Bernard Metz

Summary

Affiliation: Netherlands Vaccine Institute
Country: The Netherlands

Publications

  1. ncbi Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines
    Bernard Metz
    Laboratory for Product and Process Development, The Netherlands Vaccine Institute NVI, Bilthoven, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Vaccine 22:156-67. 2003
  2. ncbi Identification of formaldehyde-induced modifications in proteins: reactions with model peptides
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute, 3720 AL Bilthoven, The Netherlands
    J Biol Chem 279:6235-43. 2004
  3. ncbi Identification of formaldehyde-induced modifications in proteins: reactions with insulin
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute NVI, Bilthoven, The Netherlands
    Bioconjug Chem 17:815-22. 2006
  4. ncbi The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61
    Bernard Metz
    Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Altern Lab Anim 35:323-31. 2007
  5. ncbi Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute NVI, Bilthoven, The Netherlands
    Vaccine 25:6863-71. 2007
  6. doi Quality-control issues and approaches in vaccine development
    Bernard Metz
    Research and Development Unit, Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Expert Rev Vaccines 8:227-38. 2009
  7. doi Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant
    Marie Régnier
    Unit Vaccinology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 30:6783-8. 2012
  8. ncbi Reduction of animal use in human vaccine quality control: opportunities and problems
    Bernard Metz
    Laboratory for Product and Process Development, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 20:2411-30. 2002

Detail Information

Publications8

  1. ncbi Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines
    Bernard Metz
    Laboratory for Product and Process Development, The Netherlands Vaccine Institute NVI, Bilthoven, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Vaccine 22:156-67. 2003
    ....
  2. ncbi Identification of formaldehyde-induced modifications in proteins: reactions with model peptides
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute, 3720 AL Bilthoven, The Netherlands
    J Biol Chem 279:6235-43. 2004
    ..In conclusion, the use of model peptides enabled us to determine the reactivity of each particular cross-link reaction as a function of the reaction conditions and to identify new reaction products after incubation with formaldehyde...
  3. ncbi Identification of formaldehyde-induced modifications in proteins: reactions with insulin
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute NVI, Bilthoven, The Netherlands
    Bioconjug Chem 17:815-22. 2006
    ..The approach followed in this study may be generally applicable to larger formaldehyde-treated proteins, such as toxoids used in vaccines...
  4. ncbi The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61
    Bernard Metz
    Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Altern Lab Anim 35:323-31. 2007
  5. ncbi Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques
    Bernard Metz
    Unit Research and Development, The Netherlands Vaccine Institute NVI, Bilthoven, The Netherlands
    Vaccine 25:6863-71. 2007
    ..We recommend further validation of these techniques for quality control of diphtheria toxoid vaccine because of their high precision and easy performance as compared to conventional in vivo procedures...
  6. doi Quality-control issues and approaches in vaccine development
    Bernard Metz
    Research and Development Unit, Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Expert Rev Vaccines 8:227-38. 2009
    ..This review highlights the quality-control issues and approaches in vaccine development from different viewpoints: discovery, process development, assay development, clinical development and the postlicensing phase...
  7. doi Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant
    Marie Régnier
    Unit Vaccinology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 30:6783-8. 2012
    ..Since physicochemical methods can be used to monitor these conformational changes, these analytical methods might offer a tool in regulatory required vaccine quality control by demonstrating consistency in production...
  8. ncbi Reduction of animal use in human vaccine quality control: opportunities and problems
    Bernard Metz
    Laboratory for Product and Process Development, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 20:2411-30. 2002
    ..Inextricably bound up with this approach is good manufacturing practice (GMP), resulting in robust, validated production processes...