Gosse J Adema

Summary

Affiliation: Radboud University
Country: The Netherlands

Publications

  1. ncbi Immunocombination therapy for high-risk neuroblastoma
    Michiel Kroesen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences 278 TIL, 6500 HB Nijmegen, The Netherlands
    Immunotherapy 4:163-74. 2012
  2. ncbi Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
  3. ncbi Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation
    Wendy W C van Maren
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Immunol 12:23. 2011
  4. ncbi Dendritic cells from bench to bedside and back
    G J Adema
    Department of Tumorimmunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunol Lett 122:128-30. 2009
  5. ncbi Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome
    I Jolanda M de Vries
    Department of Tumor Immunology, Radbond University Nijmegen Medical Center, Geert Grooteplein 26-28, 6500 HB Nijmegen, Netherlands
    J Clin Oncol 23:5779-87. 2005
  6. ncbi Intratumoral administration of recombinant human interleukin 12 in head and neck squamous cell carcinoma patients elicits a T-helper 1 profile in the locoregional lymph nodes
    Carla M van Herpen
    Department of Medical Oncology, UMC Nijmegen, Nijmegen, The Netherlands
    Clin Cancer Res 10:2626-35. 2004
  7. ncbi Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, The Netherlands
    J Leukoc Biol 79:1083-91. 2006
  8. ncbi No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 180:7687-96. 2008
  9. ncbi Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 116:564-74. 2010
  10. ncbi Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients
    W Joost Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 17:5725-35. 2011

Detail Information

Publications94

  1. ncbi Immunocombination therapy for high-risk neuroblastoma
    Michiel Kroesen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences 278 TIL, 6500 HB Nijmegen, The Netherlands
    Immunotherapy 4:163-74. 2012
    ..Furthermore, we discuss the potential of the combined application of immunotherapy and novel tumor-targeted therapies for the treatment of both cancer in general and NBL in particular...
  2. ncbi Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
    ....
  3. ncbi Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation
    Wendy W C van Maren
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Immunol 12:23. 2011
    ..In this study, we evaluate the effect of Pam3CysSK4 and Legionella pneumophila, a natural TLR2 containing infectious agent, on effector T (Teff) cells and dendritic cells (DCs) individually and in co-cultures with Tregs...
  4. ncbi Dendritic cells from bench to bedside and back
    G J Adema
    Department of Tumorimmunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunol Lett 122:128-30. 2009
    ..Hence, DC acts at the interface of immunity and peripheral tolerance...
  5. ncbi Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome
    I Jolanda M de Vries
    Department of Tumor Immunology, Radbond University Nijmegen Medical Center, Geert Grooteplein 26-28, 6500 HB Nijmegen, Netherlands
    J Clin Oncol 23:5779-87. 2005
    ..0012). CONCLUSION: These findings demonstrate the potency of this novel approach in the monitoring of vaccination studies in cancer patients...
  6. ncbi Intratumoral administration of recombinant human interleukin 12 in head and neck squamous cell carcinoma patients elicits a T-helper 1 profile in the locoregional lymph nodes
    Carla M van Herpen
    Department of Medical Oncology, UMC Nijmegen, Nijmegen, The Netherlands
    Clin Cancer Res 10:2626-35. 2004
    ....
  7. ncbi Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, The Netherlands
    J Leukoc Biol 79:1083-91. 2006
    ..Therefore, mouse models can be used to elucidate the function of this novel DC marker...
  8. ncbi No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 180:7687-96. 2008
    ..Given the specificity with which Abs recognize their targets, this favors the use of DC receptor-specific Abs for in vivo vaccination strategies...
  9. ncbi Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 116:564-74. 2010
    ..These data thus identify a new clinical application for a mixture of commonly used preventive vaccines in the generation of Th1-inducing clinical-grade mature DCs...
  10. ncbi Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients
    W Joost Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 17:5725-35. 2011
    ....
  11. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  12. ncbi Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells
    Danita H Schuurhuis
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Immunol Immunother 58:1109-15. 2009
    ..Together these data show that electroporation of mature DC with TAA-encoding mRNA is attractive for use in DC vaccination protocols in cancer patients, but protein expression should be tested for each maturation cocktail...
  13. ncbi In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients
    Danita H Schuurhuis
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 69:2927-34. 2009
    ..Together these data show that mature DC electroporated with mRNA encoding TAA migrate and express antigens in the lymph nodes and induce specific immune responses...
  14. ncbi Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Microbiol 10:2058-66. 2008
    ..Conclusively, dectin-1 synergizes with both TLR2 and TLR4 pathways for the production of TNF-alpha in human primary PBMCs and in monocyte-derived macrophages...
  15. ncbi Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells
    Anna Sanecka
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Immunol 50:66-73. 2012
    ..Subsequent validation experiments, bioinformatics-based promoter analysis, and silencing studies confirmed that ApoA4 is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs)...
  16. ncbi Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Res 66:7285-92. 2006
    ..Therefore, in situ tumor destruction in combination with CpG-oligodeoxynucleotide administration creates a unique "in situ DC vaccine" that is readily applicable in the clinic...
  17. ncbi Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice
    Stefan Nierkens
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e8368. 2009
    ..We studied whether the efficacy of CpG as an adjuvant in cancer immunotherapy is dependent on the route of CpG administration, in particular when the tumor is destructed in situ...
  18. ncbi Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model
    Oliver M Grauer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 122:1794-802. 2008
    ....
  19. ncbi Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1278-85. 2005
    ..This identifies DC-SIGN as a promising target molecule for DC-based vaccination strategies...
  20. ncbi DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Leukoc Biol 85:518-25. 2009
    ..These data provide further support to the concept of CLR/TLR cross-talk in modulating immune responses...
  21. ncbi Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients
    Joannes F M Jacobs
    Department of Medical Oncology, Laboratory of Medical Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 16:5067-78. 2010
    ..In this study we investigated whether transient monoclonal antibody-mediated depletion of CD25(high) regulatory T cells (Treg) is capable of enhancing the immunostimulatory efficacy of dendritic cell vaccines...
  22. ncbi Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used
    W Joost Lesterhuis
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Immunol Immunother 60:249-60. 2011
    ....
  23. ncbi The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity
    Annemiek B van Spriel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    PLoS Pathog 5:e1000338. 2009
    ..Taken together, tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response...
  24. ncbi Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Blood 111:4245-53. 2008
    ..Collectively, the data show that targeting of DCIR can modulate human pDC function and may be applied in disease prevention and treatment...
  25. ncbi In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy
    Stefan Nierkens
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    Cancer Res 68:5390-6. 2008
    ..These data might aid in the design of future immunotherapeutic strategies for cancer patients...
  26. ncbi DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells
    Anna Sanecka
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Immunol 12:57. 2011
    ..In this study we knocked down DC-STAMP in mouse bone marrow-derived DCs (mBMDCs) to determine its function...
  27. ncbi Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Innate Immun 2:360-70. 2010
    ..These findings might represent a novel mechanism by which pDCs can preserve the function and viability of myeloid DCs that are attracted to a site with ongoing infection, thereby optimizing the antiviral immune response...
  28. ncbi Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid
    Antoine W T van Lieshout
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    BMC Immunol 7:23. 2006
    ..In this study we provide new insights in the regulation of CCL18 secretion by monocytes and dendritic cells...
  29. ncbi Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration
    A C Inge Boullart
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Immunol Immunother 57:1589-97. 2008
    ..We propose a novel clinical grade maturation protocol in which TLR ligands poly(I:C) and R848 are combined with PGE2 to generate DC with both high migratory capacity and IL-12p70 production upon T cell encounter...
  30. ncbi DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation
    Dagmar Eleveld-Trancikova
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Immunol 47:1963-73. 2010
    ..Moreover, we demonstrate that LUMAN is endogenously expressed by DC and becomes activated by RIP upon DC maturation induced by various different stimuli. These data define LUMAN/DC-STAMP as a novel regulatory circuit in DC...
  31. ncbi Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors
    Joannes F M Jacobs
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences 278 TIL, Post Box 9101, 6500 HB Nijmegen, The Netherlands
    Neuro Oncol 11:394-402. 2009
    ..In conclusion, using ultrasonic tumor aspirates as a biosource we identified Tregs and the PD-L1/PD-1 pathway as immune suppressive mechanisms in malignant but not benign human brain tumors...
  32. ncbi Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17
    Justin H Fransen
    Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:2304-13. 2009
    ..We undertook this study to compare the effects of apoptotic blebs and apoptotic cell bodies on maturation of dendritic cells (DCs) and their T cell stimulatory capacity in a murine setting...
  33. ncbi An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells
    Robbert van der Voort
    Laboratory Medicine, Laboratory of Hematology and Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Leukoc Biol 87:1029-39. 2010
    ..Our data demonstrate that mature DC express secreted, transmembrane, and cleaved CXCL16 isoforms to recruit and communicate efficiently with CXCR6(+) lymphoid cells...
  34. ncbi Functional differences between mesenchymal stem cell populations are reflected by their transcriptome
    Bastiaan J H Jansen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Stem Cells Dev 19:481-90. 2010
    ..Furthermore, these differences indicate a demand for effective differentiation protocols tailored to each stem cell type...
  35. ncbi Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Nijmegen Centre of Molecular Life Sciences, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Pediatr Blood Cancer 49:924-7. 2007
    ..We studied whether sufficient amounts of mature monocyte-derived DCs can be cultured from peripheral blood of pediatric cancer patients...
  36. ncbi Analysis of dendritic cell trafficking using EGFP-transgenic mice
    Andreas A O Eggert
    Tumor Immunology Laboratory, University Medical Center Nijmegen St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Immunol Lett 89:17-24. 2003
    ..c. injection. Subsequent quantitative, phenotypical and ultrastuctural analysis demonstrate that DC generated from EGFP-transgenic mice are well suited to study the migratory behavior, distribution and phenotype of DC in vivo...
  37. ncbi Selective cancer-germline gene expression in pediatric brain tumors
    Joannes F M Jacobs
    Department of Pediatric Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neurooncol 88:273-80. 2008
    ..This observation is in line with the notion that pediatric and adult glioblastomas develop along different genetic pathways...
  38. ncbi Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Cancer Immunol Immunother 58:145-51. 2009
    ..This directly links vitiligo to the immuno-therapeutic intervention and supports the hypothesis that vitiligo is a marker of immunity against melanoma cells...
  39. ncbi DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells
    Jurjen Tel
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:1014-23. 2011
    ..We observed that TLR-mediated signaling increases DEC-205 expression levels without affecting receptor internalization. Moreover, human pDCs retained the capacity to present antigens via DEC-205 following TLR activation...
  40. ncbi Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    W Joost Lesterhuis
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Clin Invest 121:3100-8. 2011
    ..This dual action of platinum compounds may extend their therapeutic application in cancer patients and provides a rationale for their use in combination with immunostimulatory compounds...
  41. ncbi Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Immunol 189:138-45. 2012
    ..Silencing of IL-10 in DC-SCRIPT knockdown DCs rescued IL-12 expression, suggesting a primary role for DC-SCRIPT in the regulation of IL-10 production...
  42. ncbi Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation
    Carla M L van Herpen
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 123:2354-61. 2008
    ..t. IL-12 treatment in HNSCC, significant activation of the B cell and the B cell compartment occurred and that the presence of tumor infiltrating B cells correlated with overall survival of HNSCC patients...
  43. ncbi Development of 111In-labeled tumor-associated antigen peptides for monitoring dendritic-cell-based vaccination
    Peter Laverman
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nucl Med Biol 33:453-8. 2006
    ..However, little is known about the fate of the MHC-peptide complex after injection of these peptide-loaded DC. The aim of the present study was to develop radiolabeled, tumor-derived peptides to monitor their binding to MHC Class I...
  44. ncbi Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor
    Carla M L van Herpen
    Department of Medical Oncology, UMC Nijmegen, 6500 HB Nijmegen, The Netherlands
    Clin Cancer Res 11:1899-909. 2005
    ..Significant effects were noted on B cells, with altered lymph node architecture in every IL-12-treated patient and excessive peritumoral infiltration in some patients...
  45. ncbi CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo
    Oliver M Grauer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 121:95-105. 2007
    ..These data illustrate that intratumoral accumulation and activation of CD4+FoxP3+ Treg act as a dominant immune escape mechanism for gliomas and underline the importance of controlling tumor-infiltrating Treg in glioma immunotherapy...
  46. ncbi Dendritic cells: tools and targets for antitumor vaccination
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Expert Rev Vaccines 4:699-710. 2005
    ....
  47. ncbi Immunogenicity of dendritic cells pulsed with CEA peptide or transfected with CEA mRNA for vaccination of colorectal cancer patients
    W Joost Lesterhuis
    Departments of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anticancer Res 30:5091-7. 2010
    ..Theoretically, transfection of DCs with RNA encoding a tumor-specific antigen may induce a broader immune response as compared to the most widely used technique of peptide pulsing...
  48. ncbi Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions
    Robbert van der Voort
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Scences, University Medical Center St Radboud, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    J Leukoc Biol 77:739-47. 2005
    ..CCL18/DC-CK1 may therefore function as an agonist (for naive T and B cells) and as an antagonist for CCR3-expressing leukocytes such as eosinophils...
  49. ncbi Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 38:184-91. 2008
    ..This demonstrates that both caspase-1-dependent and -independent mechanisms are involved in the synergy between NOD2 and TLR...
  50. ncbi Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 72:6102-10. 2012
    ....
  51. ncbi Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center St. Radboud Nijmegen and Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 9:5091-100. 2003
    ..CONCLUSIONS: We conclude that mature DC are superior to immature DC in the induction of immunological responses in melanoma patients, which may translate into improved clinical results...
  52. ncbi MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters
    Bastiaan J H Jansen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Genomics 12:330. 2011
    ..Regulatory elements in miRNA promoters are less well studied, but may reveal a link between their expression and a specific cell type...
  53. ncbi The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 119:2284-92. 2012
    ..We conclude that CLEC9A is a promising target for in vivo antigen delivery in humans to increase the efficiency of vaccines against infectious or malignant diseases...
  54. ncbi Mesenchymal stem cells respond to TNF but do not produce TNF
    Lieke C J van den Berk
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 87:283-9. 2010
    ..This limited cytokine response in combination with the well-studied immunosuppressive properties of MSC makes these cells ideal for immune-suppressive treatment modalities such as graft-versus-host disease...
  55. ncbi In situ tumor ablation creates an antigen source for the generation of antitumor immunity
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Res 64:4024-9. 2004
    ..These results illustrate that in situ tumor destruction can provide a useful antigen source for the induction of antitumor immunity, provided that additional immunostimulatory signals are coadministered...
  56. ncbi Vaccination of patients with metastatic renal cell carcinoma with autologous dendritic cells pulsed with autologous tumor antigens in combination with interleukin-2: a phase 1 study
    Jeannette C Oosterwijk-Wakka
    Experimental Urology, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Immunother (1997) 25:500-8. 2002
    ..Nevertheless, this study shows the feasibility of a completely autologous DC and tissue culture methodology for the generation of TuLy pulsed DC...
  57. ncbi Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake
    Daniel Benitez-Ribas
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, Netherlands
    J Exp Med 203:1629-35. 2006
    ..Antigen presentation by pDCs may thus modulate the strength and quality of the secondary phase of an immune response...
  58. ncbi Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Cancer Res 63:12-7. 2003
    ..Our present findings demonstrate that the ability of dendritic cells to mount a proper immune response correlates with their ability to migrate both in vitro and in vivo...
  59. ncbi The role of dendritic cells in the pathogenesis of systemic lupus erythematosus
    Justin H Fransen
    Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Department of Nephrology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:207. 2010
    ....
  60. ncbi Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands
    J Virol 82:2930-7. 2008
    ..In conclusion, recognition of viral RNA rapidly induces an antiviral state in human DCs. This might provide a mechanism by which DCs protect themselves against viruses when attracted to an environment with ongoing infection...
  61. ncbi Migration of dendritic cell based cancer vaccines: in vivo veritas?
    Gosse J Adema
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, and Medical Oncology, Nijmegen, The Netherlands
    Curr Opin Immunol 17:170-4. 2005
    ..Recent advances have been made in understanding DC migration in the context of DC-based vaccines...
  62. ncbi Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells
    Barbara M Schulte
    Department of Medical Microbiology, Nijmegen Centre for Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 59:1182-91. 2010
    ..This balance is particularly influenced by dendritic cells (DCs). The goal of this study was to investigate the interaction between enterovirus-infected human pancreatic islets and human DCs...
  63. ncbi In vivo targeting of DC-SIGN-positive antigen-presenting cells in a nonhuman primate model
    Candida F Pereira
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunother 30:705-14. 2007
    ..In conclusion, this is the first study that shows specific targeting of APCs in vivo by using antibodies directed against DC-SIGN...
  64. ncbi Immunotherapy of diffuse gliomas: biological background, current status and future developments
    Oliver M Grauer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Brain Pathol 19:674-93. 2009
    ....
  65. ncbi Cytokine and chemokine production by human pancreatic islets upon enterovirus infection
    Barbara M Schulte
    1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Diabetes 61:2030-6. 2012
    ..Our data represent the first comprehensive overview of inflammatory mediators that are secreted by human islets of Langerhans upon CVB infection and may shed light on the role of enteroviruses in type 1 diabetes pathogenesis...
  66. ncbi Phenotypical and functional characterization of clinical grade dendritic cells
    I Jolanda M de Vries
    Department of Tumot Immunology, University Medical Center St. Radboud, Nijmegen, The Netherlands
    J Immunother (1997) 25:429-38. 2002
    ..In conclusion, a culture procedure was established to generate large numbers of monocyte-derived immature and mature DC that retain their morphologic, phenotypic, and functional characteristics in vitro and can be visualized in situ...
  67. ncbi OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation
    Bastiaan J H Jansen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Immunol 46:505-15. 2009
    ..Collectively, the data indicate that OS9 is critically involved in the modulation of ER-to-Golgi transport of DC-STAMP in response to TLR triggering, suggesting a novel role for OS9 in myeloid differentiation and cell fusion...
  68. ncbi Prognostic significance and mechanism of Treg infiltration in human brain tumors
    Joannes F M Jacobs
    Nijmegen Centre for Molecular Life Sciences, Department of Tumor Immunology, Nijmegen, The Netherlands
    J Neuroimmunol 225:195-9. 2010
    ..Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors...
  69. ncbi Presence and localization of T-cell subsets in relation to melanocyte differentiation antigen expression and tumour regression as assessed by immunohistochemistry and molecular analysis of microdissected T cells
    Monique R Bernsen
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pathol 202:70-9. 2004
    ..Full understanding of these processes can only be achieved by performing more dynamic analyses of the local host-tumour interactions...
  70. ncbi Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 120:67-74. 2007
    ..Some rhabdomyosarcomas express several of these genes at high levels. Ewing's sarcomas have an overall low CGG expression...
  71. ncbi CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement
    Linda M P le Blanc
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurosci Lett 397:145-8. 2006
    ..CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system...
  72. ncbi Toll-like receptor 2 controls expansion and function of regulatory T cells
    Roger P M Sutmuller
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:485-94. 2006
    ..albicans outgrowth. This demonstrates that in vivo TLR2 also controls the function of Tregs and establishes a direct link between TLRs and the control of immune responses through Tregs...
  73. ncbi Phenotypical and functional characterization of clinical-grade dendritic cells
    I Jolanda M de Vries
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Methods Mol Med 109:113-26. 2005
    ..In this chapter we discuss the usefulness of standardized clinical and immunological criteria and the need for careful study design to further optimize the use of dendritic cells and to unequivocally prove their efficacy...
  74. ncbi Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Cancer Immunol Immunother 59:1573-82. 2010
    ..Emphasis will be given to the therapeutic potential of TLR-matured DC subsets for DC-based immunotherapy...
  75. ncbi Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands
    J Leukoc Biol 79:860-6. 2006
    ..These data indicate that the NOD2fs mutation results in a loss-of-function phenotype in human myeloid DC and imply decreased immune regulation by IL-10 as a possible mechanism for this mutation in CD...
  76. ncbi Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ....
  77. ncbi Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents
    I Jolanda M de Vries
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Clin Cancer Res 17:841-8. 2011
    ..We investigated the impact of three medications on blood Treg frequency in vaccinated cancer patients...
  78. ncbi Effect of administration of apoptotic blebs on disease development in lupus mice
    Justin H Fransen
    Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Autoimmunity 45:290-7. 2012
    ..Here, we investigated the effects of administration of apoptotic blebs, separate or in combination with dendritic cells, on disease progression and autoantibody production in lupus and normal mice...
  79. ncbi "Sweet talk": closing in on C type lectin signaling
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre of Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunity 22:399-400. 2005
    ....
  80. ncbi Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    J Immunol 178:154-62. 2007
    ..Taken together, these findings show that tetraspanin CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production...
  81. ncbi Regulation of MYCN expression in human neuroblastoma cells
    Joannes F M Jacobs
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Donders Institute for Brain, Cognition and Behaviour, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Cancer 9:239. 2009
    ..Both MYCNOS and DeltaMYCN are potential inhibitors of MYCN either at the mRNA or at the protein level...
  82. ncbi Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection
    Barbara M Schulte
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Viral Immunol 23:99-104. 2010
    ..The negative results for all throat and most stool samples argues against acute infection. Enterovirus presence was linked with HLA-DR4, but not with polymorphisms in MDA5 or OAS1...
  83. ncbi MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells
    Aneta M Schaap-Oziemlak
    Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Stem Cells Dev 19:877-85. 2010
    ..This finding suggests that hsa-miR-135b may control osteoblastic differentiation of USSCs by regulating expression of bone-related genes...
  84. ncbi Toll-like receptor triggering in cord blood mesenchymal stem cells
    Lieke C J van den Berk
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein, Nijmegen, The Netherlands
    J Cell Mol Med 13:3415-26. 2009
    ..Apparently, the outcome of TLR signalling depends on the cell type that expresses them...
  85. ncbi Antigen localization controls T cell-mediated tumor immunity
    Ingrid S Zeelenberg
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525GA Nijmegen, The Netherlands
    J Immunol 187:1281-8. 2011
    ..Therefore, we conclude that this study may have significant implications in the discovery of new tumor Ags suitable for immunotherapy and that their location should be taken into account to ensure a strong antitumor immune response...
  86. ncbi C-type lectin receptors on dendritic cells and Langerhans cells
    Carl G Figdor
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, NCMLS 187 TIL, Postbox 9101, 6500HB Nijmegen, The Netherlands
    Nat Rev Immunol 2:77-84. 2002
    ..It is now becoming clear that lectin receptors not only serve as antigen receptors but also regulate the migration of dendritic cells and their interaction with lymphocytes...
  87. ncbi Renal cell carcinoma-associated antigen G250 encodes a naturally processed epitope presented by human leukocyte antigen-DR molecules to CD4(+) T lymphocytes
    Joost L M Vissers
    Tumor Immunology Laboratory, University Medical Center Nijmegen St. Radboud, Nijmegen, The Netherlands
    Int J Cancer 100:441-4. 2002
    ..1-restricted G250 epitope recognized by CTLs. These data and the high prevalence of G250 in RCC patients make peptide G250:249-268 a potential target in peptide-based vaccines to induce both CD4(+) and CD8(+) T-cell responses in patients...
  88. ncbi The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  89. ncbi Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells
    Matthijs Kramer
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Scinces and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmigen Medical Centre, The Netherlands
    Cell Microbiol 9:1507-18. 2007
    ..These results describe for the first time the effect of EV on the function and viability of human DCs and suggest that infection of DCs in vivo can impede regulation of immune responses...
  90. ncbi Different faces of the heme-heme oxygenase system in inflammation
    Frank A D T G Wagener
    Department of Tumor Immunology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Rev 55:551-71. 2003
    ..Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury. A better understanding of the complex heme-heme..
  91. ncbi Toll-like receptors on regulatory T cells: expanding immune regulation
    Roger P M Sutmuller
    Tumor Immunology Laboratory, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Trends Immunol 27:387-93. 2006
    ..This review examines the ramifications of TLR engagement on Treg cells and conventional T cells, and discusses the potential role of TLRs on Treg cells and the consequences for disease therapy...
  92. ncbi Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness
    Peter M Emmer
    Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Transplantation 81:1451-9. 2006
    ..CONCLUSIONS: Alternatively activated DC are more efficacious than the classical imDC in the regulation of the alloimmune response, which may be related to a distinct cytokine profile characterized by an increased IL-10/IL12 ratio...
  93. ncbi Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints
    Robbert van der Voort
    Nijmegen Center for Molecular Life Sciences, University Medical Center St. Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:1381-91. 2005
    ..CONCLUSION: These data provide evidence that enhanced production of CXCL16 in RA synovia leads to recruitment of CXCR6+ memory T cells, thereby contributing to the inflammatory cascade associated with RA pathology...
  94. ncbi Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 176:1081-9. 2006
    ..Taken together, our results show that we have isolated a novel DC marker that could be involved in transcriptional repression. In contrast to other DC molecules, DC-SCRIPT identifies all DC subsets tested to date...