Hendrik C Korswagen

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. pmc Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction
    Julie E Gleason
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Genes Dev 16:1281-90. 2002
  2. ncbi request reprint Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme
    Hendrik C Korswagen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Bioessays 24:801-10. 2002
  3. ncbi request reprint Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells
    Pei Tzu Yang
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Cell 14:140-7. 2008
  4. pmc The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
    Hendrik C Korswagen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Genes Dev 16:1291-302. 2002
  5. ncbi request reprint Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
    Tony Oosterveen
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Biol 308:438-48. 2007
  6. doi request reprint The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts
    Teije C Middelkoop
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Biol 361:338-48. 2012
  7. doi request reprint A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
    Martin Harterink
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Cell Biol 13:914-23. 2011
  8. pmc Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8
    Gwen Soete
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology and Center for Biomedical Genetics, Uppsalalaan, Utrecht, The Netherlands
    BMC Dev Biol 7:20. 2007
  9. ncbi request reprint Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control
    Marie Silhankova
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Curr Opin Genet Dev 17:320-5. 2007
  10. pmc Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
    Martin Harterink
    Hubrecht Institute, Royal Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    Development 138:2915-24. 2011

Collaborators

  • Gwen Soete
  • Edwin Cuppen
  • Peter J Cullen
  • R H Plasterk
  • Jonathan Pettitt
  • Boudewijn M T Burgering
  • Teije C Middelkoop
  • Martin Harterink
  • Marco C Betist
  • Magdalena J Lorenowicz
  • Pei Tzu Yang
  • Marie Silhankova
  • Damien Y M Coudreuse
  • Damien Coudreuse
  • Alexander van Oudenaarden
  • Alex Holmes
  • Tony Oosterveen
  • Marieke A G Essers
  • Alexander M van der Linden
  • Julie E Gleason
  • Jeroen Luchtenberg
  • Lisa Williams
  • Ni Ji
  • Cynthia Kenyon
  • Thang Dinh Doan
  • Roy G H P van Heesbeen
  • Ian J McGough
  • Dong Hyun Kim
  • Konrad Basler
  • Jan R T van Weering
  • Fillip Port
  • Trevor C Dale
  • Joost Bergsma
  • Aileen Flett
  • Elizabeth Fraser
  • Giulietta Roël
  • Olivier Destree
  • Nick Barker
  • Paulien E Polderman
  • Lydia M M de Vries-Smits
  • Celine Moorman
  • David M Eisenmann

Detail Information

Publications16

  1. pmc Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction
    Julie E Gleason
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Genes Dev 16:1281-90. 2002
    ..These data suggest that hyperactivation of Wnt signaling is sufficient to cause VPCs to adopt induced fates and that a canonical Wnt pathway may play an important role during C. elegans vulval induction...
  2. ncbi request reprint Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme
    Hendrik C Korswagen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Bioessays 24:801-10. 2002
    ....
  3. ncbi request reprint Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells
    Pei Tzu Yang
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Cell 14:140-7. 2008
    ..We propose that MIG-14/Wls cycles between the Golgi and the plasma membrane to mediate Wnt secretion. Regulation of this transport pathway may enable Wnt-producing cells to control the range of Wnt signaling in the tissue...
  4. pmc The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
    Hendrik C Korswagen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Genes Dev 16:1291-302. 2002
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans...
  5. ncbi request reprint Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
    Tony Oosterveen
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Biol 308:438-48. 2007
    ..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling...
  6. doi request reprint The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts
    Teije C Middelkoop
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Biol 361:338-48. 2012
    ..We conclude that MIG-21 and UNC-40 control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the two Q neuroblasts...
  7. doi request reprint A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
    Martin Harterink
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Cell Biol 13:914-23. 2011
    ..These results demonstrate that SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of Wls from other retromer cargo...
  8. pmc Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8
    Gwen Soete
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology and Center for Biomedical Genetics, Uppsalalaan, Utrecht, The Netherlands
    BMC Dev Biol 7:20. 2007
    ..Several mutations that give a long body size (Lon) phenotype have been characterized and found to be regulated by the DBL-1/TGF-beta pathway, that controls post-embryonic growth and male tail development...
  9. ncbi request reprint Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control
    Marie Silhankova
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Curr Opin Genet Dev 17:320-5. 2007
    ..A common theme that emerges from these studies is that multiple Wnt proteins function in parallel as instructive cues or permissive signals to control neuronal patterning along this major body axis...
  10. pmc Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
    Martin Harterink
    Hubrecht Institute, Royal Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    Development 138:2915-24. 2011
    ..Our results in C. elegans support the notion that a system of posterior Wnt signaling and anterior Wnt inhibition is an evolutionarily conserved principle of primary body axis specification...
  11. doi request reprint Sailing with the Wnt: charting the Wnt processing and secretion route
    Magdalena J Lorenowicz
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Exp Cell Res 315:2683-9. 2009
    ..In this review, we will give an overview of the Wnt maturation and secretion pathway and discuss how this process may influence the spreading and signalling activity of Wnt...
  12. ncbi request reprint The making of Wnt: new insights into Wnt maturation, sorting and secretion
    Damien Coudreuse
    Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Development 134:3-12. 2007
  13. ncbi request reprint Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C
    Alexander M van der Linden
    Hubrecht Laboratory, Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Curr Biol 13:516-21. 2003
    ..elegans. Taken together, our findings provide a potential molecular mechanism for the transforming capability of G(12) proteins...
  14. ncbi request reprint Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  15. ncbi request reprint Wnt gradient formation requires retromer function in Wnt-producing cells
    Damien Y M Coudreuse
    Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands
    Science 312:921-4. 2006
    ..These results demonstrate that the ability of Wnt to regulate long-range patterning events is dependent on a critical and conserved function of the retromer complex within Wnt-producing cells...
  16. ncbi request reprint C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex
    Alex Holmes
    Cell and Developmental Biology Program, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    J Cell Sci 120:2741-51. 2007
    ....