Jan Knol

Summary

Affiliation: Numico Research
Country: The Netherlands

Publications

  1. ncbi request reprint Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants
    Jan Knol
    Numico Research B V, Wageningen, The Netherlands
    J Pediatr Gastroenterol Nutr 40:36-42. 2005
  2. doi request reprint Specific prebiotic oligosaccharides modulate the early phase of a murine vaccination response
    Arjan P Vos
    Danone Research Centre for Specialised Nutrition, Wageningen, The Netherlands
    Int Immunopharmacol 10:619-25. 2010
  3. ncbi request reprint Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomised controlled clinical trial
    Petra A M J Scholtens
    Numico Research B V, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands
    J Pediatr Gastroenterol Nutr 42:553-9. 2006
  4. ncbi request reprint Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides
    Petra A M J Scholtens
    Numico Research, Wageningen 6700 CA, The Netherlands
    J Nutr 138:1141-7. 2008
  5. ncbi request reprint Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice
    Arjan P Vos
    Department of Biomedical Research, Numico Research, Wageningen, The Netherlands
    Pediatr Allergy Immunol 18:304-12. 2007
  6. pmc Quantitative real-time PCR analysis of fecal Lactobacillus species in infants receiving a prebiotic infant formula
    Monique Haarman
    Microbiology Section, Biomedical Research Department, Numico Research B V, P O Box 7005, 6700 CA Wageningen, The Netherlands
    Appl Environ Microbiol 72:2359-65. 2006
  7. pmc Bifidobacterium population analysis in the infant gut by direct mapping of genomic hybridization patterns: potential for monitoring temporal development and effects of dietary regimens
    Rolf Boesten
    Microbiology Department, TNO Quality of Life, Zeist, The Netherlands
    Microb Biotechnol 4:417-27. 2011
  8. doi request reprint Tolerance and safety of the potentially probiotic strain Lactobacillus rhamnosus PRSF-L477: a randomised, double-blind placebo-controlled trial in healthy volunteers
    Richèle D Wind
    Danone Research Centre for Specialised Nutrition, Wageningen, The Netherlands
    Br J Nutr 104:1806-16. 2010
  9. ncbi request reprint Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity--a randomized, double-blind, placebo-controlled study
    Rania Shadid
    Pediatric Immune Regulation Clinical Cooperation Group, Ludwig Maximilians University of Munich, Germany
    Am J Clin Nutr 86:1426-37. 2007
  10. ncbi request reprint A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model
    Arjan P Vos
    Department of Biomedical Research, Numico Research, 6700 CA Wageningen, The Netherlands
    Int Immunopharmacol 6:1277-86. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants
    Jan Knol
    Numico Research B V, Wageningen, The Netherlands
    J Pediatr Gastroenterol Nutr 40:36-42. 2005
    ....
  2. doi request reprint Specific prebiotic oligosaccharides modulate the early phase of a murine vaccination response
    Arjan P Vos
    Danone Research Centre for Specialised Nutrition, Wageningen, The Netherlands
    Int Immunopharmacol 10:619-25. 2010
    ..Furthermore, the results demonstrate that it is critical to consider kinetic aspects of immune-modulatory and prebiotic effects in order to study their interaction in a meaningful way...
  3. ncbi request reprint Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomised controlled clinical trial
    Petra A M J Scholtens
    Numico Research B V, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands
    J Pediatr Gastroenterol Nutr 42:553-9. 2006
    ..The present study aimed at testing the effect of solid foods with added prebiotic galacto- and fructo-oligosaccharides (GOS/FOS) on the composition of the intestinal microbiota of fully formula-fed infants during the weaning period...
  4. ncbi request reprint Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides
    Petra A M J Scholtens
    Numico Research, Wageningen 6700 CA, The Netherlands
    J Nutr 138:1141-7. 2008
    ..were 0.0 and 3.27%, respectively (P = 0.006). In conclusion, an infant milk formula with 6 g/L scGOS/lcFOS results in higher concentrations of fecal sIgA, suggesting a positive effect on mucosal immunity...
  5. ncbi request reprint Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice
    Arjan P Vos
    Department of Biomedical Research, Numico Research, Wageningen, The Netherlands
    Pediatr Allergy Immunol 18:304-12. 2007
    ..As Th1-responses are weak in early life in humans, this might suggest that application of these oligosaccharides in infant formulas will be beneficial for the development of the infant's immune system...
  6. pmc Quantitative real-time PCR analysis of fecal Lactobacillus species in infants receiving a prebiotic infant formula
    Monique Haarman
    Microbiology Section, Biomedical Research Department, Numico Research B V, P O Box 7005, 6700 CA Wageningen, The Netherlands
    Appl Environ Microbiol 72:2359-65. 2006
    ..delbrueckii and less L. paracasei compared to breast-fed infants and OSF-fed infants. An infant milk formula containing a specific mixture of prebiotics is able to induce a microbiota that closely resembles the microbiota of BF infants...
  7. pmc Bifidobacterium population analysis in the infant gut by direct mapping of genomic hybridization patterns: potential for monitoring temporal development and effects of dietary regimens
    Rolf Boesten
    Microbiology Department, TNO Quality of Life, Zeist, The Netherlands
    Microb Biotechnol 4:417-27. 2011
    ..In conclusion, our results show the applicability of comparative genome hybridization to study bifidobacterial populations in infant faecal samples without the use of any amplification step...
  8. doi request reprint Tolerance and safety of the potentially probiotic strain Lactobacillus rhamnosus PRSF-L477: a randomised, double-blind placebo-controlled trial in healthy volunteers
    Richèle D Wind
    Danone Research Centre for Specialised Nutrition, Wageningen, The Netherlands
    Br J Nutr 104:1806-16. 2010
    ..Therefore, we conclude that L. rhamnosus PRSF-L477 can safely be administrated to healthy subjects at a daily dose of 1 × 10¹¹ cfu...
  9. ncbi request reprint Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity--a randomized, double-blind, placebo-controlled study
    Rania Shadid
    Pediatric Immune Regulation Clinical Cooperation Group, Ludwig Maximilians University of Munich, Germany
    Am J Clin Nutr 86:1426-37. 2007
    ..However, it is not known how GOS and FOS influence the microbiota of pregnant women and whether a potential prebiotic effect is transferred to the offspring...
  10. ncbi request reprint A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model
    Arjan P Vos
    Department of Biomedical Research, Numico Research, 6700 CA Wageningen, The Netherlands
    Int Immunopharmacol 6:1277-86. 2006
    ..Clinical studies are being performed to confirm this...
  11. ncbi request reprint Prebiotic oligosaccharides and the enterohepatic circulation of bile salts in rats
    Hester van Meer
    Pediatric Gastroenterology, Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 294:G540-7. 2008
    ..The present data in rats do not support the hypothesis that prebiotics naturally present in human milk contribute to a larger bile salt pool size or altered bile salt pool kinetics...
  12. ncbi request reprint Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and nondigestible oligosaccharides
    Hansjörg Schmelzle
    Centre for Paediatric Medicine, University of Greifswald, Germany
    J Pediatr Gastroenterol Nutr 36:343-51. 2003
    ....
  13. ncbi request reprint Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life
    Astrid M Bakker-Zierikzee
    Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700 EV Wageningen, The Netherlands
    Br J Nutr 94:783-90. 2005
    ..In the Bb-12 group, composition and metabolic activity of the flora were more similar to those of the standard group...
  14. ncbi request reprint Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short-chain fatty acids and microbiota
    Stephane M Schneider
    Department of Gastroenterology and Clinical Nutrition, University Hospital, Nice, France
    Clin Nutr 25:82-90. 2006
    ..The aim of this study was to compare the effects of a multi-fibre-enriched formula (15 g/l) and a fibre-free isoenergetic and isonitrogenous formula on faecal SCFAs and microbiota in long-term enteral nutrition (EN) patients...
  15. ncbi request reprint Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants
    Jan Knol
    Numico Research, Wageningen, Netherlands, and Friedrichsdorf, Germany
    Acta Paediatr Suppl 94:31-3. 2005
    ....
  16. ncbi request reprint Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review
    Silvia Fanaro
    Neonatal Intensive Care Unit, Department of Clinical and Experimental Medicine, University of Ferrara, Italy
    Acta Paediatr Suppl 94:22-6. 2005
    ....
  17. pmc Quantitative real-time PCR assays to identify and quantify fecal Bifidobacterium species in infants receiving a prebiotic infant formula
    Monique Haarman
    Microbiology Section, Biomedical Research Department, Numico Research BV, P O Box 7005, 6700 CA Wageningen, The Netherlands
    Appl Environ Microbiol 71:2318-24. 2005
    ..38% +/- 0.98% for the OSF group). In conclusion, the specific prebiotic infant formula used induces a fecal microbiota that closely resembles the microbiota of breast-fed infants also at the level of the different Bifidobacterium species...
  18. ncbi request reprint Prebiotic carbohydrates in human milk and formulas
    Gunther Boehm
    Numico Research, Friedrichsdorf, Germany
    Acta Paediatr Suppl 94:18-21. 2005
    ..Thus, prebiotic oligosaccharides such as the studied mixture provide beneficial effects for formula-fed infants...
  19. pmc Strain-specific effects of probiotics on gut barrier integrity following hemorrhagic shock
    Misha D Luyer
    Department of Surgery, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Infect Immun 73:3686-92. 2005
    ..Although pretreatment with Lactobacillus spp. may be useful to preserve gut barrier integrity following severe hypotension, a thorough assessment of specific strains seems to be essential...
  20. pmc Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
    Andrea Gori
    Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano Bicocca, Via Solferino 16 20052, Milan, Italy
    J Clin Microbiol 46:757-8. 2008
    ..This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis...
  21. ncbi request reprint The intestinal bacterial colonisation in preterm infants: a review of the literature
    Elisabeth A M Westerbeek
    Department of Pediatrics, Subdivision of Neonatology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Nutr 25:361-8. 2006
    ..As antibiotics delay the normal intestinal colonisation, caution should be given to the treatment with broadspectrum antibiotics in preterm infants at birth and every attempt has to be made to restrict the period of treatment...