D F Swaab

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. ncbi Therapeutic strategies for Alzheimer disease: focus on neuronal reactivation of metabolically impaired neurons
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 17:S114-22. 2003
  2. ncbi The stress system in the human brain in depression and neurodegeneration
    Dick F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Ageing Res Rev 4:141-94. 2005
  3. ncbi Sexual differentiation of the human brain: relevance for gender identity, transsexualism and sexual orientation
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Gynecol Endocrinol 19:301-12. 2004
  4. ncbi Reduced neuronal activity and reactivation in Alzheimer's disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 117:343-77. 1998
  5. doi Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
  6. ncbi Diminished neuronal metabolic activity in Alzheimer's disease. Review article
    A Salehi
    Netherlands Institute for Brain Research, Amsterdam
    J Neural Transm 106:955-86. 1999
  7. ncbi Glucocorticoid treatment is associated with decreased expression of processed AVP but not of proAVP, neurophysin or oxytocin in the human hypothalamus: are PC1 and PC2 involved?
    Z A Erkut
    Netherlands Institute for Brain Research, Meibergdreef 33 1105 AZ Amsterdam, The Netherlands
    Neuro Endocrinol Lett 23:33-44. 2002
  8. doi Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Neuroendocrinology 89:187-99. 2009
  9. ncbi Differential expression of estrogen receptor alpha and beta immunoreactivity in the human supraoptic nucleus in relation to sex and aging
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam
    J Clin Endocrinol Metab 85:3283-91. 2000
  10. ncbi Sex- and age-related P75 neurotrophin receptor expression in the human supraoptic nucleus
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroendocrinology 71:243-51. 2000

Collaborators

Detail Information

Publications72

  1. ncbi Therapeutic strategies for Alzheimer disease: focus on neuronal reactivation of metabolically impaired neurons
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 17:S114-22. 2003
    ..We will also discuss a procedure that has been developed to culture human postmortem brain tissue, which allows testing of the efficacy of putative stimulatory compounds...
  2. ncbi The stress system in the human brain in depression and neurodegeneration
    Dick F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Ageing Res Rev 4:141-94. 2005
    ..Although cortisol and CRH may well be causally involved in the signs and symptoms of depression, there is so far no evidence for any major irreversible damage in the human hippocampus in this disorder...
  3. ncbi Sexual differentiation of the human brain: relevance for gender identity, transsexualism and sexual orientation
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Gynecol Endocrinol 19:301-12. 2004
    ..Solid evidence for the importance of postnatal social factors is lacking. In the human brain, structural diferences have been described that seem to be related to gender identity and sexual orientation...
  4. ncbi Reduced neuronal activity and reactivation in Alzheimer's disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 117:343-77. 1998
    ..A number of pharmacological and non-pharmacological studies support the concept that activation of the brain indeed has beneficial effects on several aspects of cognition and other central functions...
  5. doi Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
    ..Whether this sex difference in hippocampal GR-ir in depression relates to the increased incidence of depression in females awaits further study. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  6. ncbi Diminished neuronal metabolic activity in Alzheimer's disease. Review article
    A Salehi
    Netherlands Institute for Brain Research, Amsterdam
    J Neural Transm 106:955-86. 1999
    ..Moreover, ApoE epsilon4 may participate in the pathogenesis of AD by decreasing neuronal metabolism. The main implication of these findings is that therapeutic strategies in AD should be focussed on reactivation of neuronal metabolism...
  7. ncbi Glucocorticoid treatment is associated with decreased expression of processed AVP but not of proAVP, neurophysin or oxytocin in the human hypothalamus: are PC1 and PC2 involved?
    Z A Erkut
    Netherlands Institute for Brain Research, Meibergdreef 33 1105 AZ Amsterdam, The Netherlands
    Neuro Endocrinol Lett 23:33-44. 2002
    ....
  8. doi Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Neuroendocrinology 89:187-99. 2009
    ..We addressed the question whether a novel ER alpha splice variant TADDI is expressed at the protein level in the human brain and whether it changes in relation to aging and Alzheimer's disease (AD)...
  9. ncbi Differential expression of estrogen receptor alpha and beta immunoreactivity in the human supraoptic nucleus in relation to sex and aging
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam
    J Clin Endocrinol Metab 85:3283-91. 2000
    ..Both receptor changes are proposed to participate in the activation of the AVP neurons in postmenopausal women...
  10. ncbi Sex- and age-related P75 neurotrophin receptor expression in the human supraoptic nucleus
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroendocrinology 71:243-51. 2000
    ..Therefore, our results suggest that p75(NTR) is involved in postmenopausal activation of vasopressinergic neurons in the human SON...
  11. ncbi Sex differences in the distribution of androgen receptors in the human hypothalamus
    A Fernandez-Guasti
    Graduate School of Neurosciences, Netherlands Institute for Brain Research, Amsterdam
    J Comp Neurol 425:422-35. 2000
    ..Species differences and similarities of the AR-ir distribution are discussed. The present results suggest the participation of androgens in the regulation of various hypothalamic processes that are sexually dimorphic...
  12. ncbi Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Neurobiol Aging 22:417-26. 2001
    ..The ApoE genotype had no effect on ER expression in the NBM in AD. In conclusion, whereas only minor sex- and age-related changes in both ERs were found in the human NBM, a clear upregulation of ERalpha and beta was observed in AD...
  13. pmc Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent
    A Salehi
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 95:11445-9. 1998
    ..Our data show that the decreased activity of nucleus basalis neurons in AD is ApoE epsilon4 dependent and suggest that ApoE epsilon4 participates in the pathogenesis of AD by decreasing neuronal metabolism...
  14. ncbi Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Brain Res 893:70-6. 2001
    ..In addition, the GA/cell size ratio correlated significantly with age in men and not in women. Our data suggest that androgens play an inhibitory role with respect to the metabolic activity of the human VMN neurons...
  15. ncbi Sex differences in androgen receptors of the human mamillary bodies are related to endocrine status rather than to sexual orientation or transsexuality
    F P Kruijver
    Graduate School of Neurosciences, Netherlands Institute for Brain Research, 1105 Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:818-27. 2001
    ..The functional implications of these alterations are discussed in relation to reproduction, cognition, and neuroprotection...
  16. ncbi Transcutaneous electrical nerve stimulation (TENS) improves the rest-activity rhythm in midstage Alzheimer's disease
    E J Scherder
    Free University, Department of Clinical Psychology, Amsterdam, The Netherlands
    Behav Brain Res 101:105-7. 1999
    ..It is concluded that TENS increased the coupling between the rest activity rhythm and supposedly stable Zeitgebers in an advanced stage of AD...
  17. doi Vasopressin and the output of the hypothalamic biological clock
    A Kalsbeek
    Department of Endocrinology and Metabolism, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Neuroendocrinol 22:362-72. 2010
    ....
  18. ncbi Neurohypophysial peptides in the human hypothalamus in relation to development, sexual differentiation, aging and disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam
    Regul Pept 45:143-7. 1993
    ..e. (i) the supraoptic and paraventricular nucleus and (ii) the suprachiasmatic nucleus, show quite different patterns of changes in the human in relation to development, aging and disease...
  19. ncbi Lack of association between depression and loss of neurons in the locus coeruleus in Alzheimer disease
    W J Hoogendijk
    Netherlands Institute for Brain Research, Department of Psychiatry, Valerius Clinic, Amsterdam
    Arch Gen Psychiatry 56:45-51. 1999
    ....
  20. ncbi Tissue cultures from adult human postmortem subcortical brain areas
    R W H Verwer
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Cell Mol Med 6:429-32. 2002
    ..Such cultures may enable us to study age and disease related processes directly in human brain tissue. Here, we present observations on subcortical brain tissue...
  21. ncbi Alterations in the human brain in menopause
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Maturitas 57:20-2. 2007
    ..No age-related changes were observed for the mentioned splice forms in women of this group...
  22. ncbi Life after death?
    R W H Verwer
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105AZ Amsterdam, The Netherlands
    Neurology 59:1355. 2002
  23. ncbi The stress system in depression and neurodegeneration: focus on the human hypothalamus
    A M Bao
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Brain Res Rev 57:531-53. 2008
    ..However, in postmortem studies we could not find the presumed hippocampal damage of steroid overexposure in either depressed patients or in patients treated with synthetic steroids...
  24. ncbi Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin
    R W H Verwer
    Netherlands Institute for Neuroscience, an Institute of the Netherlands Royal Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Brain 130:3321-35. 2007
    ..Furthermore, our results indicate that in the adult human neocortex DCX is neither a reliable nor a selective marker of neurogenesis...
  25. ncbi The human hypothalamus in metabolic and episodic disorders
    D F Swaab
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA Amsterdam, The Netherlands
    Prog Brain Res 153:3-45. 2006
  26. ncbi Introduction to the sixteenth C.U. Ariëns Kappers lecture
    D F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Prog Brain Res 147:39-41. 2005
  27. ncbi Brain aging and Alzheimer's disease; use it or lose it
    D F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Prog Brain Res 138:343-73. 2002
    ..A procedure has been developed to culture human postmortem brain tissue that allows testing of the efficacy of putative stimulatory compounds such as neurotrophins...
  28. ncbi Post-mortem brain tissue cultures from elderly control subjects and patients with a neurodegenerative disease
    R W H Verwer
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Exp Gerontol 38:167-72. 2003
    ..and fixed or frozen postmortem brain tissue examination...
  29. ncbi Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus
    A Alkemade
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:323-7. 2005
    ..02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depression may contribute to lower serum TSH or symptoms of depression by lowering hypothalamic TRH expression...
  30. ncbi Long-term effects of cranial irradiation for childhood malignancy on sleep in adulthood
    E J W Van Someren
    Netherlands Institute for Brain Research and Institute for Clinical and Experimental Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 150:503-10. 2004
    ..Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood...
  31. ncbi Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression
    J N Zhou
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:655-62. 2001
    ..A disbalance between AVP production and transport needs further investigation in future studies...
  32. ncbi The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2
    B A Gabreëls
    Graduate School Neurosciences, Netherlands Institute for Brain Research, Amsterdam
    J Clin Endocrinol Metab 83:4026-33. 1998
    ..These results indicate that in WS patients with diabetes insipidus, not only does VP neuron loss occur in the supraoptic nucleus, but there is also a defect in VP precursor processing...
  33. ncbi The human hypothalamo-neurohypophysial system in health and disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 119:577-618. 1998
    ..The present paper reviews the changes observed in the human supraoptic (SON) and paraventricular (PVN) nuclei, and their projections to the neurohypophysis, median eminence and to other brain areas in health and disease...
  34. ncbi A sex difference and no effect of ApoE type on the amount of cytoskeletal alterations in the nucleus basalis of Meynert in Alzheimer's disease
    A Salehi
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research
    Neurobiol Aging 19:505-10. 1998
    ..We also found a significant relationship between the number of Alz-50-stained neurons and the severity of dementia...
  35. ncbi Postmortem anterograde tracing of intrahypothalamic projections of the human dorsomedial nucleus of the hypothalamus
    J Dai
    Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research
    J Comp Neurol 401:16-33. 1998
    ..The functional significance of DMH intrahypothalamic connections is discussed...
  36. ncbi Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain
    J Dai
    Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research
    J Comp Neurol 400:87-102. 1998
    ....
  37. ncbi Human retinohypothalamic tract as revealed by in vitro postmortem tracing
    J Dai
    Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research
    J Comp Neurol 397:357-70. 1998
    ..No projections were observed to other hypothalamic areas. The presence of an RHT in humans suggests that the RHT may serve a function in humans similar to that demonstrated in animals...
  38. ncbi Apoptosis during sexual differentiation of the bed nucleus of the stria terminalis in the rat brain
    W C Chung
    Center for Neuroendocrine Studies and Department of Psychology, Tobin Hall, Box 37720, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurobiol 43:234-43. 2000
    ..These results are consistent with the hypothesis that gonadal steroids contribute to the sexually dimorphic differentiation of the BST by controlling the incidence of apoptosis...
  39. ncbi Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect
    B A Gabreëls
    Graduate School Neurosciences, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 83:591-9. 1998
    ..In conclusion, in the VP neurons of two PWS patients, greatly reduced amounts of 7B2 and PC2 are present, resulting in diminished VP precursor processing...
  40. ncbi Male-to-female transsexuals have female neuron numbers in a limbic nucleus
    F P Kruijver
    Graduate School Neurosciences Amsterdam, The Netherlands Institute for Brain Research
    J Clin Endocrinol Metab 85:2034-41. 2000
    ....
  41. doi Neuropeptide alterations in the infundibular nucleus of Huntington's disease patients
    D J van Wamelen
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    J Neuroendocrinol 25:198-205. 2013
    ..These findings indicate that unintended weight loss in patients suffering from this disease may be partly a result of neuropeptidergic alterations in the hypothalamic infundibular nucleus...
  42. ncbi Glucocorticoids suppress corticotropin-releasing hormone and vasopressin expression in human hypothalamic neurons
    Z A Erkut
    Netherlands Institute for Brain Research, Graduate School Neurosciences, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 83:2066-73. 1998
    ....
  43. ncbi Is brain plasticity preserved during aging and in Alzheimer's disease?
    M Mirmiran
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, The Netherlands
    Behav Brain Res 78:43-8. 1996
    ....
  44. doi Hypothalamic vasopressin and oxytocin mRNA expression in relation to depressive state in Alzheimer's disease: a difference with major depressive disorder
    G Meynen
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    J Neuroendocrinol 21:722-9. 2009
    ..This is in contrast with the enhanced AVP gene expression in MDD, suggesting a difference in pathophysiology between MDD and depression in AD...
  45. ncbi A direct androgenic involvement in the expression of human corticotropin-releasing hormone
    A M Bao
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Mol Psychiatry 11:567-76. 2006
    ..We conclude that androgens may directly affect CRH neurons in the human PVN via AR binding to the CRH-ARE, which may have consequences for sex-specific pathogenesis of mood disorders...
  46. ncbi Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock
    V D Goncharuk
    Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    J Comp Neurol 431:320-30. 2001
    ..The difficulty in adjusting from inactivity to activity might be involved in the morning clustering of cardiovascular events...
  47. doi Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances
    S S Wang
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Mol Psychiatry 13:786-99, 741. 2008
    ..These findings raise the possibility that a disturbed balance in the production of receptors may contribute to the activation of the HPA axis in depression...
  48. ncbi Neurotransmitters and neuropeptides in depression
    A M Bao
    Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Handb Clin Neurol 106:107-36. 2012
    ....
  49. doi Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients
    J Zhao
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    J Affect Disord 138:494-502. 2012
    ..The prefrontal cortex (PFC) is presumed to be involved in the pathogenesis of depression...
  50. ncbi Structural and functional sex differences in the human hypothalamus
    D F Swaab
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, 1105 AZ The Netherlands
    Horm Behav 40:93-8. 2001
    ..In this brief article we discuss a few examples of structural and functional sex differences in the human brain...
  51. ncbi Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods
    E J Van Someren
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, The Netherlands
    Chronobiol Int 16:505-18. 1999
    ..Guidelines for analyses of actigraphic data are given to improve the sensitivity to treatment effects in future studies...
  52. ncbi P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease
    A Salehi
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Exp Neurol 161:245-58. 2000
    ....
  53. ncbi Decreased neuropeptide Y (NPY) expression in the infundibular nucleus of patients with nonthyroidal illness
    E Fliers
    Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, 1100 DE, Amsterdam, The Netherlands
    Peptides 22:459-65. 2001
    ..77; p = 0.02). The results suggest a role for decreased NPY input from the IFN in the resetting of thyroid hormone feedback on hypothalamic TRH cells in NTI...
  54. doi Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis
    S Luchetti
    Netherlands Institute for Neuroscience NIN, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Neuroscience 191:6-21. 2011
    ..Finally, suggestions for therapeutic strategies will be included. This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  55. doi Familial neurohypophyseal diabetes insipidus due to a novel mutation in the arginine vasopressin-neurophysin II gene
    M de Fost
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F5 166, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 165:161-5. 2011
    ..The majority of cases is inherited in an autosomal dominant way. In this study, we present the clinical features of a mother and her son with autosomal dominant neurohypophyseal DI caused by a novel mutation...
  56. ncbi Hypothalamic lesions in multiple sclerosis
    I Huitinga
    Graduate School for Neurosciences, Netherlands Institute for Brain Research, Amsterdam
    J Neuropathol Exp Neurol 60:1208-18. 2001
    ..We conclude that systematic pathological investigation of the hypothalamus in MS patients reveals an unexpected high incidence of active lesions that may impact on hypothalamic functioning...
  57. ncbi Cortisol is increased in postmortem cerebrospinal fluid of multiple sclerosis patients: relationship with cytokines and sepsis
    Z A Erkut
    Netherlands Institute for Brain Research, Amsterdam
    Mult Scler 8:229-36. 2002
    ..78, p<0.001). We concluded that the basal level of cortisol is significantly increased in the CSF of MS patients and that IL-6 is not responsible for this rise. The relationship between cortisol and IL-6 in sepsis is discussed...
  58. ncbi Hypothalamic oxytocin mRNA expression and melancholic depression
    G Meynen
    Mol Psychiatry 12:118-9. 2007
  59. ncbi Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients
    J A P van de Nes
    Institute of Neuropathology, University Hospital Essen, 45122, Essen, Germany
    Acta Neuropathol 111:126-38. 2006
    ..These observations cannot be explained by the amyloid cascade hypothesis...
  60. ncbi [Increased activity of stress-regulating systems in Alzheimer disease]
    W J Hoogendijk
    vakgroep Psychiatrie, Vrije Universiteit Amsterdam/GGZ Buitenamstel, Valeriusplein 9, 1075 BG Amsterdam
    Tijdschr Gerontol Geriatr 32:17-23. 2001
    ..These results can be related to another stress related system, the hypothalamo-pituitary-adrenal-(HPA)axis. This means that further evaluation of both of these systems is necessary...
  61. ncbi Senescence, sleep, and circadian rhythms
    S R Pandi-Perumal
    Department of Physiology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Ageing Res Rev 1:559-604. 2002
    ..Further studies will provide additional valuable insights into the understanding of both sleep and circadian rhythms during senescence...
  62. ncbi Alzheimer's disease and NGF signaling
    A Salehi
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Neural Transm 111:323-45. 2004
    ..We will speculate about the possible mechanisms of failed NGF retrograde transport and its relationship to AD pathology...
  63. ncbi Early social stress in male Guinea-pigs changes social behaviour, and autonomic and neuroendocrine functions
    S Kaiser
    University of Munster, Department of Behavioural Biology, Munster, Germany
    J Neuroendocrinol 15:761-9. 2003
    ..Thus, the present study provides clear evidence that early social stress induces changes in endocrine, autonomic and limbic brain function, which is mirrored by changes in male social behaviour...
  64. ncbi High-frequency cranial electrostimulation (CES) in patients with probable Alzheimer's disease
    Erik J A Scherder
    Institute of Human Movement Sciences, University of Groningen, Groningen, The Netherlands
    Am J Phys Med Rehabil 85:614-8. 2006
    ..Similar to the previous study, no improvements on cognition and (affective) behavior were found...
  65. ncbi Cranial electrostimulation (CES) in patients with probable Alzheimer's disease
    E J A Scherder
    Department of Clinical Neuropsychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Behav Brain Res 128:215-7. 2002
    ..Eighteen AD patients, divided into an experimental and a placebo group, were treated for 30 min per day, 5 days a week, for 6 weeks. No improvements in cognition and (affective) behavior were found after CES...
  66. ncbi Co-localization of histamine with GABA but not with galanin in the human tuberomamillary nucleus
    S Trottier
    Unité INSERM de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
    Brain Res 939:52-64. 2002
    ..We conclude that tuberomamillary neurons in human co-express histamine with GABA but, unlike the neurons in rodents, do not express galanin, indicating that neurotransmitter co-localization patterns differ in the two species...
  67. ncbi Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression
    A Alkemade
    Mol Psychiatry 8:838-9. 2003
  68. ncbi Physical activity and executive functions in the elderly with mild cognitive impairment
    E J A Scherder
    Centre of Human Movement Sciences, Kÿksuniversiteit Groningen, Groningen, The Netherlands
    Aging Ment Health 9:272-80. 2005
    ..Firm conclusions about the effectiveness of mild physical activity on EF in the oldest old can only be drawn after studies with larger number of subjects...
  69. pmc A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus
    U Bahnsen
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, FRG
    EMBO J 11:19-23. 1992
    ..These data suggest that a single amino acid exchange within a highly conserved domain of the human vasopressin-associated neurophysin is the primary cause of one form of ADNDI...
  70. ncbi [Chronic pain in dementia and in disorders with a high risk for congnitive impairment]
    E J A Scherder
    Afdeling Klinische Neuropsychologie, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam
    Tijdschr Gerontol Geriatr 36:116-21. 2005
    ..Finally, a number of instruments which are most appropriate to assess pain in communicative and non-communicative patients are discussed...
  71. ncbi Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications
    N A Aziz
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Rev Neurosci 18:223-51. 2007
    ....
  72. ncbi The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain
    A Mayer
    Department of Anatomy and Cell Biology, University of Ulm, Germany
    Neurogenetics 1:281-8. 1998
    ..These genes are candidates for male-specific transcriptional regulators that could confer upon human brain cells the potential for hormone-independent realization and maintenance of genetic sex...