setting are discussed. Finally, future directions for the discovery of new diagnostic or prognostic candidate markers will be mentioned...
  79. pmc The influence of thermo-chemotherapy on bladder tumours: an immunohistochemical analysis
    Antoine G van der Heijden
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    World J Urol 25:303-8. 2007
    ..Seven out of nine patients treated with hyperthermia showed a decrease in p53 activity. A decrease in proliferation activity and p53 activity illustrate the potential role of thermo-chemotherapy as a promising intravesical treatment...
  80. ncbi request reprint The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression in patients with urothelial cell carcinoma
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anticancer Res 27:1025-30. 2007
    ..The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression was investigated in patients with urothelial cell carcinoma (UCC)...
  81. ncbi request reprint Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer
    Paula M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 52:464-8. 2007
    ..We aimed to study the association between presence of (high-risk) HPV DNA, p53 status, and clinical outcome in bladder cancer patients. This study must be seen as a preliminary study to investigate this potentially important problem...
  82. doi request reprint Polymorphisms in the H19 gene and the risk of bladder cancer
    Gerald W Verhaegh
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 54:1118-26. 2008
    ..In this study we examined whether sequence variants within the H19 gene are associated with the risk of developing bladder cancer...
  83. ncbi request reprint Screening for prostate cancer in Dutch hereditary prostate cancer families
    Lambertus A Kiemeney
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 122:871-6. 2008
    ..We suggest that the same PSA testing guidelines should apply to HPC families and the general population. A more aggressive screening policy in HPC families does not seem to be justified...