Rob Meloen

Summary

Affiliation: Pepscan Systems
Country: The Netherlands

Publications

  1. ncbi Bioactive peptides based on diversity libraries, supramolecular chemistry and rational design: a new class of peptide drugs. Introduction
    Rob Meloen
    Pepscan Systems BV, Lelystad, The Netherlands
    Mol Divers 8:57-9. 2004
  2. ncbi Design of synthetic peptides for diagnostics
    R H Meloen
    Pepscan Systems, P O Box 2098, 8203 AB Lelystad, The Netherlands
    Curr Protein Pept Sci 4:253-60. 2003
  3. ncbi Active immunization against gonadotrophin-releasing hormone in Chinese male pigs
    X Y Zeng
    Isotope Research Lab, Sichuan Agricultural University, Ya'an, P.R. China
    Reprod Domest Anim 36:101-5. 2001
  4. ncbi GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms
    J A Turkstra
    Pepscan Systems, Edelhertweg 15, 8219 PH, Lelystad, The Netherlands
    Vaccine 23:4915-20. 2005
  5. ncbi Effects of GnRH immunization in sexually mature pony stallions
    J A Turkstra
    Pepscan Systems, Edelhertweg 15, 8219 PH Lelystad, The Netherlands
    Anim Reprod Sci 86:247-59. 2005
  6. ncbi New transport peptides broaden the horizon of applications for peptidic pharmaceuticals
    J P M Langedijk
    Pepscan Systems B V, Lelystad, The Netherlands
    Mol Divers 8:101-11. 2004
  7. ncbi Performance of male pigs immunized against GnRH is related to the time of onset of biological response
    J A Turkstra
    Pepscan Systems B V, 8219 PH Lelystad, The Netherlands
    J Anim Sci 80:2953-9. 2002
  8. ncbi Effects of active immunization against GnRH on serum LH, inhibin A, sexual development and growth rate in Chinese female pigs
    X Y Zeng
    Isotope Research Lab, Sichuan Agricultural University, Ya'an, PR China
    Theriogenology 58:1315-26. 2002
  9. ncbi A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide
    J P M Langedijk
    Pepscan Systems Inc, Edelhertweg 15, PO Box 2098, 8203 AB Lelystad, The Netherlands
    J Virol 76:10383-92. 2002
  10. ncbi Synthetic peptides as functional mimics of a viral discontinuous antigenic site
    J Villen
    Department of Organic Chemistry, University of Barcelona, Marti i Franques 1, E 08028 Barcelona, Spain
    Biologicals 29:265-9. 2001

Collaborators

Detail Information

Publications15

  1. ncbi Bioactive peptides based on diversity libraries, supramolecular chemistry and rational design: a new class of peptide drugs. Introduction
    Rob Meloen
    Pepscan Systems BV, Lelystad, The Netherlands
    Mol Divers 8:57-9. 2004
    ..The molecules of this growing class have exciting potential, not met by classical drugs based on small molecules or recombinant proteins...
  2. ncbi Design of synthetic peptides for diagnostics
    R H Meloen
    Pepscan Systems, P O Box 2098, 8203 AB Lelystad, The Netherlands
    Curr Protein Pept Sci 4:253-60. 2003
    ..Moreover recent results indicate that synthetic molecules may also replace antibodies. Ultimately this will lead to diagnostic assays built of synthetic molecules only...
  3. ncbi Active immunization against gonadotrophin-releasing hormone in Chinese male pigs
    X Y Zeng
    Isotope Research Lab, Sichuan Agricultural University, Ya'an, P.R. China
    Reprod Domest Anim 36:101-5. 2001
    ..The present data demonstrate for the first time that the newly developed anti-GnRH vaccine works very well under practical Chinese pig farming conditions, and can be an attractive alternative to surgical castration...
  4. ncbi GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms
    J A Turkstra
    Pepscan Systems, Edelhertweg 15, 8219 PH, Lelystad, The Netherlands
    Vaccine 23:4915-20. 2005
    ..The results show that GnRH antigens can be designed which generate antibodies that specifically bind GnRH-I, without cross-reacting with other GnRH isoforms...
  5. ncbi Effects of GnRH immunization in sexually mature pony stallions
    J A Turkstra
    Pepscan Systems, Edelhertweg 15, 8219 PH Lelystad, The Netherlands
    Anim Reprod Sci 86:247-59. 2005
    ....
  6. ncbi New transport peptides broaden the horizon of applications for peptidic pharmaceuticals
    J P M Langedijk
    Pepscan Systems B V, Lelystad, The Netherlands
    Mol Divers 8:101-11. 2004
    ..In this assay, a fluorescent signal is generated by internalized enzyme in intact cells and not by membrane-bound or extracellular enzyme...
  7. ncbi Performance of male pigs immunized against GnRH is related to the time of onset of biological response
    J A Turkstra
    Pepscan Systems B V, 8219 PH Lelystad, The Netherlands
    J Anim Sci 80:2953-9. 2002
    ..However, for both characteristics L-IM pigs and intact boars performed better (P < 0.03) than E-IM pigs. Thus, growth performance in L-IM is better than in either E-IM or surgical castrates...
  8. ncbi Effects of active immunization against GnRH on serum LH, inhibin A, sexual development and growth rate in Chinese female pigs
    X Y Zeng
    Isotope Research Lab, Sichuan Agricultural University, Ya'an, PR China
    Theriogenology 58:1315-26. 2002
    ..Our results also question the beneficial effect of surgical castration on growth as compared to intact controls...
  9. ncbi A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide
    J P M Langedijk
    Pepscan Systems Inc, Edelhertweg 15, PO Box 2098, 8203 AB Lelystad, The Netherlands
    J Virol 76:10383-92. 2002
    ..The homology to mammalian RNase 6 supports a possible role of E(rns) in B-cell depletion...
  10. ncbi Synthetic peptides as functional mimics of a viral discontinuous antigenic site
    J Villen
    Department of Organic Chemistry, University of Barcelona, Marti i Franques 1, E 08028 Barcelona, Spain
    Biologicals 29:265-9. 2001
    ..These results demonstrate functional mimicry of the discontinuous site D by the peptides, which are therefore obvious candidates for a multicomponent peptide-based vaccine against FMDV...
  11. ncbi The nature of the bond between peptide and carrier molecule determines the immunogenicity of the construct
    N J Beekman
    Institute for Animal Science and Health (ID-Lelystad, Department of Molecular Recognition, Lelystad, The Netherlands
    J Pept Res 58:237-45. 2001
    ....
  12. ncbi Synthetic peptide vaccines: unexpected fulfillment of discarded hope?
    R H Meloen
    Pepscan Systems B V, 8203 AB Lelystad, The Netherlands
    Biologicals 29:233-6. 2001
    ..Moreover, the ability to mimic complex discontinuous sites by synthetic peptides will have a major impact on the rapidly developing area of therapeutic vaccines...
  13. ncbi Pharmacological characterization of STKR, an insect G protein-coupled receptor for tachykinin-like peptides
    H Torfs
    Laboratory for Developmental Physiology and Molecular Biology, Zoological Institute, K.U. Leuven, Leuven, Belgium
    Arch Insect Biochem Physiol 48:39-49. 2001
    ..calcitrans), also proved to be an STKR-agonist. Stc-TK, a potential physiological ligand for STKR, contains an Ala-residue (or A) instead of a highly conserved Gly-residue (or G). Arch...
  14. ncbi Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus
    J P Langeveld
    Institute for Animal Science and Health (ID-Lelystad, PO Box 65 NL-8200 AB, Lelystad, The Netherlands
    Vaccine 19:3661-70. 2001
    ....
  15. ncbi Monitoring health by values of acute phase proteins
    Erik Gruys
    Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, NL 3508 TD Utrecht, The Netherlands
    Acta Histochem 108:229-32. 2006
    ..Applying such technology may help to address health problems in many countries...