F W Van Leeuwen

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. ncbi The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 119:115-26. 1998
  2. ncbi Neuropeptide research discloses part of the secrets of Alzheimer's disease neuropathogenesis: state of the art 2004
    F W Van Leeuwen
    Research Team Molecular Misreading, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    Neurosci Lett 361:124-7. 2004
  3. ncbi Molecular misreading. A new type of transcript mutation in gerontology
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Ann N Y Acad Sci 908:267-81. 2000
  4. ncbi Molecular misreading in non-neuronal cells
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Research Group Molecular Misreading, Amsterdam, The Netherlands
    FASEB J 14:1595-602. 2000
  5. ncbi Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
    F W Van Leeuwen
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    Science 279:242-7. 1998
  6. ncbi Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies
    F W Van Leeuwen
    The Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
    Neurology 66:S86-92. 2006
  7. ncbi Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    J Alzheimers Dis 9:319-25. 2006
  8. ncbi Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Neural Transm Suppl 57:137-59. 1999
  9. ncbi The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2
    B A Gabreëls
    Graduate School Neurosciences, Netherlands Institute for Brain Research, Amsterdam
    J Clin Endocrinol Metab 83:4026-33. 1998
  10. ncbi Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms
    E M Hol
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Mol Psychiatry 8:786-96. 2003

Collaborators

  • E M Hol
  • D F Swaab
  • J P Burbach
  • N G Seidah
  • R Benne
  • B A Gabreëls
  • D Murphy
  • A Salehi
  • H Yamaguchi
  • A Savioz
  • R M Buijs
  • G Leuba
  • P Cras
  • A K Voss
  • Samir Kumar-Singh
  • D J Moore
  • A Neubauer
  • C Thiede
  • D F Fischer
  • C Wilhelm
  • B Alpen
  • O Windl
  • R van Dijk
  • F M S de Vrij
  • J A Sluijs
  • Z A Erkut
  • B Stierstorfer
  • F M De Vrij
  • M Stolte
  • T Wündisch
  • S Beimesche
  • M Buchholz
  • M Neumann
  • H A Kretzschmar
  • S Walter
  • M Groschup
  • W Schulz-Schaeffer
  • S Arendt
  • D M A Mann
  • M A F Sonnemans
  • B Hobo
  • L Mercken
  • C I De Zeeuw
  • W Eichhorn
  • J Eikelenboom
  • W Schmahl
  • O R Kaaden
  • D Huhn
  • C Brendel
  • M Florek
  • S Serke
  • B Mohr
  • T Lion
  • D Goldgaber
  • R Naumann
  • M Ritter
  • L Gregori
  • W T Hermens
  • F Kroschinsky
  • G Geissler
  • H Daxberger
  • G Ehninger
  • G Prange-Krex
  • J Verhaagen
  • R Leo
  • T Diedrich
  • R Grzeskowiak
  • D Scholz
  • I Cierny
  • S Herzig
  • T Alejel
  • W Knepel
  • E Liu
  • H J Gruss
  • E Hertzberg
  • C C Hoogenraad
  • E Goedknegt
  • B Wittig
  • F Grosveld
  • N Galjart
  • A Burchert
  • C Maiwald
  • W Siegert
  • H R Snodgrass
  • D K Graham
  • P Barckow
  • C A Schmidt
  • A Fiebeler
  • R Eisermann
  • L C Chen

Detail Information

Publications30

  1. ncbi The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 119:115-26. 1998
    ..In this chapter we will discuss a few of them, in particular the recent data on mutations in vasopressin RNA. It is to be expected that the HNS will retain its informative role in the next decades...
  2. ncbi Neuropeptide research discloses part of the secrets of Alzheimer's disease neuropathogenesis: state of the art 2004
    F W Van Leeuwen
    Research Team Molecular Misreading, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    Neurosci Lett 361:124-7. 2004
    ....
  3. ncbi Molecular misreading. A new type of transcript mutation in gerontology
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Ann N Y Acad Sci 908:267-81. 2000
    ..Therefore, molecular misreading can be regarded as a general biological source of transcript errors that may be involved in cellular derangements in numerous age-related pathologic conditions apart from Alzheimer's disease...
  4. ncbi Molecular misreading in non-neuronal cells
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Research Group Molecular Misreading, Amsterdam, The Netherlands
    FASEB J 14:1595-602. 2000
    ..This implies that non-neural tissues too, could be affected by cellular derangements caused by molecular misreading...
  5. ncbi Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
    F W Van Leeuwen
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    Science 279:242-7. 1998
    ..This type of transcript mutation is likely an important factor in the widely occurring nonfamilial early- and late-onset forms of Alzheimer's disease...
  6. ncbi Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies
    F W Van Leeuwen
    The Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
    Neurology 66:S86-92. 2006
    ..These data suggest that accumulation of +1 proteins contributes to the early stages of dementia and plays a pathogenic role in a number of diseases that involve the accumulation of tau...
  7. ncbi Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    J Alzheimers Dis 9:319-25. 2006
    ....
  8. ncbi Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
    F W Van Leeuwen
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Neural Transm Suppl 57:137-59. 1999
    ..In the present review some of the critical events in molecular misreading are discussed, the emphasis being on DS...
  9. ncbi The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2
    B A Gabreëls
    Graduate School Neurosciences, Netherlands Institute for Brain Research, Amsterdam
    J Clin Endocrinol Metab 83:4026-33. 1998
    ..These results indicate that in WS patients with diabetes insipidus, not only does VP neuron loss occur in the supraoptic nucleus, but there is also a defect in VP precursor processing...
  10. ncbi Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms
    E M Hol
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Mol Psychiatry 8:786-96. 2003
    ..Apparently, the hippocampal neurons in patients with Alzheimer's disease pathology are capable of expressing glia-specific genes...
  11. ncbi Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40
    R van Dijk
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Neurochem 90:712-23. 2004
    ....
  12. ncbi Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death
    F M De Vrij
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Research Group Molecular Misreading, Amsterdam, The Netherlands
    FASEB J 15:2680-8. 2001
    ..Our results demonstrate that accumulation of UBB+1 in neurones is detrimental and may contribute to neuronal dysfunction in AD patients...
  13. ncbi Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
    F M S de Vrij
    Netherlands Institute for Brain Research, Graduate School for Neurosciences, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Prog Neurobiol 74:249-70. 2004
    ..This review specifically discusses the involvement of the UPS in AD pathogenesis. First, a detailed overview of the UPS is presented, after which AD pathology and its relation to the UPS is discussed...
  14. ncbi Glucocorticoid treatment is associated with decreased expression of processed AVP but not of proAVP, neurophysin or oxytocin in the human hypothalamus: are PC1 and PC2 involved?
    Z A Erkut
    Netherlands Institute for Brain Research, Meibergdreef 33 1105 AZ Amsterdam, The Netherlands
    Neuro Endocrinol Lett 23:33-44. 2002
    ....
  15. ncbi +1 Proteins and aging
    F W Van Leeuwen
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Int J Biochem Cell Biol 34:1502-5. 2002
    ..We have hypothesized that quality control mechanisms for both transcripts and proteins work less efficiently during aging. In this manner +1 proteins may become manifest and contribute to age-related diseases...
  16. ncbi Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect
    B A Gabreëls
    Graduate School Neurosciences, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 83:591-9. 1998
    ..In conclusion, in the VP neurons of two PWS patients, greatly reduced amounts of 7B2 and PC2 are present, resulting in diminished VP precursor processing...
  17. ncbi Vasopressin and noradrenaline coexistence in the rat locus ceruleus: differential decreases of their levels in distant brain areas after thermal and neurotoxic lesions
    A R Caffe
    Netherlands Institute for Brain Research, Amsterdam
    Brain Res 459:386-90. 1988
    ..Only significant ipsilateral depletions of NA levels were found. Therefore, no indications were obtained for VP transport by LC neurons towards distant brain areas...
  18. ncbi Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy
    O Windl
    University of Munich, Istitute of Neuropathology, Munchen, Germany
    J Virol 79:14971-5. 2005
    ..The presence of the murine PrP(C) prolonged the incubation time of TME substantially...
  19. ncbi Equine herpesvirus type 1 (EHV-1) myeloencephalopathy: a case report
    B Stierstorfer
    Institute of Veterinary Pathology, Infectious and Epidemic Diseases, , Germany
    J Vet Med B Infect Dis Vet Public Health 49:37-41. 2002
    ..Virological findings confirmed an acute equine herpesvirus type 1 infection and virus was isolated from the spinal cord of a 26-year-old mare...
  20. ncbi axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
    J P O'Bryan
    Curriculum in Genetics, Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27599
    Mol Cell Biol 11:5016-31. 1991
    ....
  21. ncbi Molecular diagnostics in low-grade gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type after Helicobacter pylori eradication therapy
    B Alpen
    , , Marburg, Germany
    Clin Lymphoma 2:103-8. 2001
    ....
  22. ncbi Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer
    L C Chen
    Geraldine Brush Cancer Research Institute at Pacific Presbyterian Medical Center, San Francisco, CA 94115
    Proc Natl Acad Sci U S A 88:3847-51. 1991
    ....
  23. ncbi Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system. Purification and protein sequencing of the Staphylococcus carnosus histidine-containing protein, and cloning and DNA sequencing of the ptsH gene
    R Eisermann
    Department of Microbiology, Ruhr Universitat Bochum, Federal Republic of Germany
    Eur J Biochem 197:9-14. 1991
    ..carnosus. Comparison of the amino acid sequence of S. carnosus HPr with the HPr sequence of Staphylococcus aureus (derived from peptide sequencing) showed a high degree of similarity...
  24. ncbi Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis
    A Neubauer
    Blood 84:1931-41. 1994
    ..These results suggest that the axl kinase may be operative in normal and malignant myeloid biology...
  25. ncbi Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias
    A Neubauer
    Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin, Abteilung für Innere Medizin Hämatologie, Germany
    Leuk Lymphoma 25:91-6. 1997
    ..Furthermore, a fraction of CD34-positive progenitor cells may express Axl. The exact mechanism for transformation of myeloid progenitor cells through Axl, however, remains to be determined...
  26. ncbi CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies
    C I De Zeeuw
    Department of Anatomy, Erasmus University Rotterdam, The Netherlands
    Neuron 19:1187-99. 1997
    ..Local microtubule depolymerization leads to a temporary reduction of DLBs. These results suggest that CLIP-115 operates in the control of brain-specific organelle translocations...
  27. ncbi Tissue-specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6-binding site determined in normal adult tissues in vivo using transgenic mice
    S Beimesche
    Department of Molecular Pharmacology, University of Gottingen, Germany
    Mol Endocrinol 13:718-28. 1999
    ..The lack of PISCES-mediated transcription in adult islets indicates that the Pax6 protein(s) expressed in adult pancreatic islets function differently from the ones in the eye and cerebellum...
  28. ncbi Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR amplification of short tandem repeat-markers
    C Thiede
    Medizinische Klinik und Poliklinik I, , Dresden, Germany
    Leukemia 15:293-302. 2001
    ..In cases lacking PCR-detectable disease-specific gene products, this assay may represent an alternative to recently established real-time PCR methods...
  29. ncbi Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?
    T Wündisch
    Abteilung für Hämatologie, Onkologie und Immunologie, Philipps Universitat, Marburg, Germany
    Microsc Res Tech 53:414-8. 2001
    ..As of now the only and gold standard for the diagnosis of gastric MALT-lymphoma is histopathology...
  30. ncbi [Molecular tumour therapy: antibodies and small molecules]
    C Wilhelm
    Klinik für Innere Medizin SP Hämatologie, Onkologie, Immunologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Baldingerstrasse 1, 35033, Marburg, Deutschland
    Internist (Berl) 49:581-92. 2008
    ..The limiting factors are i) the drug can only be applied when the targeted protein is expressed; ii) the high cost associated with these therapies...