Nico H J Pijls

Summary

Country: The Netherlands

Publications

  1. doi request reprint Functional assessment of coronary stenoses: can we live without it?
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Eur Heart J 34:1335-44. 2013
  2. ncbi request reprint Fractional flow reserve to guide coronary revascularization
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Circ J 77:561-9. 2013
  3. doi request reprint Functional measurement of coronary stenosis
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 59:1045-57. 2012
  4. ncbi request reprint Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
  5. doi request reprint Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study
    Nico H J Pijls
    Catharina Hospital, Department of Cardiology, Eindhoven, The Netherlands
    J Am Coll Cardiol 56:177-84. 2010
  6. ncbi request reprint Coronary thermodilution to assess flow reserve: validation in humans
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Circulation 105:2482-6. 2002
  7. ncbi request reprint Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease
    Wilbert Aarnoudse
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Am J Cardiol 96:1627-30. 2005
  8. doi request reprint Fractional flow reserve in unstable angina and non-ST-segment elevation myocardial infarction experience from the FAME (Fractional flow reserve versus Angiography for Multivessel Evaluation) study
    Jan Willem E M Sels
    Catharina Hospital, Eindhoven, The Netherlands
    JACC Cardiovasc Interv 4:1183-9. 2011
  9. doi request reprint Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
    Pim A L Tonino
    Catharina Hospital, Eindhoven, The Netherlands
    N Engl J Med 360:213-24. 2009
  10. doi request reprint Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation
    Pim A L Tonino
    Department of Cardiology, Catharina Hospital, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
    J Am Coll Cardiol 55:2816-21. 2010

Collaborators

Detail Information

Publications53

  1. doi request reprint Functional assessment of coronary stenoses: can we live without it?
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Eur Heart J 34:1335-44. 2013
    ..In this review paper, the rationale for routine measurement of FFR will be reviewed and studies supporting its integration into everyday practice will be highlighted...
  2. ncbi request reprint Fractional flow reserve to guide coronary revascularization
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Circ J 77:561-9. 2013
    ..This review can be read as an overview of the state-of-the-art of FFR and as a guide to further reading. ..
  3. doi request reprint Functional measurement of coronary stenosis
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 59:1045-57. 2012
    ..In this state-of-the-art paper, the basic concept of FFR and its application, characteristics, and use in several subsets of patients are discussed from a practical point of view...
  4. ncbi request reprint Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
    ..The purpose of this study was to investigate the appropriateness of stenting a functionally nonsignificant stenosis...
  5. doi request reprint Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study
    Nico H J Pijls
    Catharina Hospital, Department of Cardiology, Eindhoven, The Netherlands
    J Am Coll Cardiol 56:177-84. 2010
    ..The purpose of this study was to investigate the 2-year outcome of percutaneous coronary intervention (PCI) guided by fractional flow reserve (FFR) in patients with multivessel coronary artery disease (CAD)...
  6. ncbi request reprint Coronary thermodilution to assess flow reserve: validation in humans
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Circulation 105:2482-6. 2002
    ....
  7. ncbi request reprint Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease
    Wilbert Aarnoudse
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Am J Cardiol 96:1627-30. 2005
    ..In conclusion, when measuring FFR, routinely adding an alpha-blocking agent to adenosine does not affect clinical decision making...
  8. doi request reprint Fractional flow reserve in unstable angina and non-ST-segment elevation myocardial infarction experience from the FAME (Fractional flow reserve versus Angiography for Multivessel Evaluation) study
    Jan Willem E M Sels
    Catharina Hospital, Eindhoven, The Netherlands
    JACC Cardiovasc Interv 4:1183-9. 2011
    ....
  9. doi request reprint Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
    Pim A L Tonino
    Catharina Hospital, Eindhoven, The Netherlands
    N Engl J Med 360:213-24. 2009
    ..It is unclear whether routine measurement of fractional flow reserve (FFR; the ratio of maximal blood flow in a stenotic artery to normal maximal flow), in addition to angiography, improves outcomes...
  10. doi request reprint Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation
    Pim A L Tonino
    Department of Cardiology, Catharina Hospital, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
    J Am Coll Cardiol 55:2816-21. 2010
    ..The purpose of this study was to investigate the relationship between angiographic and functional severity of coronary artery stenoses in the FAME (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation) study...
  11. ncbi request reprint Epicardial stenosis severity does not affect minimal microcirculatory resistance
    Wilbert Aarnoudse
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    Circulation 110:2137-42. 2004
    ..We investigated the feasibility of determining IMR in humans and tested the hypothesis that microvascular resistance is independent of epicardial stenosis...
  12. doi request reprint Gender differences in long-term outcome after primary percutaneous intervention for ST-segment elevation myocardial infarction
    Inge Wijnbergen
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    Catheter Cardiovasc Interv 82:379-84. 2013
    ..The objective of our study is to assess the influence of gender on long-term outcome in patients with STEMI who underwent primary percutaneous intervention (PCI) between January 2006 and May 2008...
  13. ncbi request reprint A combination of thermal methods to assess coronary pressure and flow dynamics with a pressure-sensing guide wire
    Arjen van der Horst
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Med Eng Phys 35:298-309. 2013
    ..Nevertheless, the combined methodology was able to reliably assess diastolic hemodynamics. The diastolic peak flow and average diastolic resistance could be determined with a small relative error of (8 ± 7)% and (7 ± 5)%, respectively...
  14. ncbi request reprint Direct volumetric blood flow measurement in coronary arteries by thermodilution
    Wilbert Aarnoudse
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    J Am Coll Cardiol 50:2294-304. 2007
    ..This study sought to validate a new method for direct volumetric blood flow measurement in coronary arteries in animals and in conscious humans during cardiac catheterization...
  15. doi request reprint Thermal anemometric assessment of coronary flow reserve with a pressure-sensing guide wire: an in vitro evaluation
    Arjen van der Horst
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Med Eng Phys 33:684-91. 2011
    ....
  16. ncbi request reprint Percutaneous coronary intervention or bypass surgery in multivessel disease? A tailored approach based on coronary pressure measurement
    Kees Joost Botman
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Catheter Cardiovasc Interv 63:184-91. 2004
    ..75 yields a similar favorable outcome as CABG in those with three or more culprit lesions despite a similar angiographic extent of disease...
  17. doi request reprint Comparison of drug-eluting and bare-metal stents for primary percutaneous coronary intervention with or without abciximab in ST-segment elevation myocardial infarction: DEBATER: the Eindhoven reperfusion study
    Inge Wijnbergen
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    JACC Cardiovasc Interv 5:313-22. 2012
    ..The goal of this study was to demonstrate superiority of sirolimus-eluting stents (SES) over bare-metal stents (BMS) and of abciximab over no abciximab in primary percutaneous coronary intervention (PCI)...
  18. ncbi request reprint Evaluation of the haemodynamic characteristics of drug-eluting stents at implantation and at follow-up
    Marcel van't Veer
    Department of Cardiology, Catharina Hospital, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Eur Heart J 27:1811-7. 2006
    ....
  19. doi request reprint Coronary pressure never lies
    Jacques J Koolen
    Department of Cardiology, Catharina Hospital Eindhoven, 5602 ZA, Eindhoven, The Netherlands
    Catheter Cardiovasc Interv 72:248-56. 2008
    ..Two such patients are presented in this case report and the reasons for apparent or actual false positive or negative FFR are discussed...
  20. ncbi request reprint Continuous infusion thermodilution for assessment of coronary flow: theoretical background and in vitro validation
    Marcel van't Veer
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Med Eng Phys 31:688-94. 2009
    ..Absolute coronary flow rate can be measured reliably by the continuous infusion method when full mixing is present, under the conditions mentioned above...
  21. doi request reprint Autoregulation of coronary blood flow in the isolated beating pig heart
    Stéphanie Schampaert
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Artif Organs 37:724-30. 2013
    ..e., heart valves, stent grafts, and ventricular assist devices) under well-controlled circumstances, whereas it decreases the necessity of sacrificing large mammalians for performing classical animal experiments. ..
  22. ncbi request reprint Coronary pressure measurement after stenting predicts adverse events at follow-up: a multicenter registry
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Circulation 105:2950-4. 2002
    ..In this multicenter registry, we investigated the relation between optimum physiological stent implantation as assessed by poststent fractional flow reserve (FFR) and outcome at 6 months...
  23. doi request reprint Modeling the interaction between the intra-aortic balloon pump and the cardiovascular system: the effect of timing
    Stéphanie Schampaert
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    ASAIO J 59:30-6. 2013
    ..The physiologic response makes the model an excellent tool for testing the interaction between the IABP and the cardiovascular system, and how alterations of specific IABP parameters (i.e., timing) affect this coupling...
  24. ncbi request reprint False-negative myocardial scintigraphy in balanced three-vessel disease, revealed by coronary pressure measurement
    Wilbert H Aarnoudse
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Int J Cardiovasc Intervent 5:67-71. 2003
    ..54, 0.56, and 0.66 respectively for the LAD, LCX, and RCA, unequivocally demonstrating the presence of balanced three-vessel disease. The patient underwent successful bypass surgery and remained event-free thereafter...
  25. pmc Optimum guidance of complex PCI by coronary pressure measurement
    Nico H J Pijls
    Catharina Hospital, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Heart 90:1085-93. 2004
  26. ncbi request reprint Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: the Venestent study
    Clara E E Hanekamp
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    Catheter Cardiovasc Interv 60:452-7. 2003
    ..Elective stent implantation in de novo SVG lesions is associated with a significant lower target vessel revascularization rate and a significant higher event-free survival at 1-year follow-up as compared to balloon angioplasty...
  27. pmc The relationship between fractional flow reserve, platelet reactivity and platelet leukocyte complexes in stable coronary artery disease
    Jan Willem E M Sels
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    PLoS ONE 8:e83198. 2013
    ..We hypothesized that the presence of significantly flow-limiting stenoses is associated with altered platelet reactivity and formation of platelet-leukocyte complexes...
  28. pmc Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease
    Jan Willem E M Sels
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    PLoS ONE 7:e46356. 2012
    ..We hypothesized that evidence of inducible myocardial ischemia by local lesions, as measured by fractional flow reserve (FFR), is associated with increased levels of blood based inflammatory biomarkers...
  29. ncbi request reprint The hemodynamic effect of intrinsic conduction during left ventricular pacing as compared to biventricular pacing
    Berry M van Gelder
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    J Am Coll Cardiol 46:2305-10. 2005
    ..We sought to investigate the effect of intrinsic conduction over the right bundle on the maximum rate of left ventricular pressure rise (LVdP/dt(max)) during left ventricular (LV) pacing compared to biventricular (BiV) pacing...
  30. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  31. ncbi request reprint Pressure-derived measurement of coronary flow reserve
    Philip MacCarthy
    Cardiovascular Center, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 45:216-20. 2005
    ..We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique...
  32. ncbi request reprint Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses
    Emanuele Barbato
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    Eur Heart J 25:2034-9. 2004
    ..Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia...
  33. ncbi request reprint Prognostic value of coronary blood flow velocity and myocardial perfusion in intermediate coronary narrowings and multivessel disease
    Steven A J Chamuleau
    Departments of Cardiology, Academic Medical Center University of Amsterdam, The Netherlands
    J Am Coll Cardiol 39:852-8. 2002
    ....
  34. ncbi request reprint Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 109:2269-72. 2004
    ..The effect of epicardial artery stenosis on myocardial microvascular resistance remains controversial. Recruitable collateral flow, which may affect resistance, was not incorporated into previous measurements...
  35. ncbi request reprint Validation of coronary flow reserve measurements by thermodilution in clinical practice
    Emanuele Barbato
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Eur Heart J 25:219-23. 2004
    ..The present multicentric study was performed to compare the feasibility of CFR(thermo)obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR(Doppler))...
  36. ncbi request reprint Is it time to measure fractional flow reserve in all patients?
    Nico H J Pijls
    J Am Coll Cardiol 41:1122-4. 2003
  37. ncbi request reprint Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans
    Bernard De Bruyne
    Cardiovascular Center Aalst, Moorselbaan, 164 B 9300 Aalst, Belgium
    Circulation 107:1877-83. 2003
    ..The present study compares different dosages and routes of administration of adenosine 5'-triphosphate (ATP), adenosine, contrast medium, and papaverine regarding their potential to achieve both maximal and steady-state hyperemia...
  38. ncbi request reprint [Diffuse atherosclerotic disease unmasked by invasive physiologic assessment of coronary flow]
    Fernando Mendes Sant'Anna
    Santa Helena Hospital do Coração, Cabo Frio, RJ
    Arq Bras Cardiol 85:135-7. 2005
    ..A gradient was not observed at the stent place. The patient was kept under medical treatment and has been asymptomatic so far...
  39. ncbi request reprint Influence of routine assessment of fractional flow reserve on decision making during coronary interventions
    Fernando M Sant'Anna
    Santa Helena Heart Hospital, Cabo Frio, Brazil
    Am J Cardiol 99:504-8. 2007
    ....
  40. ncbi request reprint Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology
    Morton J Kern
    University of California, Irvine, USA
    Circulation 114:1321-41. 2006
    ..The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care...
  41. ncbi request reprint Acute myocardial infarction and underlying stenosis severity
    Ole Frøbert
    Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, University of Aarhus, Denmark
    Catheter Cardiovasc Interv 70:958-65. 2007
    ..The objective of this study was to investigate the underlying stenosis severity of the culprit lesion in acute myocardial infarction...
  42. ncbi request reprint Determinants of coronary steal in chronic total coronary occlusions donor artery, collateral, and microvascular resistance
    Gerald S Werner
    Clinic for Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany
    J Am Coll Cardiol 48:51-8. 2006
    ..We aimed to assess the mechanisms of coronary steal by direct hemodynamic measurements of the collateral circulation in chronic total coronary occlusions (CTO)...
  43. ncbi request reprint Fractional flow reserve after previous myocardial infarction
    Nico H J Pijls
    Eur Heart J 28:2301-2. 2007
  44. ncbi request reprint Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Am Heart J 154:632-6. 2007
    ..However, some have suggested that invasive physiologic guidance may improve decision making...
  45. ncbi request reprint A physiologically representative in vitro model of the coronary circulation
    Maartje C F Geven
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Physiol Meas 25:891-904. 2004
    ..The pressure and flow signals obtained are similar to physiological human coronary pressure and flow, both for baseline and hyperaemic conditions. The model allows for in vitro evaluation of clinical diagnostic techniques...
  46. ncbi request reprint Assessment of renal artery stenosis severity by pressure gradient measurements
    Bernard De Bruyne
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 48:1851-5. 2006
    ..The purpose of this study was to define "significant" renal artery stenosis (i.e., a stenosis able to induce arterial hypertension)...
  47. ncbi request reprint Morphology of the RV electrogram during LV pacing is related to the hemodynamic effect in cardiac resynchronization therapy
    Berry M van Gelder
    Bakken Research Center, Maastricht, The Netherlands
    Pacing Clin Electrophysiol 30:1381-7. 2007
    ....
  48. ncbi request reprint The interventionalist's dilemma: innocent intimal hyperplasia or in-stent restenosis?
    Nico H J Pijls
    Eur Heart J 25:1970-1. 2004
  49. doi request reprint Assessment of renal artery stenosis: side-by-side comparison of angiography and duplex ultrasound with pressure gradient measurements
    Benny Drieghe
    Cardiovascular Center, OLV Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 29:517-24. 2008
    ..90 can be considered a threshold for defining a significant renal artery stenosis (RAS). The aim of this study was to compare renal angiography (QRA) and colour duplex ultrasound (CDUS) to pressure measurements in assessing RAS...
  50. ncbi request reprint Assessment of renal flow and flow reserve in humans
    Ganesh Manoharan
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 47:620-5. 2006
    ..The purpose of this work was to establish the normal range of maximal renal hyperemic response in humans and to identify the ideal renal vasodilatory stimuli...
  51. ncbi request reprint Assessment of the collateral circulation of the heart
    Nico H J Pijls
    Eur Heart J 27:123-4. 2006
  52. ncbi request reprint Functional assessment of coronary atherosclerosis in the catheterization laboratory: the key role of fractional flow reserve
    Emanuele Barbato
    Department of Cardiology, S Andrea Hospital, La Sapienza University, Rome, Italy
    Ital Heart J 6:549-56. 2005
    ..In addition, many angiographically mild stenoses happen to be hemodynamically significant and, therefore, deserve revascularization, especially in the drug-eluting stent era...